Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond

Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

Study on the Changes of Medical Income Structure in Governmentrun Hospitals of Traditional Chinese Medicine from 2012 to 2021

Objective To study the changing characteristics and trend of medical income structure in the government-run hospitals of traditional Chinese medicine(TCM),evaluate the effects of relevant reform measures,and to put forward corresponding suggestions for further optimizing their income structure.Methods The data related to the average medical income of government-run hospitals of TCM from 2012 to 2021 were sorted out.Then,descriptive analysis method was used to analyze the changes of related indicators.Besides,structural change method was applied to investigate the changes of outpatient income and inpatient income.Results and Conclusion From 2012 to 2021,the growth of medical income in government-run hospitals of TCM tended to be stable,and the proportion of medical service income increased from 22.62%(2012)to 29.38%(2021),but the average annual growth rate was only 0.68%.The main items that caused the change of outpatient income structure were medicine revenue,laboratory tests,diagnosis and treatment,and the cumulative contribution rate was 89.15%.The main items that caused the change of inpatient income structure were medicine revenue,sanitary materials,and auxiliary examinations income,with a cumulative contribution rate of 80.04%.However,the contribution rate of registration,diagnosis,treatment,surgery and nursing income reflecting the value of medical personnel’s technical labor was relatively small.The medical income structure of government-run hospitals of TCM underwent great changes and gradually became reasonable,but the medical service income increased slowly,and not all indicators achieved the expectations.To promote the sustainable development of public hospitals of TCM and enable them to provide high-quality and efficient TCM medical and health services,it is necessary to further improve the relevant policy mechanism.

Study on Spatial Structure of Traditional Villages from the Perspective of Clanism

"China's deep-rooted family culture and the resulting family spirit is one of the basic characteristics of Chinese society that differs from western society," said by Chinese sociologist Fei Xiaotong. German sociologist Max Weber defi nes Chinese society as "family structure society"[1]. And sociologist Fei Zhengqing believes that the villages in China are organized by families. In sociological studies, the traditional villages are divided into three types: single-clan villages with only one dominating family, main-clan villages which are mainly composed of several families, and multi-clan villages where some coequal families live together[2]. The authors believe that traditional villages are organized social communities with kinship as a link. They are products of the family system. There is a close connection between a village's family composition and its space construction. Single-clan village is an introverted spatial organization mode entirely based on kinship, ancestral hall is located in the center and the whole spatial structure grows toward it. Main-clan village is a decentralized family aggregate based on the ties of blood as well as region. And the organization of its village space depends on temples and pavilions where families enshrine and worship ancestors and gods. It owns obvious features of collage and collaboration. M ulticlan village is a collaborative and extroverted complex spatial system led by relationship of colleagues, where large public buildings are taken as the core to organize commercial activities. Its form is similar to the form of small towns. Taking sociological term "family" as the starting point and cases of national historic cultural villages including Hong Village, Zhuge Village, Zoumatang Village, Suzhuang Village and Guoyu Village into further study, this article analyses the correlation between kinship composition and spatial form of villages, tries to reveal the essential structure of traditional space of villages and to provide a new perspective on spatial study as well as basis for preservation of traditional villages.

Joinery and Structure:Cultural and Technical Comparison between Traditional Wooden Framing Systems in East Asia and Western Europe

Traditional wooden joinery is the craft of connecting wood pieces for buildings or producing utensils by utilizing only the geometry of the components and material properties of the wood,without other materials such as glue or metal connectors.In its thousands of years of tradition,this construction technique has achieved high accomplishment in both East Asian and European architectural civilizations.Although sharing the same basic principles,joinery techniques vary between regions and cultures,rooted in the geographical environment,available wood species and their material properties,characteristics of craftsmanship,tools,and structural systems.Wood framing systems from China,Japan,and Western Europe are selected for comparison to assess the relationship between wood joinery and other aspects of building technology.The main conclusions include:in East Asia,the building tradition pays great attention to the design and execution of joinery(sunmao榫卯),making it responsible for multiple functions including architectural mechanics and the stability of the entire frame,which leads to a broader role meant by the term“joint”itself,while in Europe joinery is treated as the“node”or literally“joint”of the structure.Although in both East Asia and Europe wooden joinery serves as an aesthetic factor of the structure,its expression in East Asia is subtle,veiled,and restrained,while in Europe it is explicit and direct.The most important lesson we learn from the study of traditional joinery technology is that it should be seen in the context of the building process as a whole,taking into account geographical environment,material resources,craftsmanship,tools,construction methods,structural form,and the structural system.

