Epigastric pain syndrome: What can traditional Chinese medicine do? A randomized controlled trial of Biling Weitong Granules

BACKGROUND Recent research suggests that although prokinetic agents,acid suppressors,and radical treatment for Helicobacter pylori infection may be effective in patients with functional dyspepsia(FD),a large proportion of patients still fail to respond to these treatments or may suffer from severe adverse reactions.Many traditional Chinese medicinal herbs can regulate the status of the entire body and have special advantages in the treatment of functional diseases.The present study was designed to verify the efficacy of Biling Weitong Granules(BLWTG),a traditional Chinese medicinal herbal compound formula,in alleviating epigastric pain syndrome(EPS)in FD patients,in an attempt to provide an effective prescription for the clinical treatment of this disease.AIM To evaluate the clinical efficacy and safety of BLWTG in treating EPS in patients with FD.METHODS In this multicenter,stratified,randomized,double-blind,placebo-controlled,parallel group clinical trial,eligible patients were randomized into the BLWTG and placebo groups who were treated for 6 wk.Efficacy indicators including the severity and frequency of EPS and the time to pain resolution and safety indicators including adverse events were observed and compared.RESULTS The baseline demographic data and clinical characteristics,such as epigastric pain symptoms,pain intensity,and frequency of attacks,were matched between the two groups before randomization.After 6 wk of treatment and after the center effect was eliminated,the epigastric pain was significantly improved in 28.33%and 85.59%of the patients in the placebo and BLWTG groups,respectively(P<0.05).At 6 wk,the resolution rate of epigastric pain was 15%and 69.49%in the placebo and BLWTG groups,respectively(P<0.05).The differences of total FD clinical score between these two groups were significant(P<0.05)at 2,4,and 6 wk(P<0.05).The scores of each item and the total score in the Functional Digestive Disorders Quality of Life Questionnaire showed significant differences between the two groups at 6 wk after both the center and interaction effects were eliminated(P<0.05).There was no significant difference in the incidence of adverse events between the two groups,and no serious adverse event was noted during the observation.CONCLUSION Compared with placebo,BLWTG markedly improved EPS in FD patients without causing serious adverse reactions.

International expert consensus on clinical application of traditional Chinese medicine formula granules

Guided by the theory of traditional Chinese medicine(TCM),TCM formula granules are made through the optimal process of extraction,concentration,drying,and granulation by combining modern new preparation technologies and pharmaceutical technologies.TCM formula granules are stable,safe,convenient,and effective.Compared with TCM decoction pieces,TCM formula granules can achieve the full process control of its industry chain from field to workshop and standardize the management of the origin of medicinal materials,processing of decoction pieces,processing technology,quality inspection,sales,and products distribution.TCM formula granules can partially replace Chinese patent medicines.Only available for around 800 common varieties of TCM,TCM formula granules cannot replace decoction pieces for many types which are not commonly used in clinical practice.A large number of formula granules are used in clinical and animal studies so that investigators no longer need to extract and control the quality of TCM decoction pieces.How to improve the production process,establish the quality standard,perfect the regulatory system,and expand the clinical application are the problems we need to solve as soon as possible for the better development of formula granules.

Efficacy and safety of Yangxue Qingnao Granules in treatment of migraine:A systematic review and meta-analysis

