Immune checkpoint inhibitors(ICPI)have shown considerable promise in the treatment of tumors.However,immune-related adverse events(irAEs)caused by ICPI have been reported in nearly every organ system.Whilst this repre...Immune checkpoint inhibitors(ICPI)have shown considerable promise in the treatment of tumors.However,immune-related adverse events(irAEs)caused by ICPI have been reported in nearly every organ system.Whilst this represents a new challenge in the field of cancer treatment,traditional Chinese medicine(TCM)provides benefits in the treatment of irAEs.This article reviews the studies of the treatment of immune-related gastrointestinal diseases and dermatosis with TCM and introduces the collaborative efforts between China and France in the implementation of TCM for the treatment of irAEs.展开更多
Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscien...Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.展开更多
目的介绍文献计量法(bibliometric methods)在中药药物警戒领域(pharmacovigilance of Chinese medicine,PVCM)中的应用。方法系统检索中国知网、万方数据、维普网、SinoMed及PubMed数据库,检索时间均从各数据库建库至2021年8月24日,并...目的介绍文献计量法(bibliometric methods)在中药药物警戒领域(pharmacovigilance of Chinese medicine,PVCM)中的应用。方法系统检索中国知网、万方数据、维普网、SinoMed及PubMed数据库,检索时间均从各数据库建库至2021年8月24日,并纳入应用文献计量法开展的针对中药药物警戒领域相关原始研究文献的二次研究进行分析,以了解文献计量法用于中药药物警戒领域的现况。结合相关具体实例,对文献计量法定义、应用价值、选题切入点及实施进行总结和讨论。结果目前已发表的中药药物警戒相关文献计量研究共50篇,涉及研究选题范围主要限定于中成药临床用药不良反应。引入文献计量法对中药药物警戒领域相关文献进行系统全面的梳理与分析,可从微观和宏观层面为研究人员掌握中药药物警戒领域研究现状、跟踪学科前沿、推断研究热点、预测学科发展方向等提供循证证据。结论应注重并规范开展更多、涉及选题范围更广的高质量中药药物警戒相关文献计量研究,为中药药物警戒领域更好、更全面发展提供证据支持。展开更多
基金funded by the National Natural Science Foundation of China:Surface Project(81573959)the Young Teacher Research Program of the Beijing University of Chinese Medicine(2017-JYB-JS-158)Young Scientist Program of the Dongzhimen Hospital,Beijing University of Chinese Medicine(DZMYS-201610).
文摘Immune checkpoint inhibitors(ICPI)have shown considerable promise in the treatment of tumors.However,immune-related adverse events(irAEs)caused by ICPI have been reported in nearly every organ system.Whilst this represents a new challenge in the field of cancer treatment,traditional Chinese medicine(TCM)provides benefits in the treatment of irAEs.This article reviews the studies of the treatment of immune-related gastrointestinal diseases and dermatosis with TCM and introduces the collaborative efforts between China and France in the implementation of TCM for the treatment of irAEs.
基金supported by the National Natural Science Foundation of China (81874514)
文摘Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.
文摘目的介绍文献计量法(bibliometric methods)在中药药物警戒领域(pharmacovigilance of Chinese medicine,PVCM)中的应用。方法系统检索中国知网、万方数据、维普网、SinoMed及PubMed数据库,检索时间均从各数据库建库至2021年8月24日,并纳入应用文献计量法开展的针对中药药物警戒领域相关原始研究文献的二次研究进行分析,以了解文献计量法用于中药药物警戒领域的现况。结合相关具体实例,对文献计量法定义、应用价值、选题切入点及实施进行总结和讨论。结果目前已发表的中药药物警戒相关文献计量研究共50篇,涉及研究选题范围主要限定于中成药临床用药不良反应。引入文献计量法对中药药物警戒领域相关文献进行系统全面的梳理与分析,可从微观和宏观层面为研究人员掌握中药药物警戒领域研究现状、跟踪学科前沿、推断研究热点、预测学科发展方向等提供循证证据。结论应注重并规范开展更多、涉及选题范围更广的高质量中药药物警戒相关文献计量研究,为中药药物警戒领域更好、更全面发展提供证据支持。
