Applications and advancements in animal models for antiviral research on mosquito-borne arboviruses

Vector-borne diseases caused by arthropod-borne viruses(arboviruses) are a considerable challenge to public health globally. Mosquito-borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito-borne arboviruses, playing a role in understanding disease mechanisms,vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal-to-human translational success. Genetically engineered mouse models, hamster models and non-human primate(NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long-tailed macaques as potential NHP models for arbovirus research is possible;however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld.

Research and Practice of the Blended Teaching Model of BOPPPS Teaching Method Under the Background of Digital Education: Taking Operations Research Course as an Example

The rapid development of digital education provides new opportunities and challenges for teaching model innovation.This study aims to explore the application of the BOPPPS(Bridge-in,Objective,Pre-assessment,Participatory learning,Post-assessment,Summary)teaching method in the development of a blended teaching model for the Operations Research course under the background of digital education.In response to the characteristics of the course and the needs of the student group,the teaching design is reconstructed with a student-centered approach,increasing practical teaching links,improving the assessment and evaluation system,and effectively implementing it in conjunction with digital educational technology.This teaching model has shown significant effectiveness in the context of digital education,providing valuable experience and insights for the innovation of the Operations Research course.

General laws of funding for scientific citations:how citations change in funded and unfunded research between basic and applied sciences

Purpose:The goal of this study is to analyze the relationship between funded and unfunded papers and their citations in both basic and applied sciences.Design/methodology/approach:A power law model analyzes the relationship between research funding and citations of papers using 831,337 documents recorded in the Web of Science database.Findings:The original results reveal general characteristics of the diffusion of science in research fields:a)Funded articles receive higher citations compared to unfunded papers in journals;b)Funded articles exhibit a super-linear growth in citations,surpassing the increase seen in unfunded articles.This finding reveals a higher diffusion of scientific knowledge in funded articles.Moreover,c)funded articles in both basic and applied sciences demonstrate a similar expected change in citations,equivalent to about 1.23%,when the number of funded papers increases by 1%in journals.This result suggests,for the first time,that funding effect of scientific research is an invariant driver,irrespective of the nature of the basic or applied sciences.Originality/value:This evidence suggests empirical laws of funding for scientific citations that explain the importance of robust funding mechanisms for achieving impactful research outcomes in science and society.These findings here also highlight that funding for scientific research is a critical driving force in supporting citations and the dissemination of scientific knowledge in recorded documents in both basic and applied sciences.Practical implications:This comprehensive result provides a holistic view of the relationship between funding and citation performance in science to guide policymakers and R&D managers with science policies by directing funding to research in promoting the scientific development and higher diffusion of results for the progress of human society.

Can ChatGPT evaluate research quality?

Purpose:Assess whether ChatGPT 4.0 is accurate enough to perform research evaluations on journal articles to automate this time-consuming task.Design/methodology/approach:Test the extent to which ChatGPT-4 can assess the quality of journal articles using a case study of the published scoring guidelines of the UK Research Excellence Framework(REF)2021 to create a research evaluation ChatGPT.This was applied to 51 of my own articles and compared against my own quality judgements.Findings:ChatGPT-4 can produce plausible document summaries and quality evaluation rationales that match the REF criteria.Its overall scores have weak correlations with my self-evaluation scores of the same documents(averaging r=0.281 over 15 iterations,with 8 being statistically significantly different from 0).In contrast,the average scores from the 15 iterations produced a statistically significant positive correlation of 0.509.Thus,averaging scores from multiple ChatGPT-4 rounds seems more effective than individual scores.The positive correlation may be due to ChatGPT being able to extract the author’s significance,rigour,and originality claims from inside each paper.If my weakest articles are removed,then the correlation with average scores(r=0.200)falls below statistical significance,suggesting that ChatGPT struggles to make fine-grained evaluations.Research limitations:The data is self-evaluations of a convenience sample of articles from one academic in one field.Practical implications:Overall,ChatGPT does not yet seem to be accurate enough to be trusted for any formal or informal research quality evaluation tasks.Research evaluators,including journal editors,should therefore take steps to control its use.Originality/value:This is the first published attempt at post-publication expert review accuracy testing for ChatGPT.