BACKGROUND Yangxue Qingnao Granules(YXQN)is a Chinese patent medicine that has been commonly used in the clinical treatment of migraine.AIM To assess the efficacy and safety of YXQN alone for the treatment of migraine.METHODS We searched 10 databases to identify relevant randomized controlled trials(RCTs)published before September 2022.Two review authors independently searched and screened the literature,extracted the data,and assessed the methodological quality of the studies using criteria from ROB 2.0,and analyzed the data using Review Manager 5.4 software.RESULTS A total of 12 RCTs including 767 participants with migraine met the selection criteria.We divided these studies into comparisons of YXQN with placebo,routine treatment drugs,and other Chinese patent medicines.The meta-analysis showed the following:(1)Efficacy:The YXQN group outperformed the placebo group[relative risk(RR)=0.29,95%confidence interval(95%CI):0.15–0.43,P<0.00001],routine treatment group(RR=0.18,95%CI:0.09–0.27,P<0.0001),and Chinese patent medicine group(RR=0.27,95%CI:0.13–0.41,P<0.001);(2)frequency of headache:There was a significant difference between YXQN vs placebo[mean difference(MD)=-1.25,95%CI:-1.60 to-0.90,P<0.00001],routine treatment drugs(MD=-0.85,95%CI:-1.15 to-0.56,P<0.00001),and Chinese patent medicine(MD=-0.91,95%CI:-1.35 to-0.46,P<0.0001);(3)headache duration:We found great heterogeneity between studies,with no differences between YXQN and placebo(MD=-0.61,95%CI:-1.53 to-0.31,P=0.19)and routine treatment drugs(MD=-0.22,95%CI:-0.89 to 0.46,P<0.53).YXQN was more effective than other Chinese patent medicines in reducing headache duration(MD=-1.24,95%CI:-1.70 to-0.77,P<0.00001);and(4)headache severity:There was no significant difference between YXQN vs placebo(MD=-1.67,95%CI:-3.52 to 0.19,P=0.08),routine treatment drugs(MD=-0.53,95%CI:-2.02 to 0.96,P=0.68),and other Chinese patent medicines(MD=-0.49,95%CI:-2.83 to 1.85,P=0.68).Mild gastrointestinal adverse reactions were reported in three cases.CONCLUSION This study revealed that YXQN is effective and safe for treatment of migraine.

Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(H.pylori),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of H.pylori only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic progression.Yiwei Xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese clinics.However,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of CAG.AIM To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS symptoms.METHODS We designed a double-blind,randomized,controlled trial.The study enrolled seventy-two H.pylori-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 wk.The pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other reasons.Seven visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh visits.We also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and gastrin-17.RESULTS Six patients did not complete the trial procedures.Treatment with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(P<0.05).YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric function,compared with WFC(P<0.05).CONCLUSION YWXY compared with WFC significantly reduced the risk of mild or moderate atrophic disease,according to OLGIM stage,significantly relieved symptoms of DSSS,and improved serum gastric function.

Research of Quality Standards for Stachydrine Hydrochloride in Chinese Medicine TJF Granule

A high-performance liquid chromatographic method was applied to the determination of stachydrine hydrochloride concentration in TJF granule (Chinese name: Tiao-Jing-Fang), using a mobile phase of methanol-acetonitrile (50:50, v/v) by the Agilent Kromasi NH2 column (250 mm × 4.6 mm, 5 μm, S/N: 22N25110). Detection wavelength was 201 nm. The result revealed good linearity of stachydrine hydrochloride and was obtained within the range of 0.20 - 1.98 μg/mL (R = 0.9995). The average recovery was 97.01%;the relative standard deviation (RSD) was 0.19%. To the best of our knowledge, this is the first report dedicated to the determination of stachydrine hydrochloride by the evaporative light scattering detector-high-performance liquid chromatographic (ELSD-HPLC) method.

Clinical Research on the Treatment of Simple Obesity by Oral Chinese Medicine Combined with Health Education to Improve Phlegm Dampness Constitution

OBJECTIVE: To observe the clinical effect of oral traditional Chinese medicine granules combined with health education to regulate phlegm constitution and treat simple obesity. METHODS: According to the method of constitution evaluation in TCM Constitution Classification and Evaluation(Chinese Association of Chinese Medicine), the TCM classification of Chinese medicine was performed on patients who came to the outpatient department of the Traditional Chinese Medicine Hospital of Pinggu District of Beijing and met the diagnostic criteria of simple obesity. One hundred patients with phlegm constitution were selected and those in accordance with the standards, were randomly divided into group with oral TCM granules combined with health education(refer to as treatment group) and health education group(refer to as control group) according to 1:1 ratio. The control group was given health education including diet and exercise instruction. Treatment group:(1) Health education includes diet and exercise instruction.(2) Oral Chinese medicine granules: ingredients: atractylodes rhizome 15g, raw barley 30g, Folium Nelumbinis 10g, Chinese hawthorn fruit 10g, Chinese waxgourd peel 15g, milk-vetch root;15g, kudzuvine root 15g, danshen root10g, 2 times/d. The two groups were intervened for 12 weeks each time, and obesity evaluation indicators such as body weight, body fat, waist circumference, hip circumference, weight index, and score table of TCM constitutional were observed before and after the intervention. Statistical software was used for statistical analysis. RESULTS: The total curative effect of the treatment group was better than that of the control group(P<0.001). The weight index, body weight, waist and hip circumference decreased significantly after treatment(P <0.01). Compared with the two groups, the treatment group is better than the control group in terms of dampness constitution improvement, weight and fat losing and waist and hip circumference reducing.(P<0.01). CONCLUSION: Oral Chinese medicine granules Jiangzhuo Fang(combined with health education) and simple health education can improve phlegm constitution, and improve the body weight, body fat percentage and other indicators of the patients, but oral granules combined with health education to improve the physical fitness of phlegm is better than simple health education. The thoughts and methods of Chinese medicine granules combined with health education to regulate phlegm constitution is effective for weight losing and is worthy of further research and promotion.

