Antioxidant Activity of 50 Traditional Chinese Medicinal Materials Varies with Total Phenolics

This study was designed to determine the total phenolic content of 50 herbs and to examine their antioxidant potential. In the sample preparation, 60% ethanol was chosen as the extraction solvent for the subsequent experiments. Folin-Cicolteau phenol reagent and a colorimetric method were used to determine the total phenolic content of the selected herbs. The result showed that total phenolic content of those herbs ranged from 2 to 185 mg/g. In antioxidant assay, the ferric reducing/antioxidant power (FRAP) values ranged from 2 to 134 mg GAE/g;the IC50 values of DPPH?·, ·OH and ?scavenging were in the range of 0.06 - 5.50 mg/mL, 0.017 - 0.636 mg/mL and 0.050 - 0.681 mg/mL respectively. Flos caryophylli was the exceptant in the ?scavenging assay because there was no linear relation between the concentration and the scavenging percentage. Compared to gallic acid, ascorbic acid and butylated hydroxytoluene (BHT) in antioxidant assay as positive control, the most potential antioxidant herbs were Cacumen platycladi, Radix et Rhizoma rhei, Rhizoma rhodiolae crenulatae, and Rhizoma sanguisorbae with considerable content of phenolics. Especially, a positive and significant correlation was found between the total phenolic content and FRAP value or DPPH· scavenging percentage.

Reason Analysis and Risk Prevention of Soaring Price of Traditional Chinese Medicinal Materials

In recent years,the price of traditional Chinese medicinal materials soars continuously,and the resulting price risk increasingly looms large,which has critically affected midstream and downstream industries and peoples' demand for drug,and imperiled healthy and orderly development of traditional Chinese medicinal industries.Based on the status quo of continuous skyrocketing price of traditional Chinese medicinal materials at present,we winkle out the root cause of soaring price as follows:the supply and demand lose balance;the production costs hike up;there are other factors responsible for soaring price.This paper further analyses the impact of sharp increase in price of traditional Chinese medicinal materials on all links of industry chain as follows:the medicinal herb growers never benefit from soaring price;the counterfeiters and forgers in midstream industry increase;the gross profit rate of Chinese medicine enterprises declines.In accordance with the risk arising from abnormal fluctuation in price of traditional Chinese medicinal materials,corresponding precautionary measures are put forward as follows:promote the quality of traditional Chinese medicinal materials through management of value chain;curtail the production and management cost of traditional Chinese medicinal materials through management of organization chain;stabilize price of traditional Chinese medicinal materials through management of information chain;reduce transaction cost of traditional Chinese medicinal materials through management of logistics chain.

Problems in the Development of Traditional Chinese Medicinal Materials Planting Industry in Shiyan City and Countermeasures

Through the analysis on the cultivation advantages and development problems of traditional Chinese medicinal planting industry in Shiyan City, Hubei Province, some measures were proposed to enlarge and enhance the traditional Chinese medicinal planting industry, namely, large-scale, standardized, market-oriented and regionalized planting, thereby making it the pillar industry for farmers to increase income.

Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer:opportunities and challenges

Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths.Surgery,radiotherapy,chemotherapy,immunotherapy,and endocrine therapy are currently the main treatments for this cancer type.However,some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy,resulting in limited treatment efficacy.Consequently,traditional Chinese medicinal materials(TCMMs)as natural products have become an attractive source of novel drugs.In this review,we summarized the current knowledge on the active components of animal-derived TCMMs,including Ophiocordyceps sinensis-derived cordycepin,the aqueous and ethanolic extracts of O.sinensis,norcantharidin(NCTD),Chansu,bee venom,deer antlers,Ostrea gigas,and scorpion venom,with reference to marked anti-breast cancer effects due to regulating cell cycle arrest,proliferation,apoptosis,metastasis,and drug resistance.In future studies,the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies.Furthermore,large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment.

