Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD b...Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.展开更多
目的:基于现代数据挖掘技术对推拿治疗小儿腹泻的选穴规律进行探析。方法:计算机检索2013年1月1日—2022年12月31日中国知网、万方、维普、中国生物医学文献服务系统(SinoMed)、PubMed、EMbase、Web of Science中关于推拿治疗小儿腹泻...目的:基于现代数据挖掘技术对推拿治疗小儿腹泻的选穴规律进行探析。方法:计算机检索2013年1月1日—2022年12月31日中国知网、万方、维普、中国生物医学文献服务系统(SinoMed)、PubMed、EMbase、Web of Science中关于推拿治疗小儿腹泻的文献,使用频率热图与关联网络图分析证型-穴位关系,进行穴位关联规则分析,运用复杂网络分析挖掘推拿治疗小儿腹泻核心穴位群,采用关联规则联合散点图分析挖掘推拿治疗小儿腹泻潜力穴位关联。结果:共纳入185篇文献,穴位处方439首,穴位79个。证型-穴位关联分析显示,足三里、七节骨、脊柱等穴位与各证型均有关联,证型-穴位频率分析显示大肠、脾经、腹、七节骨、龟尾各证型使用频率较高;关联规则分析发现,脾经、大肠、腹、七节骨为核心穴位群,足三里-龟尾-七节骨组合为最具潜力价值的穴位组合,脐-大肠-脾经组合为最常用穴位关联组合。结论:推拿治疗小儿腹泻临床处方需考虑“小儿稚阳”体质特点,“温阳扶正止泻”治法可能具有较高的临床价值,但临床使用较少。展开更多
基金supported by the National Key Research Project(2020YFE0201800)Henan Province Science and Technology Program for Tackling Key Problems(21210230347)2021 Postgraduate Scientifc Re-search Innovation Progrpm of Henan Universityof Chinese Medicine(2021KYCX008).
文摘Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.
文摘目的:基于现代数据挖掘技术对推拿治疗小儿腹泻的选穴规律进行探析。方法:计算机检索2013年1月1日—2022年12月31日中国知网、万方、维普、中国生物医学文献服务系统(SinoMed)、PubMed、EMbase、Web of Science中关于推拿治疗小儿腹泻的文献,使用频率热图与关联网络图分析证型-穴位关系,进行穴位关联规则分析,运用复杂网络分析挖掘推拿治疗小儿腹泻核心穴位群,采用关联规则联合散点图分析挖掘推拿治疗小儿腹泻潜力穴位关联。结果:共纳入185篇文献,穴位处方439首,穴位79个。证型-穴位关联分析显示,足三里、七节骨、脊柱等穴位与各证型均有关联,证型-穴位频率分析显示大肠、脾经、腹、七节骨、龟尾各证型使用频率较高;关联规则分析发现,脾经、大肠、腹、七节骨为核心穴位群,足三里-龟尾-七节骨组合为最具潜力价值的穴位组合,脐-大肠-脾经组合为最常用穴位关联组合。结论:推拿治疗小儿腹泻临床处方需考虑“小儿稚阳”体质特点,“温阳扶正止泻”治法可能具有较高的临床价值,但临床使用较少。
