Global transplantation:Lessons from organ transplantation organizations worldwide

Although national transplant organizations share common visions and goals,the creation of a unified global organization remains impractical.Differences in ethnicity,culture,religion,and education shape local practices and infrastructure,making the establishment of a single global entity unfeasible.Even with these social disparities aside,logistical factors such as time and distance between organ procurement and transplantation sites pose significant challenges.While technological advancements have extended organ preservation times,they have yet to support the demands of transcontinental transplantations effectively.This review presents a comparative analysis of the structures,operational frameworks,policies,and legislation governing various transplant organizations around the world.Key differences pertain to the administration of these organizations,trends in organ donation,and organ allocation policies,which reflect the financial,cultural,and religious diversity across different regions.While a global transplant organization may be out of reach,agreeing on best practices for the benefit of patients is essential.

Urban One-way Traffic Organization and Its Evaluation

One-way traffic organization is a direct, efficient and economic method to solve traffic congestion and expand traffie capacity. With its evolution, advantages and disadvantages introduced its setting conditions demonstrated. The general method and processes are summarized in planning for urban one-way streets project, viz. investigation, drawing out and evaluation of project, selecting of project and beneficial analysis. Fuzzy synthetical evaluation other fields is employed to evaluate the project. Its evaluation system and method is introduced and Delphi method is adopted to obtain evaluation index. Finally, taking Harbin city as an example, the application process of above-mentioned method is illuminated. Accordingly, it is proved that the method is exercisable.

Traffic Organization Optimization of Urban Road Combined Intersections

With the development of the economy and the acceleration of urbanization, the number of vehicles in cities is increasing rapidly, which greatly increases the pressure on urban traffic. Solving traffic accidents and problems to keep smooth travel and safe travel has become a top priority in road construction. In this paper, how to optimize the traffic at the intersection of the urban road was discussed with the aim of reducing traffic accidents and problems to keep peoples’ smooth travel and safe travel.

Traffic Organization of Urban Waterfront

Both of slow-moving traffic and motor traffic have an impact on waterfront development. Waterfront traffic has to based on analysis of local transport and land- scaping, road analysis vertically, horizontally and cross-section, as well as road space, structuring and the beauty of art. The target is to build waterfront traffic full of city characters.

Traffic organization during urban road constructions

This research presented a bi-level programming approach to optimize the schedule of ur- ban road construction activities based on a hypothetical transport network, with an objective of mini- mizing the overall traffic delays. A heuristic algorithm was utilized to identify a set of road construction schedules, while PARAMICS was adopted to estimate the total travel time in the network under each road construction scenario. To test the performance of proposed heuristics-simulation methodology, a numerical test was implemented. The overall results suggested that the proposed methodol- ogy could quickly find the optimum solution with good convergence.

Network traffic classification:Techniques,datasets,and challenges

In network traffic classification,it is important to understand the correlation between network traffic and its causal application,protocol,or service group,for example,in facilitating lawful interception,ensuring the quality of service,preventing application choke points,and facilitating malicious behavior identification.In this paper,we review existing network classification techniques,such as port-based identification and those based on deep packet inspection,statistical features in conjunction with machine learning,and deep learning algorithms.We also explain the implementations,advantages,and limitations associated with these techniques.Our review also extends to publicly available datasets used in the literature.Finally,we discuss existing and emerging challenges,as well as future research directions.

Applying an Improved Dung Beetle Optimizer Algorithm to Network Traffic Identification

