期刊文献+
共找到46篇文章
< 1 2 3 >
每页显示 20 50 100
Fairy shrimp Branchinella kugenumaensis displays sensitivity to microplastic exposure
1
作者 Yingying ZHANG Xinrui XU +2 位作者 Wenbo SUN Yuting WANG Hui YANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第4期1186-1199,共14页
The increasing global concern regarding plastic pollution has prompted the research into the consequences of microplastics(MPs)on aquatic ecosystems.Fairy shrimp Branchinella kugenumaensis are freshwater planktonic or... The increasing global concern regarding plastic pollution has prompted the research into the consequences of microplastics(MPs)on aquatic ecosystems.Fairy shrimp Branchinella kugenumaensis are freshwater planktonic organisms that have existed for 250 million years.This study aimed to uncover the harmful effects of MPs,with a particular focus on their size variations(0.1,1,and 5μm),on the fairy shrimp.We focused on how MPs could significantly affect the survival and growth of fairy shrimp.Notably,larger MPs,especially those measuring 5μm,caused higher mortality rates and hindered the growth compared to smaller ones.The impact of MPs continued even subsequent to depuration in clean water.The accumulation of MPs within the intestines of fairy shrimp resulted in intestinal blockages,disrupted excretory functions,and harmed intestinal epithelial cells.Examinations at the histological,cellular,and molecular levels showed that exposure to MPs triggered necroptosis in intestinal cells,accompanied by alterations in pathways related to transcription,translation,digestion,energy metabolism,and neurological functions.Furthermore,the effects of MPs on gene expression and pathways varied based on particle size,with larger MPs having a more significant effect and causing a strong response in xenobiotic biodegradation and metabolism pathways.We suggest that the increasing severity of MPs pollution could pose a significant threat to the survival of fairy shrimp.This study provided vital insights into the complex relationship between microplastics and aquatic organisms,and highlighted the urgent need to address the potential devastating impact of plastic pollution on freshwater ecosystems.Additionally,due to their rapid growth,strong reproductive capacity,sensitivity,and ease of cultivation,fairy shrimp hold the potential candidate to serve as a model organism for studying the effects of MPs and other pollutants on freshwater ecosystems. 展开更多
关键词 microplastic freshwater ecosystem toxic effects fairy shrimp model organism
下载PDF
Toxicity Effect of Hg^(2+) and Cr(VI) on Alga Growth in Eutrophic Water
2
作者 毕东苏 钱春龙 《Agricultural Science & Technology》 CAS 2007年第3期25-28,72,共5页
[ Objective] The toxicity effect of Hg^2+ and Cr(Ⅵ) on alga growth in eutrophic water was studied to provide reference for biomonitoring and bioremediation of eutrophic water. [ Method ] The mother liquid of alga,... [ Objective] The toxicity effect of Hg^2+ and Cr(Ⅵ) on alga growth in eutrophic water was studied to provide reference for biomonitoring and bioremediation of eutrophic water. [ Method ] The mother liquid of alga, which was separated from the eutrophic water, were put into the solutions of Hg^2+ and Cr(Ⅵ) with different concentrations and their mixture solution, respectively. And the toxicity effect of Hg^2+ and Cr(Ⅵ) on the growth and propagation of alga in eutrophic water was observed. [ Result] The alga in eutrophic water performed rather sensitive to Cr(Ⅵ) and when its concentration was over 1 mg/L, threre was obvious effect on alga growth. The alga was not very sensitive to Hg^2+ when its concentration was lower, but its toxicity became stronger and stronger when its concentration increased to some extent and the toxicity effect of Cr(Ⅵ) on alga growth was just on the contrary. When the ion concentration was lower than 10 mg/L, the toxicity of Hg^2+ on alga was lower than that of Cr(Ⅵ). When the concentration was over 10 mg/L, the toxicity of Hg^2+ exceeded that of Cr(Ⅵ). The toxicity of ion mixture solution of Hg^2+ and Cr(Ⅵ) had synergism inhibition on alga, which could be performed only when the concentration was over 4 mg/L. [ Conclusion] The toxicity of heavy metal on alga not only related to the alga cell, but also related to the concentration of heavy metal ion. 展开更多
关键词 ALGA Hg^2+ Cr(Ⅵ) toxicity effect
下载PDF
Bioaccumulation and Toxicity of Neodymium in the Planarian Dugesia japonica 被引量:1
3
作者 邢军 张秀珍 王学 《Agricultural Science & Technology》 CAS 2014年第8期1364-1367,共4页