Gaps and feasibility of fixed-dose combination strategy in the development of modern Chinese medicine

isTraditional Chinese medicine(TCM)is a highly complex chemical substance system,which not only reflected in the complexity of the chemical components and their interrelationships,but also in the intricacy of the prescription’s connection with the human body.Component compatibility strategy has been proposed for developing modern TCM since 2005 and established comprehensive relevant technologies and research approaches.Moreover,to meet the safety and efficacy of current pharmaceuticals,research on fixed-dose combination drugs is directed by modern scientific theories,conforms to TCM compatibility principles and clarifies material basis and pharmacological mechanisms and component-effect correlations.This review summarized gaps and feasibility of fixed-dose combination strategy in the development of modern TCM research and assessed their advantages and disadvantages in light of contemporary drug combination research practices.

Network pharmacology approaches for research of Traditional Chinese Medicines

Pharmacodynamics material basis and effective mechanisms are the two main issues to decipher the mechnisms of action of Traditional Chinese medicines(TCMs)for the treatment of diseases.TCMs,in“multi-component,multi-target,multi-pathway”paradigm,show satisfactory clinical results in complex diseases.New ideas and methods are urgently needed to explain the complex interactions between TCMs and diseases.Network pharmacology(NP)provides a novel paradigm to uncover and visualize the underlying interaction networks of TCMs against multifactorial diseases.The development and application of NP has promoted the safety,efficacy,and mechanism investigations of TCMs,which then reinforces the credibility and popularity of TCMs.The current organcentricity of medicine and the“one disease-one target-one drug”dogma obstruct the understanding of complex diseases and the development of effective drugs.Therefore,more attentions should be paid to shift from“phenotype and symptom”to“endotype and cause”in understanding and redefining current diseases.In the past two decades,with the advent of advanced and intelligent technologies(such as metabolomics,proteomics,transcriptomics,single-cell omics,and artificial intelligence),NP has been improved and deeply implemented,and presented its great value and potential as the next drug-discovery paradigm.NP is developed to cure causal mechanisms instead of treating symptoms.This review briefly summarizes the recent research progress on NP application in TCMs for efficacy research,mechanism elucidation,target prediction,safety evaluation,drug repurposing,and drug design.

葫芦岛地区中药材产业发展及装备需求分析

我国中药材种植业从播种到采收仍以传统的人工作业方式为主,劳动效率低下,会影响中药产业的长期健康稳定发展。阐述我国中药材产业发展及机械化配套现状,分析中药材机械化发展中存在的问题及其生产所需的配套装备,探讨中药材机械化的综合效益。

中药有效成分结合骨组织工程材料用于骨修复

背景:如何修复骨缺损一直以来是临床难题,中药有效成分在骨修复方面具有良好的生物活性与治疗效果,将中药有效成分与组织工程材料相结合在骨修复领域具有广阔的前景。不同中药有效成分与支架的组合在作用关系方面具有相似之处。目的:搜集常见的中药有效成分与支架材料组合的案例,基于七情配伍的启发将组织工程支架与中药有效成分类比为产生配伍关系的两类中药,以二者的作用关系为纲进行归纳总结。方法:检索1998年1月至2024年1月Pub Med和中国知网数据库中发表的相关文献,英文检索词:“traditional Chinese medicine,Chinese medicine,traditional Chinese medicine monomers,bone defect,bone repair,bone tissue engineering,tissue engineering,scaffold”,中文检索词:“中药,中药有效成分,中药单体,骨组织工程,骨组织工程支架,支架,组织工程,骨缺损,骨修复”,最终纳入88篇文献进行综述分析。结果与结论:(1)组织工程支架材料与中药有效成分各自均在骨修复领域有广泛的运用,二者在成骨方面优势明显但仍有许多缺陷,许多研究致力于将二者制备成复合材料,希望通过二者间的相互作用发挥减毒增效作用。(2)一些药物与材料在成骨、抗菌、促血管生成方面能互相促进,增强原有的效果,受到传统方剂配伍观念的启发,文章将其归纳为“相须”关系,并举实例佐证。(3)一些药物能提高材料的强度,而某些材料能对负载于其上的药物实现缓释控释效果、增加载药量与稳定性,或是进行靶向递送,文章将这种单方面的提升效果归纳为“相使”关系。(4)一些中药与材料搭配使用能减少对方的毒副反应,文章将这种减毒关系归纳为“相畏相杀”。(5)文章得出了一个由七情配伍关系启发、基于作用关系分类的关于中药复合支架的全新视角,将中药传统观念引入组织工程领域,为后续复合支架的研究者提供新的研究思路,并在选材搭配方面提供一定的便利。

