Reliability and Validity of Addiction Severity Index in Drug Users with Methadone Maintenance Treatment in Guizhou Province, China

Objective To evaluate the reliability and validity of the Chinese version of addiction severity index （ASI）-5th version （ASI-C-5）, in illegal drug users receiving methadone maintenance treatment （MMT） in China. Methods One hundred and eighty-six heroin addicts （144 men and 42 women） receivihg MMT at three clinics in Guizhou province, southwest China, were recmited. They were all interviewed with a questionnaire of ASI-C-5 and 35 were re-interviewed at an interval of seven days to assess its test-retest reliability. Results Cronbach＇s alpha for internal consistency of CSs varied from 0.60 to 0.81 in all domains. Test-retest reliability of composite scores （CSs） of ASI-C-5 were satisfactory （r=0.38-0.97）. Based on item analysis and expert＇s suggestions, five items were deleted and one item was modified in ASI-C-5. Criterion validity of ASI-C-5 was found acceptable, as compared to addicts＇ self-rating anxiety scale （SAS） and self-rating depression scale （SDS） （r=0.59 and 0.45） except for social support rating scale （SSRS）. Conclusions ASI-C-5 can be used for heroin addicts receiving MMT with acceptable reliability and validity.

The Impact of Body Mass Index on Assisted Reproductive Treatments

Multiparity amongst women with a body mass index (BMI) ≥ 30 Kg/m2 is a common occurrence despite there being a known clear association with a decline in fecundity in women who are overweight or obese. These women, also pose further concerns, as they are at increased risk of antenatal complications such as preeclampsia and gestational diabetes. Over the years, a number of different modalities of fertility treatments have been tried and tested in this cohort of women to find the optimal treatment to improve their reproductive capacity. There has been an exponential increase in knowledge and understanding towards managing patients with a raised BMI, particularly through assisted reproductive treatments. Although the efficacies of various forms of fertility treatments have been shown to be affected by a rise in BMI, there is yet to be a definitive understanding as to the optimal management of these patients. The literature supports weight loss alone as an effective intervention in improving the reproductive capacity of women with a raised BMI with unexplained infertility. Furthermore, if live birth rate is taken as the desired outcome measure, then ovarian drilling and in vitro fertilisation (IVF) treatment have been shown to yield the best results in overweight and obese patients when comparisons are drawn to other interventions such as natural conception and treatment with clomiphene citrate.

Changes of biochemical indexes in patients with acute cerebral infarction after treatment with simvastatin

BACKGROUND: At present, it is believed that the important causes of cerebral infarction are the disorders of lipid metabolism and endothelial function, and the outcomes of clinical treatment can be improved by regulating serum lipids and antiinflammation, etc. OBJECTIVE: To observe the effect of simvastatin, inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the levels of serum lipids, serum enzymic indexes and inflammatory metabolic indexes in patients with cerebral infarction. DESIGN: A comparative observation. SETTING: Department of Geriatrics, Longquanshan Hospital of Liuzhou City. PARTICIPANTS: Forty-eight patients with acute cerebral infarction were selected from the Department of Geriatrics of Longquanshan Hospital of Liuzhou from March 2004 to February 2006, including 24 males and 24 females, the mean age was (54±12) years, average disease course was (10.0±4.5) days. They were all accorded with the diagnostic standard for cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1999, and cerebral hemorrhage was excluded by cranial CT scanning. The 48 patients were randomly divided into control group (n =24) and treatment group (n =24). Informed consents were obtained from all the participants. METHODS: ① All the patients were treated according to the symptoms, besides those in the treatment group were given simvastatin (Harbin Pharm. Group Sanjing Pharmaceutical Shareholding, Co.,Ltd., No. H20010454; Batch number: 20040218; 5 mg/tablet). The initial dosage was 10 mg per day for 4 weeks, and then increased to 30 mg per day for another 4 weeks. ② Before treatment and within 1 week after treatment, the total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST), creatine kinase and C reactive protein in serum were determined with Beckman-cx7 automatic biochemical analytical apparatus in both groups. ③ The differences of intergroup and intragroup data were compared with the independent-samples t test and paired samples t test. MAIN OUTCOME MEASURES: Changes of total cholesterol, triglyceride, HDL-C, LDL-C, AST, creatine kinase and C reactive protein before and treatment in both groups. RESULTS: All the 48 patients with cerebral infarction were involved in the analysis of results. ① Changes of serum lipids: The levels of serum lipids were close between the two groups before treatment (P > 0.05). After treatment, the HDL-C level in the treatment group was obviously higher than that in the control group and that before treatment [(1.34±0.12), (0.92±0.33), (0.93±0.21) mmol/L, t =7.922, 11.699, P < 0.01], and the levels of total cholesterol, triglyceride and LDL-C were obviously lower than those in the control group and those before treatment (t =2.780-7.591, P < 0.01). ② Changes of serum enzymic indexes and C reactive protein in serum: The levels of enzymes and C reactive protein in serum had no obvious differences between the two groups before treatment (P > 0.05). The levels of AST, creatine kinase and C reactive protein in serum after treatment were obviously lower than those before treatment in both groups (t =7.259-17.996, P < 0.01). The levels of levels of creatine kinase and C reactive protein in serum after treatment in the treatment group were obviously lower than those in the control group [(3.061±0.522) μkat/L, (4.6±3.1) mg/L; (4.348±0.580) μkat/L, (12.3±4.8) mg/L, t =7.910, 6.463, P < 0.01]. CONCLUSION: Compared with common treatment according to symptoms, the additional administration of simvastatin is better for improving the serum lipids, serum enzymic indexes of patients with cerebral infarction at acute period, and benefit for repairing their inflammatory damages.