In this study, the bioaccumulation and toxicity of neodymium (Nd) in pla-narian Dugesia japonica were investigated. The results showed that with the in-creasing dietary Nd supplementation, the concentration of Nd in... In this study, the bioaccumulation and toxicity of neodymium (Nd) in pla-narian Dugesia japonica were investigated. The results showed that with the in-creasing dietary Nd supplementation, the concentration of Nd in the planarian showed a significant linear increase and the balance of mineral elements was bro-ken with the decrease of Ca, Fe and Mo, and the increase of K and Mg. The content of soluble proteins and the activities of superoxide dismutase (SOD) and catalase (CAT) decreased with the increase of Nd concentration, while the content of H2O2 rose gradual y. The mortality was directly proportional to the Nd concentra-tion. The results indicated that planarian is a very sensitive aquatic animal to Nd contamination and can be an indicator organism for Nd pol ution. 展开更多
关键词 ND PLANARIAN Antioxidant enzymes Toxic effects
下载PDF
Toxicity of perfluorononanoic acid and perfluorooctane sulfonate to Daphnia magna 被引量:1
4
作者 Guang-hua Lu Jian-chao Liu +1 位作者 Li-sha Sun Lu-jin Yuan 《Water Science and Engineering》 EI CAS CSCD 2015年第1期40-48,共9页
In order to study toxicological effects of perfluorononanoic acid (PFNA), perfluorooctane sulfonate (PFOS), and their mixtures (PFNA/ PFOS) on Daphnia magna (D. magna), a suite of comprehensive toxicity tests ... In order to study toxicological effects of perfluorononanoic acid (PFNA), perfluorooctane sulfonate (PFOS), and their mixtures (PFNA/ PFOS) on Daphnia magna (D. magna), a suite of comprehensive toxicity tests were conducted, including a 48-h acute toxicity test, a 21-day chronic test, a feeding experiment, and a biomarker assay. D. magna were exposed to aqueous solutions of PFNA and PFOS (alone and in combination) at concentrations ranging from 0.008 to 5 mg/L. The survival, growth, and reproduction of D. magna were monitored over a 21- day life cycle. The biomarkers, including acetylcholinesterase (ACHE), superoxide dismutase (SOD), and catalase (CAT) activities, were determined after seven days of exposure. PFOS was more toxic than PFNA based on the results of the acute toxicity test. Perfluorinated compounds (PFCs) inhibited both growth and reproduction of D. magna during the testing period. The ingestion rates and the biomarkers, including ACHE, SOD, and CAT activities, were significantly inhibited by PFCs in most cases. Moreover, the combined effects related to the growth and reproduction showed the antagonistic effects of PFCs. 展开更多
关键词 toxicity effect Perfluorononanoic acid Perfluorooctane sulfonate Daphnia magna REPRODUCTION Ingestion rate BIOMARKER
下载PDF
Exposure Level, Toxicity Effects and Health Risk Assessment of Organophosphorus Flame Retardants in Water Environment 被引量:1
5
作者 WEN Xin SHEN Meng +3 位作者 HAN Hui WANG An-wei ZHAI Juan WAN Yu-shan 《Agricultural Science & Technology》 CAS 2018年第6期31-42,共12页
Organophosphorus flame retardants(OPFRs) are gradually replacing brominated flame retardants(BFRs), which are widely used in the world. The increasing output of OPFRs and the increasing detection of OPFRs in environme... Organophosphorus flame retardants(OPFRs) are gradually replacing brominated flame retardants(BFRs), which are widely used in the world. The increasing output of OPFRs and the increasing detection of OPFRs in environmental media have attracted wide attention of scholars at home and abroad. OPFRs are generally semi-volatile, easy to enter the environment and accumulate in organisms,causing potential hazards to the environment and human health. In this paper, the pollution status and toxic effects of OPFRs in aquatic environment were introduced,and the research progress of human health risk caused by them was summarized.The existing problems were pointed out, and the future research was prospected. In the future, the analytical methods of various environmental and biological media should be improved, and comprehensive and in-depth environmental investigation and ecological and health risk assessment should be carried out. Attention should be paid to the effects of combined pollution on organisms and the study of biological acceptability. 展开更多
关键词 Organophosphorus flame retardant Exposure level toxicity effect Health risk assessment
下载PDF
Protective Effects of Calcium Antagonists on Cadmium-induced Toxicity in Rats 被引量:3
6
作者 YANG XIANFANG YANG YONG-NIAN(Institute of Applied Toxicology, Nanjing the Medical University,Nanjing 210029, China)Abbreviation are Ca, calcium +5 位作者 CaM, calmodulin Cd, cadmium CPZ, chlorpromazine Hb, hemogobin NIMO, nimodepine NAG, N-acetyl-β-D- gluco 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第4期402-407,共6页
