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Single-phase-to-ground fault protection based on zero-sequence current ratio coefficient for low-resistance grounding distribution network 被引量:4
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作者 Jianrui Li Yongli Li +1 位作者 Yonghuan Wang Jinzhao Song 《Global Energy Interconnection》 EI CAS CSCD 2021年第6期564-575,共12页
Definite-time zero-sequence over-current protection is presently used in systems whose neutral point is grounded by a low resistance(low-resistance grounding systems).These systems frequently malfunction owing to thei... Definite-time zero-sequence over-current protection is presently used in systems whose neutral point is grounded by a low resistance(low-resistance grounding systems).These systems frequently malfunction owing to their high settings of the action value when a high-impedance grounding fault occurs.In this study,the relationship between the zero-sequence currents of each feeder and the neutral branch was analyzed.Then,a grounding protection method was proposed on the basis of the zero-sequence current ratio coefficient.It is defined as the ratio of the zero-sequence current of the feeder to that of the neutral branch.Nonetheless,both zero-sequence voltage and zero-sequence current are affected by the transition resistance,The influence of transition resistance can be eliminated by calculating this coefficient.Therefore,a method based on the zero-sequence current ratio coefficient was proposed considering the significant difference between the faulty feeder and healthy feeder.Furthermore,unbalanced current can be prevented by setting the starting current.PSCAD simulation results reveal that the proposed method shows high reliability and sensitivity when a high-resistance grounding fault occurs. 展开更多
关键词 Low-resistance grounding system High-impedance grounding fault Grounding protection zero-sequence current ratio coefficient
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Zero-sequence Current Suppressing Strategy for Dual Three-phase Permanent Magnet Synchronous Machines Connected with Single Neutral Point 被引量:1
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作者 Zongwang Li Yuxuan Du +2 位作者 Jinghua Ji Tao Tao Wenxiang Zhao 《CES Transactions on Electrical Machines and Systems》 CSCD 2022年第4期465-472,共8页
Dual three-phase permanent-magnet synchronous machines(DTP-PMSM)connected with a single neutral point provide a loop for zero-sequence current(ZSC).This paper proposes a novel space vector pulse width modulation(SVPWM... Dual three-phase permanent-magnet synchronous machines(DTP-PMSM)connected with a single neutral point provide a loop for zero-sequence current(ZSC).This paper proposes a novel space vector pulse width modulation(SVPWM)strategy to suppress the ZSC.Five vectors are selected as basic voltage vectors in one switching period.The fundamental and harmonic planes and the zero-sequence plane are taken into consideration to synthesis the reference voltage vector.To suppress the ZSC,a non-zero zero-sequence voltage(ZSV)is generated to compensate the third harmonic back-EMF.Rather than triangular carrier modulation,the sawtooth carrier modulation strategy is used to generate asymmetric PWM signals.The modulation range is investigated to explore the variation of modulation range caused by considering the zero-sequence plane.With the proposed method,the ZSC can be considerably reduced.The simulated and experimental results are presented to validate the effectiveness of the proposed modulation strategy. 展开更多
关键词 zero-sequence current a single neutral point dual three-phase permanent-magnet synchronous machine third harmonic back-EMF
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Zero-Sequence Current Suppression Strategy for Open-End Winding Permanent Magnet Synchronous Motor Based on Model Predictive Control
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作者 刘华山 李杰 姚飞 《Journal of Donghua University(English Edition)》 EI CAS 2020年第4期286-292,共7页
Compared with the traditional three-phase star connection winding,the open-end winding permanent magnet synchronous motor(OW-PMSM)system with a common direct current(DC)bus has a zero-sequence circuit,which makes the ... Compared with the traditional three-phase star connection winding,the open-end winding permanent magnet synchronous motor(OW-PMSM)system with a common direct current(DC)bus has a zero-sequence circuit,which makes the common-mode voltage and the back electromotive force(EMF)harmonic generated by the inverters produce the zero-sequence current in the zero-sequence circuit,and the zero-sequence current has great influence on the operation efficiency and stability of the motor control system.A zero-sequence current suppression strategy is presented based on model predictive current control for OW-PMSM.Through the mathematical model of OW-PMSM to establish the predictive model and the zero-sequence circuit model,the common-mode voltage under different voltage vector combinations is fully considered during vector selection and action time calculation.Then zero-sequence loop constraints are established,so as to suppress the zero-sequence current.In the end,the control strategy proposed in this paper is verified by simulation experiments. 展开更多