Network traffic identification is critical for maintaining network security and further meeting various demands of network applications.However,network traffic data typically possesses high dimensionality and complexity,leading to practical problems in traffic identification data analytics.Since the original Dung Beetle Optimizer(DBO)algorithm,Grey Wolf Optimization(GWO)algorithm,Whale Optimization Algorithm(WOA),and Particle Swarm Optimization(PSO)algorithm have the shortcomings of slow convergence and easily fall into the local optimal solution,an Improved Dung Beetle Optimizer(IDBO)algorithm is proposed for network traffic identification.Firstly,the Sobol sequence is utilized to initialize the dung beetle population,laying the foundation for finding the global optimal solution.Next,an integration of levy flight and golden sine strategy is suggested to give dung beetles a greater probability of exploring unvisited areas,escaping from the local optimal solution,and converging more effectively towards a global optimal solution.Finally,an adaptive weight factor is utilized to enhance the search capabilities of the original DBO algorithm and accelerate convergence.With the improvements above,the proposed IDBO algorithm is then applied to traffic identification data analytics and feature selection,as so to find the optimal subset for K-Nearest Neighbor(KNN)classification.The simulation experiments use the CICIDS2017 dataset to verify the effectiveness of the proposed IDBO algorithm and compare it with the original DBO,GWO,WOA,and PSO algorithms.The experimental results show that,compared with other algorithms,the accuracy and recall are improved by 1.53%and 0.88%in binary classification,and the Distributed Denial of Service(DDoS)class identification is the most effective in multi-classification,with an improvement of 5.80%and 0.33%for accuracy and recall,respectively.Therefore,the proposed IDBO algorithm is effective in increasing the efficiency of traffic identification and solving the problem of the original DBO algorithm that converges slowly and falls into the local optimal solution when dealing with high-dimensional data analytics and feature selection for network traffic identification.

Attention Markets of Blockchain-Based Decentralized Autonomous Organizations

The attention is a scarce resource in decentralized autonomous organizations(DAOs),as their self-governance relies heavily on the attention-intensive decision-making process of“proposal and voting”.To prevent the negative effects of pro-posers’attention-capturing strategies that contribute to the“tragedy of the commons”and ensure an efficient distribution of attention among multiple proposals,it is necessary to establish a market-driven allocation scheme for DAOs’attention.First,the Harberger tax-based attention markets are designed to facilitate its allocation via continuous and automated trading,where the individualized Harberger tax rate(HTR)determined by the pro-posers’reputation is adopted.Then,the Stackelberg game model is formulated in these markets,casting attention to owners in the role of leaders and other competitive proposers as followers.Its equilibrium trading strategies are also discussed to unravel the intricate dynamics of attention pricing.Moreover,utilizing the single-round Stackelberg game as an illustrative example,the existence of Nash equilibrium trading strategies is demonstrated.Finally,the impact of individualized HTR on trading strategies is investigated,and results suggest that it has a negative correlation with leaders’self-accessed prices and ownership duration,but its effect on their revenues varies under different conditions.This study is expected to provide valuable insights into leveraging attention resources to improve DAOs’governance and decision-making process.

Network Intrusion Traffic Detection Based on Feature Extraction

With the increasing dimensionality of network traffic,extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems(IDS).However,both unsupervised and semisupervised anomalous traffic detection methods suffer from the drawback of ignoring potential correlations between features,resulting in an analysis that is not an optimal set.Therefore,in order to extract more representative traffic features as well as to improve the accuracy of traffic identification,this paper proposes a feature dimensionality reduction method combining principal component analysis and Hotelling’s T^(2) and a multilayer convolutional bidirectional long short-term memory(MSC_BiLSTM)classifier model for network traffic intrusion detection.This method reduces the parameters and redundancy of the model by feature extraction and extracts the dependent features between the data by a bidirectional long short-term memory(BiLSTM)network,which fully considers the influence between the before and after features.The network traffic is first characteristically downscaled by principal component analysis(PCA),and then the downscaled principal components are used as input to Hotelling’s T^(2) to compare the differences between groups.For datasets with outliers,Hotelling’s T^(2) can help identify the groups where the outliers are located and quantitatively measure the extent of the outliers.Finally,a multilayer convolutional neural network and a BiLSTM network are used to extract the spatial and temporal features of network traffic data.The empirical consequences exhibit that the suggested approach in this manuscript attains superior outcomes in precision,recall and F1-score juxtaposed with the prevailing techniques.The results show that the intrusion detection accuracy,precision,and F1-score of the proposed MSC_BiLSTM model for the CIC-IDS 2017 dataset are 98.71%,95.97%,and 90.22%.