Protective effects of calcium antagonists, chlorpromazine (CPZ) and nimodepine (NI-MO), on cadmium-induced toxicity were investigated. After giving CdCl2 (0. 44mg Cd/kg,ip), CPZ (5mg/kg, ip) or NIMO (8mg/kg, po) were ... Protective effects of calcium antagonists, chlorpromazine (CPZ) and nimodepine (NI-MO), on cadmium-induced toxicity were investigated. After giving CdCl2 (0. 44mg Cd/kg,ip), CPZ (5mg/kg, ip) or NIMO (8mg/kg, po) were administered every day to Sprague-Dawley (S. D. ) rats for a week. Then, urinary N- acetyl-β-D- glucosaminidase (NAG ), uri -nary cadmium and bloocl cadmium were measured. The accumulation of cadmium in the kid-ney cortex, content of renal calmodulin, hemoglobin and the ultrastructural damage of proxi-mal convoluted tubules of rats were examined three weeks after the last administration. Re-sults indicated that the calcium antagonists partly protected against toxic effects induced bycadmium in different manners. These data provide further evidence for the new hypothesisthat the cross effect of cadmium and calcium in calmodulin regulated systems may be responsi-ble for the mechanism of cadmium intoxication. 'The results suggested that the calcium antag-onists could be a new and promising approach in the therapy of heavy metaLinduced diseases 展开更多
关键词 RE Protective Effects of Calcium Antagonists on Cadmium-induced toxicity in Rats
下载PDF
Review of Modern Research on Toxicity of Traditional Chinese Medicine Aconm Lateralis Radix Praeparaia
7
作者 Lingyu DENG Si LIN +1 位作者 Huizhen QIN Hua ZHU 《Medicinal Plant》 CAS 2021年第3期55-59,71,共6页
The traditional Chinese medicine Aconm Lateralis Radix Praeparaia(Fuzi)is pungent and sweet in taste,hot in nature,and has high toxicity.It governs the meridians of the heart,kidney and spleen.It has the functions of ... The traditional Chinese medicine Aconm Lateralis Radix Praeparaia(Fuzi)is pungent and sweet in taste,hot in nature,and has high toxicity.It governs the meridians of the heart,kidney and spleen.It has the functions of restoring yang to save from collapse,dispersing cold and removing dampness,and warming the middle to relieve pain.It is often used for the treatment of yang collapse,cold limbs,weak pulse,heart yang deficiency,heart pain due to chest impediment,abdominal cold-pain,kidney yang deficiency,impotence and cold in womb,and syndrome of exogenous disease due to yang deficiency,etc.Its great yang qi and strong medicinal properties often bring about toxic and adverse effects.However,after processing or combination with other medicinal materials,the effects of Aconm Lateralis Radix Praeparaia are quite different.Not only the toxicity is greatly reduced,but also the curative effects are strengthened.Through searching related literature,this paper reviewed the researches about the toxicity reduction and curative effect improvement of Aconm Lateralis Radix Praeparaia,in order to provide a certain theoretic reference for future further research of Aconm Lateralis Radix Praeparaia. 展开更多
关键词 Aconm Lateralis Radix Praeparaia toxicity reduction and curative effect improvement REVIEW
下载PDF
Effect of TCDD on Maternal Toxicity and Chorionic Gonadotropin──Bioactivity in the Immediate Post-implantation Period of Macaque
8
作者 GUOYUMEI WANGSHUYI +1 位作者 WANGXINRU LASLEYBILL 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2000年第1期26-31,共6页
The purpose of this experiment was to observe the alterations in bioactivity of chorionic gonadotropin (CG) associated with early fetal loss (EFL), induced by the environmental toxin TCDD (2,3,7,8\|tetrachlorodibenzo\... The purpose of this experiment was to observe the alterations in bioactivity of chorionic gonadotropin (CG) associated with early fetal loss (EFL), induced by the environmental toxin TCDD (2,3,7,8\|tetrachlorodibenzo\| p \|dioxin) in the cynomolgus macaque. Ten of twelve females administered single doses of 1, 2 or 4 μg/kg TCDD on gestational day (GD) 12 had EFL from ten to twenty days later. Seven control animals treated only with the vehicle had normal pregnancies. Blood samples were repeatedly collected for hormone evaluation, from two days before treatment to thirty\|one days following treatment. Immunoreactive monkey chorionic gonadotropin (mCG) was measured in serum using ELISA, and bioactive mCG was measured using a luminescence LH/CG bioassay. No change in immunoreactive mCG levels was detected as a result of TCDD, treatment, but bioactive mCG levels were significantly lower in TCDD\|treated animals compared to controls. This change in bioactivity of mCG was also reflected in the ratio of mCG bioactivity to mCG immunoreactivity (B/I ratio) which began to rise in normal pregnancies by GD 20, but did not rise in TCDD treated animals. These results demonstrate that normal pregnancy in the monkey, as in humans, is characterized by a post\|implantation change in the B/I ratio of CG. These findings therefore suggest that changes in the production of bioactive CG may be used as a biomarker of environmental toxicant exposures which lead to EFL. 展开更多
