Effects of Traditional Chinese Herbal Medicine on Immune Organ Indexes and Macrophages Phagocytic Indexes in Chickens Infected by Infectious Bronchitis Virus

[ Objective] To study the therapeutic effects of traditional Chinese medicine prescriptions on infectious bronchitis （IB） and find a novel avenue for prevention and treatment of viral diseases in poultry. [Method] A total of 160 cockerels at the age of 15 d were divided into four groups randomly, including traditional Chinese medicine group, moroxydine control group, challenge control group and healthy control group. Except the healthy control group, other groups were challenged with infectious bronchitis virus （IBV） on Day 15. After 48 h post challenge, the traditional Chinese medicine groupand moroxydine control group were respectively administrated with Chinese herbal medicine prescription and moroxydine, continuously for 5 d. The immune organ indexes and macrephage phagocytic indexes were detected on Day 18, 24 and 30, respectively. [ Result] The immune organ indexes and macrophage phagocytic indexes were not significantly different between traditional Chinese medicine group and moroxydine control group on Day 18. But all the indexes of the traditional Chinese medicine groups were increased significantly （ P 〈 0.05） on Day 24 and 30, and showed extremely significant difference （ P 〈 0.01 ） with those of challenge control group on Day 30. [ Conclusion] The traditional Chinese herbal medicine can enhance macrophage phagocytic indexes and immune organs indexes of chickens infected by IBV.

TRADITIONAL CHINESE MEDICINE IN TREATMENT OF BRONCHITIS AND BRONCHIAL ASTHMA

According to the onset, acute or chronic, and the disease course, long or short, bronchitis can be divided into acute and chronic bronchitis, with their common main symptoms of cough, expectoration and oppression in the chest, and basically they belong to the category of 'cough' in traditional Chinese medicine (TCM).

CONTROLLING INFANTILE AIDS WITH NATURAL REMEDIES—A Romanian Case Study

With the permission of the RomanianGovernment, I had used Shoyaku, aJapanese term for crude herbalprescriptions, to treat infantile AIDS pa-tients at Constanta Municipal Hospital,Constanta, Romania, for a period of thirtymonths (beginning from March, 1992),cooperated with Dr. Rodica Matusa, Chiefof the AIDS Section of Constanta Munici-

Fifty-Four Infantile Intractable Diarrhea Patients Treated with Integrated Traditional Chinese and Western Medicine

Objective: To explore the treatment on infantile intractable diarrhea with integrated traditional Chinese and western medicine. Methods: Paired control method was used to study 54 cases of infantile intractable diarrhea patients, who were randomly divided into the treated group and the control group (western medicine treated group). The treated group was further subdivided into two syndrome-types: Spleen deficiency diarrhea type and Spleen-Kidney Yang deficiency diarrhea type, and modified Shenling Baizhu powder (参苓白术散) and Sijunzi decoction (四君子汤) with modified Sishen pill (四神丸) were used for them respectively, while the control group was given only the conventional western drugs. At the same time, immunoglobulin (IG) and T lymphocyte transformation rate (TLTR) were observed. Results: Before treatment, IgG, IgA and TLTR of all the patients in both groups were lowered; after treatment, all of them improved, and the improvement of the treated group was more significant than that of control group (P<0.01). In the treated group, the cure rate and total effective rate were significantly higher than that of control group (P<0.01). Conclusion: Using integrated traditional Chinese and western method, the immune function of the patients were enhanced, and the function of Spleen-Stomach was recuperated, therefore satisfactory results were reached.

Fifty Patients of Infantile Protracted Chronic Pneumonia Treated withIntegrated Traditional Chinese and Western Medicine

Objective: To investigate the effects of integrated traditional Chinese and Western medicine in treating infantile protracted chronic pneumonia （IPCP）. Methods: One hundred patients of IPCP were divided equally into two groups, the TCM-WM group treated with Maqin Qizhu Decoction combining with antibiotics and the control group treated with antibiotics alone. Efficacy of the two groups was compared after 1 course（15）days） of treatment. Results: The total effective rate of the TCM-WM group was better than that of the control group. Moreover, the days needed in curing coughing, dyspnea, rales and X-ray shadow absorption of the former were fewer than those of the latter. Conclusion: The integrated TCM-WM therapy in treating IPCP could both inhibit the pathogens effectively and improve the humoral immunity and resistant ability of organism.