Validity assessment and determination of the cutoff value for the Index of Complexity, Outcome and Need among 12-13 year-olds in Southern Chinese

To validate the use of the Index of Complexity, Outcome and Need （ICON） in assessing orthodontic treatment need among 12-13 year-olds in southern China, we determined the threshold value of ICON based on Chinese orthodontists＇ judgments. The samples consisted of 335 students in grade 7 from 16 randomly selected middle schools in Chengdu, China. Three associate professors provided ICON scores for each participant and the results were compared with the gold standard judgments from 25 experts on treatment needs. Based on the gold standard, 195 casts belonged to the treatment category, while the rest 140 belonged to the no-treatment category. With the international cutoff point of 43, the sensitivity and specificity of the iCON score were 0.29 and 0.98. The best compromise between sensitivity and specificity in Chengdu, compared with the gold standard, was found at a cutoff point of 29, and the sensitivity and specificity were 0.88 and 0.83. When used to evaluate the treatment need of 12-13 year-olds in southern China, the international ICON cutoff value did not correspond well with Chinese orthodontists＇ judgments; a lower cutoff value of 29 offered a ~reater sensitivitv and soecificitv with respect to exoert orthodontists＇ oerceotion of treatment need.

Effect of seed treatment for laboratory germination of Albizia chinensis

Seeds of Albizia chinensis（Osb.） Merr. in addition to water were also treated with different treatments by incubating in ethyl alcohol, acetone, and petroleum ether at room temperature for different durations. Seed heat treatment was done at temperatures of 30, 40 and 60℃ for different durations up to 24 h. To overcome dormancy caused by the impermeable seed coat, seeds were nicked and also treated with concen- trated sulphuric acid for different durations. Seeds responded to treat- ments with sulphuric acid and nicking only. Treatment with sulphuric acid for 20 and 30 min showed maximum germination at all incubation temperatures as compared to untreated controls and seeds treated with sulphuric acid for 10 min and nicking. Seedling length was greatest from seeds treated with sulphuric acid for 20 and 30 min and incubated at 30 ℃. Seedling dry weight was highest from nicked seeds incubated at 20℃ The most favourable incubation temperature was 30 ℃ as evidenced from GR （germination rate index） and Gv （germination value）. After ascertaining the seed response and performance we recommend that seeds ofAlbizia chinensis be treated with sulphuric acid for 20 or 30 min and incubation temperature of 25 to 30℃.

