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Tropical Cyclones in Nicaragua:Historical Impact and Contemporary Exposure to Disaster Risk
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作者 Gema Velásquez‑Espinoza Irasema Alcántara‑Ayala 《International Journal of Disaster Risk Science》 SCIE CSCD 2024年第4期579-593,共15页
In tropical regions such as Nicaragua,the population’s vulnerability to hazards has escalated in recent decades.This increase in vulnerability has led to a surge in disasters,particularly those triggered by intense h... In tropical regions such as Nicaragua,the population’s vulnerability to hazards has escalated in recent decades.This increase in vulnerability has led to a surge in disasters,particularly those triggered by intense hurricanes.The implications at the national level are still poorly understood.The aim of this article has,therefore,been two-fold.First,to present a historical review of the direct efects of tropical cyclones on society in Nicaragua from 1852 to 2020.Second,to analyze the statistical probabilities of future hurricane-spawned high winds over Nicaragua.Data on cyclones hitting Nicaragua’s coasts were collected,including direct efects,wind speed,pressure,category,direction,and time of landfall.A database was created to classify intensity based on wind speed and frequency.Between 1852 and 2020,Nicaragua experienced 58 tropical cyclones with varying degrees of intensity between September and November.The trajectories of six past hurricanes were considered here regarding the areas that might have been under potential threat.Three zones of infuence were delimited along each trajectory according to three wind intensities and the trajectory of these hurricanes.The consequent exposure of each Nicaraguan department and autonomous region was established.The fndings are essential to delimitating priority areas for attention regarding the likely impact of tropical cyclones,mainly category 4 and 5 hurricanes.Public ofcials and the general public can use these data to identify the pressing need for enhanced strategies to mitigate disaster risk and avoid potential disasters. 展开更多
关键词 EXPOSURE historical impact Hurricanes Nicaragua Tropical cyclones VULNERABILITY
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Navigating interdisciplinary research:Historical progression and contemporary challenges
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作者 Xiaoqiang Li Fen Cai +3 位作者 Jintao Bao Yuqing Jian Zehui Sun Xin Xie 《Journal of Data and Information Science》 CSCD 2024年第3期14-28,共15页
Interdisciplinary research plays a crucial role in addressing complex problems by integrating knowledge from multiple disciplines.This integration fosters innovative solutions and enhances understanding across various... Interdisciplinary research plays a crucial role in addressing complex problems by integrating knowledge from multiple disciplines.This integration fosters innovative solutions and enhances understanding across various fields.This study explores the historical and sociological development of interdisciplinary research and maps its evolution through three distinct phases:pre-disciplinary,disciplinary,and post-disciplinary.It identifies key internal dynamics,such as disciplinary diversification,reorganization,and innovation,as primary drivers of this evolution.Additionally,this study highlights how external factors,particularly the urgency of World War II and the subsequent political and economic changes,have accelerated its advancement.The rise of interdisciplinary research has significantly reshaped traditional educational paradigms,promoting its integration across different educational levels.However,the inherent contradictions within interdisciplinary research present cognitive,emotional,and institutional challenges for researchers.Meanwhile,finding a balance between the breadth and depth of knowledge remains a critical challenge in interdisciplinary education. 展开更多
关键词 Interdisciplinary research historical sociology Development phases Interdisciplinary challenges
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Investigating the reactivation of historical landslides during the 2022 Luding M_(S)6.8 earthquake
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作者 Tao Wei Mingyao Xia +1 位作者 Xinxin Zhang Shaojian Qi 《Earthquake Science》 2024年第3期200-209,共10页
On September 5,2022,a strong earthquake with a magnitude of MS6.8 struck Luding County in Sichuan Province,China,triggering thousands of landslides along the Dadu River in the northwest-southeast(NW-SE)direction.We in... On September 5,2022,a strong earthquake with a magnitude of MS6.8 struck Luding County in Sichuan Province,China,triggering thousands of landslides along the Dadu River in the northwest-southeast(NW-SE)direction.We investigated the reactivation characteristics of historical landslides within the epicentral area of the Luding earthquake to identify the initiation mechanism of earthquake-induced landslides.Records of the two newly triggered and historical landslides were analyzed using manual and threshold methods;the spatial distribution of landslides was assessed in relation to topographical and geological factors using remote sensing images.This study sheds light on the spatial distribution patterns of landslides,especially those that occur above historical landslide