Transmission distortion （TD） is a significant departure from Mendelian predictions of genes or chromosomes to offspring. While many biological processes have been implicated, there is still much to be understood abo...Transmission distortion （TD） is a significant departure from Mendelian predictions of genes or chromosomes to offspring. While many biological processes have been implicated, there is still much to be understood about TD in humans. Here we present our findings from a genome-wide scan for evidence of TD using haplotype data of 60 trio families from the International HapMap Project. Fisher＇s exact test was applied to assess the extent of TD in 629,958 SNPs across the autosomes. Based on the empirical distribution of PFisher and further permutation tests, we identified 1,205 outlier loci and 224 candidate genes with TD. Using the PANTHER gene ontology database, we found 19 categories of biological processes with an enrichment of candidate genes. In particular, the “protein phosphorylation” category contained the largest number of candidates in both HapMap samples. Further analysis uncovered an intriguing non-synonymous change in PPPIR12B, a gene related to protein phosphorylation, which appears to influence the allele transmission from male parents in the YRI （Yoruba from Ibadan, Nigeria） population. Our findings also indicate an ethnicity-related property of TD signatures in HapMap samples and provide new clues for our understanding of TD in humans.展开更多
In theoty, engineered anomalous transmission in passive materials and waveguide devices can be used to compensate for wavetorm distortions. However, they suffer from inherent dissipation. Recently, active non-Foster e...In theoty, engineered anomalous transmission in passive materials and waveguide devices can be used to compensate for wavetorm distortions. However, they suffer from inherent dissipation. Recently, active non-Foster elements with imaginary immittance monotonically decreasing with frequency have shown important potentials in broadening bandwidths of electromagnetic devices. So far, they are implemented besed on negative impedance convertors （NICs） loaded with Foster devices. This makes them intrinsically one-port elements and thus cannot be used to compensate for distortions of signals. We construct a two-port network with a non-Foster transmission coefticient based on an unconventional use of NICs. Simulation and experiments show that it can compensate for extremely distorted signals. The proposed method can be used to broaden existing applications in different areas such as antennas, circuits and systems, and physical-layer signal processing.展开更多
基金supported by the National Nature Science Foundation of China (No.30225017)
文摘Transmission distortion （TD） is a significant departure from Mendelian predictions of genes or chromosomes to offspring. While many biological processes have been implicated, there is still much to be understood about TD in humans. Here we present our findings from a genome-wide scan for evidence of TD using haplotype data of 60 trio families from the International HapMap Project. Fisher＇s exact test was applied to assess the extent of TD in 629,958 SNPs across the autosomes. Based on the empirical distribution of PFisher and further permutation tests, we identified 1,205 outlier loci and 224 candidate genes with TD. Using the PANTHER gene ontology database, we found 19 categories of biological processes with an enrichment of candidate genes. In particular, the “protein phosphorylation” category contained the largest number of candidates in both HapMap samples. Further analysis uncovered an intriguing non-synonymous change in PPPIR12B, a gene related to protein phosphorylation, which appears to influence the allele transmission from male parents in the YRI （Yoruba from Ibadan, Nigeria） population. Our findings also indicate an ethnicity-related property of TD signatures in HapMap samples and provide new clues for our understanding of TD in humans.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61771421,61771422,61528014 and 6140139the Zhejiang Provincial Natural Science Foundation under Grant No LY16F010009
文摘In theoty, engineered anomalous transmission in passive materials and waveguide devices can be used to compensate for wavetorm distortions. However, they suffer from inherent dissipation. Recently, active non-Foster elements with imaginary immittance monotonically decreasing with frequency have shown important potentials in broadening bandwidths of electromagnetic devices. So far, they are implemented besed on negative impedance convertors （NICs） loaded with Foster devices. This makes them intrinsically one-port elements and thus cannot be used to compensate for distortions of signals. We construct a two-port network with a non-Foster transmission coefticient based on an unconventional use of NICs. Simulation and experiments show that it can compensate for extremely distorted signals. The proposed method can be used to broaden existing applications in different areas such as antennas, circuits and systems, and physical-layer signal processing.