山东省济南市钢城区中药资源现状调查及分析

为摸清山东省济南市钢城区中药资源分布现状,按照全国第四次中药资源普查的统一要求,通过野外调查、内业整理、数据分析等过程对钢城区野外药用植物资源的分布、中药材栽培等进行调查梳理。结果表明:钢城区现有野生中药资源180种,隶属于65科、151属,其中优势科有菊科、豆科、十字花科等,野生商陆、茜草、益母草的蕴藏量较大,野生中药资源中有69种被《中国药典》2020版收录;栽培品种丹参、黄芩、山楂、花椒、金银花、生姜的种植面积较大,其中白花丹参为地理标志性资源。本次资源普查对钢城区的野生药用植物资源种类和分布进行了全面了解,为区域性中药资源的开发利用以及中药产业可持续发展提供了科学依据。

小檗碱促进骨再生的机制、安全性及在骨组织工程中的应用

背景:小檗碱具有诱导各种间充质干细胞在正常状态和高糖、感染及炎症等特殊状态下成骨分化的潜力,可替代生长因子诱导种子细胞成骨,是一种具有骨诱导潜力的天然小分子药物,在骨组织工程领域有着巨大的应用前景。目的:回顾和总结小檗碱成骨机制及效能,尤其是在高糖、感染及炎症环境下的成骨潜力,以及小檗碱生物安全性方面的研究进展,为其在骨组织工程中的发展应用提供理论依据。方法:在PubMed、万方及中国知网数据库,以英文检索词“berberine,bone defects,bone repair,bone regeneration,osteoinductive,osteoporosis,osteoblast,osteoclast,bone tissue engineering,bone,high glucose,diabetes,inflam*,infect*”,中文检索词“黄连素,小檗碱,骨缺损,骨修复,骨再生,骨诱导,骨质疏松,成骨细胞,破骨细胞,骨组织工程,骨,高糖,糖尿病,炎症,感染”进行文献检索,最终筛选后纳入105篇文献进行综述。结果与结论:(1)小檗碱能用于治疗包括骨病在内的多种疾病,其具有促进骨再生作用,文章系统综述了小檗碱对骨再生作用机制及体内外研究。(2)研究表明小檗碱能够通过促骨生成、抑制破骨细胞形成及其活性、抗骨质疏松等方面发挥骨修复作用,主要通过参与Wnt/β-catenin,PI3K/AKT,EGFR/MEK/p38MAPK,cAMP/PKA/CREB和ERK等信号通路,表现出优异的成骨诱导分化潜力。(3)小檗碱还可以解除因高糖、感染及炎症引起的细胞成骨分化抑制,这为治疗患有糖尿病的骨缺损患者或骨缺损部位有感染及炎症的患者提供了更多可能。(4)小檗碱还具有毒性小、价格低廉和易于获取(目前已经能够人工合成)等优点,是较为理想的骨诱导潜力药物。(5)近年来应用小檗碱治疗骨缺损趋于局部使用,主要通过与骨组织工程技术结合改善生物利用度,在动物实验中表现出良好的骨修复作用和生物安全性,而且临床前实验表明,小檗碱在糖尿病、局部感染及炎症状态下仍然表现出优秀的骨再生潜力。(6)未来还需要更多的研究完整地揭示小檗碱的成骨机制和生物安全性等问题,并寻求最合适的控释载体制作出机械强度、疗效及生物安全性均佳的人工骨替代材料。