areas.Our results revealed a similarity in the spatial distribution trends between historical landslides and new ones induced by earthquakes.These landslides tend to be concentrated within a range of 0.2 km from the river and 2 km from the fault.Notably,both rivers and faults predominantly influenced the reactivation of historical landslides.Remarkably,the reactivated landslides are characterized by their small to medium size and are predominantly situated in historical landslide zones.The number of reactivated landslides surpassed that of previously documented historical landslides within the study area.We provide insights into the critical factors responsible for historical landslides during the 2022 Luding earthquake,thereby enhancing our understanding of the potential implications for future co-seismic hazard assessments and mitigation strategies. 展开更多
关键词 Luding earthquake co-seismic landslides historical landslides spatial distribution landslide reactivation
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Stress triggering effect on the 2022 Honghe M_(S)5.0 earthquake with historical strong earthquakes
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作者 Mingce Wang Zifeng Liu Ruijie Luo 《Geodesy and Geodynamics》 EI CSCD 2024年第2期107-113,共7页
The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)5.0.To elucidate the seismogenic mechani... The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)5.0.To elucidate the seismogenic mechanism and scrutinize stress-triggered interactions,we calculated co-seismic and post-seismic Coulomb stress alterations induced by nine historical seismic events(M≥6.0).The analysis reveals that these substantial seismic events provoked co-seismic stress augmentations of 1.409 bar and postseismic stress increments of 0.159 bar.Noteworthy seismic events,such as the 1833 Songming,1877Shiping,1913 Eshan,and 1970 Tonghai earthquakes,catalyzed the occurrence of the Honghe earthquake.Areas of heightened future seismic risk include the southern region of the Red River Fault and the eastern segments of the Shiping-Jianshui and Qujiang faults.Additionally,we assessed the correlation between the spatial distribution of aftershocks and the Coulomb stress shift triggered by the mainshock,taking into account the influence of calculation parameter settings. 展开更多
关键词 Honghe Ms5.0 earthquake Coulomb failurestress Stress triggering historical strongearthquakes
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Could bright γ-ray burst optical transients have been recorded historically?
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作者 Richard G. Strom Fu-Yuan Zhao Cheng-Min Zhang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第3期260-268,共9页
The brightest optical flash from a γ-ray burst (GRB) was, briefly, a naked- eye object. Several other GRBs have produced optical transients only slightly fainter. We argue that, based upon the recently accumulated ... The brightest optical flash from a γ-ray burst (GRB) was, briefly, a naked- eye object. Several other GRBs have produced optical transients only slightly fainter. We argue that, based upon the recently accumulated data from hundreds of GRB transients, many such optical events should have been visible to the unaided eye in the course of human history. The most likely repositories of such observations are histor- ical records from the Orient, and we have located and discuss a number of candidates. We also consider the value of such observations, should any very likely ones be uncovered, to modern astrophysics. 展开更多
关键词 γ-rays: bursts—optical transients—historical records
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Understanding the Historical Significance and Contemporary Value of the Distinctive Features of Chinese Civilisation
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作者 《International Understanding》 2024年第2期8-17,共10页
At a meeting on cultural inheritance and development held in Beijing,June 2,2023,President Xi Jinping put forward a holistic and systematic explanation of the distinctive features of Chinese civilisation-consistency,o... At a meeting on cultural inheritance and development held in Beijing,June 2,2023,President Xi Jinping put forward a holistic and systematic explanation of the distinctive features of Chinese civilisation-consistency,originality,unity,inclusiveness,and a peaceful nature.Underpinned by the scientific methodology of dialectical and historical materialism and an overarching strategic perspective on the great undertakings of socialism with Chinese characteristics in the new era,President Xi Jinping's profound exposition has granted us a deeper understanding of the laws underlying the development of Chinese civilisation by shedding light on its intrinsic characteristics.This understanding bears not just immense historical importance but also significant contemporary value. 展开更多
关键词 PEACE historical CIVIL
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Methods for ice velocity mapping in West Antarctica using historical optical satellite images
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作者 ZHANG Yujie AN Lu +3 位作者 TANG Leyue LI Hongwei HE Meixi LI Rongxing 《Advances in Polar Science》 CSCD 2024年第2期252-263,共12页