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Chaigui granules(CG)are a compound composed of six herbal medicines with significant antidepressant effects.However,the antidepressant mechanism of CG remains unclear.In the present study,we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergic signaling.First,the regulatory effect of CG on purine metabolites in the prefrontal cortex(PFC)of chronic unpredictable mild stress(CUMS)rats was analyzed by ultra high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)targeted quantitative analysis.Meanwhile,purinergic receptors(P2X7 receptor(P2X7R),A1 receptor(A1R)and A2A receptor(A2AR))and signaling pathways(nod-like receptor protein 3(NLRP3)inflammasome pathway and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)pathway)associated with purine metabolism were analyzed by western blotting and enzyme-linked immunosorbent assay(ELISA).Besides,antidepressant mechanism of CG by modulating purine metabolites to activate purinergic receptors and related signaling pathways was dissected by exogenous supplementation of purine metabolites and antagonism of purinergic receptors in vitro.An in vivo study showed that the decrease in xanthine and the increase in four purine nucleosides were closely related to the antidepressant effects of CG.Additionally,purinergic receptors(P2X7R,A1R and A2AR)and related signaling pathways(NLRP3 inflammasome pathway and cAMP-PKA pathway)were also significantly regulated by CG.The results of exogenous supplementation of purine metabolites and antagonism of purinergic receptors showed that excessive accumulation of xanthine led to activation of the P2X7R-NLRP3 inflammasome pathway,and the reduction of adenosine and inosine inhibited the A1R-cAMP-PKA pathway,which was significantly ameliorated by CG.Overall,CG could promote neuroprotection and ultimately play an antidepressant role by inhibiting the xanthine-P2X7R-NLRP3 inflammasome pathway and activating the adenosine/inosine-A1R-cAMP-PKA pathway.

基于化学成分与药理作用评价当归-黄芪药对配方颗粒汤剂与传统汤剂的差异

目的评价当归-黄芪药对配方颗粒汤剂(DGD)与传统汤剂在化学成分和药理效应方面的差异,为合理应用该配方颗粒提供参考。方法以原料来源批次统一和不统一2种对比方式,设不同样品组,采用高效液相色谱(HPLC)法建立特征图谱,从特征图谱相似度、成分种类、指标成分含量、共有峰面积等角度对化学成分进行评价;采用失血性血虚模型小鼠评价药效。结果①DGD特征图谱与传统汤剂相似度较高(相似度>0.87);②共有色谱峰数目不一致,传统汤剂-自购饮片和传统汤剂-A厂饮片共有色谱峰各12个,A厂DGD共有色谱峰15个,B厂DGD共有色谱峰10个;③A厂DGD中阿魏酸、毛蕊异黄酮苷含量高于传统汤剂(P<0.05);B厂DGD与传统汤剂阿魏酸含量差异无统计学意义,但毛蕊异黄酮苷含量较传统汤剂低(P<0.05);④DGD共有峰面积总和与传统汤剂相比,自购传统汤剂、A厂传统汤剂及A厂配方颗粒、B厂配方颗粒中各成分含量相对比值分别为1.00、0.96、2.14、0.60;⑤DGD及传统汤剂均能明显促进失血性贫血模型小鼠血红蛋白(Hb)、红细胞(RBC)恢复(P<0.01);与模型对照组比较,除B厂DGD组外均差异有统计学意义(P<0.05);A厂DGD与传统汤剂差异无统计学意义,B厂DGD与传统汤剂差异有统计学意义(P<0.01)。结论无论原料来源批次是否一致,DGD与传统汤剂在化学成分上均存在一定差异;在药理作用上,来源于同一批次饮片制备的DGD与传统汤剂对改善失血性贫血药效相当,来源于不同批次饮片制备的DGD与传统汤剂在药效上存在一定差异;不同来源批次的饮片和不同制备工艺造成不同厂家配方颗粒存在质量差异,说明国家统一配方颗粒质量标准及制定相关过程规范具有必要性与紧迫性。