Spatial Structure of Traditional Villages in Coastal Areas of Jiangsu Province

The village is the product of the objectification of human spirit, bearing the human production, life and other behaviors. Traditional villages in coastal area are the important carrier of sea salt culture, reflect a unique human landscape, form the unique structure characteristics and become China’s rural society’s important component. But in recent years, due to the urban renewal and the accelerating of the socialism new rural construction and the deterioration of the natural environment, traditional villages in Jiangsu coastal areas relying on the natural and cultural environment are experiencing an unprecedented test. In this paper, according to the investigation of the coastal areas of existing traditional village, after the comparative analysis, some basic spatial structure characteristics were summarized. It is expected to provide a reference for the planning, construction and management of villages.

Cultural Structure of Solar Terms and Traditional Festivals

Solar terms and festivals differ from and relate to each other in terms of application scope and cultural structure.The cultural association and application of the 24 Solar Terms are studied in the areas including philosophy,farming and society,and are exhibited in the natural convergence of views on space and time,life and customs,as well as the facilitation of agricultural practice.The connotations of traditional Chinese festivals concern basic areas such as beliefs,rites,language,symbols,diets and art,which are exhibited in the co-existent "festival tokens," "festival events," "festival messages," "festival symbols," "festival food" and "festival art forms." Festivals feature fixed and periodic occurrence and multi-channel cultural inheritance.

The Practice and Method of Integrating Fine Traditional Culture into Data Structure Course Teaching

To capitalize on the primary role of major course teaching and to facilitate students’understanding of abstract concepts in the data structure course,it is essential to increase their interest in learning and develop case studies that highlight fine traditional culture.By incorporating these culture-rich case studies into classroom instruction,we employ a project-driven teaching approach.This not only allows students to master professional knowledge,but also enhances their abilities to solve specific engineering problems,ultimately fostering cultural confidence.Over the past few years,during which educational reforms have been conducted for trial runs,the feasibility and effectiveness of these reform schemes have been demonstrated.

Computational investigation on the molecular structure and chemical reactivity of a traditional Chinese medicine extract MK-1 molecule

MK-1 molecule(C_(16)H_(16)O_(2)),the simplest structure of vitamin K(VK)compound family,is an extract from traditional Chinese medicine Cymbopogon distans(Nees ex Steud.)Wats(Chinese name YunXiangCao),which has attracted a great deal of attention in recent years due to its antiasthmatic,antitussives and expectorant effects.To investigate the molecular structure and chemical reactivity of MK-1 molecule,computational investigations on six conformational minima structures were carried out at the MP2/6-311++G(2d,2p)level of theory.Several local reactivity descriptors including condensed Fukui function,average local ionization energy,and molecular electrostatic potential on each individual atom were determined to predict the intrinsic reactivity of MK-1 molecule.

“3 Degrees and 8 Combinations” Teaching Mode of Anti-Seismic Design of Building Structures

Earthquakes pose a significant threat to people’s property and personal safety.Improving the teaching of civil engineering and building structure anti-seismic design courses can enable students to do a good job in anti-seismic design in the future and effectively reduce the damage on buildings caused by earthquakes.In this paper,we analyzed the basic characteristics of a course in civil engineering major,which is Anti-Seismic Design of Building Structures,and the shortcomings of traditional teaching.It is proposed that the 3-degrees and 8-combinations teaching mode of anti-seismic design of building structures can effectively improve students’autonomy and enthusiasm in learning,helps to cultivate professional ethics among students,and improve their ability to apply what they have learned.

Construction of Teaching Case Base of Anti-Seismic Design of Building Structure

Anti-Seismic Design of Building Structures is an important course in civil engineering majors,and it is also a course that pays equal attention to theory and practice.Therefore,by establishing a case base for Anti-Seismic Design of Building Structures,the obscure theoretical knowledge can be taught to students in the form of examples,and the knowledge becomes intuitive.In this way,the students’understanding of anti-seismic design theory and the efficiency of teaching can be improved,and the students’interest in learning can be stimulated.