“Flipped Classroom” Teaching Model Research: A Case Study of “Innovation and Entrepreneurship Education and Practice (Theory)”

The flipped classroom model differs significantly from the traditional classroom teaching model and offers numerous advantages. This article draws inspiration from the flipped classroom concept, using the “Innovation and Entrepreneurship Education and Practice (Theory)” course as an example to introduce the innovation and characteristics of the flipped classroom model: it is problem-oriented, addressing the “pain points” in teaching, motivating students towards “active learning,” and integrating diverse teaching methods. In the conclusion, the article proposed suggestions on the application of this model, encouraging teachers to summarize their teaching experiences, enhance their knowledge base, and foster students’ awareness of innovation and entrepreneurship.

Research on the New Model of Student Education Management in Vocational Colleges

Vocational colleges are an important type of higher education in China.Higher vocational education aims to adapt to social needs and designs students’knowledge,ability,quality structure,and training plans based on the cultivation of technical application skills.Emphasizing both theoretical teaching and practical training,graduates have the skills to work directly.At this stage,vocational education in China is in an important period of transformation and development.In order to better adapt to the rapid development of society,many vocational colleges have carried out management system reforms in student education management,with the aim of cultivating more high-quality and skilled talents that meet the needs of social development,and providing higher quality vocational education services for the country and society.In the process of physical education reform,due to regional and other factors,many reform models cannot adapt to the current situation of student education management in vocational colleges in the new era.Therefore,it is necessary to continuously explore new models suitable for vocational colleges.Based on the background of the physical education reform in vocational colleges,this article uses methods such as literature research and visits to analyze the current situation of education management in vocational colleges,the problems and possible reasons that exist in student education management in vocational colleges.This article discusses the possible new models of student education management in vocational colleges from the perspectives of repeated management methods,management concepts,management mechanisms,and evaluation systems,and elaborates on their new paths.Efforts are made to improve the management mode of student education in vocational colleges,innovate the management mechanism of vocational colleges,and actively explore the improvement of the management mode of student education in vocational colleges.

AI-Powered Innovations in High-Tech Research and Development: From Theory to Practice

This comparative review explores the dynamic and evolving landscape of artificial intelligence(AI)-powered innovations within high-tech research and development(R&D).It delves into both theoreticalmodels and practical applications across a broad range of industries,including biotechnology,automotive,aerospace,and telecom-munications.By examining critical advancements in AI algorithms,machine learning,deep learning models,simulations,and predictive analytics,the review underscores the transformative role AI has played in advancing theoretical research and shaping cutting-edge technologies.The review integrates both qualitative and quantitative data derived from academic studies,industry reports,and real-world case studies to showcase the tangible impacts of AI on product innovation,process optimization,and strategic decision-making.Notably,it discusses the challenges of integrating AI within complex industrial systems,such as ethical concerns,technical limitations,and the need for regulatory oversight.The findings reveal a mixed landscape where AI has significantly accelerated R&D processes,reduced costs,and enabled more precise simulations and predictions,but also highlighted gaps in knowledge transfer,skills adaptation,and cross-industry standardization.By bridging the gap between AI theory and practice,the review offers insights into the effectiveness,successes,and obstacles faced by organizations as they implement AI-driven solutions.Concluding with a forward-looking perspective,the review identifies emerging trends,future challenges,and promising opportunities inAI-poweredR&D,such as the rise of autonomous systems,AI-driven drug discovery,and sustainable energy solutions.It offers a holistic understanding of how AI is shaping the future of technological innovation and provides actionable insights for researchers,engineers,and policymakers involved in high-tech Research and Development(R&D).

A synthetic differencein-differences model for the influence of CR Express on Chongqing's economy

Purpose-The China-Europe Railway Express(CR Express)in Chongqing has operated regularly and undergone large-scale development.Its impact on Chongqing's economic growth has become increasingly evident,necessitating further research in this field.Design/methodology/approach-This study employs the opening of CR Express as a quasi-natural experiment,designating Chongqing,which inaugurated the CR Express in 2011,as the treatment group.13 provinces and cities that had not yet opened the CR Express until 2017 were selected as the control group.Utilizing panel data from 14 provinces across China spanning from 2006 to 2017,the synthetic control method(SCM)is employed to synthetically construct Chongqing.To quantify the difference in economic development levels between Chongqing with the operation of the CR express and Chongqing without its operation.Key metrics such as gross domestic product(GDP),per capita GDP,total retail sales of consumer goods,import and export value and the proportions of the secondary and tertiary industries are employed to measure urban economic development capabilities.Chongqing is designated as the experimental group,and a double-difference model is constructed to regress the operation of the CR Express against economic development capabilities.Robustness tests are conducted to validate the analytical results.Findings-The results indicate that,compared to provinces without the operation of the CR Express,the initiation of the CR Express in Chongqing significantly enhances the economic development level of the city.The opening of the CR Express exhibits a pronounced positive impact on Chongqing's economic development,and these findings remain robust and effective even after parallel trend tests and placebo tests.Originalitylvalue-The study represents an expansion of the theoretical framework.In contrast to previous studies that relied on a single indicator such as GDP,this study selects six indicators from the dimensions of economy,trade and industry to measure regional economic development capabilities.Furthermore,employing the grey relational analysis method,the study screens these indicators,thereby providing a theoretical basis for the selection of indicators for measuring regional economic development capabilities.