TCM aerosol inhalation treatment in acute exacerbations of chronic bronchitis： a meta-analysis

Objectives： To determine whether traditional Chinese medicine （TCM） aerosol inhalation treatment is effective inthe treatment of acute exacerbation of chronic bronchitis. Methods： Search double-blind randomised clinical trials（RCT） about the use of TCM aerosol inhalation in patient with acute exacerbation of chronic bronchitis via database including Chinese biomedicine literature database, Wanfang Data, CNKI, Pubmed, EMBASE and CochraneLibrary from the beginning to October 2016. Quality evaluation, data extraction and data analysis of these RCT wascarried out with reference to the Cochrane systematic review. Results： 16 studies with 738 patients in TCM aerosolinhalation group and 675 in control group were included. The results of meta-analysis showed, （1） TCM aerosolinhalation group could improve the total cure rate. （2） TCM aerosol inhalation could increase the expression of IL-2while decrease the expression of IL-8 and MDA in sputum and blood. （3） TCM aerosol inhalation could improvethe symptoms of cough, cough with sputum, cough with dyspnea and lung wet rales. It also improve the symptomsof cough, expectorate and lung wet rales. （4） Shorten the time of cough and lung rale. （5） The adverse reactionswere light only with 1 occurrence of nausea and vomiting. Conclusions： The use of TCM aerosol inhalation in thetreatment of acute exacerbation of chronic bronchitis was effective. However, the inclusion researches quality werenot very high, which only provided limited evidence for clinical application. Higher-quality randomized controlledtrials were needed for further study.

CLINICAL OBSERVATION ON TREATMENT OF ACUTE BRONCHITIS PRIMARILY WITH PRICKING-CUPPING ON BACK-SHU POINTS

To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods. The patients of acute bronchitis were randomly divided into 2 groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results： The total effective rate of the observation group was 97.2% while that of the control group was 82,8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group （P 〈 0.01） and on the fifth and seventh days, the comparison showed no significant difference （P〉0.05）. Conclusion： The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.

基于中医治未病理论综合干预治疗慢性支气管炎痰湿质患者临床研究

目的观察基于中医治未病理论综合干预治疗慢性支气管炎(CB)痰湿质患者的临床疗效。方法选择2019年1月至2020年12月收治的92例CB痰湿质患者为研究对象,按照随机数字表法分为2组,对照组46例予西医常规干预治疗,治疗组46例在对照组的基础上予基于中医治未病理论的综合干预治疗。2组均连续干预12周,比较2组治疗前后痰湿质体质量表评分、肺功能指标[包括用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))及FEV_(1)/FVC]及炎症因子[包括C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)及白细胞介素6(IL-6)]水平变化情况。结果与本组治疗前比较,2组治疗后痰湿质体质量表评分均降低(P<0.05),且治疗组治疗后痰湿质体质量表评分低于对照组(P<0.05)。与本组治疗前比较,2组治疗后肺功能指标FVC、FEV_(1)及FEV_(1)/FVC水平均升高(P<0.05),且治疗组治疗后FVC、FEV_(1)及FEV_(1)/FVC水平均高于对照组(P<0.05)。与本组治疗前比较,2组治疗后炎症因子血清CRP、TNF-α及IL-6水平均降低(P<0.05),且治疗组治疗后血清CRP、TNF-α及IL-6水平均低于对照组(P<0.05)。结论基于中医治未病理论综合干预CB痰湿质患者临床疗效确切,可有效改善患者痰湿质状况,提高肺功能,减轻机体的炎症反应,积极控制病情。

小儿推拿联合中医护理在婴幼儿运动发育迟缓康复中的应用

目的 探究小儿推拿联合中医护理在婴幼儿运动发育迟缓康复治疗中的临床效果。方法 选取聊城市人民医院2021年12月—2022年2月收治的68例运动发育迟缓患儿作为研究对象,随机分成对照组和试验组,各34例。对照组予常规治疗和护理,试验组在对照组基础上予小儿推拿联合中医护理干预,比较2组患儿干预前后的粗大运动发育商(GMQ)、精细运动发育商(FMQ)和总体发育商(TMQ)变化情况。结果 干预前,2组患者的GMQ、FMQ、TMQ评分比较,差异无统计学意义(P>0.05);干预后,试验组患者的GMQ、FMQ、TMQ评分均显著高于对照组,差异有统计学意义(P<0.05)。结论 小儿推拿联合中医护理应用于婴幼儿运动发育迟缓康复的临床效果显著,可有效提高患儿的运动发育水平,改善生活质量,值得在临床推广。

骨伤洗剂熏洗对桡骨远端骨折术后功能恢复的影响

目的探讨骨伤洗剂熏洗在桡骨远端骨折术后患者功能恢复的疗效。方法纳入该院2021年7月—2022年4月符合纳入标准的掌侧入路锁定钢板内固定治疗桡骨远端骨折术后患者共66例,常规指导功能锻炼组(对照组)33例和常规指导功能锻炼+骨伤洗剂熏洗组(治疗组)33例进行干预。比较两组患者术后疼痛、肿胀、关节功能的恢复情况。结果两组患者术后3个月总有效率均为100%,治疗组在治疗后及术后3个月视觉模拟(VAS)评分、肿胀减轻程度、活动度均优于对照组。术后3个月治疗组患者腕关节Gardmld-Werley功能评分明优于对照组。结论桡骨远端骨折术后指导性功能锻炼+骨伤洗剂熏洗可有效促进桡骨远端骨折术后早期功能的恢复,提高临床疗效,值得临床推广。