关键词 Effect of TCDD on Maternal toxicity and Chorionic Gonadotropin Bioactivity in the Immediate Post-implantation Period of Macaque
下载PDF
Clinical Observation on the Efficacy Enhancing and Toxicity Attenuating Effect of Nuzhen Yangyin Granule to the Anti-Parkinsonism Therapy Mainly with Medopa
9
作者 胡学军 杨晓苏 +4 位作者 杨旭光 周东阳 谭光波 伍大华 阳立 《Chinese Journal of Integrated Traditional and Western Medicine》 2004年第1期28-28,共1页
Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with medopa and ar-tane. Methods: Adopting t... Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with medopa and ar-tane. Methods: Adopting the randomized double-blinded method, the effect of adding NYG to 30 patients with Parkinsonism in the treated group, 展开更多
关键词 Clinical Observation on the Efficacy Enhancing and toxicity Attenuating Effect of Nuzhen Yangyin Granule to the Anti-Parkinsonism Therapy Mainly with Medopa
下载PDF
Protective Effects of Certain Natural and Synthetic Complexans on the Toxicity of Chromium and Tin to a N_2-Fixing Cyanobacterium, Anabaena doliolum
10
作者 LC.RAI S.K.DUBEY 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1989年第3期271-281,共11页
The effects of chromium and tin on survival, growth, carbon fixation, nitrate reduction, ammonia assimilation, and nitrogenase activity of a N_2-fixing cyanobacterium, Anabaena doliolum, and their amelioration by synt... The effects of chromium and tin on survival, growth, carbon fixation, nitrate reduction, ammonia assimilation, and nitrogenase activity of a N_2-fixing cyanobacterium, Anabaena doliolum, and their amelioration by synthetic and natural complexans, viz., EDTA, nitrilotriacetic acid (NTA), pyridine dicarboxylic acid (PDA), and citrate, have been studied. Chromium proved to be much more toxic than tin, as it inhibited growth yield (49%), carbon fixation (53%), and nitrate reductase (79%), glutamine synthetase (30%), and nitrogenase activities (77%) at its sublethal concentration, whereas tin induced less inhibition of growth yield (42%), carbon fixation (50%). and nitrate reductase (66%), glutamine synthetase (32.4%), and nitrogenase activities (70%). Despite its inhibitory effects at 10μml^(-1), EDTA supplementation in metal-spiked medium counteracted the toxicity of chromium and tin more significantly than NTA, PDA, and citrate. When supplemented with LD_(50) of Cr, EDTA protected growth, carbon fixation, NR, GS. and Noase, respectively, by 32.6, 50.0, 33.3. 17.7. and 65.4%. However, EDTA-induced restoration of the above parameters at a sublethal concentration of tin was only 30.2, 50.0,28.1, 27.7, and 61.5%, respectively. Although NTA and citrate at 10/μgml^(-1) each were stimulatory to various processes of test cyanobacterium, they were comparatively less effective than EDTA in the amelioration of metal toxicity. On the basis of these observations, a generalized hierarchical sequence of protective efficiency of synthetic and natural cornplexing ligands may be given as EDTA > NTA > citrate > PDA. It seems plausible that the toxicity of various heavy metals may be regulated by a large array of organic complexing agents of the aquatic environment because they possess various metal binding sites. (c) 1989 Academic Press,lnc. 展开更多
关键词 NTA Anabaena doliolum Protective Effects of Certain Natural and Synthetic Complexans on the toxicity of Chromium and Tin to a N2-Fixing Cyanobacterium PDA EDTA 络合试剂 Cr
下载PDF
Histological Assessment and Transcriptome Analysis Provide Insights into the Toxic Effects of Perfluorooctanoic Acid to Juvenile Half Smooth Tongue Sole Cynoglossus semilaevis
11
作者 ZHAN Min SHI Kunpeng +7 位作者 ZHANG Xue FAN Qingxin XU Qian LIU Xinbao LI Zhujun LIU Hongning XIA Yanting SHA Zhenxia 《Journal of Ocean University of China》 SCIE CAS CSCD 2023年第6期1635-1648,共14页
Perfluorooctanoic acid(PFOA)is a widespread synthetic persistent organic pollutant that may enrich along the food chain and affect the growth,development,reproduction,and lipid metabolism of aquatic organisms,particul... Perfluorooctanoic acid(PFOA)is a widespread synthetic persistent organic pollutant that may enrich along the food chain and affect the growth,development,reproduction,and lipid metabolism of aquatic organisms,particularly the benthic organisms.How-ever,the toxic effects of PFOA on the half-smooth tongue sole Cynoglossus semilaevis,a commercial benthic fish in China,have rarely been reported.Because juvenile fish are sensitive to environmental pollutants,in the present study,histological assessment and tran-scriptome sequencing were performed to determine