The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms

Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the world.Traditional Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of COVID-19.WHO evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM formulae.However,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those formulae.Methods:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association rules.We then determined the BC-TCM and screened main compounds and therapeutic targets.Finally,the potential molecular mechanisms were explored by using enrichment analyses and molecular docking.Results:This study screened 123 patented TCM formulae,including 312 herbs.According to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu Ling,Huang Qi,Jie Geng,Lian Qiao,Cang Zhu,Ku Xingren)were selected as the BC-TCM.The BC-TCM involved 166 main compounds and 48 therapeutic targets.The active compounds Hederagenin,Spinasterol,Beta-sitosterol,and Liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking results.Interestingly,Hederagenin might be a potential compound for the prevention and treatment of COVID-19.Conclusion:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on COVID-19.This has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research.

Study on Agricultural Intellectual Property Protection and High-Quality Development of Traditional Chinese Medicine of Ginseng

Agricultural intellectual property has the functions of carrying forward agricultural cultural heritage,encouraging agricultural scientific and technological innovation,cultivating the brand of agricultural products and so on. The protection and application of agricultural intellectual property rights can enhance the vitality,innovation and competitiveness of agricultural economy,and promote the strategy of high-quality agricultural development and rural revitalization. Ginseng is a traditional medicinal variety with superior characteristics in Northeast China,and it is one of the most famous " three treasures" in Northeast China. This paper introduces ginseng( Panax ginseng C. A. Mey.) and its medicinal value,analyzes the traditional knowledge,biological genetic resources,new plant varieties,patents,geographical indications,trademarks and other agricultural intellectual property resources of ginseng,studies the traditional Chinese medicine GAP certification and certification of " Three Agricultural Products" and the construction of the dominant area of agricultural product( Fusong ginseng) with Chinese characteristics,and explores the rural revitalization strategy and traditional Chinese medicine development strategy,ginseng agricultural intellectual property protection and high quality development strategy.

Property theory of Chinese materia medica: Clinical pharmacodynamics of traditional Chinese medicine

The property theory of Chinese materia medica is one of the foundations of traditional Chinese medicine.The property of Chinese materia medica(PCMM)is a multi-dimensional expression of the effect of Chinese materia medica(CMM),and it is related to the clinical prescription that fully reflects the clinical effect evaluation of CMM in a holistic,systematic,and scientific way.This paper discusses the source,development,and application of the PCMM by considering not only the five dimensions that constitute the PCMM but also the recognition of the human body and disease as given in traditional Chinese medicine.This paper aims to provide theoretical guidance for the rational use and development of CMM.

Effect of Traditional Chinese Medicine inImproving Hot Flashes Symptom ofBreast Cancer

Breast cancer (BC) is the most common malignant tumor in women. Around 50% of BC receptor-positive patients are hormone-dependent cases, and it is necessary for them to use endocrine after operation. Through inhibition of estrogen level

Discussion on the Application of Ascending and Descending Property of Traditional Chinese Medicine in Compatibility of Clinical Prescriptions

Through the method of literature mining,the classics of traditional Chinese medicine,materia medica works,medical cases and documents are studied.Based on common prescriptions for the treatment of diseases such as abnormal Zang-fu viscera and qi movement,dysfunction,etc.,and combined with the theory of ascending and descending property of traditional Chinese medicine,the application of ascending and descending property of traditional Chinese medicine in clinical prescription compatibility and the factors affecting the application are summarized.The ascending and descending properties of traditional Chinese medicine have been widely used in prescription compatibility for the clinical treatment of impairment of purifying and descending function of the lung,spleen and stomach's ascending and descending disorders and heart-kidney noninteractionpatte.

Protection of Intellectual Property and Authenticity of Chinese Herbal Medicine Chrysanthemum morifolium

This paper first introduced Chrysanthemum morifolium Ramat. and its medicinal value. Then, it studied agricultural intellectual property resources such as geographical indications, trademarks, patents, new plant varieties, biological genetic resources, and traditional knowledge related to C. morifolium . Finally, it summarized poverty-stricken areas ecologically suitable for planting C. morifolium , analyzed the GAP certification of C. morifolium , pollution-free agricultural product certification, green food certification, and organic food certification, and discussed the strategies for C. morifolium intellectual property protection and authenticity protection in the context of TCM development strategy and rural revitalization strategy.