关键词 open-end winding permanent magnet synchronous motor(OW-PMSM) zero-sequence current HARMONIC model predictive current control common-mode voltage
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Analytical solutions of transient pulsed eddy current problem due to elliptical electromagnetic concentrative coils 被引量:2
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作者 肖春燕 张军 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第12期30-42,共13页
The electromagnetic concentrative coils are indispensable in the functional magnetic stimulation and have potential applications in nondestructive testing. In this paper, we propose a figure-8-shaped coil being compos... The electromagnetic concentrative coils are indispensable in the functional magnetic stimulation and have potential applications in nondestructive testing. In this paper, we propose a figure-8-shaped coil being composed of two arbitrary oblique elliptical coils, which can change the electromagnetic concentrative region and the magnitude of eddy current density by changing the elliptical shape and/or spread angle between two elliptical coils. Pulsed current is usually the excitation source in the functional magnetic stimulation, so in this paper we derive the analytical solutions of transient pulsed eddy current field in the time domain due to the elliptical concentrative coil placed in an arbitrary position over a half-infinite plane conductor by making use of the scale-transformation, the Laplace transform and the Fourier transform are used in our derivation. Calculation results of field distributions produced by the figure-8-shaped elliptical coil show some behaviours as follows: 1) the eddy currents are focused on the conductor under the geometric symmetric centre of figure-8-shaped coil; 2) the greater the scale factor of ellipse is, the higher the eddy current density is and the wider the concentrative area of eddy current along y axis is; 3) the maximum magnitude of eddy current density increases with the increase of spread angle. When spread angle is 180°, there are two additional reverse concentrative areas on both sides of x axis. 展开更多
关键词 transient pulsed eddy current analytical solution elliptical electromagnetic concentra-tive coil functional magnetic stimulation
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Influence of eddy current on transient characteristics of common rail injector solenoid valve 被引量:1
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作者 李丕茂 张幽彤 《Journal of Beijing Institute of Technology》 EI CAS 2015年第1期26-34,共9页
Influence of eddy current on transient characteristics of common rail injector solenoid valve was studied in this paper. Experimental investigations of drive current and power source volt- age of both drive current as... Influence of eddy current on transient characteristics of common rail injector solenoid valve was studied in this paper. Experimental investigations of drive current and power source volt- age of both drive current ascending and descending process were conducted on a common rail injec- tor solenoid valve. A new discretizing calculation method of solenoid valve flux linkage was put for- ward for the first time based on the experimental results and drive circuit principle, and flux linkage of both drive current ascending and descending process were evaluated. New inductance calculation methods for drive current ascending and descending process respectively were also presented. Influ- ence of parasitic inductance was evaluated. Results indicate that the air gap, under which the transi- ent flux linkage of the solenoid valve is the biggest, varies with drive current due to eddy current. Flux linkage of drive current descending process is bigger than that of drive current ascending process under the same drive current and the same air gap width. Eddy current can reduce the delay between the time that drive current begins to descend and the time that armature begins to move downward. Inductance of drive current descending process is bigger than that of drive current as- cending process over larger scope of drive current, but the difference becomes smaller with the in- creasing of air gap width. The differences of both flux linkage and inductance between drive current ascending and descending process are caused by the eddy current in core and armature materials. 展开更多
关键词 common rail injector solenoid valve transient characteristic flux linkage INDUCTANCE eddy current
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Effects of Volsartan on Transmural Heterogeneous Changes of Transient Outward Potassium Currents in Hypertrophic Cardiomyocytes in Rabbits 被引量:1
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作者 肖建民 付晖 +2 位作者 马业新 李泱 陆再英 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2004年第5期437-440,共4页