the short-term impact of PFOA on juvenile half-smooth tongue soles.Histologi-cal analysis showed that PFOA exposure caused hepatocyte rupture,intestinal villi breakage,increased goblet cell count,and brain ab-normal.Transcriptome results showed that some interesting signaling pathways,such as glycolysis/gluconeogenesis,PPAR signaling pathway and GABAergic synapse signaling pathway,were enriched after PFOA exposure.In addition,some metabolic,immune and neural genes were differentially expressed,which including ependymin,hbb1-like and gad 1,and they were up-regulated after 14 days of exposure.Transcriptome results also indicated that half-smooth tongue sole might improve energy metabolism in response to PFOA toxicity after 7 days of exposure.These findings provide a basis for studying the ecological effects of PFOA on marine benthic fishes. 展开更多
关键词 Cynoglossus semilaevis histological assessment perfluorooctanoic acid transcriptome analysis toxic effect
下载PDF
Study on Tolerance and Biosorption of Various Microalgae Species to Arsenic
12
作者 李妍丽 柯林 《Agricultural Science & Technology》 CAS 2012年第6期1303-1308,1327,共7页
[Objective] This study aimed to select microalgae species which are capable to effectively remove arsenic contamination from water under natural conditions. [Method] Four microalgae species [Chlorella sp. (zfsaia), ... [Objective] This study aimed to select microalgae species which are capable to effectively remove arsenic contamination from water under natural conditions. [Method] Four microalgae species [Chlorella sp. (zfsaia), Chlorella minata, Chlorella vulgaris and Selenastrum capricormulum] were used as experimental materials and cultured with six different concentrations of As (Ⅲ) (0.5, 1.0, 2.0, 5.0, 10.0, 20.0 mg/L). Biomass, chlorophyll a content and other physiological indicators were determined to investigate the arsenic tolerance and biosorption of four microalgae species. [Result] Chlorella sp. is sensitive to arsenic toxicity, its growth was inhibited when arsenic concentration exceeded 10 mg/L, with an EC 50 of 17.32 mg/L; when the arsenic concentration was 0-20 mg/L, growth of S.c, ww1 and C.v was not affected, which showed relatively high tolerance to arsenic, with arsenic removal rates of 77.02% , 72.18% and 81.36% respectively after 24 h. [Conclusion] This study indicates that microalgae have good application prospects for processing arsenic wastewater and being indicator plants of arsenic wastewater. 展开更多
关键词 As(Ⅲ) MICROALGAE toxicity effect BIOSORPTION
下载PDF
Toxic Effects of Lanthanum, Cerium, Chromium and Zinc on Potamogeton Malaianus 被引量:14
13
作者 王学 施国新 +1 位作者 徐勤松 王春涛 《Journal of Rare Earths》 SCIE EI CAS CSCD 2005年第3期367-371,共5页
The toxic effects of rare earth elements such as lanthanum, cerium and heavy metal elements such as chromium, zinc on Potamogeton malaianus Miq. were studied. The results show that the contents of chlorophyll and solu... The toxic effects of rare earth elements such as lanthanum, cerium and heavy metal elements such as chromium, zinc on Potamogeton malaianus Miq. were studied. The results show that the contents of chlorophyll and soluble protein increase to a certain degree and then decrease under La3+ Ce3+ Zn2+ stress, while there is a constantly dropping tendency under Cr6+ stress. The four ions have different effects on protective enzyme systems of Potamogeton malaianus. They can induce rises of the activities of catalase (CAT) and peroxides (POD) at lower concentration, however, with the increase of ions concentration, the activities decline. The change of SOD activity is exactly opposite to that of CAT and POD activity. It falls at first and rises later. An increasing tendency of MDA content appears with the increasing concentration. The toxicities of La3+, Zn2+, Ce3+ and Cr6+ become more serious in the order. The lethal concentration of Cr6+ to Potamogeton malaianus ranges from 0.5 to I mg(-1) that of Ce3+ and Zn2+ ranges from 3 to 5 mg(-1) and that of La3+ ranges from 7 to 10 mg(.)L(-1). The toxic mechanism of La3 + and Ce3+ is similar to that of Cr6+ and Zn2+. 展开更多
关键词 BOTANY LANTHANUM CERIUM CHROMIUM ZINC Potamogeton malaianus Miq. toxic effect rare earths
下载PDF
Toxic effects of acetochlor, methamidophos and their combination on nifH gene in soil 被引量:8
14
作者 SU Zhen-cheng ZHANG Hui-wen +2 位作者 LI Xin-yu ZHANG Qin ZHANG Cheng-gang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第7期864-873,共10页