From ancient wisdom to modern science:Gut microbiota sheds light on property theory of traditional Chinese medicine

The property theory of traditional Chinese medicine(TCM) has been practiced for thousands of years,playing a pivotal role in the clinical application of TCM. While advancements in energy metabolism,chemical composition analysis, machine learning, ion current modeling, and supercritical fluid technology have provided valuable insight into how aspects of TCM property theory may be measured, these studies only capture specific aspects of TCM property theory in isolation, overlooking the holistic perspective inherent in TCM. To systematically investigate the modern interpretation of the TCM property theory from multidimensional perspectives, we consulted the Chinese Pharmacopoeia(2020 edition) to compile a list of Chinese materia medica(CMM). Then, using the Latin names of each CMM and gut microbiota as keywords, we searched the PubMed database for relevant research on gut microbiota and CMM. The regulatory patterns of different herbs on gut microbiota were then summarized from the perspectives of the four natures, the five flavors and the meridian tropism. In terms of the four natures, we found that warm-natured medicines promoted the colonization of specific beneficial bacteria,while cold-natured medicines boosted populations of some beneficial bacteria while suppressing pathogenic bacteria. Analysis of the five flavors revealed that sweet-flavored and bitter-flavored CMMs positively influenced beneficial bacteria while inhibiting harmful bacteria. CMMs with different meridian tropism exhibited complex modulative patterns on gut microbiota, with Jueyin(Liver) and Taiyin(Lung) meridian CMMs generally exerting a stronger effect. The gut microbiota may be a biological indicator for characterizing the TCM property theory, which not only enhances our understanding of classic TCM theory but also contributes to its scientific advancement and application in healthcare.

In silico method for studying property combination of traditional Chinese herbs

Objective:This paper discusses the composition of prescription qualitative,quantitative design principles and methods based on herbal property combination,describing the method application in new prescription design.Method:Qualitative property-combination pattern(PP)calculation was based on bipartite graphing and performing a greedy algorithm which was designed to optimize obtaining a new herbal prescription.Quantitative PP calculation was based on the qualitative computation.To calculate the Euclidean distance for the PP of the new prescription,an optimized algorithm for solving the unknown minimum Euclidean distance was used with,the new weighted proportions.Finally,non-linear optimization software was used to find the minimum Euclidean distance.Results:Using the PP of classic prescription Large Yin-Nourishing Pill,applying quantitative PP calculation a new prescription was created.Mathematical algorithms based on property combinations of traditional Chinese herbs can be applied to identify compatibility and synergies of herbs within prescriptions,especially classic formulas.Conclusion:In silico methods can then be used to create new prescriptions or modify existing ones depending on need.This type of automated approach may increase efficiency in designing new drugs based on Chinese herbs.

A preliminary study on the properties of red traditional Chinese medicine

Objective: From the aspect of meridian tropism, this paper makes a preliminary discussion on the medicinal properties of red traditional Chinese medicine belonging to the heart meridian, with a view to providing a reference for the further study of the relationship between the color of traditional Chinese medicine and its medicinal properties. Method: Based on clinical practice and modern pharmacology, pharmacochemistry and other research, this paper analyzed the material basis of red traditional Chinese medicine belonging to the heart meridian. Result: Finally, it was found that most of the chemical constituents of red traditional Chinese medicine were flavonols, and their pharmacological effects were related to cardiovascular system. Conclusion: Red Chinese medicine belonging to the heart meridian has a certain theoretical basis and modern research basis, which can provide a reference to the further study of the relationship between color and drug properties of Chinese medicine in the future.

An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica

Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine （TCM） researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory （CHPT）, this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong＇s Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property （qi, flavor and their combinations） and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated： （1） the many-to-one mapping of herbal efficacy to herbal property; （2） the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research.

