Evolution mechanism and treatment timing of penetrating fissures

The Inner Mongolia mining area in western China are characterized by the development of numerous penetrating fissures,resulting in severe land damage.It is significant to reveal the underlying evolution mechanism and identify treatment timing for restoring the ecological environment.The Guanbanwusu mining subsidence area in Inner Mongolia,China was selected as the research case for this study.The evolution mechanism of different penetrating fissures was revealed by field measurement,physical simulation and theoretical analysis.The treatment timing prediction model for the mining subsidence area was established based on the enhanced Weibull time function.The results show that the ground fissures are mainly step-type and collapse-type fissures.The breaking form of overlying strata determines their vertical opening and horizontal dislocation.The high mining intensity in the western mining area results in a shortened period of dynamic fissure expansion and reduced closure degree.The damage extent of the overlying strata exhibits zoning characteristics both vertically and horizontally.The relative standard deviation of the prediction model is only 3.7%.Concurrently,the prediction model is employed to determine the optimal timing for treatment in the study area,estimated to be 259 days.Subsequently,once this threshold is reached,the study area undergoes treatment and restoration of its e cological environment.This study addresses the knowledge gap in this field by highlighting the interconnectedness between rock strata structure and evolution mechanism of penetrating fissures,thereby providing a method for determining the treatment timing in mining subsidence areas.

Clinical evaluation of timing of endovascular embolization treatment for intracranial aneurysm

Objective To evaluate the effects of endovascular embolization treatment for intracranial aneurysms in different time. Methods The clinical data of 165 cases of ruptured intracranial aneurysm treated by endovascular treatment were analysed retrospectively. The patients were divided into 3 groups accrodding to

Professor YANG Yu-fei’s Experience on the Integrated Chinese and Western Medicine Treatment Strategy for Advanced Colorectal Cancer

Colorectal cancer is one of the common malignant tumors in China.It poses a serious threat to the national health of China.For advanced colorectal cancer, the main goal of treatment is to prolong survival and improve quality of life.It complements other advantages, showing good therapeutic results.However, how to grasp the timing of integrated Chinese and Western Medicine for the treatment of advanced colorectal cancer and use the integrated Chinese and Western Medicine treatment methods flexibly contains profound therapeutic art.Prof.YANG Yu-fei is an authoritative expert in the field of integrated Chinese and Western medicine for colorectal cancer.She is good at accurately grasping the timing of treatment of integrated Chinese and Western Medicine, and flexibly adjusts the treatment strategy according to the specific conditions.In this paper, we shared Professor YANG Yu-fei's strategy for treating advanced colorectal cancer with emphasis on integrated Chinese and Western Medicine and attached a typical case, with a view to provide reference for the treatment of advanced colorectal cancer with integrated Chinese and Western Medicine.

Effect of solution treatment time on plasticity and ductile fracture of 7075 aluminum alloy sheet in hot stamping process

The effect of solution treatment time on the post-formed plasticity and ductile fracture of 7075 aluminum alloy in the hot stamping process was studied.Tensile tests were conducted on the specimens subjected to the hot stamping process with different solution treatment time.The digital image correlation(DIC)analysis was used to obtain the strain of the specimen.Based on the experiments and modeling,the Yld2000-3d yield criterion and the DF2014 ductile fracture criterion were calibrated and used to characterize the anisotropy and fracture behavior of the metal,respectively.Furthermore,the microstructure of specimens was studied.The experimental and simulation results indicate that the 7075 aluminum alloy retains distinct anisotropy after the hot stamping process,and there is no obvious effect of extending the solution treatment time on the material anisotropy.However,it is found that a longer solution treatment time can increase the fracture strain of the aluminum alloy during the hot stamping process,which may be related to the decrease of the second-phase particles size.

EFFECTS OF TREATMENT TIME ON CORROSION OF DIFFUSION-ALLOYED COATINGS OF PURE MAGNESIUM

The corrosion resistance of pure magnesium with surface alloying layer obtained by a solid diffusion alloying technique has been analyzed. To establish the optimum treatment time, the experiments were performed at 480℃ for different solid diffusion time （8, 16, and 24h）. The diffusion interaction effectiveness between Zn, Al mix powder and the sample surface, depending on the treatment time for diffusion at given temperatures, has an obvious influence on corrosion resistance and corrosion mechanism. Corrosion properties were studied using the constant immersion test （in 3.0% NaCl solution, temperature is （28±1）℃, and time is 96h）. Optical microscopy （OM） and EDS （energy dispersive spectrum） composition analysis were used to examine the cross-sectional microstructural characteristics of alloyed layer of treated samples. It is shown that in comparison with the untreated samples, the treated ones possess a better corrosion resistance. The Al5Mg11Zn4 phase, which formed as a continuous phase due to the diffusion of Al, Zn, and Mg elements and subsequent interaction on the outermost layer of diffusion alloying zones （especially the samples treated for 24h at 480℃）, was inert to the chloride solution compared with pure magnesium and acted as a corrosion barrier, and therefore the best corrosion resistance was obtained. This protective action of Al5Mg11Zn4 phase was found to change with its amount, which was controlled by the diffusion time at given temperature. It was concluded that the continuous Al5Mg11Zn4 phase （WP-zone） of the reacted layer in pure magnesium was beneficial from the point of view of corrosion resistance.

