Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer

BACKGROUND There are limited data on the use of glucose transport protein 1(GLUT-1)expre-ssion as a biomarker for predicting lymph node metastasis in patients with colorectal cancer.GLUT-1 and GLUT-3,hexokinase(HK)-II,and hypoxia-induced factor(HIF)-1 expressions may be useful biomarkers for detecting primary tumors and lymph node metastasis when combined with fluorodeoxyglucose(FDG)uptake on positron emission tomography/computed tomography(PET/CT).AIM To evaluate GLUT-1,GLUT-3,HK-II,and HIF-1 expressions as biomarkers for detecting primary tumors and lymph node metastasis with 18F-FDG-PET/CT.METHODS This retrospective study included 169 patients with colorectal cancer who underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National University Hospital between January 2009 and May 2012.Two tissue cores from the central and peripheral areas of the tumors were obtained and were examined by a dedicated pathologist,and the expressions of GLUT-1,GLUT-3,HK-II,and HIF-1 were determined using immunohisto-chemical staining.We analyzed the correlations among their expressions,various clinicopathological factors,and the maximum standardized uptake value(SUVmax)of PET/CT.RESULTS GLUT-1 was found at the center or periphery of the tumors in 109(64.5%)of the 169 patients.GLUT-1 positivity was significantly correlated with the SUVmax of the primary tumor and lymph nodes,regardless of the biopsy site(tumor center,P<0.001 and P=0.012;tumor periphery,P=0.030 and P=0.010,respectively).GLUT-1 positivity and negativity were associated with higher and lower sensitivities of PET/CT,respectively,for the detection of lymph node metastasis,regardless of the biopsy site.GLUT3,HK-II,and HIF-1 expressions were not significantly correlated with the SUVmax of the primary tumor and lymph nodes.CONCLUSION GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph nodes.Clinicians should consider GLUT-1 expression in preoperative endoscopic biopsy in interpreting PET/CT findings.

Effects of octreotide on glucose transporter type 2expression in obese rat small intestine

AIM： TO investigate the effects of the somatostatin analogue, octreotide, on maltose and sucrase activities and expression of glucose transporter type 2 （GLUT2） in obese rat intestinal mucosa. METHODS： We divided 49 Sprague-Dawley rats into a group of 31 high fat diet-induced obese rats and a group of 18 normal controls. The obese rats were separated into an octreotide treated group 9f 16 rats and an obese group of 15. The intervention （：jroup was injected with octreotide at 40 ±g/kg body weight every 12 h for 8 d. Rat body weight was measured weekly to calculate Lee＇s index. After euthanization, maltase and sucrase activities in the small intestine were measured by activity assays, and the fasting plasma glucose level was measured. The expression of GLUT2 in small intestinal mucosa was analyzed by immunohistochemistry, reverse transcriptase polymerase chain reaction and Western blotting assays. RESULTS： Body weight, Lee＇s index, fasting plasma glucose level, maltase activity in small intestinal mucosa, mucosa and apical GLUT2, GLUT2 mRNA and protein expression levels were all significantly higher in the obese group than in the normal control group （605.61 ± 141.00 vs 378.54 ±111.75, 337.61 ± 10.82 vs 318.73 ± 20.10, 8.60± 1.38 vs 7.33 ± 0.70, 156.01 ± 58.81 vs 50.43 ± 30.49, 390 744.2± 62 469.21 vs 170 546.50 ± 50 646.14, 26 740.18 ±3809.60 vs 354.98± 57.19, 0.26± 0.11 vs 0.07± 0.02, and 2.08 ± 0.59 vs 1.27 ± 0.38, respectively, all P 〈 0.01）. Sucrase activity did not differ between the two groups. Octreotide intervention significantly decreased the body weight and fasting plasma glucose level of obese rats （508.27 ± 94.39 vs 605.61 ± 141.00, 7.58 ± 1.51 vs 8.60±1.38, respectively, all P 〈 0.05）. The intestinal mucosa and apical GLUT2, expression of GLUT2 mRNA and protein were also significantly lower in the octreotide intervention group than in the obese group （269 975.2 ± 53 730.94 vs 390 744.2 ± 62 469.21, 3758.06 ± 364.51 vs 26 740.18 ± 3809.60, 0.08 ± 0.02 vs 0.26 ±0.11, and 1.31 ± 0.27 vs 2.08 ±0.59, respectively, all P 〈 0.01）. CONCLUSION： High fat dietinduced obesity is associated with elevated intestinal maltase activity, GLUT2 expression, and permanent apical GLUT2 in the small intestinal mucosa of rats. Octreotide can inhibit these effects.