基于正交实验优化中药配方颗粒调剂工艺

目的:探讨影响中药配方颗粒药品下药量因素,优化最佳配药、储存条件,保证患者用药安全、有效,提高患者对中药配方颗粒药品的满意度。方法:通过正交实验法优化最佳配药、储存条件,对中药配方颗粒进行质量监管。结果:配方颗粒调剂工艺的影响因素依次为:湿度>粒径>温度;最佳调剂工艺为温度21℃,湿度45%,粒径为全部通过2号筛且不通过3号筛。结论:温度、湿度、粒径三者对配方颗粒的调剂工艺都有显著影响,依据本实验所得最佳配药条件,能达到最准确配药量。

基于双心理论的强心康颗粒+耳穴贴压联合西药治疗慢性心衰合并中重度焦虑临床观察

目的观察强心康颗粒+耳穴贴压联合氟哌噻吨美利曲辛片对慢性心力衰竭(以下简称“心衰”)合并中重度焦虑的疗效。方法纳入合并中重度焦虑[广泛性焦虑量表(GAD-7)测评≥10分]的慢性心衰患者72例,纽约心脏病协会(NYHA)心功能分级Ⅱ~Ⅲ级,分为观察组与对照组,各36例;两组均给予血管紧张素转化酶抑制剂(ACEI)、β受体阻滞剂等心衰基础治疗,观察组给予强心康颗粒+耳穴贴压联合氟哌噻吨美利曲辛片,对照组给予强心康颗粒。观察两组的心功能分级、6 min步行试验、N末端B型脑钠肽原(NT-proBNP)、中医证候评分、GAD-7评分。结果治疗后,两组患者的心功能分级疗效、6 min步行试验、NT-proBNP、中医证候评分、GAD-7评分等指标均较治疗前明显改善,且观察组优于对照组(P<0.05)。结论强心康颗粒+耳穴贴压联合氟哌噻吨美利曲辛片可明显提高慢性心衰合并中重度焦虑患者的临床疗效。

多指标降维判别分析方法在中药配方颗粒汤剂与传统汤剂等效性对比中的应用

针对传统汤剂和配方颗粒汤剂等效性评价方法不直观,未从多维度指标综合评价等问题,该研究建立了一种基于多指标(化学成分、药效作用)降维判别分析二者等效性关系的评价方法。为验证方法的有效性,将A、B、C厂炙甘草,D、E厂白芍,F、G、H厂砂仁配方颗粒汤剂与传统汤剂的化学成分等数据进行验证分析。结果显示建立的判别方法可快速、直观判别两者之间的关系,A、B、C三厂的炙甘草配方颗粒在当量比校正前均不能判定与其传统汤剂等效,经当量比校正后,代表传统汤剂和配方颗粒汤剂的两个置信椭圆部分相交或包含,表明二者可部分或完全替代;D、E厂白芍,F、G、H厂砂仁的配方颗粒在当量比校正前和校正后均不能判定与传统汤剂等效,二者无法相互替代。所建立的方法通过图形化形式快速直观综合判断配方颗粒汤剂与传统汤剂之间的关系,可用于二者之间的等效性评价。

甲亢颗粒理论依据及组方规律探讨

甲状腺功能亢进症(简称甲亢)是一种常见的内分泌系统疾病。近年来,中医药治疗甲亢在理论和临床上均取得很大进展。辽宁中医药大学附属第二医院内分泌科研制的甲亢颗粒以“益气养血、滋阴制阳”为功能主治,能够有效改善甲亢患者的临床症状,帮助恢复甲状腺功能,不但具有较高的安全性,而且疗效显著。本文结合甲亢的病因、病机及甲亢颗粒的组方规律进行探讨。