BSTFNet:An Encrypted Malicious Traffic Classification Method Integrating Global Semantic and Spatiotemporal Features

While encryption technology safeguards the security of network communications,malicious traffic also uses encryption protocols to obscure its malicious behavior.To address the issues of traditional machine learning methods relying on expert experience and the insufficient representation capabilities of existing deep learning methods for encrypted malicious traffic,we propose an encrypted malicious traffic classification method that integrates global semantic features with local spatiotemporal features,called BERT-based Spatio-Temporal Features Network(BSTFNet).At the packet-level granularity,the model captures the global semantic features of packets through the attention mechanism of the Bidirectional Encoder Representations from Transformers(BERT)model.At the byte-level granularity,we initially employ the Bidirectional Gated Recurrent Unit(BiGRU)model to extract temporal features from bytes,followed by the utilization of the Text Convolutional Neural Network(TextCNN)model with multi-sized convolution kernels to extract local multi-receptive field spatial features.The fusion of features from both granularities serves as the ultimate multidimensional representation of malicious traffic.Our approach achieves accuracy and F1-score of 99.39%and 99.40%,respectively,on the publicly available USTC-TFC2016 dataset,and effectively reduces sample confusion within the Neris and Virut categories.The experimental results demonstrate that our method has outstanding representation and classification capabilities for encrypted malicious traffic.

Urban Traffic Control Meets Decision Recommendation System:A Survey and Perspective

Urban traffic control is a multifaceted and demanding task that necessitates extensive decision-making to ensure the safety and efficiency of urban transportation systems.Traditional approaches require traffic signal professionals to manually intervene on traffic control devices at the intersection level,utilizing their knowledge and expertise.However,this process is cumbersome,labor-intensive,and cannot be applied on a large network scale.Recent studies have begun to explore the applicability of recommendation system for urban traffic control,which offer increased control efficiency and scalability.Such a decision recommendation system is complex,with various interdependent components,but a systematic literature review has not yet been conducted.In this work,we present an up-to-date survey that elucidates all the detailed components of a recommendation system for urban traffic control,demonstrates the utility and efficacy of such a system in the real world using data and knowledgedriven approaches,and discusses the current challenges and potential future directions of this field.

Spatiotemporal Prediction of Urban Traffics Based on Deep GNN

Traffic prediction already plays a significant role in applications like traffic planning and urban management,but it is still difficult to capture the highly non-linear and complicated spatiotemporal correlations of traffic data.As well as to fulfil both long-termand short-termprediction objectives,a better representation of the temporal dependency and global spatial correlation of traffic data is needed.In order to do this,the Spatiotemporal Graph Neural Network(S-GNN)is proposed in this research as amethod for traffic prediction.The S-GNN simultaneously accepts various traffic data as inputs and investigates the non-linear correlations between the variables.In terms of modelling,the road network is initially represented as a spatiotemporal directed graph,with the features of the samples at the time step being captured by a convolution module.In order to assign varying attention weights to various adjacent area nodes of the target node,the adjacent areas information of nodes in the road network is then aggregated using a graph network.The data is output using a fully connected layer at the end.The findings show that S-GNN can improve short-and long-term traffic prediction accuracy to a greater extent;in comparison to the control model,the RMSE of S-GNN is reduced by about 0.571 to 9.288 and the MAE(Mean Absolute Error)by about 0.314 to 7.678.The experimental results on two real datasets,Pe MSD7(M)and PEMS-BAY,also support this claim.

