AIM: To investigate the efficacy of pegylated interferon alfa(PEG-IFNα) therapy with and without entecavir in patients with chronic hepatitis D. METHODS: Forty hepatitis D virus(HDV) RNA positive patients were random...AIM: To investigate the efficacy of pegylated interferon alfa(PEG-IFNα) therapy with and without entecavir in patients with chronic hepatitis D. METHODS: Forty hepatitis D virus(HDV) RNA positive patients were randomized to receive either PEG-IFNα-2a 180 μg weekly in combination with entecavir 0.5 mg daily(n = 21) or PEG-IFNα alone(n =19). Patients who failed to show 2 log reduction in HDV RNA level at 24 wk of treatment, or had detectable HDV RNA at 48 wk of therapy were considered as treatment failure. Treatment was continued for 72 wk in the rest of the patients. All the patients were followed for 24 wk post treatment. Intention to treat analysis was performed.RESULTS: The mean age of the patients was 26.7 ± 6.8 years, 31 were male. Two log reduction in HDV RNA levels at 24 wk of therapy was achieved in 9(43%) patients receiving combination therapy and 12(63%) patients receiving PEG-IFNα alone(P = 0.199). Decline in hepatitis B surface antigen(HBs Ag) levels was insignificant. At the end of treatment, HDV RNA was negative in 8 patients(38%) receiving combination therapy and 10 patients(53%) receiving PEG-IFNα-2a alone. Virological response persisted in 7(33%) and 8(42%) patients, respectively at the end of the 24 wk follow-up period. One responder patient in the combination arm lost HBs Ag and became hepatitis B surface antibody positive. Six out of 14 baseline hepatitis B e antigen reactive patients seroconverted and four of these seroconverted patients had persistent HDV RNA clearance.CONCLUSION: Administration of PEG-IFNα-2a with or without entecavir, resulted in persistent HDV RNA clearance in 37% of patients. The addition of entecavir did not improve the overall response.展开更多
Surface science of natural fibers plays an important role in polymer/natural fiber composites. The Xanthoceras sorbifolia husk fibers were selected and chemically treated by sodium hydroxide(Na OH) solution,coupling a...Surface science of natural fibers plays an important role in polymer/natural fiber composites. The Xanthoceras sorbifolia husk fibers were selected and chemically treated by sodium hydroxide(Na OH) solution,coupling agents,their combination,and the mixtures of acetic acid with hydrogen peroxide,respectively. 3-aminopropyltriethoxysilane(KH550),γ-methacryloxypropyltrimethoxylsilane(KH570) and organic titanate(JN-9A) were used as coupling agents in this work. Cellulose content was found to be increased after alkalization due to the removal of the non-cellulose substances,which was evidenced by attenuated total reflectance-Fourier transform infrared(ATR e FTIR) spectroscopy spectrum analysis and thermogravimetric analysis(TGA) measurements. The highest cellulose content was obtained in the bleached fibers. TGA analysis revealed an improvement in thermal stability of the treated fibers,especially for alkali-KH570 treated fibers. The tensile strength of the alkali-KH570 treated fiber and the alkali-bleached fiber were higher than that of other fibers due to high cellulose content and high crystallinity.展开更多
文摘AIM: To investigate the efficacy of pegylated interferon alfa(PEG-IFNα) therapy with and without entecavir in patients with chronic hepatitis D. METHODS: Forty hepatitis D virus(HDV) RNA positive patients were randomized to receive either PEG-IFNα-2a 180 μg weekly in combination with entecavir 0.5 mg daily(n = 21) or PEG-IFNα alone(n =19). Patients who failed to show 2 log reduction in HDV RNA level at 24 wk of treatment, or had detectable HDV RNA at 48 wk of therapy were considered as treatment failure. Treatment was continued for 72 wk in the rest of the patients. All the patients were followed for 24 wk post treatment. Intention to treat analysis was performed.RESULTS: The mean age of the patients was 26.7 ± 6.8 years, 31 were male. Two log reduction in HDV RNA levels at 24 wk of therapy was achieved in 9(43%) patients receiving combination therapy and 12(63%) patients receiving PEG-IFNα alone(P = 0.199). Decline in hepatitis B surface antigen(HBs Ag) levels was insignificant. At the end of treatment, HDV RNA was negative in 8 patients(38%) receiving combination therapy and 10 patients(53%) receiving PEG-IFNα-2a alone. Virological response persisted in 7(33%) and 8(42%) patients, respectively at the end of the 24 wk follow-up period. One responder patient in the combination arm lost HBs Ag and became hepatitis B surface antibody positive. Six out of 14 baseline hepatitis B e antigen reactive patients seroconverted and four of these seroconverted patients had persistent HDV RNA clearance.CONCLUSION: Administration of PEG-IFNα-2a with or without entecavir, resulted in persistent HDV RNA clearance in 37% of patients. The addition of entecavir did not improve the overall response.
文摘Surface science of natural fibers plays an important role in polymer/natural fiber composites. The Xanthoceras sorbifolia husk fibers were selected and chemically treated by sodium hydroxide(Na OH) solution,coupling agents,their combination,and the mixtures of acetic acid with hydrogen peroxide,respectively. 3-aminopropyltriethoxysilane(KH550),γ-methacryloxypropyltrimethoxylsilane(KH570) and organic titanate(JN-9A) were used as coupling agents in this work. Cellulose content was found to be increased after alkalization due to the removal of the non-cellulose substances,which was evidenced by attenuated total reflectance-Fourier transform infrared(ATR e FTIR) spectroscopy spectrum analysis and thermogravimetric analysis(TGA) measurements. The highest cellulose content was obtained in the bleached fibers. TGA analysis revealed an improvement in thermal stability of the treated fibers,especially for alkali-KH570 treated fibers. The tensile strength of the alkali-KH570 treated fiber and the alkali-bleached fiber were higher than that of other fibers due to high cellulose content and high crystallinity.