The Antarctic Ice Sheet harbors more than 90%of the Earth ice mass,with significant losses experienced through dynamic thinning,particularly in West Antarctica.The crucial aspect of investigating ice mass balance in h... The Antarctic Ice Sheet harbors more than 90%of the Earth ice mass,with significant losses experienced through dynamic thinning,particularly in West Antarctica.The crucial aspect of investigating ice mass balance in historical periods preceding 1990 hinges on the utilization of ice velocities derived from optical satellite images.We employed declassified satellite images and Landsat images with normalized cross correlation based image matching,adopting an adaptive combination of skills and methods to overcome challenges encountered during the mapping of historical ice velocity in West Antarctica.A basin-wide synthesis velocity map encompassing the coastal regions of most large-scale glaciers and ice shelves in West Antarctica has already been successfully generated.Our results for historical ice velocities cover over 70%of the grounding line in most of the West Antarctic basins.Through adjustments,we uncovered overestimations in ice velocity measurements over an extended period,transforming our ice velocity map into a spatially deterministic,temporally average version.Among all velocity measurements,Thwaites Glacier exhibited a notable spatial variation in the fastest ice flowline and velocity distribution.Overestimation distributions on Thwaites Glacier displayed a clear consistency with the positions of subsequent front calving events,offering insights into the instabilities of ice shelves. 展开更多
关键词 ANTARCTICA ice velocity overestimation correction historical imagery
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The Exploration of Teaching Historical Narratives Through Edith Wharton’s The Age of Innocence
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作者 LIU Zhuo SUN Zhengyifu 《Sino-US English Teaching》 2024年第8期377-382,共6页
Wharton’s novels serve as compelling cases for understanding the complexities of late 19th-century American society.The paper uses The Age of Innocence as an example to examine detailed depiction of the era’s social... Wharton’s novels serve as compelling cases for understanding the complexities of late 19th-century American society.The paper uses The Age of Innocence as an example to examine detailed depiction of the era’s social hierarchy,fashion,architecture,and the intricate social rituals that defined New York’s upper class.It explores the constraints and dilemmas women faced within a patriarchal society,highlighting Wharton’s personal experiences and her critical stance on the social norms of her time.The characters of Newland Archer,May Welland,and Ellen Olenska are analyzed to reveal the pressures of societal expectations and the struggles for individual desires within a rigid social structure.Additionally,the paper proposes various teaching methods,including contextual understanding,literary analysis with a historical focus,and historical research projects,to enhance students’comprehension of the cultural and historical context of the novel.These methods aim to immerse students in the narrative and promote their understanding of the Gilded Age’s social dynamics. 展开更多
关键词 The Age of Innocence Edith Wharton historical narrative Gilded Age
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Heritage Communities in Consumer Contexts Spatial Production of Tourism Research-Take Qixian Zhao Yu Historical City as an Example
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作者 BAI Zhao-yi ZHU Jun-jie WEN Jia-hao 《Journal of Literature and Art Studies》 2024年第1期95-108,共14页
Taking Zhaoyu Historical City in Qixian County as an example,this paper explores the production process of tourism space in Zhaoyu Historical City in the context of consumption,based on Lefebvre's triadic dialecti... Taking Zhaoyu Historical City in Qixian County as an example,this paper explores the production process of tourism space in Zhaoyu Historical City in the context of consumption,based on Lefebvre's triadic dialectic theory.The study reveals that,driven by the development of tourism,subjects such as the government and planners possess absolute dominance over spatial representations,while residents demonstrate receptive and adaptive action strategies and social relations are reproduced,presenting a harmonious state.Further exploring the tourism community in the environmental performance of the subject of action,social relations,consumption demand,daily life practice,cultural capital,etc.,the daily life practice of the tourism community has transcended the original logic of tourism spatial production and has a certain extension.The mechanism analysis in this paper can help guide the healthy development of tourism space in the neighboring historical cities or communities and achieve the dual purpose of promoting the economic development of the community and heritage protection. 展开更多
关键词 spatial production theory tourism space consumption context heritage community ZhaoYu historical City
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Mitigation of Transients in Capacitor Coupled Substations Using Traditional RLC Filter Techniques
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作者 Sinqobile Wiseman Nene Bolanle Tolulope Abe Agha Francis Nnachi 《Journal of Power and Energy Engineering》 2024年第5期60-75,共16页