Electrical Transport Properties of Type-Ⅷ Sn-Based Single-Crystalline Clathrates (Eu/Ba)8Ga16Sn30 Prepared by Ga Flux Method

Single-crystalline samples of Eu/Ba-filled Sn-based type-Ⅷ clathrate are prepared by the Ga flux method with different stoichiometric ratios. The electrical transport properties of the samples are optimized by Eu doping. Results indicate that Eu atoms tend to replace Ba atoms. With the increase of the Eu initial content, the carrier density increases and the carrier mobility decreases, which leads to an increase of the Seebeck coefficient. By contrast, the electrical conductivity decreases. Finally, the sample with Eu initial content of x = 0.75 behaves with excellent electrical properties, which shows a maximal power factor of 1.51 mW·m^-1K^-2 at 480K, and the highest ZT achieved is 0.87 near the temperature of 483K.

Feasibility neutronic design for the reactor core configurations of a 5 MWth transportable block-type HTR

Small long-life transportable high temperature gas-cooled reactors(HTRs) are interesting because they can safely provide electricity or heat in remote areas or to industrial users in developed or developing countries.This paper presents the neutronic design of the U-Battery,which is a 5 MWth block-type HTR with a fuel lifetime of 5–10 years.Assuming a reactor pressure vessel diameter of less than 3.7 m,some possible reactor core configurations of the 5 MWth U-Battery have been investigated using the TRITON module in SCALE 6.The neutronic analysis shows that Layout 12×2B,a scattering core containing 2 layers of 12 fuel blocks each with 20% enriched235U,reaches a fuel lifetime of 10 effective full power years(EFPYs).When the diameter of the reactor pressure vessel is reduced to 1.8 m,a fuel lifetime of 4 EFPYs will be achieved for the 5 MWth U-Battery with a 25-cm thick graphite side reflector.Layouts 6×3 and 6×4 with a 25-cm thick BeO side reflector achieve a fuel lifetime of 7 and 10 EFPYs,respectively.The comparison of the different core configurations shows that,keeping the number of fuel blocks in the reactor core constant,the annular and scattering core configurations have longer fuel lifetimes and lower fuel cost than the cylindrical ones.Moreover,for the 5 MWth U-Battery,reducing the fuel inventory in the reactor core by decreasing the diameter of fuel kernels and packing fraction of TRISO particles is more effective to lower the fuel cost than decreasing the 235U enrichment.

n-type ZnS used as electron transport material in organic light-emitting diodes

This paper reports on the n-type ZnS used as electron transport layer for the organic light-emitting diodes （OLEDs）. The naphthyl-substituted benzidine derivative （NPB） and tris （8-hydroxyquinoline） aluminium （Alq3） are used as the hole transport layer and the emitting layer respectively. The insertion of the n-type ZnS layer enhances the electron injection in the OLEDs. The study was carried out on OLEDs of structures： indium-tin-oxide （ITO）/NPB/Alq3/ZnS/LiF/AL, ITO/NPB/Alq3/LiF/AL and ITO/NPB/Alq3/AL. The luminance and efficiency of the device containing this electron transport layer are increased significantly over those obtained from conventional devices due to better carrier balance.