Effect of Dehulling and Hydrothermal Treatment on the Amino Acid Content of Soriz (<i>Sorghum oryzoidum</i>)

Cereals are the basic element in ensuring the food security of the population through the significant intake of carbohydrates, proteins, dietary fiber, vitamins and minerals. The processing of cereals leads to changes in their nutritional quality, which could lead to both reduced nutrients and anti-nutrients. Gluten-free cereal varieties attract attention as raw materials to improve the nutritional quality of food and to diversify the product range. Sorghum (Sorghum oryzoidum) is a hybrid of sorghum, obtained at the Institute for Scientific Research for Corn and Sorghum in the Republic of Moldova, by crossing Sudan grass (S. sudanense) and bicolor sorghum (S. bicolor). The research aimed to determine the impact of dehulling and hydrothermal treatment on the amino acid content of soriz. The obtained results reported that the dehulling and hydrothermal treatment led to the uneven modification of the amino acid content in the investigated samples. As a result of dehulling, the total amount of essential amino acids decreased by 19.8% compared to the native grain. Boiling whole grains without prior hydration led to 34% loss of essential amino acids compared to native grains, and pre-hydration of the grains and subsequent boiling reduced essential amino acid losses by 8% compared to cooked grains without hydration. Boiling grains with pre-hydration had a positive effect on the chemical index of lysine, methionine and cysteine, leucine and tryptophan. However, the nutritional quality of sorghum grain proteins and derivatives obtained, evaluated according to the chemical index, is low. The results obtained reported that dehulling and hydrothermal treatment unevenly altered the amino acid content, and the method of boiling grains with pre-hydration had a positive effect on the CSI of lysine, methionine and cysteine, leucine and tryptophan.

Alkali Treatment and Cellulose Nanowhiskers Extracted from Maize Stalk Residues

The aim of this study was to investigate the use of effect of pulveriser and extraction of cellulosenanowhiskers (CNWs) on Maize stalks. Maize stalk residues were first subjected to a cutting mill for size reduction purified using mechanical, chemical extraction and bleaching. After chemical extraction, high quality cellulose resulted and cellulose nanowhiskers (CNW) were then extracted using chemical acid hydrolysis. The chemical compositions and mechanical properties of the maize stalk residues were examined before and after purification by using standard methods, Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM) and thermo gravimetric analysis (TGA). The morphology and dimensions of the isolated cellulose nanowhiskers were characterized using atomic force microscope (AFM). The crystallinity index increased upon mechanical and chemical extraction. Thermal stability of cellulose derived from maize stalk improved with chemical treatment due to new functional groups introduced on the surface and enhancement in crystallinity. Highly dispersed cellulose nanowhiskers (CNWs) were successfully extracted from maize stalk residues with diameters ranging between 3 and 7 nm, length ranges between 150 - 450 nm, respectively.

Prevalence and Incidence of Metabolic Syndrome in a Cohort of Patients with Rheumatoid Arthritis: A Correlation between Body Mass Index and Disease Activity

Rheumatoid Arthritis (RA) is an inflammatory disease associated with high morbidity and increased cardiovascular disease, and Metabolic Syndrome (MS) is understood as a set of metabolic disorders that correlates with obesity and sedentary lifestyle. The aim of this study is to evaluate the prevalence of MS in a cohort of patients with RA and its correlation to specific factors of the disease. A retrospective cohort study was conducted with 283 patients with RA, followed at the Rheumatology Outpatient Clinic of the Hospital de Clínicas de Porto Alegre (HCPA) between 2008 and 2016;187 continued to be followed and agreed to be reevaluated between January and November 2016. MS was defined according to the National Cholesterol Education Program and disease activity was assessed using the Disease Activity Score (DAS28). Clinical, biochemical, and anthropometric evaluations were conducted. The prevalence of MS in the first evaluation was 43.9% and, after 8 years, 59.4%. Increased waist circumference and blood pressures, elevated triglycerides and low High-Density Lipoprotein were the most frequent features of MS. The DAS28 was significantly lower in the reevaluation (p = 0.006). The prevalence of MS was higher at the end of 8 years;disease activity, as well as blood pressure, decreased during this period. Steroid use had also decreased at the end of follow-up. There was an increase of 15% of cases with MS in an 8-year follow-up cohort of patients, which was in agreement with the current literature and showed how the inflammatory process in RA is correlated to MS. The parameters of MS that varied the most were blood pressure, cholesterol and triglycerides. Ultimately, these parameters and disease activity must be observed closely in order to improve the prognosis of patients with RA.