This article presents an extensive examination and modeling of Capacitor Coupled Substations (CCS), noting some of their inherent constraints. The underlying implementation of a CCS is to supply electricity directly f... This article presents an extensive examination and modeling of Capacitor Coupled Substations (CCS), noting some of their inherent constraints. The underlying implementation of a CCS is to supply electricity directly from high-voltage (HV) transmission lines to low-voltage (LV) consumers through coupling capacitors and is said to be cost-effective as compared to conventional distribution networks. However, the functionality of such substations is susceptible to various transient phenomena, including ferroresonance and overvoltage occurrences. To address these challenges, the study uses simulations to evaluate the effectiveness of conventional resistor-inductor-capacitor (RLC) filter in mitigating hazardous overvoltage resulting from transients. The proposed methodology entails using standard RLC filter to suppress transients and its associated overvoltage risks. Through a series of MATLAB/Simulink simulations, the research emphasizes the practical effectiveness of this technique. The study examines the impact of transients under varied operational scenarios, including no-load switching conditions, temporary short-circuits, and load on/off events. The primary aim of the article is to assess the viability of using an established technology to manage system instabilities upon the energization of a CCS under no-load circumstances or in case of a short-circuit fault occurring on the primary side of the CCS distribution transformer. The findings underscore the effectiveness of conventional RLC filters in suppressing transients induced by the CCS no-load switching. 展开更多
关键词 Capacitor Coupled Substation System Modeling FERRORESONANCE RLC filters Power Electronics transients Capacitor Voltage Transformers Transmission Lines
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Traditional medicine in Tanzania:a review of historical perspective,current practices and challenges
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作者 Obadia Bishoge Robert Njee +16 位作者 Yolanda Mbatia Judith Msovela Vitus Nyigo Mwanaidi Kafuye Justine Omolo Godfrey Mubyazi Calister Imeda Emmanuel Peter Paul Kazyoba Michael Munga Shaban Katani Maryyusta Nguyamu Otilia Gowelle Mwanaidi Omary Richard Sunguruma Abel Mdemu Ahmed Abdallah 《History & Philosophy of Medicine》 2024年第4期7-15,共9页
The use of traditional medicine(TM)is essential for preventing and treating diseases and thus improving human health.Worldwide,TM has been used since time immemorial.In Tanzania,the use of TM was most common during pr... The use of traditional medicine(TM)is essential for preventing and treating diseases and thus improving human health.Worldwide,TM has been used since time immemorial.In Tanzania,the use of TM was most common during precolonial era before it was discriminated during the Germany colonial rule.However,it regained the attention during the private sector emergence era(1985-2004).Currently,there are ongoing efforts to integrate TM and modern medicine to improve healthcare systems in developing countries for sustainable healthcare management.This review aims to provide an overview of the historical and current status,challenges,and future direction for TM in Tanzania.The analysis revealed that the development of TM was somehow underdeveloped during the colonial rule but regained its popularity after independence.Currently,there are many opportunities such as the presence of legal and institutional frameworks,a varied medicinal biodiversity,with some of them being endemic to Tanzania,political will etc.Despite the available opportunities,there are numerous challenges to the development and use of TM.These include inadequate financial and human resources for research,poor conservation of medicinal biodiversity;modernization;intellectual property rights of TM knowledge;lack of safety,efficacy,and quality data of medicinal products.The development and utility of TM as a resource is crucial to protect practise.Thus,the study recommends more capacity building in terms of finances,technology development,human resources training,advocacy and integration of TM into healthcare system. 展开更多
关键词 traditional medicine historical perspective Tanzania
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Historical Changes,Contemporary Characteristics,and Five Transformations of Environmental Design in China
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作者 Tijin Gui 《Journal of Contemporary Educational Research》 2024年第7期7-17,共11页