Toxic effects of two agrochemicals on nifH gene in agricultural black soil were investigated using denaturing gradient gel electrophoresis (DGGE) and sequencing approaches in a microcosm experiment. Changes of soil ... Toxic effects of two agrochemicals on nifH gene in agricultural black soil were investigated using denaturing gradient gel electrophoresis (DGGE) and sequencing approaches in a microcosm experiment. Changes of soil nifH gene diversity and composition were examined following the application of acetochlor, methamidophos and their combination. Acetochlor reduced the nifH gene diversity (both in gene richness and diversity index values) and caused changes in the nifH gene composition. The effects of acetochlor on nifH gene were strengthened as the concentration of acetochlor increased. Cluster analysis of DGGE banding patterns showed that nifH gene composition which had been affected by low concentration of acetochlor (50 mg/kg) recovered firstly. Methamidophos reduced nifH gene richness that except at 4 weeks. The medium concentration of methamidophos (150 mg/kg) caused the most apparent changes in nifH gene diversity at the first week while the high concentration of methamidophos (250 mg/kg) produced prominent effects on nifH gene diversity in the following weeks. Cluster analysis showed that minimal changes of nifH gene composition were found at 1 week and maximal changes at 4 weeks. Toxic effects of acetochlor and methamidophos combination on nifH gene were also apparent. Different nifH genes (bands) responded differently to the impact of agrochemicals: four individual bands were eliminated by the application of the agrochemicals, five bands became predominant by the stimulation of the agrochemicals, and four bands showed strong resistance to the influence of the agrochemicals. Fifteen prominent bands were partially sequenced, yielding 15 different nifH sequences, which were used for phylogenetic reconstructions. All sequences were affiliated with the alpha- and beta-proteobacteria, showing higher similarity to eight different diazotrophic genera. 展开更多
关键词 agrochemicals ACETOCHLOR methamidophos toxic effects nifH gene PCR-DGGE
下载PDF
ZnO,TiO_2,SiO_2,and Al_2O_3 Nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts 被引量:6
15
作者 ZHANG Xiao Qiang YIN Li Hong +1 位作者 TANG Meng PU Yue Pu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2011年第6期661-669,共9页
Objective This study aims to investigate and compare the toxic effects of four types of metal oxide (ZnO, TiO2, SiO2, and Al2O3) nanoparticles with similar primary size (-20 nm) on human fetal lung fibroblasts (H... Objective This study aims to investigate and compare the toxic effects of four types of metal oxide (ZnO, TiO2, SiO2, and Al2O3) nanoparticles with similar primary size (-20 nm) on human fetal lung fibroblasts (HFL1) in vitro.Methods The HFL1 cells were exposed to the nanoparticles, and toxic effects were analyzed by using MTT assay, cellular morphology observation and Hoechst 33 258 staining.Results The results show that the four types of metal oxide nanoparticles lead to cellular mitochondrial dysfunction, morphological modifications and apoptosis at the concentration range of 0.25-1.50 mg/mL and the toxic effects are obviously displayed in dose-dependent manner. ZnO is the most toxic nanomaterials followed by TiO2, SiO2, and Al2O3 nanoparticles in a descending order.Conclusion The results highlight the differential cytotoxicity associated with exposure to ZnO, TiO2, SiO2, and Al2O3 nanoparticles, and suggest an extreme attention to safety utilization of these nanomaterials. 展开更多
关键词 Metal oxide nanoparticles Toxic effects FIBROBLASTS
下载PDF
Toxic Effects of Tetrabromobisphenol A on Thyroid Hormones in SD Rats and the Derived-reference Dose 被引量:3
16
作者 YANG Yan NI Wei Wei +2 位作者 YU Lin CAI Ze YU Yun Jiang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2016年第4期295-299,共5页
The present study determined the thyroid hormone interference of tetrabromobisphenol A (TBBPA) in Sprague-Dawley (SD) rats, and the derived-reference dose (RfD) of different endpoint effects on mammals based on ... The present study determined the thyroid hormone interference of tetrabromobisphenol A (TBBPA) in Sprague-Dawley (SD) rats, and the derived-reference dose (RfD) of different endpoint effects on mammals based on experimental results and data collection. Based on repeated exposure toxicity tests on mammals and extensive research, the present study used BMDS240 Software to derive a benchmark dose, and analyzed the accuracy and uncertainty, and similarity with other studies. Test results on triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) demonstrated that all the indicators presented a non-monotonous dose-effect relationship clearly, except TSH in male rats exposed to 0-1000 mg/kg BW per day. Therefore, RfDs were derived from different critical effects. In summary, RfD for mammals in the present study was found to be 0.6 mg/kg per day. 展开更多