天然产物抗肺癌作用及其机制的研究进展

目的总结天然产物抗肺癌的机制,为候选治疗肺癌新的前瞻性药物提供理论基础。方法利用肺癌、中药、药理学及其组合等关键词,收集中国知网、万方、维普、PubMed、Science Direct和Web of science等数据库有关天然产物抗肺癌作用研究的文章,并进行总结。结果中医药治疗肺癌优势明显,具有药理机制新颖、毒性低、不良反应小的特点,可增效减毒、提高患者生活质量。天然产物主要包括黄酮类、生物碱类、多糖类、萜类、皂苷类和酚类,具有抑制肿瘤细胞周期、抑制增殖、诱导凋亡、促进自噬、抑制肿瘤细胞侵袭和转移的作用;天然产物与细胞毒性药物联合使用,可以增强疗效或降低耐药性,延缓肺癌的进展,延长患者的生存时间。结论中药含有多种黄酮、生物碱、萜及其苷类、多酚和其他可有效对抗肺癌的活性化合物,适合作为治疗肺癌的候选药物。

中药配方颗粒药品追溯系统研究进展

目的探讨有效保障中药配方颗粒质量安全的方法。方法总结中药配方颗粒全供应链追溯系统的内涵、相关法规和应用情况。通过中药配方颗粒药品追溯系统强化信息互通共享,实现药品全品种、全过程追溯,促进药品质量安全的综合治理。结果与结论中药配方颗粒药品追溯系统为相关系统的开发及应用提供了借鉴,可推进药品信息化追溯体系的建设。

陈玉峰生平与著述史料研究

2023年是东北著名中医陈玉峰教授诞辰120周年。挖掘整理陈玉峰学术著述,研究其中医学术思想,继承中医临证经验具有重要意义,且十分紧迫。从个人成长历程、医教生涯、医事活动三方面开展陈玉峰生平研究;从学术著作、医话随笔、序跋文章三方面开展陈玉峰著述研究;从中医学术思想、中医临床治疗、中医教育思想等三方面对陈玉峰学术思想进行研究。

中药材经磷化铝熏蒸后残留磷化氢的降解规律研究

目的:研究经磷化铝熏蒸后中药材中磷化氢残留水平的变化规律。方法:选取党参、黄芪、当归等易生虫的十种中药材经过模拟实验建立阳性样本,通过建立磷化铝残留的测定方法,对制备样本进行磷化铝残留水平监测。结果:不同品种的中药材样品经磷化铝熏蒸后残留水平有明显差异,对于含有色素的款冬花药材,外观颜色发生明显变化。同时发现,阳性样品在自然通风条件下,磷化氢残留降解速度较快,在48h内降幅可达约50%以上,8天后残留量明显减少,12天后部分样品残留量低于检出限。结论:不同基质的中药材样品经磷化铝熏蒸后,残留水平有明显差异,且磷化氢残留随贮存时间延长降解速度加快。

中药有效成分结合支架材料促进骨组织再生

背景:随着淫羊藿苷、黄连素等中药被证实可以促进骨再生,研究者将中药活性成分与骨组织工程相结合,发现其在骨缺损的修复中具有独特优势。目的:从促进成骨的中药有效成分出发,筛选其与不同载药支架材料有效结合的案例,归纳总结有潜力应用于骨组织工程的中药有效成分。方法:应用计算机检索中国知网、万方、PubMed、Web of Science等数据库,以“骨组织工程,骨组织工程支架材料,骨缺损,骨修复,骨再生,中医药”为中文检索词,以“bone tissue engineering,bone tissue-engineered scaffold materials,bone defect,bone repair,bone regeneration,traditional Chinese medicine”为英文检索词,检索时限限定为2000-2023年,根据纳入和排除标准进行筛选,最终纳入87篇文献进行综述。结果与结论:促进骨再生的中药有效成分种类繁多,主要包括黄酮类化合物、非黄酮类多酚、生物碱、苷类,有消炎止痛、促进成骨细胞和抑制破骨细胞以及促进血管早期生成的作用。中药有效成分与骨组织工程结合后在抗炎、加速胶原蛋白和骨骼形成、促进成骨基因表达等方面效果显著,为中药在骨组织再生中的应用提供了理论依据,同时为骨缺损修复提供了新的思路。

