According to palaeoenvironmental analysis on the fossil fauna dominated by Foraminifera and Ostracoda, core QC2 contains 8 marine transgressive beds, called (from up to bottom) Transgressive Beds Ⅰ,Ⅱ, Ⅲ, …,Ⅷ resp...According to palaeoenvironmental analysis on the fossil fauna dominated by Foraminifera and Ostracoda, core QC2 contains 8 marine transgressive beds, called (from up to bottom) Transgressive Beds Ⅰ,Ⅱ, Ⅲ, …,Ⅷ respectively. Together with dating data, the transgressive sequence since 1. 7 Ma B. P. has been established, indicating that the core went through middle and late Early Pleistocene, early and late Middle Pleistocene, early and late (Substages A and B) Late Pleistocene and the Holocene transgressions. Within these 8 transgressions, late Middle Pleistocene, early Late Pleistocene and the Holocene transgressions-had rather strong activities proved by shallow sea (of 50 or 20-50 m water depth) deposits in the prime, while 2 of the 8, during middle Early Pleistocene and late Late Pleistocene (Substage A), were much weaker only with supratidal deposits. The transgressive cycles also differ from each other. Transgressions in the Holocene and in Substage B of late Late Pleistocene are made up of 3 and 2 subcycles of marine ingressions and regressions respectively, but most transgressions only have a single ingressive or regressive sequence. With the core, some important problems concerning, the study of Quaternary transgression such as correlation of transgressive beds and climatic periods and dating of the transgressive beds are discussed in this paper.展开更多
目的了解极早产儿生后1个月肠道菌群的动态变化及分布特征,为益生菌早期干预提供理论依据。方法采取前瞻性研究方法,选取2022年9月至2023年3月本院收治的极早产儿为研究对象,收集生后第7、14、21、28天的粪便标本行16 S rRNA高通量测序...目的了解极早产儿生后1个月肠道菌群的动态变化及分布特征,为益生菌早期干预提供理论依据。方法采取前瞻性研究方法,选取2022年9月至2023年3月本院收治的极早产儿为研究对象,收集生后第7、14、21、28天的粪便标本行16 S rRNA高通量测序及生物信息分析。结果共纳入极早产儿35例,男22例,女13例,出生胎龄210±11天,出生体重1419±339 g,收集粪便样本140份。在门水平上检测到的优势菌群包括厚壁菌门、变形菌门,占80%以上;属水平上检测到的优势菌群主要以条件致病菌为主,包括埃希菌属、梭菌属、葡萄球菌属、不动杆菌属和克雷伯杆菌属,而双歧杆菌属相对丰度均<5%。关键菌群差异分析发现,门及属水平的差异菌群主要为拟杆菌门(P=0.029)、蓝藻菌门(P=0.011)及葡萄球菌属(P=0.010)、罗氏菌属(P=0.040)。肠道菌群的多样性分析发现,四个时间点Alpla多样性指数Ace值及Shannon值比较差异无统计学差异(P>0.05),而Chao值呈逐渐下降趋势(P=0.001);四个时间点的Beta多样性分析Weighted-unifrac值分别为0.412(0.281~0.493)、0.498(0.214~0.526)、0.428(0.289~0.490)、0.143(0.077~0.423),差异有统计学意义(P<0.001)。结论极早产儿生后7~28天肠道优势菌群从厚壁菌门逐渐转变为变形菌门,并以条件致病菌为主,而双歧杆菌属定植数量少,肠道菌群多样性呈下降趋势。展开更多
文摘According to palaeoenvironmental analysis on the fossil fauna dominated by Foraminifera and Ostracoda, core QC2 contains 8 marine transgressive beds, called (from up to bottom) Transgressive Beds Ⅰ,Ⅱ, Ⅲ, …,Ⅷ respectively. Together with dating data, the transgressive sequence since 1. 7 Ma B. P. has been established, indicating that the core went through middle and late Early Pleistocene, early and late Middle Pleistocene, early and late (Substages A and B) Late Pleistocene and the Holocene transgressions. Within these 8 transgressions, late Middle Pleistocene, early Late Pleistocene and the Holocene transgressions-had rather strong activities proved by shallow sea (of 50 or 20-50 m water depth) deposits in the prime, while 2 of the 8, during middle Early Pleistocene and late Late Pleistocene (Substage A), were much weaker only with supratidal deposits. The transgressive cycles also differ from each other. Transgressions in the Holocene and in Substage B of late Late Pleistocene are made up of 3 and 2 subcycles of marine ingressions and regressions respectively, but most transgressions only have a single ingressive or regressive sequence. With the core, some important problems concerning, the study of Quaternary transgression such as correlation of transgressive beds and climatic periods and dating of the transgressive beds are discussed in this paper.
文摘目的了解极早产儿生后1个月肠道菌群的动态变化及分布特征,为益生菌早期干预提供理论依据。方法采取前瞻性研究方法,选取2022年9月至2023年3月本院收治的极早产儿为研究对象,收集生后第7、14、21、28天的粪便标本行16 S rRNA高通量测序及生物信息分析。结果共纳入极早产儿35例,男22例,女13例,出生胎龄210±11天,出生体重1419±339 g,收集粪便样本140份。在门水平上检测到的优势菌群包括厚壁菌门、变形菌门,占80%以上;属水平上检测到的优势菌群主要以条件致病菌为主,包括埃希菌属、梭菌属、葡萄球菌属、不动杆菌属和克雷伯杆菌属,而双歧杆菌属相对丰度均<5%。关键菌群差异分析发现,门及属水平的差异菌群主要为拟杆菌门(P=0.029)、蓝藻菌门(P=0.011)及葡萄球菌属(P=0.010)、罗氏菌属(P=0.040)。肠道菌群的多样性分析发现,四个时间点Alpla多样性指数Ace值及Shannon值比较差异无统计学差异(P>0.05),而Chao值呈逐渐下降趋势(P=0.001);四个时间点的Beta多样性分析Weighted-unifrac值分别为0.412(0.281~0.493)、0.498(0.214~0.526)、0.428(0.289~0.490)、0.143(0.077~0.423),差异有统计学意义(P<0.001)。结论极早产儿生后7~28天肠道优势菌群从厚壁菌门逐渐转变为变形菌门,并以条件致病菌为主,而双歧杆菌属定植数量少,肠道菌群多样性呈下降趋势。