对远视性儿童弱视几个新认识

我们22年来,对儿童弱视临床治疗的实践,和公开发表的14篇论文对儿童弱视未知领域探讨进行总结,有如下几个新认识:1.提出远视性儿童弱视愈后脱镜指标和进一步补充与修正;2.儿童弱视愈后复发概念与分期;3.儿童弱视痊愈或脱镜后近视化;4.治疗年龄限制;5.结束治疗。

神经介入术后护理质量评价指标体系的构建

目的:构建神经介入术后护理质量评价指标体系,旨在为临床评价神经介入术后的护理质量提供参考依据。方法:以“结构-过程-结果”质量模型为理论基础,通过文献检索、半结构式访谈、专家会议法、德尔菲专家函询法和层次分析法,确定神经介入术后护理质量评价指标体系的内容及各指标的权重。结果:2轮专家函询的积极系数分别为90.91%、95.00%。19名专家的权威系数为0.85。肯德尔和谐系数为0.28,0.37(P<0.01)。最终形成的神经介入术后护理质量评价指标体系包括3个一级指标、9个二级指标、38个三级指标。结论:本研究构建的神经介入术后护理质量评价指标具有较好的科学性和可靠性,对科学评价神经介入术后护理质量具有指导意义。

“零转介”AIDS诊疗管理模式的临床验证

目的探讨“零转介”诊疗管理模式对人类免疫缺陷病毒(HIV)感染患者治疗疗效和满意度的效果。方法选取石家庄市第五医院2022年7月至12月新增HIV感染者100例,随机分为对照组和研究组,每组50例。对照组给予常规认知干预和健康指导、心理干预,研究组在确诊前较对照组提前7~10 d即给予认知干预、生活指导和心理干预。比较对照组和研究组患者的HIV感染患者睡眠[匹兹堡睡眠质量指数表(PSQI)]、服药依从性、焦虑抑郁量表分值。结果对照组患者的PSQⅠ评分高于研究组患者(P<0.01);研究组患者的焦虑抑郁的心理状况要优于对照组(P<0.05);对照组患者服药依从性良好者比例低于研究组患者(P<0.01);研究组患者对疾病的接受度和认知评定量表均好于对照组患者(P<0.01)。结论“零转介”模式,提前给予认知干预、生活指导和心理干预,可提高HIV感染患者满意度,对社会层面的AIDS预防具有积极意义。

肺康复综合治疗对慢性阻塞性肺疾病急性加重期患者肺功能及运动能力的影响研究

目的:探讨肺康复综合治疗对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能及运动能力的影响。方法:110例AECOPD患者随机分为对照组与观察组,每组55例。两组均给予常规治疗,对照组在此基础上给予孟鲁司特钠片治疗,观察组在对照组基础上采用肺康复综合治疗。比较两组患者ICU住院时间、总住院时间、住院病死率、生活质量评分、第1秒用力呼吸容积(FEV1)、FEV1/最大呼气容积(FVC)、氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、C反应蛋白(CRP)及α1-抗胰蛋白酶(α1-AT)水平。结果:与治疗前比较,两组FEV1、FEV1/FVC、Pa0_(2)升高,PaCO_(2)降低,差异有统计学意义(P<0.01);治疗后观察组上述指标优于对照组(P<0.01)。CRP及α1-AT水平均明显低于本组治疗前(P<0.01),观察组治疗后CRP明显低于对照组治疗后(P<0.01),差异均具有统计学意义。治疗后观察组总体健康、日常生活能力、疼痛、性生活、积极感受及对医疗手段的依赖评分均明显高于本组治疗前及对照组治疗后(P<0.05,P<0.01)。观察组ICU住院时间、总住院时间及病死率均明显小于对照组(P<0.05,P<0.01)。结论:肺康复综合治疗AECOPD疗效显著,临床应加以推广。

微创旋切术与开放手术治疗乳腺良性肿瘤的临床效果分析

目的分析微创旋切术与开放手术治疗乳腺良性肿瘤的临床效果。方法研究样本选自我院收治的乳腺良性肿瘤患者,共有90例,其选取时间为2023.01-2024.07。将纳入样本以手术治疗方式进行分组,参考组(n=45)施行开放手术治疗,观察组(n=45)施行微创旋切术治疗。对比分析二组的治疗有效性、并发症发生率。结果对比治疗有效性,治疗后观察组高于参考组(P<0.05)。对比并发症发生率,治疗后观察组低于参考组(P<0.05)。结论相较于开放手术而言,对乳腺良性肿瘤患者施行微创旋切术的效果更佳,减少并发症发生,值得借鉴。