关键词 TBBPA Toxic Effects of Tetrabromobisphenol A on Thyroid Hormones in SD Rats and the Derived-reference Dose SD
下载PDF
Efficacy of different antibiotics in treatment of children with respiratory mycoplasma infection 被引量:2
17
作者 Mei-Ying Zhang Yan Zhao +3 位作者 Jin-Feng Liu Guo-Ping Liu Rui-Yun Zhang Li-Min Wang 《World Journal of Clinical Cases》 SCIE 2021年第23期6717-6724,共8页
BACKGROUND Respiratory infections in children are common pediatric diseases caused by pathogens that invade the respiratory system.Children are considerably susceptible to Mycoplasma pneumoniae infection.There has bee... BACKGROUND Respiratory infections in children are common pediatric diseases caused by pathogens that invade the respiratory system.Children are considerably susceptible to Mycoplasma pneumoniae infection.There has been widespread clinical attention on treatment strategies for this disease.AIM To analyze the clinical efficacy of different antibiotics in treating pediatric respiratory mycoplasma infections.METHODS We included 106 children with a confirmed diagnosis of respiratory mycoplasma infection who were admitted to our hospital from April 2017 to July 2019 and grouped them using a random number table.Among them,53 children each received clarithromycin or erythromycin.The clinical efficacy of both drugs was evaluated and compared.We performed the multiplex polymerase chain reaction(MP-PCR)test and determined the MP-PCR negative rate in children after the end of the treatment course.We compared the incidence of toxic and side effects,including nausea,diarrhea,and abdominal pain;further,we recorded the length of hospitalization,antipyretic time,and drug costs.Additionally,we evaluated and compared the compliance of the children during treatment.RESULTS The erythromycin group showed a significantly higher total effective rate of clinical treatment than the clarithromycin group.MP-PCR test results showed that the clarithromycin group had a significantly higher MP-PCR negative rate than the erythromycin group.Moreover,children in the clarithromycin group had shorter fever time,shorter hospital stays,and lower drug costs than those in the erythromycin group.The clarithromycin group had a significantly higher overall drug adherence rate than the erythromycin group.The incidence of toxic and side effects was significantly lower in the clarithromycin group than in the erythromycin group(P<0.05).CONCLUSION Our findings indicate that clarithromycin has various advantages over erythromycin,including higher application safety,stronger mycoplasma clearance,and higher medication compliance in children;therefore,it can be actively promoted. 展开更多
关键词 CLARITHROMYCIN ERYTHROMYCIN Mycoplasma respiratory infection CHILDREN Clinical efficacy Drug compliance Toxic side effects
下载PDF
Influences of Chloropazine, Nimodipine and Their Combination on the Toxic Effects of Cadmium in Liver and Kidney of Mice 被引量:3
18
作者 TANG LINC-FANG YANG YONC-NIAN +2 位作者 CHEN YAN-MENG ZHANG ZHEN-LING SONG LINGAND FENG ZHI-YING(Department of Toxicology, Nanjing Medical University, 140 Hanzhong Road,Nanjing 210029, China) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1999年第3期212-221,共10页
The influences of the calmodulin antagonist chlorpromazine (CPZ), and calcium channel blocker nimodipine (NIMO) and their combination on cadmium (Cd) poisoning of mice were studied. A seties of biochemical parameters... The influences of the calmodulin antagonist chlorpromazine (CPZ), and calcium channel blocker nimodipine (NIMO) and their combination on cadmium (Cd) poisoning of mice were studied. A seties of biochemical parameters including urinary enzyme activities, blood and urine Cd levels, metallothionein (MT) contents in liver and kidney, hepatic ultrastructure and Ca2+ -Mg2+ AT-Pase activity in erythrocyte membrane were determined. Animal models for Cd poisoning were established by peritoneal injection of 1/5 LD50 CdCl2. The experimental groups were protected by administration of CPZ, NIMO and CPZ and NIMO in combination l h before the injection of CdCl2. Five days later, samples were collected for analysis. The data showed that Crs could protect kidney tissue against Cd-induced damage, as the urinary γ-glutamyl traspepti dase (γ- GT ) and N- acetyl-β-D-glucosaminidase (NAG) activities were reduced significantly. There was neither evidence of the protective effect of NIMO on kidney tissue nor an indication of a synergistic effecf of Crs and NIMO.Both CPZ and NIMO showed a considerable protective effect against the deerease in Ca2+ -Mg2+ AT-Pase activity, and a synergistic action was observed. Cd content in blood was reduced significanily by CPZ or the combination of CPZ and NIMO, but elevated by NIMO. Both CPZ and NIMO consideraby increased MT contents in livers and kidneys and ameliorated damaged to the hepatic ultrastructures caused by Cd. The results indicated that these inhibitors could protect mice against the toxic effects of Cd in liver and kidney tissues, while CPZ was more efficient than NIMO. The combination of CPZ and NIMO exerted a synergistic action. The protective action of these two drugs might be relevent to the function of MT. 展开更多