《神农本草经》与《中国药典》2020年版对中药四气五味表述异同分析

目的明确《神农本草经》与现代中药四气五味表述的差异,为进一步指导临床合理用药提供参考。方法以《神农本草经》收载的365种中药为来源进行统计,《中国药典》2020年版和《临床用药须知》(2015版)收录《神农本草经》记载的药物为研究对象,建立数据库,对比分析中药“四气”“五味”的表述差异。结果本研究共统计203种中药,其中中药四气表述完全不相同的有66种,占32.51%;中药五味表述完全不一致的有20种,占9.85%。结论通过对比《中国药典》《临床用药须知》与《神农本草经》中药“四气”“五味”,大部分中药表述一致,表述不一致的中药值得进一步深入研究。

《中华中医药学刊》刊文特征与热点分析

目的 系统总结和分析《中华中医药学刊》2007—2022年所刊文的内容特征与热点,以期为《中华中医药学刊》的发展提供参考。方法 综合运用CiteSpace、VOSviewer等文献计量工具,从刊文量、研究者、研究机构、刊文主要关键词、刊文热点主题、刊文研究趋势等,进行多维视角的可视化分析。结果 年刊文数量呈下降趋势,但刊文质量显著提升;研究者之间连线较为密集;研究者群体相对稳定。结论 刊文研究者合作关系相对紧密;呈现以高校及其附属医院为核心研究者群体特征;中西医结合、中药现代化和针灸治疗现代化三大主题,是《中华中医药学刊》2007—2022年的研究热点。

中医康复护理对脑卒中偏瘫患者肢体功能及生活质量的影响

目的观察中医康复护理对脑卒中偏瘫患者肢体功能及生活质量的影响。方法选取108例脑卒中偏瘫患者,按照住院时间分成对照组和观察组各54例;对照组实施常规康复训练,观察组在此基础上结合中医特色护理康复,包括坐式八段锦、中药热敷、按摩等。结果干预3个月后,两组肢体运动功能评分、生活质量评分比较,差异有统计学意义(均P<0.05)。结论对脑卒中偏瘫患者实施中医特色康复护理,可促进患者肢体功能康复,提高生活质量。

中药热奄包联合隔姜灸在脾胃虚寒型胃脘痛患者中的临床应用

目的:探究中药热奄包联合隔姜灸在脾胃虚寒型胃脘痛患者中的临床护理效果。方法:选择2023年1—12月广东省第二中医院脾胃病科收治的80例明确诊断为脾胃虚寒型胃脘痛患者作为研究对象,采用随机数表法将患者分为观察组与对照组,各40例。观察组给予中药热奄包联合隔姜灸中医护理,对照组给予该病内科基础性护理服务。比较两组护理效果、中医症候积分、生活质量及护理服务满意度。结果:观察组护理总有效率、护理服务满意度高于对照组,差异有统计学意义(P<0.05);护理7 d后,两组中医症候积分均低于护理前,且观察组低于对照组,差异有统计学意义(P<0.05);护理7 d后,两组躯体职能、躯体疼痛、躯体功能、总体健康评分均高于护理前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:中药热奄包联合隔姜灸干预脾胃虚寒型胃脘痛患者护理效果显著,可缓解临床症状,提高生活质量,提升护理满意度。

中药热敷及穴位贴敷防治肛肠疾病术后便秘的临床效果观察

目的分析中药热敷及穴位贴敷防治肛肠疾病术后便秘的应用价值。方法选取肛肠疾病(混合痔和肛瘘)术后便秘患者160例,按随机数字表法分为观察组、对照组,各80例。对照组采取常规西药治疗,观察组在对照组基础上实施中药热敷及穴位贴敷治疗。比较两组治疗效果及治疗前后便秘评分、生活质量评分。结果观察组治疗总有效率98.75%较对照组的82.50%明显更高(P<0.05)。治疗前,观察组躯体不适、心理社会、担心和焦虑、满意度评分与对照组比较无意义(P>0.05);治疗后,观察组躯体不适、心理社会、担心和焦虑、满意度评分分别为(10.27±1.34)、(12.26±1.32)、(15.28±1.43)、(5.78±1.44)分,显著低于对照组的(22.03±1.31)、(21.04±1.21)、(25.43±1.12)、(12.43±1.22)分(P<0.05)。治疗前,两组便秘评分比较无意义(P>0.05);治疗后,观察组便秘评分(11.02±2.28)分较对照组的(16.72±2.32)分更低(P<0.05)。结论中药热敷及穴位贴敷防治肛肠疾病术后便秘的效果显著,可改善患者生活质量。

Metabolomics coupled with similarity analysis advances the elucidation of the cold/hot properties of traditional Chinese medicines

It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance(NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.