河北省中医研究院(保定)概况考证

河北省中医研究院(保定)是解放后河北省设立最早的省级中医研究机构,创立于1956年6月,最初称河北省中医研究所筹备处。1960年1月正式改设为河北省中医研究院,下设附属门诊部、附属医院。1965年8月撤销。从创立到撤销短短十年之内,中医研究工作卓有成效,院内人员重临床,务实效,勇于创新,多渠道推动中医交流,编审出版了大批优质中医书籍,影响深远,有效推动了中医学术的发展。因撤销近60年,资料散佚,通过查证史料,搜集实物资料,对河北省中医研究院(保定)概况进行考证。

应用型中药资源与开发专业建设必要性与人才培养探索

中药材是关系国计民生的战略性资源,当前大健康产业的迅猛发展推动中药材需求量及需求层次的增长。在中药材产业进入高质量发展并逐步接轨国际的关键时刻,对应用型中药资源与开发专业人才培养建设的研究与探索意义重大。本文阐述建设中药资源与开发专业的必然性、人才培养模式及现状,并从人才培养方案、应用型课程体系与教学模式、师资队伍结构与实验实训平台五个方面对应用型中药资源与开发专业人才培养建设进行探讨,旨在培养更高质量的具有中医药特色的应用型专业技术人才,为中医药产业可持续发展与推动地区经济发展筑牢人才基础。

辐照植物性中药材热释光鉴定方法研究

目的:采用热释光分析仪建立鉴定人参、甘草、苏叶、菊花和山楂等中药材中辐照与否的方法与标准。方法:将试样中的硅酸盐分离后,测定其热释光发光曲线的发光峰面积积分值G_(1),硅酸盐再经剂量1.0 kGy照射后,再次测定其热释光发光曲线的发光峰面积积分值G_(2);判断样品是否经过辐照时,以G_(1)/G_(2)的比值作为判断依据。结果判定:当G_(1)/G_(2)≥0.10时,可被判定为辐照样品;该样品在G_(1)/G_(2)<0.10时被判定为未经辐照。结论:本研究建立了可供其鉴定、评价参考的辐照植物性中药材热释光鉴别方法。

黔产松树皮质量标准研究

目的:为了建立松树皮的质量标准。方法:参考2020年版《中国药典》的质量控制方法对松树皮的质量控制进行探索研究。结果:3批松树皮的水分在7.00%~10.85%,平均值为8.70%;总灰分在2.44%~2.64%,平均值为2.53%,浸出物在30.42%~33.41%,平均值为31.90%,薄层色谱鉴别通过方法学验证,而且方法简单可行,结果准确。结论:该试验方法可以用于松树皮质量控制。

中医药产业发展现状与存在问题分析——以甘肃省定西市为例

以甘肃省定西市中医药产业发展现状为例,对中医药产业发展过程中出现的问题进行梳理分析。近年来,定西市中医药产业发展成效明显,表现在中药材良种繁育初见成效,药材种植面积稳定增长,中药材加工能力不断提升,中药材仓储交易规模持续增大,中药材质量标准体系逐步建立,以及中医药康养产业正在兴起。而中医药产业发展过程中呈现的中药材种业专业化水平不高、中医药产业科技化程度不高、中药材流通溯源体系不全、中医药文化塑造宣传不足等问题,亟需通过政府的主动担当、积极引导,协调多方合作,制定相关政策以有效推进中医药产业的发展壮大。通过分析定西市中医药产业发展的现状与存在问题,以期为全国其他地方中医药产业的发展提供借鉴。