The transmural heterogeneous changes of transient outward potassium currents (Ito) in rabbit hypertrophic cardiaomyocytes and the effects of long-term prophylactic treatment with volsartan were investigated. Rabbits w... The transmural heterogeneous changes of transient outward potassium currents (Ito) in rabbit hypertrophic cardiaomyocytes and the effects of long-term prophylactic treatment with volsartan were investigated. Rabbits were divided into hypertrophy group (left ventricular hypertrophy induced by partial ligation of abdominal aorta), vol-treated group (volsartan was administrated after the ligation), and control group (sham operated). Myocytes were isolated by a two-step enzymatical method. The sub-endocardial (Endo) and sub-epicardium (Epi) tissues were separated from midmyocardium (Mid) with a razor. Whole-cell patch-clamp technique was used to record potassium currents. The results showed that membrane capacitance was larger in hypertrophic cells than those in control and vol-treated cells (P<0.01 vs control cells, n=30). The densities of Ito in hypertrophic cells were reduced by sub-epicardium (Epi) (27.8±2.9) %, midmyocardium (Mid) (41.0±4.7) %, and sub-endocardium (Endo) (20.3±3.4) % compared with those in control cells. The decrease of Ito density was more pronounced in Mid than in Epi and Endo (P<0.01 vs Epi or Endo). There were no significant differences in Ito densities between vol-treated group and control group in three layers separately. In conclusion, volsartan can inhibit the transmural heterogeneous changes of Ito in left ventricular hypertrophic cardiomyocytes in rabbit. 展开更多
关键词 cardiac hypertrophy transient outward potassium current volsartan RABBIT
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Transient and Steady State Currents of Bisphenol A Corncobs Sample 被引量:1
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作者 Taha A. Hanafy 《Advances in Materials Physics and Chemistry》 2011年第3期99-107,共9页
Transient current (I-t), current-voltage (I-V) characteristics, and dc conductivity ln(σ) for bisphenol A corn-cobs (BPACC) sample were investigated. At higher temperatures, I-V characteristics reveal that the dc cur... Transient current (I-t), current-voltage (I-V) characteristics, and dc conductivity ln(σ) for bisphenol A corn-cobs (BPACC) sample were investigated. At higher temperatures, I-V characteristics reveal that the dc cur-rent for the sample undergoes two regions one due to ohmic conduction and the other has been attributed to Space charge limited current (SCLC). The activation energy (Ea), the electron mobility μo), effective electron mobility ?μe), the concentration of the charge’s concentrations in conduction band, trapping factor (θ) and the trap concentration (Nt) were calculated. At lower temperatures, the dc current exhibits a peculiar behavior for I-t regime and I-V characteristics. Transient current of BPACC sample exhibits approximately constant value at constant electric field and it has saturation value for I-V characteristics. The attained results suggest strongly the applicability of this material in the electrical applications. 展开更多
关键词 BISPHENOL A Corncobs transient current I-V Characteristics Conduction MECHANISM
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Heavy Ion and Laser Microbeam Induced Current Transients in SiGe Heterojunction Bipolar Transistor 被引量:1
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作者 李培 贺朝会 +4 位作者 郭刚 郭红霞 张凤祁 张晋新 史淑廷 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第10期100-103,共4页
Silicon-germanium (SiGe) hereto-junction bipolar transistor current transients induced by pulse laser and heavy iron are measured using a real-time digital oscilloscope. These transients induced by pulse laser and h... Silicon-germanium (SiGe) hereto-junction bipolar transistor current transients induced by pulse laser and heavy iron are measured using a real-time digital oscilloscope. These transients induced by pulse laser and heavy iron exhibit the same waveform and charge collection time except for the amplitude of peak current. Different laser energies and voltage biases under heavy ion irradiation also have impact on current transient, whereas the waveform remains unchanged. The position-correlated current transients suggest that the nature of the current transient is controlled by the behavior of the C/S junction. 展开更多
关键词 HBT Heavy Ion and Laser Microbeam Induced current transients in SiGe Heterojunction Bipolar Transistor
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New Method for 3D Transient Eddy Current Field Calculation and Its Application in Magneto-Acoustic Tomography 被引量:1
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作者 李元园 刘国强 +1 位作者 夏慧 胡丽丽 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第11期75-79,共5页