Urate Transporter 1 Protein Levels and Localization in Type 2 Diabetic and Non-Diabetic Zucker Rat Kidneys

Objective: Persons with type 2 diabetes have increased incidence of hyperuricemia and gout. The hypothesis that Urate transporter 1 (URAT1) levels are increased in type 2 diabetic Zucker rats and this is responsible for elevation of uric acid was tested. Methods: Male 12-week-old obese Zucker rats were compared to non-diabetic lean counterparts. Plasma glucose, uric acid and creatinine were measured. URAT1 protein levels in the renal cortex and medulla were determined by Western blot. Immunohistochemistry was used to determine the location of URAT1 inrenal tubules. Results: Plasma glucose and uric acid levels were higher in the diabetic rats. There was no difference in plasma createnine. URAT1 antibody-positive bands of 27, 31, 50, 62 and 70 kDa were observed in cortex. A similar pattern was observed in medulla with addition of a 44 kDa band. No differences were observed in URAT1 proteins in the cortex between obese and lean rats. In the medulla, expression of the 44 and 50 kDa proteins was higher in lean rats. Expression of 27, 50, 62 kDa URAT1 proteins in the cortex was higher than in the medulla, while expression of the 70 kDa URAT1 was higher in medulla than in cortex. Localization of URAT1 did not differ between groups and included tubules in both cortex and medulla. Conclusions: In male Zucker rats, URAT1 protein expression was observed in both kidney cortex and medulla. Uric acid elevation in the obese group was associated with decreases in the 44 and 50 kDa URAT1 proteins in renal medulla.

“禹城式”矽卡岩型富铁矿的形成机制

山东省西北部齐河—禹城地区矽卡岩型富铁矿找矿工作取得了重大突破,有望成为继莱芜、金岭和济南之后又一个重要的富铁矿基地。与传统的矽卡岩型铁矿产于岩体与碳酸盐岩接触带不同的是,齐河—禹城地区李屯铁矿的矿体产于石炭系—二叠系含煤地层内,富铁矿体与围岩呈截然的接触关系,并且矿体附近的围岩发生了强烈的角岩化。针对这一现象,本文提出上覆的煤系极低的热导率使得含矿热液能够保持高温状态,发生长距离迁移而就位于远接触带的石炭系—二叠系中。李屯铁矿的形成可能是高温的岩浆流体与低温的大气降水混合,导致温度和盐度下降发生快速沉淀的结果。另外,近矿岩体普遍发生强烈的钠长石化,导致了闪长质岩石“铁的丢失”,为出溶高浓度富铁流体以及富铁矿的形成奠定了重要的物质基础。幔源“高分异”的闪长岩以及浅侵位时岩浆流体的出溶,也是邯邢式铁矿形成的先决条件。

五大连池老黑山熔岩溢出过程和传输系统

五大连池老黑山火山曾在公元1720-1721年喷发,熔岩出露面积60.2km^(2)。老黑山具有我国境内最新喷溢的熔岩流区,使其成为研究单成因火山熔岩表壳类型、熔岩传输系统和熔岩流灾害的理想对象。老黑山火山喷发兼具爆炸性与溢流性,以溢流性为主。本文使用0.05~0.92m/pix无人机航拍数据和12.5m/pix卫星数据,在实地验证的基础上,制作了11000比例尺熔岩流分布过程图。我们将老黑山的6个熔岩流区界定为相应熔岩溢出口的产物,并区分出每个熔岩流区内部的亚区和岩流组。本文归纳出不同尺度熔岩流边界界定的2个标准:(1)熔岩流区的边界界定,需要以大尺度的地形凹陷和沟谷为线索,以熔岩趾分布和压盖关系辅助确定;(2)熔岩流区内部岩流组的界定,更多地依赖于熔岩表壳相组合分析,并辅以地形特征确定。通过对岩流表壳相的分析,本文总结出老黑山熔岩流主要由渣状岩流传输模式主导,同时具有结壳岩流传输和膨胀传输类型。根据老黑山不同岩流的分布和传输特征,我们提出了使用逐层、逐组估算岩流体积的方法。老黑山火山爆炸性碎屑物体积为70×10^(6)m^( 3),爆炸性喷发指数VEI=1~2;熔岩流体积为290×10^(6)m^( 3),溢流式喷发的等级(magnitude)为4.9。根据与Puu Oo 1983-84岩流特征进行对比,推测老黑山喷发烈度为弱-中等(intensity=4~8)。