Metabolomic and structural brain connectomic evidence validating traditional Chinese medicine diagnostic classification of major depressive disorder

OBJECTIVE Major depressive disorder(MDD) is a highly heterogeneous mental illness.Further classification may help characterize its heterogeneity.The purpose of this study was to examine metabolomic and brain connectomic associations with traditional Chinese medicine(TCM) diagnostic classification of MDD.METHODS Fifty unmedicated depressed patients were classified into Liver Qi Stagnation(LQS,n=30) and Heart and Spleen Deficiency(HSD,n=20) subtypes according to TCM diagnosis.Healthy volunteers(n=28) were included as controls.Gas chromatography-mass spectrometry(GC-MS) and diffusion tensor imaging were used to detect serum and urinary metabolomic profiles and whole-brain white matter connectivity,respectively.RESULTS In metabolomic analysis,28 metabolites were identified for good separations between TCM subtypes and healthy controls in serum and urine samples.While both TCM subtypes had similar profiles in proteinogenic branched-chain amino acids and energy metabolism-related metabolites that were differentiated from healthy controls,the LQS subtype additionally differed from healthy controls in multiple amino acid metabolites that are involved in the biosynthesis of monoamine and amino acid neurotransmitters.Several metabolites are differentially associated with the two subtypes.In connectomic analysis,The LQS subtype showed significant differences in multiple network metrics of the angular gyrus,middle occipital gyrus,calcarine sulcus,and Heschl′ s gyrus when compared to the other two groups.The HSD subtype had markedly greater regional connectivity of the insula,parahippocampal gyrus,and posterior cingulate gyrus than the other two groups,and microstructural abnormalities of the frontal medial orbital gyrus and middle temporal pole.The insular betweenness centrality was strongly inversely correlated with the severity of depression and dichotomized the two subtypes at the optimal cutoff value with acceptable sensitivity and specificity.CONCLUSION The LQS subtype may represent an MDD subpopulation mainly characterized by abnormalities in the biosynthesis of monoamine and amino acid neurotransmitters,closer associations with stress-related pathophysiology,and aberrant connectivity of the audiovisual perception-related temporal-occipital network,whereas the HSD subtype is more closely associated with hyperconnectivity and microstructural abnormalities of the limbicparalimbic network.Certain metabolomic and connectomic variables are potential biomarkers for TCM diagnostic subtypes which is perhaps an alternative classification for depressive disorders.

Decline of Traditional Landscape in a Protected Area of the Southwestern Alps:the Fate of Enclosed Pasture Patches in the Land Mosaic Shift

【Title】【Author】【Addresses】1Traditional landscape elements such as pasture patches enclosed in a forest matrix are progressively disappearing throughout the European Alps. We assessed the land mosaic shift of a protected area located in the western Italian Alps. In particular, the dynamics of pasture patches were studied at both landscape and stand level. Land-cover mapping through object-oriented analysis of historical aerial photographs was used to assess land-cover changes between 1954 and 2000. Spatial statistics were used to quantify landscape patterns, and field samplings within pasture patches were used to explore tree regeneration structure and composition. Our results showed a significant increase in the number of pasture patches caused by their fragmentation following forest expansion. The total surface area of pasture patches decreased by 43% and their core area decreased by 94%. The encroachment of trees on less accessible areas of the pasture patches caused a reduction of patch shape at landscape scale. The gap filling process started 40-50 years ago and began with an early invasion of light demanding species like sycamore maple （Acer pseudoplatanus L.） and common ash （Fraxinus excelsior L.）, followed by European beech （Fagus sylvatica L.） and secondarily silver fir （Abies alba Mill.）. Traditional land-use and population decline in the Pesio Valley led to a reduction in ecotone areas. A transition to a more homogeneous landscape is expected in the next decades. Given the cultural and productive nature of these mountain meadow-pasture communities, extensive livestock grazing systems could be used to manage their future conservation.

Original Frame of Organizational Model from the Chinese Traditional Philosophy

In this paper, the studies show that the framework of the original organizational models based on the philosophy view is constructed. The driving forces are also expatiated in the paper. Matching with the time and space in which the organization exists, fitted with the extra environment, making the organization take effect and properly controlling the important potential factors for the organizations further are the four driving forces development. The supporting pillars are cooperation in the competition, communication, negotiation and proper equal culture environment. At last, the researches point out that organization is a process, while organizational model is only a tool for us to realize the world.

Overviews to organizational model from Chinese traditional philosophy

This paper reviews the literatures of the traditional and the modem organizational model to generalize their categories, features and faults. Based on the unification of the Chinese traditional culture and the “YIN and YANG” principles, it discusses how to understand the hypotheses of the organizational models, analyzes the traditional and the leading models, and puts forward two hypotheses, the fixed structure and the flexible structure of organizations.

A Critical Study of William Faulkner's A Rose for Emily:Its Narrative Technique and Structure

A Rose for Emily, written by William Faulkner in the twentieth century, is an absorbing mystery story with a surprisingly chilling ending. This paper intends to analyze the symbolic meaning of the rose, and the relationship between the rose and Emily, giving people a thorough understanding of the theme and the heroine's personality. Although simple, the story shows great narrative techniques and typical and artful structure in Faulkner's works.