A new method of 3D transient eddy current field calculation is proposed. The Maxwell equations with time component elimination (METCE) are derived under the assumption of magnetic quasi static approximation, especia... A new method of 3D transient eddy current field calculation is proposed. The Maxwell equations with time component elimination (METCE) are derived under the assumption of magnetic quasi static approximation, especially for the sample of low conductivity. Based on METCE, we deduce a more efficient reconstruction algorithm of a 3D transient eddy current field. The computational burden is greatly reduced through the new algorithm, and the computational efficiency is improved. This new algorithm decompounds the space-time variables into two individual variables. The idea is to solve the spatial vector component firstly, and then multiply it by the corresponded time component. The iterative methods based on METCE are introduced to recover the distribution of conductivity in magneto-acoustic tomography. The reconstructed images of conductivity are consistent with the original distribution, which validate the new method. 展开更多
关键词 New Method for 3D transient Eddy current Field Calculation and Its Application in Magneto-Acoustic Tomography
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Modeling of Propagation and Transformation of Transient Nonlinear Waves on A Current
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作者 Wojciech Sulisz Maciej Paprota 《China Ocean Engineering》 SCIE EI CSCD 2013年第5期579-592,共14页
A novel theoretical approach is applied to predict the propagation and transformation of transient nonlinear waves on a current. The problem was solved by applying an eigenfunction expansion method and the derived sem... A novel theoretical approach is applied to predict the propagation and transformation of transient nonlinear waves on a current. The problem was solved by applying an eigenfunction expansion method and the derived semi-analytical solution was employed to study the transformation of wave profile and the evolution of wave spectrum arising from the nonlinear interactions of wave components in a wave train which may lead to the formation of very large waves. The results show that the propagation of wave trains is significantly affected by a current. A relatively small current may substantially affect wave train components and the wave train shape. This is observed for both opposing and following current. The results demonstrate that the application of the nonlinear model has a substantial effect on the shape of a wave spectrum. A train of originally linear and very narrow-banded waves changes its one-peak spectrum to a multi-peak one in a fairly short distance from an initial position. The discrepancies between the wave trains predicted by applying the linear and nonlinear models increase with the increasing wavelength and become significant in shallow water even for waves with low steepness. Laboratory experiments were conducted in a wave flume to verify theoretical results. The free-surface elevations recorded by a system of wave gauges are compared with the results provided by the nonlinear model. Additional verification was achieved by applying a Fourier analysis and comparing wave amplitude spectra obtained from theoretical results with experimental data. A reasonable agreement between theoretical results and experimental data is observed for both amplitudes and phases. The model predicts fairly well multi-peak spectra, including wave spectra with significant nonlinear wave components. 展开更多
关键词 numerical modeling transient waves current boundary conditions initial conditions
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Transient simulation and analysis of current collapse due to trapping effects in AlGaN/GaN high-electron-mobility transistor
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作者 周幸叶 冯志红 +3 位作者 王元刚 顾国栋 宋旭波 蔡树军 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第4期530-534,共5页
In this paper, two-dimensional (2D) transient simulations of an A1GaN/GaN high-electron-mobility transistor (HEMT) are carded out and analyzed to investigate the current collapse due to trapping effects. The coupl... In this paper, two-dimensional (2D) transient simulations of an A1GaN/GaN high-electron-mobility transistor (HEMT) are carded out and analyzed to investigate the current collapse due to trapping effects. The coupling effect of the trapping and thermal effects are taken into account in our simulation. The turn-on pulse gate-lag transient responses with different quiescent biases are obtained, and the pulsed current-voltage (l-V) curves are extracted from the transients. The experimental results of both gate-lag transient current and pulsed I-V curves are reproduced by the simulation, and the current collapse due to the trapping effect is explained from the view of physics based on the simulation results. In addition, the results show that bulk acceptor traps can influence the gate-lag transient characteristics of A1GaN/GaN HEMTs besides surface traps and that the thermal effect can accelerate the emission of captured electrons for traps. Pulse transient simulation is meaningful in analyzing the mechanism of dynamic current collapse, and the work in this paper will benefit the reliability study and model development of GaN-based devices. 展开更多
关键词 transient simulation A1GaN/GaN HEMT current collapse trapping effect
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Busbar Differential Relaying Method Based on Combined Amplitude and Phase Information of High Frequency Transient Currents