Impacts of bus holding strategy on the performance and pollutant emissions of a two-lane mixed traffic system

This paper investigates the impacts of a bus holding strategy on the mutual interference between buses and passenger cars in a non-dedicated bus route,as well as the impacts on the characteristics of pollutant emissions of passenger cars.The dynamic behaviors of these two types of vehicles are described using cellular automata(CA)models under open boundary conditions.Numerical simulations are carried out to obtain the phase diagrams of the bus system and the trajectories of buses and passenger cars before and after the implementation of the bus holding strategy under different probabilities of passenger cars entering a two-lane mixed traffic system.Then,we analyze the flow rate,satisfaction rate,and pollutant emission rates of passenger cars together with the performance of a mixed traffic system.The results show that the bus holding strategy can effectively alleviate bus bunching,whereas it has no significant impact on the flow rate and pollutant emission rates of passenger cars;the flow rate,satisfaction rate,and pollutant emission rates of passenger cars for either the traffic system or for each lane are influenced by the bus departure interval and the number of passengers arriving at bus stops.

Segment routing for traffic engineering and effective recovery in low-earth orbit satellite constellations

Low-Earth Orbit Satellite Constellations(LEO-SCs)provide global,high-speed,and low latency Internet access services,which bridges the digital divide in the remote areas.As inter-satellite links are not supported in initial deployment(i.e.the Starlink),the communication between satellites is based on ground stations with radio frequency signals.Due to the rapid movement of satellites,this hybrid topology of LEO-SCs and ground stations is time-varying,which imposes a major challenge to uninterrupted service provisioning and network management.In this paper,we focus on solving two notable problems in such a ground station-assisted LEO-SC topology,i.e.,traffic engineering and fast reroute,to guarantee that the packets are forwarded in a balanced and uninterrupted manner.Specifically,we employ segment routing to support the arbitrary path routing in LEO-SCs.To solve the traffic engineering problem,we proposed two source routings with traffic splitting algorithms,Delay-Bounded Traffic Splitting(DBTS)and DBTS+,where DBTS equally splits a flow and DBTS+favors shorter paths.Simu-lation results show that DBTS+can achieve about 30%lower maximum satellite load at the cost of about 10%more delay.To guarantee the fast recovery of failures,two fast reroute mechanisms,Loop-Free Alternate(LFA)and LFA+,are studied,where LFA pre-computes an alternate next-hop as a backup while LFA+finds a 2-segment backup path.We show that LFA+can increase the percentage of protection coverage by about 15%.

HGNN-ETC: Higher-Order Graph Neural Network Based on Chronological Relationships for Encrypted Traffic Classification

Encrypted traffic plays a crucial role in safeguarding network security and user privacy.However,encrypting malicious traffic can lead to numerous security issues,making the effective classification of encrypted traffic essential.Existing methods for detecting encrypted traffic face two significant challenges.First,relying solely on the original byte information for classification fails to leverage the rich temporal relationships within network traffic.Second,machine learning and convolutional neural network methods lack sufficient network expression capabilities,hindering the full exploration of traffic’s potential characteristics.To address these limitations,this study introduces a traffic classification method that utilizes time relationships and a higher-order graph neural network,termed HGNN-ETC.This approach fully exploits the original byte information and chronological relationships of traffic packets,transforming traffic data into a graph structure to provide the model with more comprehensive context information.HGNN-ETC employs an innovative k-dimensional graph neural network to effectively capture the multi-scale structural features of traffic graphs,enabling more accurate classification.We select the ISCXVPN and the USTC-TK2016 dataset for our experiments.The results show that compared with other state-of-the-art methods,our method can obtain a better classification effect on different datasets,and the accuracy rate is about 97.00%.In addition,by analyzing the impact of varying input specifications on classification performance,we determine the optimal network data truncation strategy and confirm the model’s excellent generalization ability on different datasets.

Network Traffic Synthesis and Simulation Framework for Cybersecurity Exercise Systems