高血压接诊医师诊疗能力评估指标体系的构建

目的基于德尔菲法初步构建高血压接诊医师规范化诊疗能力评估指标体系,为进一步衡量医师在高血压诊疗方面的整体水平提供新的工具。方法通过文献检索和半结构化访谈法拟定高血压接诊医师规范化诊疗的能力评估指标体系初稿。选择专家进行两轮函询后,通过研究小组分析讨论确定最终条目。采用权威系数(Cr)衡量咨询结果的权威程度;采用变异系数(CV)及Kendall协调系数(W)评价专家意见协调程度。结果第一轮专家咨询发出15份问卷,回收问卷11份,应答率为73.33%;第二轮发出11份问卷,回收11份,应答率为100.00%。两轮咨询专家Cr分别为0.908和0.900。与第一轮咨询结果相比,第二轮专家意见协调性更佳。结论本研究初步编制了一个包括6个一级指标、20个二级指标、33个三级指标的高血压接诊医师规范化诊疗的能力评估指标体系。

中医针刺治疗重症患者胃肠功能障碍的应用效果

目的探讨中医针刺治疗重症患者胃肠功能障碍的应用效果。方法选取2020年11月至2023年8月在兰州市第一人民医院重症医学科住院的142例重症伴有胃肠功能障碍患者作为研究对象,根据患者及家属意愿将其分为针刺组和常规组,每组各71例。针刺组在原发疾病治疗的基础上,通过相关穴位进行中医针刺治疗;常规组在治疗原发病的基础上,给予莫沙必利进行治疗。比较两组患者治疗前及治疗期间的胃排空时间(GET)、胃窦收缩频率(ACF)、胃窦运动指数(MI)、肠蠕动情况,并比较两组患者的通便时间、住ICU时间、住院总费用及死亡率。结果两组患者治疗7 d的GET短于本组治疗5 d,治疗5 d的GET短于本组治疗3 d,治疗3 d的GET短于本组治疗前,差异有统计学意义(P<0.05);针刺组治疗3、5、7 d的GET均短于常规组,差异有统计学意义(P<0.05)。两组患者治疗7 d的ACF快于本组治疗5 d,治疗5 d的ACF快于本组治疗3 d,治疗3 d的ACF快于本组治疗前,差异有统计学意义(P<0.05);针刺组治疗3、5、7 d的ACF均快于常规组,差异有统计学意义(P<0.05)。两组患者治疗7 d的MI高于本组治疗5 d,治疗5 d的MI高于本组治疗3 d,差异有统计学意义(P<0.05);针刺组治疗3 d的MI高于本组治疗前,差异有统计学意义(P<0.05);针刺组治疗3、5、7 d的MI均高于常规组,差异有统计学意义(P<0.05)。两组患者治疗7 d的肠蠕动快于本组治疗5 d,治疗5 d的肠蠕动快于本组治疗3 d,差异有统计学意义(P<0.05);针刺组治疗3 d的肠蠕动快于本组治疗1 d,治疗1 d的肠蠕动快于本组治疗前,差异有统计学意义(P<0.05);针刺组治疗1、3、5、7 d的肠蠕动均快于常规组,差异有统计学意义(P<0.05)。针刺组的通便时间短于常规组,住院总费用少于常规组,针刺组治疗后第10~42天的死亡率低于常规组,差异有统计学意义(P<0.05)。结论莫沙必利治疗重症患者胃肠功能障碍有一定疗效,但通过内关、合谷、中脘、天枢、气海、足三里、丰隆、三阴交穴位等穴位进行中医针刺治疗来促进重症患者胃肠功能障碍的疗效明确,通过中医针刺治疗重症患者胃肠功能障碍较莫沙必利治疗的获益更大,能缩短胃排空时间,增加胃窦运动幅度及肠蠕动,提高MI,更早改善胃肠功能障碍,减少住院总费用,改善患者预后。

基于质量三环理论构建肝硬化序贯治疗患者延续性护理评价指标体系

目的探讨质量三环理论构建肝硬化序贯治疗患者延续性护理的评价指标体系在临床评价肝硬化序贯治疗的应用价值。方法2020年2月至2021年4月中山大学附属第三医院消化内科以Donabedian提出的"结构-过程-结果"三环质量评价模式作为理论框架,通过文献研究、半结构访谈法初步构建延续性护理质量评价指标条目及初始专家咨询问卷,采用德尔菲法开展3轮专家咨询确定评价指标体系终稿。结果3轮专家问卷回收有效率均为100.0%,专家权威系数均为0.82,专家一致性系数Kendall’s W分别为0.158、0.161、0.224。最终形成一级指标3个,二级指标15个,三级指标49个的肝硬化序贯治疗患者延续性护理评价指标体系。结论基于质量三环理论构建肝硬化序贯治疗患者延续性护理的评价指标体系涵盖内容全面科学,专家对其意见高度集中,值得进一步深入临床研究。