Starting from the characteristics of modernization in three different historical stages since the founding of the People’s Republic of China,this paper analyses the internal changes in the professional name,subordina... Starting from the characteristics of modernization in three different historical stages since the founding of the People’s Republic of China,this paper analyses the internal changes in the professional name,subordinate disciplines and categories,and professional mission of the environmental design profession,and summarizes the changes in the characteristics of the environmental design profession in 10 aspects such as subordinate disciplines,design objects,design types,cultural characteristics,and aesthetic values on the basis of the results of the analysis,and explores five transformations of the environmental design profession in the process of China’s development in the future.The five transformations in the future development of China are to serve the harmony and beauty of the three major urban and rural spaces with“small and micro-renewal and reconstruction”;to serve the transmission of Chinese culture and the spread of Chinese civilization with“spatial heritage and innovation”;to serve the balance and sufficiency of the four functions of urban and rural settlements with“friendliness and equilibrium”;to serve the intelligence,wisdom,and enjoyment of indoor and outdoor living environment space with“scientific and technological achievements”;and to serve the co-construction,co-management,and sharing of indoor and outdoor public space in urban and rural areas with“public participation.” 展开更多
关键词 Environmental design historical changes Contemporary characteristics Five transformations
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Research on the Constitutional,Historical and Practical Logic of the Chinese Path of Human Rights Development——From the Perspective of the Inclusion of Human Rights Clause in the Constitution
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作者 FAN Jinxue 《The Journal of Human Rights》 2024年第3期521-547,共27页
The inclusion of the human rights clause in the Chi-nese Constitution is a concern and expression of the spirit of the Con-stitution,which has laid the institutional regulations of the fundamen-tal law for the develop... The inclusion of the human rights clause in the Chi-nese Constitution is a concern and expression of the spirit of the Con-stitution,which has laid the institutional regulations of the fundamen-tal law for the development of human rights in China,provided the principles and value norms of the highest level of effectiveness for the legal protection of human rights,and built a profound constitutional basis for the formation and improvement of the Chinese path of human rights development.The human rights clause is not only a summariza-tion and affirmation of the historical practice of Chinese human rights development under the leadership of the Communist Party of China,but also a new starting point for the development of human rights in China under the leadership of the Communist Party of China.It marks that the development of human rights in China has entered a new era.The Party and the state have finally embarked on a path of human rights development with Chinese characteristics by formulating and implementing the Human Rights Action Plan of China,eliminating ab-solute poverty through the national poverty alleviation campaign,and promoting human rights protection through the rule of law. 展开更多
关键词 inclusion of the human rights clause in the Consti-tution regulations on fundamental rights Chinese path of human rights development historical logic practice logic
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The Arctic Sea Ice Thickness Change in CMIP6’s Historical Simulations 被引量:1
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作者 Lanying CHEN Renhao WU +3 位作者 Qi SHU Chao MIN Qinghua YANG Bo HAN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第12期2331-2343,共13页
This study assesses sea ice thickness(SIT)from the historical run of the Coupled Model Inter-comparison Project Phase 6(CMIP6).The SIT reanalysis from the Pan-Arctic Ice Ocean Modeling and Assimilation System(PIOMAS)p... This study assesses sea ice thickness(SIT)from the historical run of the Coupled Model Inter-comparison Project Phase 6(CMIP6).The SIT reanalysis from the Pan-Arctic Ice Ocean Modeling and Assimilation System(PIOMAS)product is chosen as the validation reference data.Results show that most models can adequately reproduce the climatological mean,seasonal cycle,and long-term trend of Arctic Ocean SIT during 1979-2014,but significant inter-model spread exists.Differences in simulated SIT patterns among the CMIP6 models may be related to model resolution and sea ice model components.By comparing the climatological mean and trend for SIT among all models,the Arctic SIT change in different seas during 1979-2014 is evaluated.Under the scenario of historical radiative forcing,the Arctic SIT will probably exponentially decay at-18%(10 yr)-1 and plausibly reach its minimum(equilibrium)of 0.47 m since the 2070s. 展开更多
关键词 sea ice thickness Arctic Ocean climate change historical simulation CMIP6
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Legacy effects of historical woodland changes on contemporary plant functional composition 被引量:1
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作者 Ji-Zhong Wan Chun-Jing Wang 《Forest Ecosystems》 SCIE CSCD 2023年第5期569-578,共10页