基于“脾主运化,在体合肌”理论探析T2DM肌少症骨骼肌细胞铁死亡发病机制及辨证论治

2型糖尿病(Type 2 diabetes mellitus,T2DM)伴随的衰老性疾病是目前糖尿病领域研究热点,肌少症现已成为T2DM继微血管和大血管病变之外的第三大类并发症,能够导致骨折、失能、活动障碍等多种不良事件的发生发展。脾属土,居中焦,主运化,在体合肌。脾之健运、精气得布、肌肉充养,方可发挥正常生理功能。近年研究表明,骨骼肌细胞铁死亡在T2DM肌少症发病机制中具有重要作用。基于“脾主运化,在体合肌”理论,从中医学“脾失运化、精气亏虚、湿浊困阻、肌肉失养”病机观及现代医学“骨骼肌细胞铁死亡”病理机制的角度对T2DM肌少症发病机制进行探讨,归纳T2DM肌少症从脾论治的中医防治原则,为丰富脾藏象理论内涵以及中医药防治T2DM肌少症基础研究和临床试验提供理论支撑。

面向船舶大型化的渤海湾适航客滚船船型尺度研究

为科学指导渤海湾客滚运输船舶合理大型化,统筹过海运输发展与安全,厘清客滚船大型化发展历程,研判市场需求、企业运营、行业管理等影响因素与供需矛盾。系统梳理客滚运输航线及港口布局特征,分析客滚运输企业及船舶运力结构分布,找准船港航一体化发展需求导向。基于海港总体设计规范中通航基础设施尺度的计算方法,采用逆向工程思维推导船型计算式,匹配调整理论结果、归并数值,提出渤海湾4种客滚船大型化标准船型,确定船舶总长、型宽、满载吃水、吨级等主要参数,研判提出渤海湾30个客滚泊位的大型化船型并开展适用性评价。对引导渤海湾新建省际客滚船标准化、序列化发展,强化船舶适港、适航安全保障性具有技术支撑作用。

基于改进蝙蝠算法的多目标移动储能调度

在大规模电动汽车的随机充电等因素的影响下,电网峰谷差等问题突出。首先,计算所需多类型移动储能(电动汽车、移动储能车、氢燃料发电车)调度功率,考虑交通能耗,建立各类移动储能模型。其中,针对电动汽车交通能耗,根据电价对用户参与意愿的影响,建立相应的补贴体系。其余类型则只计及交通能耗成本。然后,建立以的配电网负荷峰谷差、新能源利用率、配电网运行成本为目标,利用超平面的概念自适应地确定不同目标函数的权重,将多目标归一化,建立三类移动储能协调调度模型。而后,使用改进蝙蝠算法求解,得到多类型移动储能协同调度的方案。其中,基本蝙蝠算法引入柯西变异逆累积分布函数等改进,得到改进蝙蝠算法,该算法有效提升优化速度、全局搜索能力。最后,在IEEE33节点系统中,进行仿真验证,结果证明了该调度方案的有效性。

青钱柳多糖调节胰岛和肝脏葡萄糖转运蛋白4转位干预2型糖尿病大鼠的作用机制

目的 观察青钱柳多糖调节胰岛和肝脏葡萄糖转运蛋白4(GLUT4)转位改善2型糖尿病(T2DM)大鼠外周胰岛抵抗的作用。方法 建立T2DM大鼠模型(给予高脂饲料后注射链脲佐菌素35 mg·kg^(-1)),将造模成功的大鼠随机分为模型对照组,青钱柳多糖提取物小、大剂量组(5,10 g·kg^(-1))和盐酸二甲双胍组(0.25 g·kg^(-1)),每组9只,给药8周。测定空腹血糖、血脂变化;苏木精-伊红染色法观察胰岛和肝脏病理形态的改变;免疫组化法观察胰岛磷酸化磷酯酰肌醇3激酶(p-PI3K)、磷酸化丝氨酸苏氨酸蛋白激酶1(p-Akt1)、GLUT4蛋白的表达;免疫荧光观察肝脏和胰岛GLUT4转位。结果 与模型对照组比较,青钱柳多糖提取物小、大剂量组和盐酸二甲双胍组大鼠胰岛和肝脏结构较完整,血糖下降(P<0.05),高密度脂蛋白升高(P<0.05),胰岛p-PI3K、p-Akt1、GLUT4蛋白表达升高(P<0.05),肝脏和胰岛GLUT4转位增强(P<0.05)。结论 青钱柳多糖可调节T2DM大鼠糖脂紊乱,其机制可能是增强胰岛p-PI3K、p-Akt1、GLUT4蛋白的表达,促进肝脏和胰岛GLUT4转位,从而调节外周胰岛抵抗。