中药熏洗配合火龙灸治疗寒痰阻肺型慢性支气管炎的临床研究

目的探讨中药熏洗配合火龙灸治疗寒痰阻肺型慢性支气管炎(CB)的临床效果。方法选取2021年10月至2023年10月九江市第一人民医院收治的74例CB患者作为研究对象,采用随机数字表法分为对照组(37例)和观察组(37例)。对照组采用常规治疗,观察组加用中药熏洗配合火龙灸治疗。比较两组患者临床疗效、肺功能、炎症指标、BODE指数及免疫功能。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗后呼气峰流速(PEF)、第1秒用力呼气容积(FEV1)、FEV1占预计值百分比(FEV1%pred)及免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)高于本组治疗前,且观察组PEF、FEV1、FEV1%pred、IgA、IgM、IgG高于对照组,两组治疗后C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平及BODE指数低于本组治疗前,且观察组CRP、TNF-α水平和BODE指数低于对照组,差异有统计学意义(P<0.05)。结论寒痰阻肺型CB患者应用中药熏洗配合火龙灸治疗效果较佳,利于改善肺功能及免疫功能,减轻炎症反应,改善病情,值得临床推广。

下肢洗剂治疗膝骨关节炎临床观察

目的探讨下肢洗剂治疗膝骨关节炎的效果。方法选择60例膝骨关节炎患者作为研究对象,将其随机分成试验组和对照组,各30例。对照组给予双氯芬酸二乙胺乳胶剂外用,试验组给予下肢洗剂外用,2组均持续治疗2周。观察2组的临床疗效,比较2组治疗前后西安大略大学和麦克马斯特大学骨关节炎指数(WOMAC)量表评分、膝关节综合评分、血清学指标变化情况,以及不良反应发生情况。结果试验组的愈显率为66.67%(20/30),高于对照组的50.00%(15/30),差异有统计学意义(P<0.05)。治疗后,2组患者的WOMAC量表评分、膝关节综合评分及白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平均有不同程度下降,且试验组下降程度大于对照组,差异有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论下肢洗剂对于阳虚寒凝型膝骨关节炎具有治疗作用,可以很好地改善其临床症状,使血清炎性因子水平降低,在临床有一定的应用推广价值。

清咽散瘀汤治疗肺胃瘀热型小儿腺样体肥大临床观察

目的探讨自拟清咽散瘀汤每治疗肺胃瘀热型小儿腺样体肥大的临床效果。方法选取肺胃瘀热型小儿腺样体肥大患儿64例,随机分为对照组与观察组,每组32例。对照组常规西医用药,观察组自拟清咽散瘀汤治疗,2组连续治疗1个月,评价患儿症状、炎症指标变化以及临床效果。结果2组治疗后中医证候积分评分比较,观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗后炎症指标WBC、CRP、PCT均低于对照组(P<0.05);2组总有效率比较,观察组高于对照组,差异有统计学意义(P<0.05)。结论自拟清咽散瘀汤从肺胃瘀热型证型特点着手,发挥清热解毒、活血化瘀、消肿散结的功效,标本兼治,快速改善临床症状,调控机体炎症状态,效果显著,值得推广。

摩腹配合下推七节骨治疗食积内热型小儿便秘临床观察

目的 观察摩腹配合下推七节骨治疗食积内热型小儿便秘的临床效果。方法 门诊收集60例食积内热型便秘患儿,随机分为治疗组和对照组,每组30例。治疗组给予摩腹配合下推七节骨的推拿手法,对照组予口服乳果糖口服溶液,对比2组临床疗效。结果 2个疗程后,治疗组的治疗组愈显率90.00%(27/30)明显高于对照组的66.67%(20/30)(P<0.05);1个疗程后、2个疗程后,治疗组的中医证候疗效明显优于对照组(P<0.05)。2个疗程后,治疗组主证积分、次证积分及证候总积分均低于对照组(P<0.05)。结论 摩腹配合下推七节骨手法简单、易于操作,安全性高,治疗小儿食积内热型便秘效果确切,且易被患者接受,可在临床加强推广。

