Objective To study the effects of 1% tetracaine hydrochloride jelly for pain control of patients receiving transrectal ultrasound （TRUS）-guided prostate biopsy. Methods A total of 100 patients receiving TRUS-guided ...Objective To study the effects of 1% tetracaine hydrochloride jelly for pain control of patients receiving transrectal ultrasound （TRUS）-guided prostate biopsy. Methods A total of 100 patients receiving TRUS-guided prostate biopsy were divided into two groups with 50 in each. In Group 1, patients received liquid paraffin, and in Group 2, patients were given 1% tetracaine hydrochloride jelly before biopsy. Pain score was measured by horizontal visual analogue scales （ VAS ）, and pain and discomfort were compared between the two groups. Results The average pain scores at the time of insertion of the ultrasound probe were 2. 9 ＋_1. 7 and 1. 4 ＋_1. 8 （ P =0. 000） and the average pain scores at the time of performing biopsy were 5. 2 ＋-1. 5 and 3. 1 ＋ 1. 7 （P =0. 000） in Group 1 and Group 2, respectively. There were no significant differences between the two groups in terms of age, serum prostate specific antigen, digital rectal examination, TRUS, and biopsy core number （ P 〉 O. 05 ）. There were no significant differences of complications after biopsy, such as hematuria, acute urinary retention, urinary tract infection, rectum bleeding, and fever （ P 〉0. 05）. Conclusion TRUS-guided prostate biopsy is safe. Use of 1% tetracaine hydrochloride jelly in the rectum and anus before TRUS-guided prostate biopsy is an effective method for relieving TRUS-guided prostate biopsy-induced pain during the procedure.展开更多
We investigated the performance characteristics of prostate-specific antigen （PSA） and PSA density （PSAD） in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy （TRUS-PB） fro...We investigated the performance characteristics of prostate-specific antigen （PSA） and PSA density （PSAD） in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy （TRUS-PB） from year 2000 to 2013 were included. The receiver operating characteristic （ROC） curves for both PSA and PSAD were analyzed. The sensitivity, specificity, positive predictive value （PPV） and negative predictive value （NPV） at different cut-off levels were calculated. A total of 2606 Chinese men were included. For the ROC, the area under curve was 0.770 for PSA （P〈 0.001） and 0.823 for PSAD （P〈 0.001）. PSA of 4.5 ng ml^-1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml^-1cc^-1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%. On multivariate logistic regression analyses, PSA cut-off at 4.5 ng ml^-1 （OR 1.61, 95% CI 1.05-2.45, P = 0.029） and PSAD cut-off at 0.12 ng ml^-1 cc^-1 （OR 6.22, 95% CI 4.20-9.22, P 〈 0.001） were significant predictors for prostate cancer detection on TRUS-PB. In conclusion, the performances of PSA and PSAD at different cut-off levels in Chinese men were very different from those in Caucasians. PSA of 4.5 ng ml^-1 and PSAD of O. 12 ng ml^-1 cc^-1 had near 95% sensitivity and were significant predictors of prostate cancer detection in Chinese men.展开更多
文摘Objective To study the effects of 1% tetracaine hydrochloride jelly for pain control of patients receiving transrectal ultrasound （TRUS）-guided prostate biopsy. Methods A total of 100 patients receiving TRUS-guided prostate biopsy were divided into two groups with 50 in each. In Group 1, patients received liquid paraffin, and in Group 2, patients were given 1% tetracaine hydrochloride jelly before biopsy. Pain score was measured by horizontal visual analogue scales （ VAS ）, and pain and discomfort were compared between the two groups. Results The average pain scores at the time of insertion of the ultrasound probe were 2. 9 ＋_1. 7 and 1. 4 ＋_1. 8 （ P =0. 000） and the average pain scores at the time of performing biopsy were 5. 2 ＋-1. 5 and 3. 1 ＋ 1. 7 （P =0. 000） in Group 1 and Group 2, respectively. There were no significant differences between the two groups in terms of age, serum prostate specific antigen, digital rectal examination, TRUS, and biopsy core number （ P 〉 O. 05 ）. There were no significant differences of complications after biopsy, such as hematuria, acute urinary retention, urinary tract infection, rectum bleeding, and fever （ P 〉0. 05）. Conclusion TRUS-guided prostate biopsy is safe. Use of 1% tetracaine hydrochloride jelly in the rectum and anus before TRUS-guided prostate biopsy is an effective method for relieving TRUS-guided prostate biopsy-induced pain during the procedure.
文摘We investigated the performance characteristics of prostate-specific antigen （PSA） and PSA density （PSAD） in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy （TRUS-PB） from year 2000 to 2013 were included. The receiver operating characteristic （ROC） curves for both PSA and PSAD were analyzed. The sensitivity, specificity, positive predictive value （PPV） and negative predictive value （NPV） at different cut-off levels were calculated. A total of 2606 Chinese men were included. For the ROC, the area under curve was 0.770 for PSA （P〈 0.001） and 0.823 for PSAD （P〈 0.001）. PSA of 4.5 ng ml^-1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml^-1cc^-1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%. On multivariate logistic regression analyses, PSA cut-off at 4.5 ng ml^-1 （OR 1.61, 95% CI 1.05-2.45, P = 0.029） and PSAD cut-off at 0.12 ng ml^-1 cc^-1 （OR 6.22, 95% CI 4.20-9.22, P 〈 0.001） were significant predictors for prostate cancer detection on TRUS-PB. In conclusion, the performances of PSA and PSAD at different cut-off levels in Chinese men were very different from those in Caucasians. PSA of 4.5 ng ml^-1 and PSAD of O. 12 ng ml^-1 cc^-1 had near 95% sensitivity and were significant predictors of prostate cancer detection in Chinese men.