玉蚕颗粒联合氯沙坦钾片治疗气虚湿瘀型糖尿病肾病的临床观察

目的观察玉蚕颗粒联合氯沙坦钾片治疗糖尿病肾病的临床疗效及其安全性。方法将90例气虚湿瘀型糖尿病肾病患者随机分为治疗组、对照组,每组45例。在常规治疗基础上,治疗组加用玉蚕颗粒、氯沙坦钾片,对照组加用玉蚕颗粒安慰剂、氯沙坦钾片,两组疗程均为12周。观察临床疗效,比较治疗前后24 h尿蛋白定量、尿蛋白-肌酐比值(UACR)以及实验室指标[血肌酐(Scr)、尿素氮(BUN)、估算肾小球滤过率(eGFR)、总胆固醇(TC)、低密度脂蛋白(LDL)、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、白介素-6(IL-6)]的变化情况,并进行安全性评价。结果①最终完成试验者治疗组、对照组各44例。②治疗组、对照组临床总有效率分别为79.55%、56.82%,中医证候总有效率分别为86.36%、72.73%,差异均有统计学意义(P<0.05),治疗组疗效优于对照组。③治疗前后组内比较,两组24 h尿蛋白定量、UACR降低(P<0.05);组间治疗后比较,治疗组24 h尿蛋白定量、UACR低于对照组(P<0.05)。④治疗前后组内比较,两组Scr、BUN、eGFR、TC、LDL、CRP、SAA、IL-6水平降低(P<0.05);组间治疗后比较,治疗组Scr、TC、LDL、CRP、SAA、IL-6水平低于对照组(P<0.05)。⑤试验期间两组均未出现明显不良反应。结论玉蚕颗粒联合氯沙坦钾片治疗糖尿病肾病疗效满意,可有效改善患者蛋白尿水平和机体炎症状态,延缓疾病进展,且安全性良好。

基于虚拟仿真技术构建模拟中药房及其应用评价

目的 构建基于虚拟仿真技术的模拟中药房,助力开发中药调剂教育培训新模式。方法 通过实地调研和问卷调查,明确中医药学生及从业人员对模拟中药房建设知识内容、表现形式的需求;以中药房建设的法律法规及中药调剂学相关教材、文献为知识源,应用虚拟仿真技术构建模拟中药房,实现中药房浏览、中药调剂知识学习和实践技能培训等功能;基于平台运行测试,开展多地模拟中药房评价量表研究。结果 构建了以教学视频、动画视频、仿真药房、模拟体验4个核心模块组成的模拟中药房;评价量表整体得分为93.31分,所有条目评价得分均高于80分,其中高于90分的评价量表占比达92.31%(60/65)。结论 基于虚拟仿真技术的模拟中药房满足了用户的学习需求,提升了中药调剂技术培训的教学效果。

清肺排毒颗粒治疗新型冠状病毒肺炎的回顾性研究及应用前景分析

目的分析早期应用清肺排毒颗粒对轻型新型冠状病毒肺炎患者核酸转阴时间、住院天数及核酸转阴率的影响。方法采取回顾性研究法,收集2022年3月15日—2022年4月22日吉林市第七方舱医院收治的、符合标准的轻型新型冠状病毒肺炎病例资料400例,在第九版诊疗方案的基础上,根据早期是否服用清肺排毒颗粒分为观察组和对照组,各200例。统计分析并比较两组核酸转阴时间、住院总天数及核酸复阳率相关性。结果从核酸转阴率及住院总时长来看,观察组明显优于对照组(P<0.05)。两组核酸复阳率比较,差异无统计学意义(P>0.05)。结论在西医常规治疗基础上,早期应用清肺排毒颗粒,可有效缩短轻型新型冠状病毒肺炎患者的核酸转阴时间及住院天数,对其治疗和预后有着积极的临床意义,对日后疫病防治具有一定参考价值。

含荜铃胃痛颗粒的中西医结合疗法治疗幽门螺杆菌的Meta分析

目的:探究荜铃胃痛颗粒联合西药三联或四联的中西医结合疗法与传统西药疗法根除幽门螺杆菌(H.pylori)的有效性及安全性。方法:检索PubMed、Embase、Cochrane Library、中国知网、万方数据库、中国生物医学文献服务系统,收集有关荜铃胃痛颗粒应用于H.pylori根除治疗的随机对照研究,检索年限均为数据库建库至2022年11月,根据Cochrane系统评价方法对检索到的文献进行数据提取以及文献质量评估。采用RevMan 5.4软件进行Meta分析。结果:共纳入4篇文献,506例患者。Meta分析结果显示,在H.pylori根除率方面,试验组高于对照组(OR=4.18,95%CI:2.57~6.79,I 2=0%,P<0.00001)。在安全性方面,试验组不良反应发生率低于对照组(OR=0.30,95%CI:0.10~0.85,I 2=0%,P=0.02)。结论:含荜铃胃痛颗粒的中西医整合治疗方案在疗效与安全性方面均明显优于西药四联、三联疗法。