抗鸡传染性支气管炎病毒中药的筛选

【目的】对鸡传染性支气管炎病毒(Infectious bronchitis virus,IBV)进行抗病毒中药的筛选,并验证其治疗效果,为临床用药提供一定参考。【方法】采用鸡胚培养法,通过预防和治疗2个角度对24味单一中药、6种市售复方中药进行抗IBV的有效成分或方剂筛选试验,即在SPF鸡胚中先注射中药2 h后再接种病毒和先接种病毒2 h后再注射中药。使用SPSS 20.0软件对鸡胚重量进行方差分析,利用实时荧光定量PCR法辅助判定治疗效果。【结果】对鸡胚净重进行方差分析显示,桔梗组与阳性对照组差异显著(P<0.05),与阴性对照组差异不显著(P>0.05),表明预防和治疗均有效果。实时荧光定量PCR检测鸡胚尿囊液病毒滴度结果显示,桔梗、鱼腥草、宣肺败毒方、绞股蓝、蒲公英、甘草对IBV增殖均有抑制作用,其中桔梗抑制效果最佳。【结论】桔梗对IBV有显著的预防及抑制效果,结果为深入研究桔梗作用机理提供了依据。

除湿养发汤联合参柏洗剂治疗脂溢性脱发

目的探讨除湿养发汤联合参柏洗剂治疗脂溢性脱发的临床疗效。方法选择脂溢性脱发患者62例,随机分为对照组与研究组,各31例。对照组口服非那雄胺片联和外用米诺地尔酊治疗,研究组口服非那雄胺片与除湿养发汤联合参柏洗剂治疗,观察2组临床疗效,比较2组治疗前后中医证候积分、血清性激素清睾酮(T)、雌二醇(E2)水平,2组不良反应发生情况。结果研究组临床疗效总有效率(96.77%,30/31)高于对照组(80.65%,25/31)(P<0.05);2组治疗后中医主症、次症积分、血清T水平均下降(P<0.05),研究组中医主症、次症积分、血清T水平均低于对照组(P<0.05);2组治疗后E2水平均升高(P<0.05),研究组E2水平高对于照组(P<0.05);治疗期间,2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论除湿养发汤联合参柏洗剂治疗脂溢性脱发患者效果显著,可有效减轻临床症状,调节血清性激素水平,安全性良好,值得临床推广应用。

儿童塑型性支气管炎的分期论治

本研究认为儿童塑型性支气管炎应分期论治。初期以风、热、痰为主要病理因素,以风热夹痰为主要病机,常用方如银翘散合麻杏石甘汤加减以祛风宣肺、清热化痰;极期以痰、热、毒、瘀为主要病理因素,以痰热夹瘀、毒热夹瘀多见,常用《千金》苇茎汤、麻杏石甘汤、桔梗汤等加减以清热豁痰、凉血解毒、排脓祛瘀;后期以燥、虚、痰、瘀为主要病理因素,以虚热夹痰夹瘀为主要病机,以麦门冬汤合六君子汤加减以益气养阴、化痰祛瘀。痰浊贯穿疾病始终,瘀血存在于疾病中后期。

穴位贴敷联合耳穴压豆治疗慢性支气管炎临床观察

目的 探讨穴位贴敷联合耳穴压豆治疗慢性支气管炎的临床效果。方法 选择江西省中西医结合医院2021年4月—2022年3月收治的60例慢性支气管炎患者作为研究对象,随机分为试验组和对照组,每组30例。对照组行常规治疗,试验组在对照组的基础上运用穴位贴敷联合耳穴压豆治疗。结果 试验组总有效率96.7%(29/30)显著高于对照组的86.7%(26/30),差异有统计学意义(P<0.05)。结论 穴位贴敷联合耳穴压豆可以有效缓解慢性支气管炎患者咳嗽、喘息症状,改善患者生活质量,提高临床疗效。

名老中医医案小儿遗尿证候特点分析

目的探究小儿遗尿证型的中医证候特点,为临床辨证提供指导。方法采用线上数据库检索和线下图书馆人工检索相结合的方式,以“遗尿”or“遗溺”and“名老中医”or“名中医”and“医案”or“经验”为关键词,收集1949—2022年名老中医治疗小儿遗尿医案,构建名老中医诊治小儿遗尿医案数据库。运用频数分析、主要成分因子分析与聚类分析,归纳常见证型的证候特征,研究医案中遗尿患儿的中医证候分布特点。结果共纳入350例医案,将频次≥15的四诊信息进行因子分析,得到12个公因子。将公因子进行聚类分析,结合中医专业知识,最终确定6种常见证候特点。结论小儿遗尿主要病位证素为肾、脾、肝,病性证素为阳虚、气虚、血虚、阴虚。从肝论治小儿遗尿以热证及郁证多见。因此临床治疗应以温补脾肾为主,配合泻肝清热利湿或疏肝之法。