Common gastrointestinal diseases such as radiation enteritis(RE),acute pancreatitis,inflammatory bowel diseases(IBD)and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level,mostly inv...Common gastrointestinal diseases such as radiation enteritis(RE),acute pancreatitis,inflammatory bowel diseases(IBD)and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level,mostly involving the activation of many pathways of the immune response,ultimately leading to tissue injury.Increased oxidative stress,inflammatory cytokine release,inflammatory cell infiltration and activation and the up-regulation of inflammatory transcription factors participate in the pathophysiology of these complex entities.Treatment varies in each specific disease,but at least in the cases of RE and IBD immunosuppressors are effective.However,full therapeutic responses are not always achieved.The pathophysiology of ischemiareperfusion(IR)injury shares many of these mechanisms.Brief and repetitive periods of ischemia in an organ or limb have been shown to protect against subsequent major IR injury in distant organs,a phenomenon called remote ischemic preconditioning(RIP).This procedure has been shown to protect the gut,pancreas and liver by modulating many of the same inflammatory mechanisms.Since RIP is safe and tolerable,and has shown to be effective in some recent clinical trials,I suggest that RIP could be used as a physiologicallyrelevant adjunct treatment for non-ischemic gastrointestinal inflammatory conditions.展开更多
The concept of approximate generalized conditional symmetry （AGCS） for the perturbed evolution equations is introduced, and how to derive approximate conditional invariant solutions to the perturbed equations via th...The concept of approximate generalized conditional symmetry （AGCS） for the perturbed evolution equations is introduced, and how to derive approximate conditional invariant solutions to the perturbed equations via their A GCSs is illustrated with examples.展开更多
In a semi-discretized Euler-Bernoulli beam equa- tion, the non-nearest neighboring interaction and large span of temporal scales for wave propagations pose challenges to the effectiveness and stability for artificial ...In a semi-discretized Euler-Bernoulli beam equa- tion, the non-nearest neighboring interaction and large span of temporal scales for wave propagations pose challenges to the effectiveness and stability for artificial boundary treat- ments. With the discrete equation regarded as an atomic lattice with a three-atom potential, two accurate artificial boundary conditions are first derived here. Reflection co- efficient and numerical tests illustrate the capability of the proposed methods. In particular, the time history treatment gives an exact boundary condition, yet with sensitivity to nu- merical implementations. The ALEX （almost EXact） bound- ary condition is numerically more effective.展开更多
In this paper we prove the existence of conditional expectations in the noncom- mutative Lp（M, Ф）-spaces associated with center-valued traces. Moreover, their description is also provided. As an application of the ...In this paper we prove the existence of conditional expectations in the noncom- mutative Lp（M, Ф）-spaces associated with center-valued traces. Moreover, their description is also provided. As an application of the obtained results, we establish the norm convergence of weighted averages of martingales in noncommutative Lp（M, Ф）-spaces.展开更多
文摘Common gastrointestinal diseases such as radiation enteritis(RE),acute pancreatitis,inflammatory bowel diseases(IBD)and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level,mostly involving the activation of many pathways of the immune response,ultimately leading to tissue injury.Increased oxidative stress,inflammatory cytokine release,inflammatory cell infiltration and activation and the up-regulation of inflammatory transcription factors participate in the pathophysiology of these complex entities.Treatment varies in each specific disease,but at least in the cases of RE and IBD immunosuppressors are effective.However,full therapeutic responses are not always achieved.The pathophysiology of ischemiareperfusion(IR)injury shares many of these mechanisms.Brief and repetitive periods of ischemia in an organ or limb have been shown to protect against subsequent major IR injury in distant organs,a phenomenon called remote ischemic preconditioning(RIP).This procedure has been shown to protect the gut,pancreas and liver by modulating many of the same inflammatory mechanisms.Since RIP is safe and tolerable,and has shown to be effective in some recent clinical trials,I suggest that RIP could be used as a physiologicallyrelevant adjunct treatment for non-ischemic gastrointestinal inflammatory conditions.
基金The project supported by National Natural Science Foundation of China under Grant No. 10447007, the China Postdoctoral Science Foundation, and the Natural Science Foundation of Shanxi Province under Grant No. 2005A13
文摘The concept of approximate generalized conditional symmetry （AGCS） for the perturbed evolution equations is introduced, and how to derive approximate conditional invariant solutions to the perturbed equations via their A GCSs is illustrated with examples.
基金supported by the National Natural Science Foundation of China(11272009)National Basic Research Program of China(2010CB731503)U.S. National Science Foundation(0900498)
文摘In a semi-discretized Euler-Bernoulli beam equa- tion, the non-nearest neighboring interaction and large span of temporal scales for wave propagations pose challenges to the effectiveness and stability for artificial boundary treat- ments. With the discrete equation regarded as an atomic lattice with a three-atom potential, two accurate artificial boundary conditions are first derived here. Reflection co- efficient and numerical tests illustrate the capability of the proposed methods. In particular, the time history treatment gives an exact boundary condition, yet with sensitivity to nu- merical implementations. The ALEX （almost EXact） bound- ary condition is numerically more effective.
文摘In this paper we prove the existence of conditional expectations in the noncom- mutative Lp（M, Ф）-spaces associated with center-valued traces. Moreover, their description is also provided. As an application of the obtained results, we establish the norm convergence of weighted averages of martingales in noncommutative Lp（M, Ф）-spaces.