中医药传统知识专门保护制度构建研究

中医药传统知识是中医药的核心内容,兼具卫生、经济、科技、文化、生态五重资源价值。目前中医药传统知识面临国外不当占有、盗用,国内传承、保护不力的双重困局,现行法律制度无法实现全面、系统保护,建立专门保护制度已成为必然选择。专门保护制度需要解决四个核心问题:对外防御侵占和不当占有,对内保护持有人权利并规范知识的获取与利用,化解持有人利益与社会公共利益之间的矛盾,处理与现行法律制度的衔接。在此基础上,提出构建中医药传统知识专门保护制度的四个机制,即阻却外国不当专利申请的防御机制、持有人权利保护机制、持有人利益与社会公共利益平衡机制、与现行法律制度的衔接机制,以更好促进中医药传统知识的保护、传承、创新、发展。

祛瘀复元方内服联合中药热熨在腰椎管狭窄症术后患者中的应用

目的探讨祛瘀复元方内服联合中药热熨治疗腰椎管狭窄症(LSS)术后患者的效果。方法纳入2021年5月至2022年10月河南科技大学第二附属医院收治的60例LSS患者,以随机数表法分为对照组(30例,内服祛瘀复元方治疗)和观察组(30例,内服祛瘀复元方+中药热熨治疗),均持续治疗3个月。比较两组治疗3个月时临床疗效、疼痛程度及治疗前、治疗3个月时日本骨科协会评估治疗分数(JOA)评分,以及不良反应发生率。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,观察组疼痛程度低于对照组(P<0.05),JOA评分高于对照组(P<0.05)。治疗期间,两组不良反应总发生率差异无统计学意义(P>0.05)。结论祛瘀复元方内服联合中药热熨对LSS术后患者临床疗效较好,可缓解患者疼痛程度,改善其腰椎功能,且不会增加不良反应。

中药热敷联合多磺酸粘多糖乳膏治疗动静脉内瘘血肿的效果观察

目的探讨中药热敷联合多磺酸粘多糖乳膏对动静脉内瘘血肿的护理效果。方法本研究为随机对照试验。选取2021年2月至2023年2月连云港市中医院门诊动静脉内瘘血肿患者60例,按照随机数字表法分为参照组30例和联合组30例。参照组男21例,女9例,年龄(47.58±7.15)岁,采用多磺酸粘多糖乳膏联合常规护理;联合组男20例,女10例,年龄(46.45±6.14)岁,在参照组基础上实施中药热敷。记录并比较两组患者的皮下血肿消退时间和疼痛持续时间、并发症发生情况、护理满意度。采用t检验、χ^(2)检验。结果联合组患者的皮下血肿消退时间、疼痛持续时间均短于参照组[(7.54±2.25)d比(10.85±3.14)d、(4.25±0.48)d比(6.50±0.51)d],差异均有统计学意义(t=6.934、9.072,均P<0.001);联合组患者的并发症发生率低于参照组[6.67%(2/30)比26.67%(8/30)],护理总满意度高于参照组[90.00%(27/30)比66.67%(20/30)],差异均有统计学意义(χ^(2)=4.320、4.812,P=0.038、0.028)。结论中药热敷联合多磺酸粘多糖乳膏可加快动静脉内瘘血肿患者的皮下血肿消退,缩短疼痛持续时间,提升护理满意度,减少并发症发生,缓解炎症,值得临床推广。

中医特色健康管理模式联合中药热敷对腰突症患者疼痛及功能康复的影响

目的研究探讨中医特色健康管理模式联合中药热敷对腰突症患者疼痛及功能康复的影响。方法选取2021年6月—2023年6月本院收治的100例腰突症患者为对象,随机数字表法分为观察组、对照组,每组50例。对照组以常规护理干预结合中药热敷干预,观察组在此基础上增加中医特色健康管理模式干预。评估对比两组中医症状评分、疼痛程度、康复效果、不良事件发生率。结果观察组在干预2、4、8、12周时中医症状评分低于对照组(P<0.05)。观察组在干预2、4、8、12周时视觉模拟评分低于对照组(P<0.05)。观察组在干预2、4、8、12周时日本骨科协会评估治疗评分低于对照组(P<0.05)。观察组不良事件发生率6.00%,低于对照组的22.00%(P<0.05)。结论中医特色健康管理模式联合中药热敷对腰突症效果良好,缓解中医症状和疼痛程度,恢复腰椎功能,降低各种不良事件发生。