Risk assessment of high-speed railway CTC system based on improved game theory and cloud model

Purpose-In order to solve the problem of inaccurate calculation of index weights,subjectivity and uncertainty of index assessment in the risk assessment process,this study aims to propose a scientific and reasonable centralized traffic control(CTC)system risk assessment method.Design/methodologylapproach-First,system-theoretic process analysis(STPA)is used to conduct risk analysis on the CTC system and constructs risk assessment indexes based on this analysis.Then,to enhance the accuracy of weight calculation,the fuzzy analytical hierarchy process(FAHP),fuzzy decision-making trial and evaluation laboratory(FDEMATEL)and entropy weight method are employed to calculate the subjective weight,relative weight and objective weight of each index.These three types of weights are combined using game theory to obtain the combined weight for each index.To reduce subjectivity and uncertainty in the assessment process,the backward cloud generator method is utilized to obtain the numerical character(NC)of the cloud model for each index.The NCs of the indexes are then weighted to derive the comprehensive cloud for risk assessment of the CTC system.This cloud model is used to obtain the CTC system's comprehensive risk assessment.The model's similarity measurement method gauges the likeness between the comprehensive risk assessment cloud and the risk standard cloud.Finally,this process yields the risk assessment results for the CTC system.Findings-The cloud model can handle the subjectivity and fuzziness in the risk assessment process well.The cloud model-based risk assessment method was applied to the CTC system risk assessment of a railway group and achieved good results.Originality/value-This study provides a cloud model-based method for risk assessment of CTC systems,which accurately calculates the weight of risk indexes and uses cloud models to reduce uncertainty and subjectivity in the assessment,achieving effective risk assessment of CTC systems.It can provide a reference and theoretical basis for risk management of the CTC system.

Progress in biological research on Tupaia belangeri

Tupaia belangeri,as a typical tropical species,has high value in biological research.It has the characteristics of small body size,high brain to body mass ratio,short reproductive cycle,short lifespan,and low maintenance cost.In biomedical research,experimental animals considered as substitutes for primates.This review discusses the systematic classification,distribution,and research progress of Scandentia.Emphasis was focus on the research progress,developmental status,and basic biological research in T.belangeri.Believing that the T.belangeri,as the closest species to humans,has many advantages as an experimental animal,and it can be further widely applied in human disease research.Therefore,how to create a clear and stable strain of T.belangeri with a clear genetic background is crucial for the development of the national economy and scientific research.

Comprehensive Evaluation of Talent Training Model for Modern Rehabilitation Therapy Technology:A Case Study of School Y

The purpose of this study is to comprehensively evaluate the modern training model of rehabilitation therapy technology talents.Selecting the third-year students of the rehabilitation therapy technology program in School Y as the research subject,300 questionnaires were collected and the effective response rate was 92%.The strengths and weaknesses of the modern training model were analyzed through a mixed qualitative and quantitative research method.It was found that 68%of the students thought that the modern model had obvious advantages in practical teaching,but 42%of the students thought that it still needed to be improved in personalized teaching.This study provides an empirical basis and specific suggestions for optimizing the cultivation of rehabilitation therapy technology talents.

Study of The Technical Index of Online Learning Behavior Analysis of Nursing Majors on The Superstar Platform Based on The Kirkpatrick Evaluation Model

Objective:To analyze the technical indexes of students’online learning behavior analysis based on Kirkman’s evaluation model,sort out the basic indexes of online learning behavior,and extract scientific and efficient evaluation indexes of online learning effect through statistical analysis.Methods:The online learning behavior data of Physiology of nursing students from 2021-2023 and the first semester of 22 nursing classes(3 and 4)were collected and analyzed.The preset learning behavior indexes were analyzed by multi-dimensional analysis and a correlation analysis was conducted between the indexes and the final examination scores to screen for the dominant important indexes for online learning effect evaluation.Results:The study found that the demand for online learning of nursing students from 2021-2023 increased and the effect was statistically significant.Compared with the stage assessment results,the online learning effect was statistically significant.Conclusion:The main indicators for evaluating and classifying online learning behaviors were summarized.These two indicators can help teachers predict which part of students need learning intervention,optimize the teaching process,and help students improve their learning behavior and academic performance.