学四诊之法 把结构之脉

为解决中药化学课程教学中,因中药化学成分结构复杂、结构鉴定难度大导致学生较难掌握的问题,借鉴中医“四诊”之法的整体观,构建“四诊法”教学。即在讲授中药化学成分结构鉴定内容时,借鉴“望、闻、问、切”四诊之法,综合分析其成分的来源与结构类型、性质与结构特点、波谱特征与结构取代情况之间的关系,培养学生综合理解和运用所学知识解决实际问题的能力。该法分析中药化学成分结构鉴定的相关信息,依照望、闻、问、切的次序,抽丝剥茧地解析出化合物结构,有助于学生理解中药化学成分结构鉴定的过程和意义。将此法应用于中药化学成分结构鉴定课程教学中,将中医整体观与现代科学研究结果有机结合,可解决教学重难点问题,有助于培养学生的中医药思维和科学思维。

基于词性结构的中医妇科学杂病术语英译对比研究

妇科杂病作为中医妇科学疾病体系的重要组成部分,其术语内容较丰富、术语名称较特殊,是中医妇科学术语的重要研究对象。但由于中西医思维及诊疗方式各异,国内外学者在英译妇科杂病相关术语时面临较多困难。从谓词性、体词性、加词三种词性结构的英语语言应用入手,分析中医妇科杂病术语英译,对翻译策略及方法进行辨析并总结相应的翻译建议,以期为国内外学者研究中医妇科学术语英译提供参考。

骨组织工程中传统与仿生支架结构设计的差异

背景:多孔支架作为新骨生长的临时基质在骨修复过程中起着关键作用,其中多孔支架的结构设计是骨修复过程中的研究重点。目的:综述传统支架(规则、均匀的支架)和仿生支架(不规则、不均匀的支架)在骨组织工程研究领域的应用。方法:检索中国知网(CNKI)、维普、万方、Web of Science、Science Direct、PubMed、EI等数据库,选取2008年1月至2024年3月发表的文献,中文检索词为“骨组织工程,仿生支架,骨小梁,传统支架,骨修复,三周期极小曲面”,英文检索词为“bone tissue engineering,bionic scaffolds,bone trabeculae,traditional scaffolds,bone repair,TPMS”。最终纳入81篇文献进行综述。结果与结论:骨支架的结构设计是实现骨修复和骨再生的关键,骨组织工程中的支架技术已取得显著进展。传统的规则多孔支架因简单的制造流程和良好的机械性能被广泛应用,然而这类支架往往缺乏生物活性,难以模拟自然骨组织的复杂微环境,限制了其在促进细胞增殖和骨再生方面的能力。相反,仿生支架通过模拟自然骨组织的结构特征,提供了更适宜的生理微环境,促进了成骨细胞的增殖、分化及新骨的形成,为骨缺损有效治疗提供了新的思路。尽管仿生支架在理论上具有巨大的潜力,但在实际应用中仍面临诸多挑战,支架的生物相容性、生物活性及长期稳定性等因素仍需通过临床试验进行进一步验证。

Geometric spatial structure of traditional Tibetan settlements of Degger County, China： A case study of four villages

This study investigates the characteristics of spatial elements and structure in a multi-cultural traditional settlement in Degger County, Sichuan Province, in the Tibetan area of China. This study aims to clarify the geometric spatial representation of traditional settlements. The geometric features of their settlement plans are compared using mathematical analysis after examining the spatial arrangement of four typical settlements. Results indicate that the settlement structure has strong centrality. The spatial structure characteristics and proposed spatial models of traditional settlements in this area are discussed to aim for the results to contribute to new village planning and preserve a traditional settlement heritage.

Digitalizing Traditional Manufacturing Enterprises:A Three-Stage Evolutionary Model from the Perspective of Structure and Agency

Emerging digital technology are bringing convenience to the global economy and transforming business organizations.The structural changes brought about by digitalization are particularly significant for enterprises in traditional industries.Starting from the perspective of the debate between structure and agency in sociology,this paper first discusses the necessity of digital transformation of traditional manufacturing enterprises under the background of digital economy,and then explains the drivers and potential obstacles of digital transformation from the perspective of the coexistence of structure regulation and agency initiative.Based on this,this paper further studies the practice of enterprise digital transformation,and proposes a three-stage model of organizational adaptation(EEI model),namely,the experimentation period(partial digitalization),the expansion period(platform digitalization)and the integration period(ecosystem digitalization).Each of these three stages has its own independent characteristics,and is also an indispensable link in the process of enterprise digitalization,which determines the continuity and integrity of its transformation.The three-stage evolution model based on the structure and agency perspective has important theoretical and practical significance for enterprise digital development.