Introduction of effective drugs in the treatment of hepatitis C virus(HCV)infection has prompted the World Health Organization to declare a global eradication target by 2030.Propositions have been made to screen the g...Introduction of effective drugs in the treatment of hepatitis C virus(HCV)infection has prompted the World Health Organization to declare a global eradication target by 2030.Propositions have been made to screen the general population and treat all HCV carriers irrespective of the disease status.A year ago the new severe acute respiratory syndrome coronavirus 2 virus appeared causing a worldwide pandemic of coronavirus disease 2019 disease.Huge financial resources were redirected,and the pandemic became the first priority in every country.In this review,we examined the feasibility of the World Health Organization elimination program and the actual natural course of HCV infection.We also identified and analyzed certain comorbidity factors that may aggravate the progress of HCV and some marginalized subpopulations with characteristics favoring HCV dissemination.Alcohol consumption,HIV coinfection and the presence of components of metabolic syndrome including obesity,hyperuricemia and overt diabetes were comorbidities mostly responsible for increased liverrelated morbidity and mortality of HCV.We also examined the significance of special subpopulations like people who inject drugs and males having sex with males.Finally,we proposed a different micro-elimination screening and treatment program that can be implemented in all countries irrespective of income.We suggest that screening and treatment of HCV carriers should be limited only in these particular groups.展开更多
Should grammar be taught at all?Is it a hindrance or anaid?Communicative language teaching approach seems to havecast doubts on the value of grammar teaching.The present paperargues that the positive effect of grammar...Should grammar be taught at all?Is it a hindrance or anaid?Communicative language teaching approach seems to havecast doubts on the value of grammar teaching.The present paperargues that the positive effect of grammar in College Englishteaching and learning should not be overlooked.Grammar servesas a means to the final achievement of language proficiency.Itis time for language teachers to reconsider the role of grammarand to come up with a more appropriate and thus,moreeffective treatment of grammar in College English teaching.展开更多
基金Corresponding author:Elias Kouroumalis,MD,PhD,Emeritus Professor,Department of Gastroenterology,University of Crete Medical School,Voutes,Heraklion 71500,Crete,Greece.kouroumi@uoc.gr。
文摘Introduction of effective drugs in the treatment of hepatitis C virus(HCV)infection has prompted the World Health Organization to declare a global eradication target by 2030.Propositions have been made to screen the general population and treat all HCV carriers irrespective of the disease status.A year ago the new severe acute respiratory syndrome coronavirus 2 virus appeared causing a worldwide pandemic of coronavirus disease 2019 disease.Huge financial resources were redirected,and the pandemic became the first priority in every country.In this review,we examined the feasibility of the World Health Organization elimination program and the actual natural course of HCV infection.We also identified and analyzed certain comorbidity factors that may aggravate the progress of HCV and some marginalized subpopulations with characteristics favoring HCV dissemination.Alcohol consumption,HIV coinfection and the presence of components of metabolic syndrome including obesity,hyperuricemia and overt diabetes were comorbidities mostly responsible for increased liverrelated morbidity and mortality of HCV.We also examined the significance of special subpopulations like people who inject drugs and males having sex with males.Finally,we proposed a different micro-elimination screening and treatment program that can be implemented in all countries irrespective of income.We suggest that screening and treatment of HCV carriers should be limited only in these particular groups.
文摘Should grammar be taught at all?Is it a hindrance or anaid?Communicative language teaching approach seems to havecast doubts on the value of grammar teaching.The present paperargues that the positive effect of grammar in College Englishteaching and learning should not be overlooked.Grammar servesas a means to the final achievement of language proficiency.Itis time for language teachers to reconsider the role of grammarand to come up with a more appropriate and thus,moreeffective treatment of grammar in College English teaching.