以中医症状评分为指标应用TreeAge Pro对金叶败毒颗粒治疗急性上呼吸道感染的药物经济性评价

目的:探索以中医症状评分为指标应用Tree Age Pro对金叶败毒颗粒治疗急性上呼吸道感染的经济性评价。方法:以治疗前后咽痛单症状计分差值和咽喉疼痛症状总计分差值2个指标评价2组治疗方案的经济性。结果:对于“治疗5天后咽痛单症状计分差值”,计算达到临床意义界值需多花费92.82元,约为2021年人均可支配收入的0.26%;对于“治疗5天后咽喉疼痛症状总计分差值”,计算达到临床意义界值需多花费100.94元,约为2021年人均可支配收入的0.29%。结论:基于2021年人均可支配收入作为患者支付意愿阈值的假设,急性上呼吸道感染患者使用金叶败毒颗粒治疗方案比使用复方双花颗粒治疗方案更具有经济性。以中医症状评分为指标开展金叶败毒颗粒治疗急性上呼吸道感染的经济学评价,更适用于中医药临床实际应用,为临床医生决策提供最优方案,同时为中医药经济学研究提供更符合中医药特色的新指标。

补肾启枢强心颗粒治疗慢性心力衰竭临床观察

目的观察补肾启枢强心颗粒对慢性心力衰竭的临床疗效。方法选取120例江西中医药大学附属医院心血管科2019年1月—2020年12月收治的住院患者,采用随机数字表分为治疗组和对照组,各60例,对照组常规西药治疗,治疗组在常规西药治疗基础上加用补肾启枢强心颗粒,疗程8周。观察比较2组患者中医证候积分、左室射血分数、左室舒张末期内径、左室收缩末期内径、心功能分级变化、脑钠肽水平、6 min步行距离、明尼苏达生活质量量表调查积分等的改善情况。结果治疗组疗效明显优于对照组,差异有统计学意义(P<0.05)。结论补肾启枢强心颗粒治疗慢性心力衰竭临床效果显著,值得推广应用。

“10S”管理法在中药房工作管理的应用效果评价

目的 本研究旨在验证“10S”管理法在提高中药房工作效率方面的效果。方法 采用对照试验法,以“10S”管理实施前(2022年1至7月)作为对照组,“10S”管理实施后(2023年1至7月)作为试验组,比较中药房日常用品开支、场所环境、药师药学服务胜任力、调剂工作质量与效率、调剂差错率、患者满意度等内容。结果 在实施“10S”管理后,中药房日常开支减少,场所更整洁有序,药师药学服务胜任力明显提高,调剂工作的质量和效率显著改善,调剂差错率降低,患者的满意度进一步提升。数据显示,中药房工作繁忙阶段调剂时间由(7.77±0.21)min缩减至(6.64±0.27)min,工作繁忙阶段平均发药时间由(32.44±1.32)min缩减至(17.05±2.23)min。结论 “10S”管理法建议在中药房推广应用,以提高中药师工作效率和服务质量。

中药房药师开展优质中药学服务的有效途径思路分析

目的分析中药房药师开展优质中药学服务的有效途径及实践效果。方法以泰安市中医医院中药房为试点,2021年1—6月应用常规中药学服务;2021年7—12月应用优质中药学服务。比较不同管理模式下中药学服务质量提升效果、患者对服用中药知识的理解度。结果干预后不规范处方开具率为1.00%(1/100),低于干预前的9.00%(9/100)(P<0.05);干预后超常处方中无适应证用药处方开具率为0,低于干预前的5.00%(5/100)(P<0.05);干预后用药不适宜处方开具率为0,低于干预前的8.00%(8/100),差异有统计学意义(P<0.05)。优质中药学服务模式下调研患者对服药知识的理解度(服药时间、服药温度、特殊中药的服用方式、服药饮食禁忌)要较常规中药学服务模式下更高,差异有统计学有意义(P<0.05)。结论通过采取多种措施应用,使得中药房药师能够顺利地开展中药学服务,利于患者对中药房多方面服务的满意度提升。