In the rapidly evolving field of cybersecurity,the challenge of providing realistic exercise scenarios that accurately mimic real-world threats has become increasingly critical.Traditional methods often fall short in capturing the dynamic and complex nature of modern cyber threats.To address this gap,we propose a comprehensive framework designed to create authentic network environments tailored for cybersecurity exercise systems.Our framework leverages advanced simulation techniques to generate scenarios that mirror actual network conditions faced by professionals in the field.The cornerstone of our approach is the use of a conditional tabular generative adversarial network(CTGAN),a sophisticated tool that synthesizes realistic synthetic network traffic by learning fromreal data patterns.This technology allows us to handle technical components and sensitive information with high fidelity,ensuring that the synthetic data maintains statistical characteristics similar to those observed in real network environments.By meticulously analyzing the data collected from various network layers and translating these into structured tabular formats,our framework can generate network traffic that closely resembles that found in actual scenarios.An integral part of our process involves deploying this synthetic data within a simulated network environment,structured on software-defined networking(SDN)principles,to test and refine the traffic patterns.This simulation not only facilitates a direct comparison between the synthetic and real traffic but also enables us to identify discrepancies and refine the accuracy of our simulations.Our initial findings indicate an error rate of approximately 29.28%between the synthetic and real traffic data,highlighting areas for further improvement and adjustment.By providing a diverse array of network scenarios through our framework,we aim to enhance the exercise systems used by cybersecurity professionals.This not only improves their ability to respond to actual cyber threats but also ensures that the exercise is cost-effective and efficient.

RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border.However,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely unknown.Here,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during osteoclastogenesis.Mice lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in vivo.Furthermore,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular space.Mechanistically,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary lysosomes.Consequently,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone loss.Thus,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

Classified VPN Network Traffic Flow Using Time Related to Artificial Neural Network

VPNs are vital for safeguarding communication routes in the continually changing cybersecurity world.However,increasing network attack complexity and variety require increasingly advanced algorithms to recognize and categorizeVPNnetwork data.We present a novelVPNnetwork traffic flowclassificationmethod utilizing Artificial Neural Networks(ANN).This paper aims to provide a reliable system that can identify a virtual private network(VPN)traffic fromintrusion attempts,data exfiltration,and denial-of-service assaults.We compile a broad dataset of labeled VPN traffic flows from various apps and usage patterns.Next,we create an ANN architecture that can handle encrypted communication and distinguish benign from dangerous actions.To effectively process and categorize encrypted packets,the neural network model has input,hidden,and output layers.We use advanced feature extraction approaches to improve the ANN’s classification accuracy by leveraging network traffic’s statistical and behavioral properties.We also use cutting-edge optimizationmethods to optimize network characteristics and performance.The suggested ANN-based categorization method is extensively tested and analyzed.Results show the model effectively classifies VPN traffic types.We also show that our ANN-based technique outperforms other approaches in precision,recall,and F1-score with 98.79%accuracy.This study improves VPN security and protects against new cyberthreats.Classifying VPNtraffic flows effectively helps enterprises protect sensitive data,maintain network integrity,and respond quickly to security problems.This study advances network security and lays the groundwork for ANN-based cybersecurity solutions.

Scalable Temporal Dimension Preserved Tensor Completion for Missing Traffic Data Imputation With Orthogonal Initialization

Dear Editor,This letter puts forward a novel scalable temporal dimension preserved tensor completion model based on orthogonal initialization for missing traffic data(MTD)imputation.The MTD imputation acts directly on accessing the traffic state,and affects the traffic management.

Integrating Levels of Hierarchical Organization in Porous Organic Molecular Materials

Porous organic molecular materials(POMMs)are an emergent class of molecular-based materials characterized by the formation of extended porous frameworks,mainly held by non-covalent interactions.POMMs represent a variety of chemical families,such as hydrogen-bonded organic frameworks,porous organic salts,porous organic cages,C-H···πmicroporous crystals,supramolecular organic frameworks,π-organic frameworks,halogen-bonded organic framework,and intrinsically porous molecular materials.In some porous materials such as zeolites and metal organic frameworks,the integration of multiscale has been adopted to build materials with multifunctionality and optimized properties.Therefore,considering the significant role of hierarchy in porous materials and the growing importance of POMMs in the realm of synthetic porous materials,we consider it appropriate to dedicate for the first time a critical review covering both topics.Herein,we will provide a summary of literature examples showcasing hierarchical POMMs,with a focus on their main synthetic approaches,applications,and the advantages brought forth by introducing hierarchy.