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作者 Xiao Wu Zhengyou He Xiaopeng Li 《Energy and Power Engineering》 2013年第4期1288-1292,共5页
Busbar differential relaying method based on combined amplitude and phase information of high frequency transient currents is put forward in this paper for the speed and reliability problems of busbar protection based... Busbar differential relaying method based on combined amplitude and phase information of high frequency transient currents is put forward in this paper for the speed and reliability problems of busbar protection based on fundamental frequency. Under the analysis of features of bus high frequency differential currents, complex wavelet analysis is used to extract the amplitude and phase features of 1/4 period high frequency differential currents, and amplitude and phase information are used to form the polar coordinates. Bus fault is identified intuitively and precisely according to polar locus differences. This polar coordinates represented busbar differential protection scheme based on high frequency transient signals can not only avoid TA saturation, realizing quick protection, lots of PSCAD/EMTDC simulations also show that this busbar differential protection scheme works well under different fault conditions. 展开更多
关键词 BUSBAR Protection High Frequency transient currentS Complex Wavelet Analysis POLAR COORDINATE
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MHD Transient Flow with Hall Current Past an Accelerated Horizontal Porous Plate in a Rotating System
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作者 Nazibuddin Ahmed Jiwan Krishna Goswami Dhruba Prasad Barua 《Open Journal of Fluid Dynamics》 2013年第4期278-285,共8页
An exact solution to the problem of an MHD transient flow with Hall current past a uniformly accelerated horizontal porous plate in a rotating system has been presented. The dimensionless governing equations of the fl... An exact solution to the problem of an MHD transient flow with Hall current past a uniformly accelerated horizontal porous plate in a rotating system has been presented. The dimensionless governing equations of the flow problem are solved by Laplacetransform technique in closed form. A uniform magnetic field is assumed to be applied transversely to the direction of the flow. The expressions for velocity fields and skin-frictions are obtained in non-dimensional form. The primary and secondary velocity distributions and skin-frictions at the plate due to primary and secondary velocity field are demonstrated graphically and the effects of the different parameters namely, rotational parameter, Hartmann number, Hall parameter and acceleration parameter are discussed and the results are physically interpreted. 展开更多
关键词 MHD ROTATING System transient HALL current Mass Transfer SKIN-FRICTION
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Enhancement of Transient Stability of the Nigeria 330 kV Transmission Network Using Fault Current Limiter
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作者 Ignatius K. Okakwu Emmanuel A. Ogujor 《Journal of Power and Energy Engineering》 2017年第9期92-103,共12页
The dynamic responses of generators when subjected to disturbances in an interconnected power system have become a major challenge to power utility companies due to increasing stress on the power network. Since the oc... The dynamic responses of generators when subjected to disturbances in an interconnected power system have become a major challenge to power utility companies due to increasing stress on the power network. Since the occurrence of a disturbance or fault cannot be completely avoided, hence, when it occurs, control measures need to be put in place to limit the fault current, which invariably limit the level of the disturbances. This paper explores the use of Superconductor Fault Current Limiter (SFCL) to improve the transient stability of the Nigeria 330 kV Transmission Network. During a large disturbance, the rotor angle of the generator is enhanced by connecting a Fault Current Limiter (FCL) which reduces the fault current and hence, increases transient stability of the power network. In this study, the most affected generator was taken into consideration in locating the SFCL. The result obtained reveals that the Swing Curve of the generator without FCL increases monotonically which indicates instability, while the Swing Curve of the System with FCL reaches steady state. 展开更多
关键词 transient Stability FAULT current LIMITER NIGERIA 330 KV Power System
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THE THEORY OF CURRENT TRANSIENTS AT TUBULAR ELECTRODES IN A FLOWING FLUID
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作者 Song Ying MO Ying Sing FUNG Department of Chemistry,University of Hong Kong,Hong Kong 《Chinese Chemical Letters》 SCIE CAS CSCD 1991年第9期719-722,共4页
A theoretical equation is developed which describes the response of the current transients to a constant potential at tubular electrodes for a reversible electrode reaction in the flowing fluid.