Considering the legacy of plant functional composition can help assess ecosystem functions and ecosystem services across different spatial scales under land cover changes.Woody plants likely respond to natural and ant... Considering the legacy of plant functional composition can help assess ecosystem functions and ecosystem services across different spatial scales under land cover changes.Woody plants likely respond to natural and anthropogenic perturbations due to historical events(e.g.,agricultural development),thus contemporary plant functional composition may be explained by historical woodland change,a type of land cover change.We propose that historical woodland changes may have legacy effects on contemporary plant functional composition.Here,we used partial least squares regression and linear mixed model analyses to test this assumption by coupling data on community weighted means(CWM)and community weighted variance(CWV)of vegetation plots and calculating the time of woodland existence across different periods from AD 0 to 2017.We found that the legacy effects of historical land cover changes on CWM and CWV during the existence time of woodland,particularly from AD 0 to 900,were drivers of contemporary plant functional composition at large spatial scales.Furthermore,historical woodland changes can affect contemporary plant functional composition,depending on the biome type.Particularly,the CWM of plant height,seed mass,and seed length showed the strongest correlations with woodland changes from AD 1910 to 2010 in tropics with year-round rain,and the CWM of leaf traits correlated with woodland changes from AD 0 to 1700 in tropics with summer rain.Our study provides the effective evidence on the legacy of historical woodland changes and the effects on contemporary plant functional composition,which is crucial with respect to effective management of plant diversity and assessing ecosystem functions and services from local to global scales over time. 展开更多
关键词 BIOME Community weighted means Global scale historical woodland Land cover Plant functional trait
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Analysis of Landscape Vitality of Historical and Cultural Blocks Based on AHPFuzzy Comprehensive Evaluation Method:A Case Study of Daopashi Street in Anqing City 被引量:1
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作者 YANG Xinru LIU Hongyun +1 位作者 LI Tianjiao WANG Xingyi 《Journal of Landscape Research》 2023年第3期59-62,66,共5页
Historical and cultural blocks are witnesses of history and inheritors of culture. As one of the main spaces for outdoor interaction in historical and cultural blocks, the improvement of its vitality is of great signi... Historical and cultural blocks are witnesses of history and inheritors of culture. As one of the main spaces for outdoor interaction in historical and cultural blocks, the improvement of its vitality is of great significance for the improvement of residential environment and the better inheritance of history and culture. Taking Daopashi Street in Anqing City as an example, an evaluation model of landscape spatial vitality of historical and cultural blocks was constructed from three aspects of viewing function, store status and service facilities, and analytic hierarchy process was used to determine the index weight and vaguely evaluate the landscape spatial vitality of historical and cultural blocks. The results show that through the comparison of weight, architectural style(0.317), the practicability of service facilities(0.168) and plant landscape(0.165) had a significant impact on the landscape spatial vitality of historical and cultural blocks,and the landscape spatial vitality of historical and cultural blocks in Daopashi Street in Anqing City was at a good level. 展开更多
关键词 Analytic hierarchy process Fuzzy comprehensive evaluation method historical and cultural blocks Landscape vitality
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The History of Controlling and Treating Infectious Diseases in Ancient China 被引量:1
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作者 Cui-ling LIU Tao ZHOU +5 位作者 Liang-bin CHENG David FISHER Khrystyna PRONYUK Erkin MUSABAEV Yi-ping DANG Lei ZHAO 《Current Medical Science》 SCIE CAS 2024年第1期64-70,共7页
Infectious diseases are the common enemies of mankind.In the course of historical development,they persistently threaten human health and safety.Even today,despite the developments in medical science,we cannot escape ... Infectious diseases are the common enemies of mankind.In the course of historical development,they persistently threaten human health and safety.Even today,despite the developments in medical science,we cannot escape the fear and suffering caused by infectious diseases.Whether in ancient or modern times,the source of infection,route of transmission,and a susceptible population are the three key conditions for the prevalence and spread of infectious diseases.All factors closely related to these three conditions can affect the prevalence of infectious diseases.China is one of the cradles of world civilization.The ancient people accumulated a great deal of experience and lessons in the long struggle against infectious diseases.In the face of the current threat posed by widespread infectious disease,it is imperative to review and summarize ancient Chinese ideas and health policies on epidemic prevention and control to inspire contemporary efforts in the prevention and control of infectious disease.The combination of prevention-oriented epidemic prevention ideology and traditional medicine provides valuable insights,especially for impoverished and medically underserved regions. 展开更多
关键词 infectious diseases Chinese medicine public health historical review
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Mutation in the Agrobacterium his I gene enhances transient expression in pepper 被引量:1
