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Distribution specificity of polarized populations of T helper cells in patients with chronic hepatitis B virus infection
1
作者
姜荣龙
冯筱榕
+2 位作者
卢桥生
骆抗先
富宁
《Journal of Medical Colleges of PLA(China)》
CAS
2001年第4期235-238,共4页
Objective:To investigatetherolesof thepolarizedpopulationsof T helpercellsisolatedfromtheperipheral bloodmononuclearcells(PBMCs)of individualswithchronichepatitisB virus(HBV)infection.Methods:PBMCsfrom patientswithchr...
Objective:To investigatetherolesof thepolarizedpopulationsof T helpercellsisolatedfromtheperipheral bloodmononuclearcells(PBMCs)of individualswithchronichepatitisB virus(HBV)infection.Methods:PBMCsfrom patientswithchronicHBVinfectionwereseparatedroutinely,stimulatedby PMA,ionomycinandmonensin,andthepro-ductionof IL-4,IFN-γandTGF-βby CD4 + T cellswas observedby flowcytometry(FACS).Results:Thepercentagesof theT cellsproducingIFN-γ,IL-4or TGF-βrangedfrom2.3%to18.6%,1.1%to8.7%and0.7%to7.1%respectivelya-mongCD4 + cellsfromnon-infectedindividuals.Themajorityof CD4 + T cellsin PBMCsfromindividualswithchronic HBVinfectionwereTh0cells.Theproportionof Th1cellsinpatientswithactivechronichepatitisB washigherthanthat in patientsat inactivestageof thedisease(P<0.05),indicatinga significantelevationof Th1cellswiththehepaticinflam-mationactivity.Thepercentageof Th2cellsinindividualswithHBVinfectionwashigherthanthatincontrols(P<0.05),butshowedno differencebetweendifferentpatients(P>0.05).Thepercentageof Th3cellswas higherin asymptomatic HBVcarriersthanthatinpatientswithchronichepatitisB andinhealthycontrols(P<0.05).Conclusions:Th1-typecy-tokinesarerelatedwithhepaticinflammationactivityof chronichepatitisB,andTh2cellsmaybe associatedwiththeper-sistenceof HBVinfection.Th3cellscooperatingwithTh2cellsarelikelyto functionas negativeimmunoregulator,and maybe responsiblefortheimmunetolerancestateof chronicHBVinfection.
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关键词
chronic
HEPATITIS
B
virus
INFECTION
INTERLEUKIN-4
INTERFERON-Γ
TRANSFORMING
growth
factor-β
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职称材料
题名
Distribution specificity of polarized populations of T helper cells in patients with chronic hepatitis B virus infection
1
作者
姜荣龙
冯筱榕
卢桥生
骆抗先
富宁
出处
《Journal of Medical Colleges of PLA(China)》
CAS
2001年第4期235-238,共4页
文摘
Objective:To investigatetherolesof thepolarizedpopulationsof T helpercellsisolatedfromtheperipheral bloodmononuclearcells(PBMCs)of individualswithchronichepatitisB virus(HBV)infection.Methods:PBMCsfrom patientswithchronicHBVinfectionwereseparatedroutinely,stimulatedby PMA,ionomycinandmonensin,andthepro-ductionof IL-4,IFN-γandTGF-βby CD4 + T cellswas observedby flowcytometry(FACS).Results:Thepercentagesof theT cellsproducingIFN-γ,IL-4or TGF-βrangedfrom2.3%to18.6%,1.1%to8.7%and0.7%to7.1%respectivelya-mongCD4 + cellsfromnon-infectedindividuals.Themajorityof CD4 + T cellsin PBMCsfromindividualswithchronic HBVinfectionwereTh0cells.Theproportionof Th1cellsinpatientswithactivechronichepatitisB washigherthanthat in patientsat inactivestageof thedisease(P<0.05),indicatinga significantelevationof Th1cellswiththehepaticinflam-mationactivity.Thepercentageof Th2cellsinindividualswithHBVinfectionwashigherthanthatincontrols(P<0.05),butshowedno differencebetweendifferentpatients(P>0.05).Thepercentageof Th3cellswas higherin asymptomatic HBVcarriersthanthatinpatientswithchronichepatitisB andinhealthycontrols(P<0.05).Conclusions:Th1-typecy-tokinesarerelatedwithhepaticinflammationactivityof chronichepatitisB,andTh2cellsmaybe associatedwiththeper-sistenceof HBVinfection.Th3cellscooperatingwithTh2cellsarelikelyto functionas negativeimmunoregulator,and maybe responsiblefortheimmunetolerancestateof chronicHBVinfection.
关键词
chronic
HEPATITIS
B
virus
INFECTION
INTERLEUKIN-4
INTERFERON-Γ
TRANSFORMING
growth
factor-β
Keywords
chronichepatitisB virus
infection
interleukin-4
interferon-γ
transforminggrowthfactor-β
分类号
R512.6 [医药卫生—内科学]
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1
Distribution specificity of polarized populations of T helper cells in patients with chronic hepatitis B virus infection
姜荣龙
冯筱榕
卢桥生
骆抗先
富宁
《Journal of Medical Colleges of PLA(China)》
CAS
2001
0
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