关键词 THE THEORY OF current transientS AT TUBULAR ELECTRODES IN A FLOWING FLUID AT
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Transient Current Behaviour for Iron in 3.5%NaCl and 3.5%NaCl+ 1%NaNO_2 Solutions during Corrosion Fatigue
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作者 Zhengfu WANG Xuejun WEI Jin LI and Wei KE(State Key Lab. for Corrosion and Protection, Institute of Corrosion and Protection of Metals,Chinese Academy of Sciences, Shenyang 110015, China) 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 1996年第4期291-298,共8页
The transient current behaviour for Iron in 3.5%NaCl and 3.5%NaCl +1%NaNO2 solutions during corrosion fatigue (CF) process has been investigated at different given strain amplitudes and strain rates. The results show ... The transient current behaviour for Iron in 3.5%NaCl and 3.5%NaCl +1%NaNO2 solutions during corrosion fatigue (CF) process has been investigated at different given strain amplitudes and strain rates. The results show that elastic strain has little contribution to material dissolution. The elastic tension strain results in the decrease in the transient current, while the elastic compression strain increases the transient current. Compared to the elastic deformation, plastic deformation affects material dissolution evidently For iron in 3.5%NaCl solution, the strain amplitude plays a dominant role in the dissolution process accelerated by the plastic strain, while in 3.5%NaCl+1%NaNO2 solution, both the strain amplitude and strain rate play an important role in this process. In this paper, the effect of the elastic deformation on the material dissolution and the relation between the tension and compression current peak values under the plastic cycle deformation are discussed 展开更多
关键词 transient current Behaviour for Iron in 3.5%NaCl and 3.5%NaCl SCE NaNO2 Solutions during Corrosion Fatigue
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A novel transient rotor current control scheme of a doubly-fed induction generator equipped with superconducting magnetic energy storage for voltage and frequency support
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作者 沈阳武 柯德平 +3 位作者 孙元章 Daniel Kirschen 王轶申 胡元朝 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第7期52-63,共12页
A novel transient rotor current control scheme is proposed in this paper for a doubly-fed induction generator(DFIG)equipped with a superconducting magnetic energy storage(SMES) device to enhance its transient volt... A novel transient rotor current control scheme is proposed in this paper for a doubly-fed induction generator(DFIG)equipped with a superconducting magnetic energy storage(SMES) device to enhance its transient voltage and frequency support capacity during grid faults. The SMES connected to the DC-link capacitor of the DFIG is controlled to regulate the transient dc-link voltage so that the whole capacity of the grid side converter(GSC) is dedicated to injecting reactive power to the grid for the transient voltage support. However, the rotor-side converter(RSC) has different control tasks for different periods of the grid fault. Firstly, for Period I, the RSC injects the demagnetizing current to ensure the controllability of the rotor voltage. Then, since the dc stator flux degenerates rapidly in Period II, the required demagnetizing current is low in Period II and the RSC uses the spare capacity to additionally generate the reactive(priority) and active current so that the transient voltage capability is corroborated and the DFIG also positively responds to the system frequency dynamic at the earliest time. Finally, a small amount of demagnetizing current is provided after the fault clearance. Most of the RSC capacity is used to inject the active current to further support the frequency recovery of the system. Simulations are carried out on a simple power system with a wind farm. Comparisons with other commonly used control methods are performed to validate the proposed control method. 展开更多
关键词 doubly-fed induction generator transient rotor current control superconducting magnetic energy storage voltage support
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THE VERIFICATION OF THE CURRENT TRANSIENT EQUATION AT TUBULAR ELECTRODES IN A FLOWING FLUID UNDER POTENTIAL STEP
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作者 Song Ying MO and Ying Sing FUNG Department of Chemistry, University of Hong Kong, Hong Kong 《Chinese Chemical Letters》 SCIE CAS CSCD 1992年第3期191-192,共2页
The equation derived for the response of the current transients in the flowing fluid is verified experimentally.