关键词 Influences of Chloropazine Nimodipine and Their Combination on the Toxic Effects of Cadmium in Liver and Kidney of Mice
下载PDF
Monitoring bioaccumulation and toxic effects of hexachlorobenzene using the polyurethane foam unit method in the microbial communities of the Fuhe River,Wuhan 被引量:1
19
作者 LIU Ting CHEN Zhu-lei +3 位作者 SHEN Yun-fen GAN Lu CAO Li LV Zi-zhong 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第6期738-744,共7页
Hexachlorobenzene (HCB) is a chlorinated aromatic hydrocarbon that was widely used for seed dressing in prevention of fungal growth on crops, and also as a component of fireworks, ammunition, and synthetic rubbers. ... Hexachlorobenzene (HCB) is a chlorinated aromatic hydrocarbon that was widely used for seed dressing in prevention of fungal growth on crops, and also as a component of fireworks, ammunition, and synthetic rubbers. Because of its resistance to degradation and mobility, HCB is widely distributed throughout the environment and is accumulated through food chains in different ecosystems. In this study, a preliminary investigation was carried out on the bioaccumulation and the toxic effects of HCB in the microbial (protozoan in particular) communities in the Fuhe River, Wuhan, a water body receiving industrial wastewaters containing HCB and other pollutants, using the standardized polyurethane foam units (PFU) method. Field samples were taken from eight stations established along the Fuhe River in January and August 2006. The concentration ratios of HCB in microbial communities and in water were 9.66-18.64, and the microbial communities accumulated 13.29-56.88 μg/L of HCB in January and 0.82-10.25 μg/L HCB in August. Correlation analysis showed a negative correlation between the HCB contents in the microbial assemblage, and the number of species and the diversity index of the protozoan communities. This study demonstrated the applicability of the PFU method in monitoring the effects of HCB on the level of microbial communities. 展开更多
关键词 BIOACCUMULATION toxicity effect HEXACHLOROBENZENE PFU method microbial community protozoan communities
下载PDF
Efficacy and safety of S-1 maintenance therapy in advanced nonsmall- cell lung cancer patients 被引量:2
20
作者 Xiao-Wei Cheng Wen-Hua Leng Chun-Ling Mu 《World Journal of Clinical Cases》 SCIE 2020年第21期5172-5179,共8页
BACKGROUND Previous reports have demonstrated that S-1 has remarkable effects in the maintenance treatment of advanced non-small-cell lung cancer(NSCLC),and has less toxic and side effects than conventional drugs.AIM ... BACKGROUND Previous reports have demonstrated that S-1 has remarkable effects in the maintenance treatment of advanced non-small-cell lung cancer(NSCLC),and has less toxic and side effects than conventional drugs.AIM To investigate the efficacy and safety of S-1 maintenance therapy in patients with advanced NSCLC.METHODS Ninety-four patients with NSCLC admitted to our hospital from September 2015 to April 2018 were included in the study and divided into the S-1 group(47 cases)and the gemcitabine group(47 cases)by random digital table method.The S-1 group was treated with S-1,while the gemcitabine group received gemcitabine treatment.The clinical efficacy and quality of life of the patients after treatment in the two groups were evaluated.RESULTS There was no significant difference in the total effectiveness rate between the two groups(P=0.519).The quality-of-life scores indicated that there was no significant difference between the two groups in terms of four dimensions of the GQOLI-74 questionnaire(P=0.518,0.094,0.338,0.418).The incidence of nausea and vomiting,granulocytopenia and diarrhea in the S-1 group was significantly lower than that in the gemcitabine group(P=0.001,0.001 and 0.001,respectively).There was no significant difference in the incidence of thrombocytopenia(P=0.366),the progression-free survival(P=0.064),and the survival between the two groups(P=0.050).CONCLUSION S-1 maintenance therapy shows a significant therapeutic effect in patients with advanced NSCLC.It has the same clinical efficacy as gemcitabine,but with less toxic and side effects than conventional drugs. 展开更多
关键词 Advanced non-small cell lung cancer Maintenance therapy S-1 GEMCITABINE EFFICACY Toxic and side effects
下载PDF
上一页 1 2 3 下一页 到第
使用帮助 返回顶部