基于大数据分析的高速公路分车型拥堵态势评估

针对面向全车型的道路拥堵状态评估统一化和静态管控方法的局限性,围绕不同类型车辆的交通拥堵问题开展研究。首先,基于沈海高速公路福建段龙门架数据,采用聚类方法分析不同类型车辆在不同指标下的交通拥堵特征;其次,提出分车型数据驱动的模糊云模型,根据行业专家给出的数字特征计算不同车型下的拥堵等级隶属度;然后,选取拥堵指标作为模糊逻辑系统的输入,并采用Mamdani方法建立模糊关联矩阵,量化不同专家评价的可信度;引入Dempster-Shafter证据理论对所有专家的综合可信度进行模糊融合,根据隶属度最大原则综合评判道路交通状态;最后,验证了提出模型的精度及对车型间差异表征的准确性,分车型下的拥堵评价结果一致性达84.51%。结果表明:相比1~4型客车及小型货车,大型货车在移动过程中形成的瓶颈对高速公路上堵塞的消散表现出明显的迟滞作用;在低密度下,客车、少轴货车、多轴货车渗透率的提高对路况的影响依次提升;在高密度下,3~6轴货车渗透率的改变对拥堵状态的影响最为明显,1~4轴客车次之。分车型拥堵研究可为制订适应各类车型的主动交通管理提供定量的数据支撑,特别是在动态调控措施如错峰出行、可变限速等方面具有重要指导意义。

胎盘体积结合葡萄糖转运蛋白3对胎儿生长受限的预测价值

目的探讨胎盘体积联合血清中葡萄糖转运蛋白3(GLUT3)对胎儿生长受限的预测价值。方法以我院2018年12月—2020年5月行MRI检查的100例胎儿生长受限的孕妇作为观察组,孕检正常的100例孕妇作为对照组。根据MRI检查获取受试者胎盘体积,并检测受试者血清GLUT3的水平;采用logistics回归模型构建胎盘体积与血清GLUT3联合诊断模型,应用ROC曲线下面积(AUC)评判胎盘体积和血清GLUT3独立或两者联合应用对胎儿生长受限的预测价值。结果两组孕妇胎盘体积和血清GLUT3水平比较差异均具有显著性(t=13.380、54.173,P<0.05)。以胎盘体积联合血清GLUT3预测胎儿生长受限的模型为Logit(P)=-0.647×胎盘体积+0.598×GLUT+0.431;胎盘体积联合血清GLUT3预测胎儿生长受限的灵敏度、特异度及AUC均明显高于单个指标(P<0.05)。结论胎盘体积联合血清GLUT3对胎儿生长受限具有一定的预测价值。

基于YOLO+DeepSort的出租车检测及交通流影响研究

为了解决出租车与黄色小型车辆外观相似、不易区分的问题,以哈尔滨市出租车为研究对象,以YOLOv5+DeepSort为基本框架,新增交通量与速度检测模块。基于视频采集数据,建立出租车目标检测数据集与出租车图像数据集,采用深度学习方法构建车型识别模型。建立了考虑出租车比例因素的速度影响模型,分析了畅行状态下出租车运行特征。结果表明:结合深度学习的出租车车型识别精确率高达0.88;畅行状态下出租车平均速度比其他车型高5~15 km/h;出租车比例对全局平均速度及速度-流量曲线增长趋势存在一定影响;考虑出租车比例的速度影响模型在继承传统BPR模型优点的同时,精度提升了20%左右。