关键词 THE VERIFICATION OF THE current transient EQUATION AT TUBULAR ELECTRODES IN A FLOWING FLUID UNDER POTENTIAL STEP AT
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EFFECTS OF THE HOE 694 ON TRANSIENT INWARD CURRENT AND NA^+- CA^(2+) EXCHANGE IN GUINEA PIG CARDIOMYOCYTES
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作者 刘华军 陈灏珠 +1 位作者 杨学义 程介士 《Chinese Medical Sciences Journal》 CAS CSCD 2001年第1期5-9,共5页
To determine the effects of HOE 694, a new and potent Na+- H+ exchanger blocker, on transient inward current (Iti) and Na+- Ca2+ exchange during hypoxia- reoxygenation in guinea pig cardiomyocytes. Methods. Cardio... To determine the effects of HOE 694, a new and potent Na+- H+ exchanger blocker, on transient inward current (Iti) and Na+- Ca2+ exchange during hypoxia- reoxygenation in guinea pig cardiomyocytes. Methods. Cardiomyocytes were isolated from adult guinea pig ventricle. Experiment was performed in an experimental chamber that allowed the cells to be exposed to a sufficiently low O2 pressure. The cells were subjected to hypoxia and reoxygenation. The ionic currents were studied with patch clamp technique. Results. In the absence of HOE 694, hypoxia- reoxygenation induced Iti in 12 of 15 experiments; but in cardiomyocytes pretreated with HOE 694 (10~ 50μ mol/L), the incidence of Iti observed during reoxygenation was reduced to 5 of 11 experiments and 3 of 10 experiments, P Conclusions. Blockade of the Na+- H+ exchange by HOE 694 could reduce Ca2+ overload upon hypoxia- reoxygenation, and inhibition of Na+- H+ exchange may also indirectly decrease Na+- Ca2+ exchange activity during hypoxia. 展开更多
关键词 HOE694 瞬时内向电流 钠-钙交换 心肌细胞 动物实验
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Different suppressive effect of lidocaine on persistent Na^+ current and transient Na^+ current in dorsal root ganglion neurons
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作者 董辉 范延红 +2 位作者 王育英 王文挺 胡三觉 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第6期325-328,共4页
Objective:To investigate the different suppressive effect of lidocaine on persistent Na^+ current and transient Na^+ current in injured or uninjured dorsal root ganglion neurons.Methods:Totally 23 SD rats were randoml... Objective:To investigate the different suppressive effect of lidocaine on persistent Na^+ current and transient Na^+ current in injured or uninjured dorsal root ganglion neurons.Methods:Totally 23 SD rats were randomly divided into 2 groups:control group(n=10) and chronically compressed DRG(dorsal root ganglion) group (CCD group,n=13).Rats were anesthetized and DRG was isolated.Single DRG neuron was isolated by enzymatic disassociation method.Persistent Na^+ current(I_(NaP)) and transient Na^+ current(I_(NaT)) were elicited in voltage clamp mode.Results:The presence of I_(NaP) was testified in most DRG neurons (38/46 neurons in CCD group and 31/39 neurons in control group,P>0.05).However,the cur- rent density of I_(NaP) in CCD group(4.6±0.6 pA/pF,n=38 neurons) was greater than that in control group (2.5±0.4 pA/pF,n=31 neurons)(P<0.05).The characteristics of I_(NaP) was observed and found that I_(NaP) could be blocked by 0.2μmol/L tetrodotoxin easily.Furthermore,the does-effect relationship of lidocaine on I_(NaP) and I_(NaT) were also examined.I_(NaP) and I_(NaT) were suppressed by different concentrations of li- docaine,the range for I_(NaP) was 5-20μmol/L and for I_(NaT) was 0.05-2 mmol/L.Conclusion:I_(NaP) and I_(NaT) were suppressed by different concentrations of iidocaine.I_(NaP) was suppressed by very low concentration of lidocaine(5-20μmol/L).However,I_(NaT) could only be blocked by high concentration of lidocaine(0.05-2 mmol/L). 展开更多
关键词 背神经 神经节 神经痛 利多卡因 镇痛效果
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