The Flemish Performance-based Research Funding System: A Unique Variant of the Norwegian Model

The BOF-key is the performance-based research funding system that is used in Flanders, Belgium. In this paper we describe the historical background of the system, its current design and organization, as well as its effects on the Flemish higher education landscape. The BOFkey in its current form relies on three bibliometric parameters: publications in Web of Science, citations in Web of Science, and publications in a comprehensive regional database for SSH publications. Taken together, the BOF-key forms a unique variant of the Norwegian model: while the system to a large extent relies on a commercial database, it avoids the problem of inadequate coverage of the SSH. Because the bibliometric parameters of the BOF-key are reused in other funding allocation schemes, their overall importance to the Flemish universities is substantial.

A STUDY OF THE INFLUENCE OF MICROPHYSICAL PROCESSES ON TYPHOON NIDA(2016) USING A NEW DOUBLE-MOMENT MICROPHYSICS SCHEME IN THE WEATHER RESEARCH AND FORECASTING MODEL

The basic structure and cloud features of Typhoon Nida(2016) are simulated using a new microphysics scheme(Liuma) within the Weather Research and Forecasting(WRF) model. Typhoon characteristics simulated with the Liuma microphysics scheme are compared with observations and those simulated with a commonly-used microphysics scheme(WSM6). Results show that using different microphysics schemes does not significantly alter the track of the typhoon but does significantly affect the intensity and the cloud structure of the typhoon. Results also show that the vertical distribution of cloud hydrometeors and the horizontal distribution of peripheral rainband are affected by the microphysics scheme. The mixing ratios of rain water and graupel correlate highly with the vertical velocity component and equivalent potential temperature at the typhoon eye-wall region. According to the simulation with WSM 6 scheme,it is likely that the very low typhoon central pressure results from the positive feedback between hydrometeors and typhoon intensity. As the ice-phase hydrometeors are mostly graupel in the Liuma microphysics scheme, further improvement in this aspect is required.

Redesigning the Model of Book Evaluation in the Polish Performance-based Research Funding System

Purpose: This study aims to present the key systemic changes in the Polish book evaluation model to focus on the publisher list, as inspired by the Norwegian Model. Design/methodology/approach: In this study we reconstruct the framework of the 2010 and 2018 models of book evaluation in Poland within the performance-based research funding system. Findings: For almost 20 years the book evaluation system in Poland has been based on the verification of various technical criteria(e.g. length of the book). The new 2018 model is based on the principle of prestige inheritance(a book is worth as much as its publisher is) and is inspired by the publisher list used in the Norwegian Model. In this paper, we argue that this solution may be a more balanced policy instrument than the previous 2010 model in which neither the quality of the publisher nor the quality of the book played any role in the evaluation.Research limitations: We work from the framework of the 2018 model of book evaluation specified in the law on higher education and science from 20 July 2018, as implementation acts are not available yet. Practical implications: This study may provide a valuable point of reference on how structural reforms in the research evaluation model were implemented on a country level. The results of this study may be interesting to policy makers, stakeholders and researchers focused on science policy. Originality/value: This is the very first study that presents the new framework of the Polish research evaluation model and policy instruments for scholarly book evaluation. We describe what motivated policy makers to change the book evaluation model, and what arguments were explicitly raised to argue for the new solution.

A Review of the Logistic Regression Model with Emphasis on Medical Research

This study explored and reviewed the logistic regression (LR) model, a multivariable method for modeling the relationship between multiple independent variables and a categorical dependent variable, with emphasis on medical research. Thirty seven research articles published between 2000 and 2018 which employed logistic regression as the main statistical tool as well as six text books on logistic regression were reviewed. Logistic regression concepts such as odds, odds ratio, logit transformation, logistic curve, assumption, selecting dependent and independent variables, model fitting, reporting and interpreting were presented. Upon perusing the literature, considerable deficiencies were found in both the use and reporting of LR. For many studies, the ratio of the number of outcome events to predictor variables (events per variable) was sufficiently small to call into question the accuracy of the regression model. Also, most studies did not report on validation analysis, regression diagnostics or goodness-of-fit measures;measures which authenticate the robustness of the LR model. Here, we demonstrate a good example of the application of the LR model using data obtained on a cohort of pregnant women and the factors that influence their decision to opt for caesarean delivery or vaginal birth. It is recommended that researchers should be more rigorous and pay greater attention to guidelines concerning the use and reporting of LR models.

Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling

We examine the role of big data and machine learning in cancer research.We describe an example in cancer research where gene-level data from The Cancer Genome Atlas(TCGA) consortium is interpreted using a pathway-level model.As the complexity of computational models increases,their sample requirements grow exponentially.This growth stems from the fact that the number of combinations of variables grows exponentially as the number of variables increases.Thus,a large sample size is needed.The number of variables in a computational model can be reduced by incorporating biological knowledge.One particularly successful way of doing this is by using available gene regulatory,signaling,metabolic,or context-specific pathway information.We conclude that the incorporation of existing biological knowledge is essential for the progress in using big data for cancer research.

Impact of systems modelling on agronomic research and adoption of new practices in smallholder agriculture

An analysis of the impact of simulation modelling in three diverse crop-livestock improvement projects in Agricultural Research for Development（AR4D） reveals benefits across a range of aspects including identification of objectives, design and implementation of experimental programs, effectiveness of participatory research with smallholder farmers, implementation of system change and scaling-out of results.In planning change, farmers must consider complex interactions within both biophysical and socioeconomic aspects of their crop and animal production activities.For this, whole-farm models that include household models of food, workload and financial requirements have the most utility and impact.The analysis also proposes improvements in design and implementation of AR4 D projects to improve the utility of simulation modelling for securing positive agronomic and livestock outcomes and lasting legacies.

A Methodological Study on Using Weather Research and Forecasting(WRF) Model Outputs to Drive a One-Dimensional Cloud Model

A new method for driving a One-Dimensional Stratiform Cold （1DSC） cloud model with Weather Research and Fore casting （WRF） model outputs was developed by conducting numerical experiments for a typical large-scale stratiform rainfall event that took place on 4-5 July 2004 in Changchun, China. Sensitivity test results suggested that, with hydrometeor pro files extracted from the WRF outputs as the initial input, and with continuous updating of soundings and vertical velocities （including downdraft） derived from the WRF model, the new WRF-driven 1DSC modeling system （WRF-1DSC） was able to successfully reproduce both the generation and dissipation processes of the precipitation event. The simulated rainfall intensity showed a time-lag behind that observed, which could have been caused by simulation errors of soundings, vertical velocities and hydrometeor profiles in the WRF output. Taking into consideration the simulated and observed movement path of the precipitation system, a nearby grid point was found to possess more accurate environmental fields in terms of their similarity to those observed in Changchun Station. Using profiles from this nearby grid point, WRF-1DSC was able to repro duce a realistic precipitation pattern. This study demonstrates that 1D cloud-seeding models do indeed have the potential to predict realistic precipitation patterns when properly driven by accurate atmospheric profiles derived from a regional short range forecasting system, This opens a novel and important approach to developing an ensemble-based rain enhancement prediction and operation system under a probabilistic framework concept.

Vibration Response Analysis of a New Scientific Research Ship Based on Finite Element Modeling

To control the vibration level of ships under construction,MSC Software’s Patran&Nastran modeling solutions can be used to establish a detailed finite element model of a new manned submersible support mother ship based on a line drawing,including the deck layout,bulkhead section,and stiffener distribution.After a comprehensive analysis of the ship simulation conditions,boundaries,and excitation forces of the main operating equipment,modal analysis and calculation of the ship vibration can be conducted.In this study,we calculated and analyzed the vibration response of key points in the stern area of the ship’s main deck and the submersible warehouse area under design loading working conditions.We then analyzed the vibration response of typical decks(including the compass deck,steering deck,captain’s deck,forecastle deck,and main deck)under the main excitation forces and moments(such as the full swing pod and generator sets).The analysis results showed that under DESIDEP working conditions,the vibration of each deck and key areas of the support mother ship could meet the vibration code requirements of the ship’s preliminary design(using the pod excitation and generator sets).Similarly,the vibration response of a scientific research ship under other loading conditions also met the requirements of the code and provided data support for a comprehensive understanding of the ship’s vibration and noise levels.Using actual vibration measurements,the accuracy of the vibration level simulations using finite element modeling was verified,the vibration of each area of the ship comfortably meeting the requirements of the China Classification Society.