新癀片糊剂联合牙周基础治疗对慢性牙周炎患者临床疗效观察

目的评估新癀片糊剂联合牙周基础治疗对慢性牙周炎临床疗效。方法选取我科2022年4月至2023年6月门诊收治的慢性牙周炎患者120例,依据随机数字表法分为对照组、观察组,各60例。对照组在牙周基础治疗龈下刮治操作后,用双氧水冲洗,放置碘甘油于牙周袋内;观察组在牙周基础治疗龈下刮治操作后,用双氧水冲洗,放置新癀片糊剂于牙周袋内。统计分析两组牙周指数、术后24 h VRS评分、临床疗效。结果两组患者龈下刮治术前的PD、BI、GI、BOP、AL、牙齿松动度之间的差异无统计学意义(P>0.05),龈下刮治术后3个月、6个月,观察组患者的PD、BI、GI、BOP、AL、牙齿松动度均低于对照组(P<0.05)。观察组患者的术后24 h VRS评分低于对照组(P<0.05)。观察组患者的总有效率高于对照组(P<0.05)。结论新癀片糊剂联合牙周基础治疗能更加有效地杀灭牙周致病菌,减轻患者治疗后的疼痛,促进牙周组织的愈合。

急诊急救专科护士创伤救治胜任力评价指标体系的构建

目的 构建急诊急救专科护士创伤救治胜任力评价指标体系,为我国急诊专科护士培养及评价提供参考。方法 以胜任力的“冰山模型”为理论依据,通过文献回顾法、小组讨论法、德尔菲专家函询法以及层次分析法,确定急诊急救专科护士各级创伤救治胜任力评价指标及权重。结果 最终形成的急诊急救专科护士创伤救治胜任力评价指标体系包括知识、技能、动机、个人特质、自我概念和社会角色6个一级指标,18个二级指标,53个三级指标。3轮函询专家积极系数均为100%,专家权威系数分别为0.903、0.908、0.925,各级指标的肯德尔和谐系数分别为0.184~0.495、0.119~0.177和0.298~0.719(均P<0.05)。结论 构建的急诊急救专科护士创伤救治胜任力评价指标体系具有系统性和专科性,可为急诊急救专科护士岗位培训及考核评价提供参考。

探讨胰岛素泵短期强化治疗围绝经期妇女糖尿病对糖代谢指标的影响

目的探究围绝经期妇女糖尿病采用胰岛素泵短期强化治疗的效果。方法选取2021年4月—2023年11月包头市中心医院收治的46例糖尿病患者为研究对象,均为围绝经期女性,按照随机数表法分为两组,每组23例。对照组行基础治疗+胰岛素皮下治疗,研究组采用胰岛素泵短期强化治疗,对比两组血糖、治疗指标、降糖有效率和低血糖发生率。结果治疗后,研究组空腹血糖、餐后2 h血糖以及糖化血红蛋白水平低于对照组,差异有统计学意义(P均<0.05);研究组治疗后血糖达标时间更快,胰岛素用量低于对照组,差异有统计学意义(P均<0.05);与对照组相比,研究组降糖有效率高,低血糖发生率更低,差异有统计学意义(P均<0.05)。结论围绝经期糖尿病采用短期强化胰岛素泵治疗,起效快、及早调节血糖代谢,合理设置胰岛素用量,加速胰岛功能恢复。

Temporal Model for Dengue Disease with Treatment

This paper examines the effect of treatment of Dengue fever disease. A non linear mathematical model for the problem is proposed and analysed quantitatively using the stability theory of the differential equations. The results show that the disease-free equilibrium point is locally andglobally asymptotically stable if the reproduction number (R0) is less than unity. The additive compound matrices approach is used to show that the dengue fever model’s endemic equilibrium point is locally asymptotically stable when trace, determinant and determinant of second additive compound matrix of the Jacobian matrix are all negative. However, treatment will have a control of dengue fever disease. Numerical simulation of the model is implemented to investigate the sensitivity of certain key parameters on the dengue fever disease with treatment.