西南山区高速铁路非正常情况下列车运行调整探讨

西南山区与平原地区的地域特点存在显著差异,高速铁路运输组织在装备上、组织上、要求上明显不同。通过分析西南山区高速铁路非正常情况下列车运行调整类型,按轻微事故及严重干扰事故类型进行模型构建。以成渝高速铁路列车运行调整为例,计算验证结果表明,该模型求解速度快,具有较高的求解质量,对西南山区高速铁路非正常情况下干扰列车运行的不同场景均有一定的适应性,为提高山区高速铁路运行的安全系数提供支撑。

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

基于NAGA的物流企业自有及外包运力配置鲁棒优化

为深入优化物流企业的自有及外包运力配置,综合考虑运输需求不确定性和运输车型异质性,以全年运输利润最大化为目标,构建了多车型参与下运力配置鲁棒优化模型.依据决策变量的层次特性,设计了一种内外双层结构的嵌套式自适应遗传算法(NAGA).依托上海某物流企业的实际数据,进行了需求确定及不确定情形下的实例分析.结果表明,所构建的鲁棒优化模型兼顾经济性与鲁棒性,NAGA能对该模型进行高效求解.在需求确定情形下,优化后的运输利润提高了6.2%,且NAGA在求解质量及稳定性方面表现优于典型嵌套式启发算法;在需求不确定情形下,采用所提出的运力配置方法,决策者可根据市场波动水平及风险偏好调整鲁棒优化模型参数取值,以灵活获取合适的自有及外包运力配置方案.

从血脑屏障药物转运机制探究平痫冲剂的抗痫作用

目的观察平痫冲剂的抗痫作用,并探讨其作用机制。方法将62只3周龄Wistar大鼠随机分为空白组12只,造模组50只,采用戊四唑(pentetrazol,PTZ)腹腔注射制备癫痫模型;模型制备成功后,随机分成模型组、西药组及平痫冲剂组,每组各12只,西药组给予丙戊酸钠灌胃,平痫冲剂组给予平痫冲剂灌胃。干预7 d后,观察癫痫大鼠运动皮质区的组织形态结构;免疫组化、RT-qPCR以及Western blot检测大脑运动皮质区组织L型氨基酸转运体(L-type amino acid transporter,LAT)1、P糖蛋白(P-glycoprotein,P-gp)、乳腺癌耐药蛋白(breast cancer resistance protein,BCRP)的表达情况。结果与空白组比较,模型组大鼠大脑运动皮质区神经元数量减少(P<0.01),LAT1蛋白及mRNA表达下降(P<0.05),P-gp、BCRP及其mRNA表达升高(P<0.05)。与模型组比较,平痫冲剂组大鼠大脑运动皮质区神经元数量增多(P<0.05),神经元病理形态有所改善,LAT1及其mRNA表达升高(P<0.01),P-gp、BCRP及其mRNA表达下降(P<0.01)。结论平痫冲剂可能通过调控血脑屏障(blood-brain barrier,BBB)药物转运体P-gp、BCRP、LAT1的表达,从而发挥抗痫作用。

单轨吊集散式运行、立体化换装模式的探析

协庄煤矿-550 m水平3-3采区和4-2采区共布置三个掘进工作面和一个回采工作面,辅助运输方式为大巷轨道机车加采区单轨吊机车运输,采区之间通过地轨相连,且单轨吊线路未实现网络化运输;单轨吊机车和地轨运输之间,需多次转载、换装后方可将物料运送到采掘工作面,运行效率较低,地轨机车和单轨吊机车交叉运行,占用的辅助运输人员较多,存在诸多安全隐患。为提高辅助运输效率,协庄煤矿通过敷设单轨吊重轨代替地轨运输,将采区之间的单轨吊线路进行了联网,实施“大功率单轨吊+小功率单轨吊”集散式运行、立体化换装模式,实现大巷至采区单轨吊机车之间的快速接驳和连续运输,减少了辅助运输环节和人员占用,提高了运输效率,解决了掘进工作面最后100 m的机械运料难题。