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作者 Dan Liu Shengnan Zhao +3 位作者 Jubin Wang Xi Zhang Yingtian Deng Feng Li 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第3期809-822,共14页
Agrobacterium-mediated plant transformation is widely used in plant genetic engineering.However,its efficiency is limited by plant immunity against Agrobacterium.Chili pepper(Capsicum annuum L.)is an important vegetab... Agrobacterium-mediated plant transformation is widely used in plant genetic engineering.However,its efficiency is limited by plant immunity against Agrobacterium.Chili pepper(Capsicum annuum L.)is an important vegetable that is recalcitrant to Agrobacterium-mediated transformation.In this work,Agrobacterium was found to induce a strong immune response in pepper,which might be the reason for T-DNA being difficult to express in pepper.An Agrobacterium mutant screen was conducted and a point mutation in the hisI gene was identified due to a weak immune response and enhanced transient expression mediated by this Agrobacterium mutant in pepper leaves.Further genetic analysis revealed that histidine biosynthesis deficiency caused by mutations in many genes of this pathway led to reduced pepper cell death,presumably due to reduced bacterial growth.However,mutation analysis of threonine and tryptophan biosynthesis genes showed that the biosynthesis of different amino acids may play different roles in Agrobacterium growth and stimulating the pepper immune response.The possible application of Agrobacterium amino acid biosynthesis mutations in plant biology was discussed. 展开更多
关键词 Capsicum annuum L. AGROBACTERIUM transient transformation efficiency MUTATION Amino acid Immune response
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Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer 被引量:1
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作者 WEI HU THOMAS WARTMANN +5 位作者 MARCO STRECKER ARISTOTELIS PERRAKIS ROLAND CRONER ARPAD SZALLASI WENJIE SHI ULF D.KAHLERT 《Oncology Research》 SCIE 2024年第1期227-239,共13页
Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TR... Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient samples.Kaplan-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,respectively.Additionally,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.The support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy outcomes.The findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD patients.Analysis of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk counterparts.High-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression profiles.Moreover,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of chemoresistance.Ultimately,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data and real-world patients.Overall,this bioinformatics study provides valuable insights into the prognostic implications and potential chemotherapy resistance mechanisms associated with TRPs-related genes in colon cancer. 展开更多
关键词 Colon cancer transient receptor potential channels Prognostic signature Chemotherapy efficiency TRPM5
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Temperature dependence of single-event transients in SiGe heterojunction bipolar transistors for cryogenic applications
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作者 潘霄宇 郭红霞 +4 位作者 冯亚辉 刘以农 张晋新 付军 喻国芳 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第9期535-544,共10页
We experimentally demonstrate that the dominant mechanism of single-event transients in silicon-germanium heterojunction bipolar transistors(SiGe HBTs)can change with decreasing temperature from+20℃to-180℃.This is a... We experimentally demonstrate that the dominant mechanism of single-event transients in silicon-germanium heterojunction bipolar transistors(SiGe HBTs)can change with decreasing temperature from+20℃to-180℃.This is accomplished by using a new well-designed cryogenic experimental system suitable for a pulsed-laser platform.Firstly,when the temperature drops from+20℃to-140℃,the increased carrier mobility drives a slight increase in transient amplitude.However,as the temperature decreases further below-140℃,the carrier freeze-out brings about an inflection point,which means the transient amplitude will decrease at cryogenic temperatures.To better understand this result,we analytically calculate the ionization rates of various dopants at different temperatures based on Altermatt's new incomplete ionization model.The parasitic resistivities with temperature on the charge-collection pathway are extracted by a two-dimensional(2D)TCAD process simulation.In addition,we investigate the impact of temperature on the novel electron-injection process from emitter to base under different bias conditions.The increase of the emitter-base junction's barrier height at low temperatures could suppress this electron-injection phenomenon.We have also optimized the built-in voltage equations of a high current compact model(HICUM)by introducing the impact of incomplete ionization.The present results and methods could provide a new reference for effective evaluation of single-event effects in bipolar transistors and circuits at cryogenic temperatures,and could provide a new evidence of the potential of SiGe technology in applications in extreme cryogenic environments. 展开更多
关键词 SiGe heterojunction bipolar transistors pulsed laser TCAD simulation single-event transient
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