High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis

Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern. The current study aimed to observe the incidence of thalidomide-induced peripheral neuropathy among an- kylosing spondylitis patients for 1 year after treatment. In this study, 207 ankylosing spondylitis cases received thalidomide treatment, while 116 ankylosing spondylitis cases received other treat- ments. Results showed that the incidence of thalidomide-induced peripheral neuropathy in the thalidomide group was higher than that in the non-thalidomide group. There was no significant difference in the incidence of neuropathy between the 〈 6 months medication and 〉 6 months medication groups. There were no differences in the mean age, gender, or daily dose between the two groups. The incidence of peripheral neuropathy among patients receiving 25, 50, 75, or 100 mg thalidomide per day was 4.6%, 8.5%, 17.1%, 21.7%, respectively. The incidence was significantly different between the groups receiving 25 mg and 100 mg thalidomide. In conclu- sion, thalidomide can induce peripheral neuropathy within 1 year after treatment of ankylosing spondylitis; however, age and gender have no obvious impact on the incidence of peripheral neuropathy. The incidence of peripheral neuropathy is associated with increasing daily doses of thalidomide.

Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment

To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group （18 cases） or a denosumab plus vitamin D supplementation group （combination group; 23 cases）. We measured serum bone alkaline phosphatase （BAP）, tartrate-resistant acid phosphatase （TRACP）-5b and urinary N-terminal telopeptide of type-I collagen （NTX） at baseline, 1 week, as well as at I month and 2, 4, 8 and 12 months. We also measured bone mineral density （BMD） of L1-4 lumbar vertebrae （L）-BMD and bilateral hips （H）-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5b and urinary NTX were significantly suppressed in both groups from I week to 12 months （except at 12 months for NTX）. In the combination group, TRACP-5b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months （P 〈 0.05）. BAP was significantly suppressed in both groups at 2-12 months. L-BMD significantly increased at 8 and 12 months （8.9%） in the combination group and at 4, 8 and 12 months （6.0%） in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group （3.6%） compared with the denosumab group （1.2%） at 12 months （P 〈 0.05）. Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD （especially at the hips）.

Stochastic Model of a Cold-Stand by System with Waiting for Arrival &Treatment of Server

The service facility or server is the key constituent to keep a system operational for desired period of time. As any eventuality with the system necessitates immediate presence of it (server) so the time point of arrival and treatment of server significantly affects the system performance. This paper works out the steady state behavior of a cold standby system equipped with two similar units and a server with elapsed arrival and treatment times following general probability distributions. It practices the theory of semi-Markov processes, regenerative point technique and Laplace transforms to derive the expressions for state transition probabilities, mean sojourn times, mean time to system failure, system availability, server busy period and expected frequencies of repairs and treatments. The profit function is also developed taking different costs and revenue in to account. For tracing wider applicability of the model for different reliability and cost-effective systems, a particular case study is also presented as an illustration.

Impact of Anaerobic Soil Disinfestation Treatment on the Properties of Tomato Continuous Cropping Soil

To investigate the impact of anaerobic soil disinfestation(ASD)treatment with different processing duration on tomato continuous cropping soil,a total of eight treatments were designed,which included two treatment temperatures of 10℃ and 30℃,and four treatment times of 3,4,5 and 7 weeks(w).The results showed that whether the temperature was 10℃ or 30℃,the pH values,TOC and available K contents in the soil treated by the ASD method were significantly increased(P<0.05),while the EC values and NO_(3)^(-)contents in soils treated by ASD were significantly reduced compared with the untreated group(P<0.05).The Fusarium oxysporum population in soils treated by ASD decreased with the extension of the treatment time.When the treatment temperature was 30℃,the effect on the removal of the NO_(3)^(-)that had accumulated in soils treated by ASD was significantly better than the treatment temperature of 10℃(P<0.05).When soil was treated by ASD for more than 5 w at 30℃,the NH4+content in soil was significantly increased(P<0.05)compared with the untreated soil.In conclusion,NO_(3)^(-)accumulation in soils could not be completely eliminated with treatment by ASD,even when the treatment time at 10℃ was prolonged.Whether the treatment temperature was 10℃ or 30℃,the F.oxysporum population in soils treated by ASD decreased significantly with the extension of the treatment time to more than 5 w compared with treatment only for only 3 w.

Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity

AIM: Tumor response and normal tissue toxicity of seven-day-per-week continuous accelerated irradiation (CAIR) for patients with esophageal carcinoma were evaluated and compared to conventional irradiation (CR). METHODS: Sixty patients with squamous cell carcinoma of the esophagus were randomized into two groups: the CAIR group (30 patients) and the CR group (30 pa- tients). Patients in the CAIR group received radiotherapy (RT) with 2 Gy/fraction per day at 7 d/wk with a total dose of 50-70 Gy (average dose 64.2 Gy). The overall time of irradiation was 3.6-5.0 wk (average 4.6 wk). RT in the CR group was 2 Gy/fraction per day at 5 d/wk with a total dose of 40-70 Gy (average dose 61.7 Gy). The overall time of irradiation was 4.0-7.0 wk (average 6.4 wk). RESULTS: The data showed that the immediate tumor response to RT was better in the CAIR group than in the CR group. Efficiency rates (CR plus PR) were 82.8% (24/29) and 58.6% (17/29), respectively (P = 0.047). In both groups the incidences of esophagitis and tracheitis were insignificant (P = 0.376, 0.959), and no patient re- ceived toxicity that could not be tolerated. CONCLUSION: CAIR shortens overall treatment time and is well tolerated by patients. It may be superior to CR in enhancing the local response of tumor, but its remote effect for esophageal carcinoma awaits further follow-up.

Alkaloid variations in Catharanthus roseus seedlings treated by different temperatures in short term and long term

A study was conducted to investigate the effects of high temperature on variations of alkaloid metabolism in C. roseus seedlings in Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Heilongiang, China. 60-day-old C. roseus seedlings with 3-4 pairs of leaves were incubated in chambers with temperature of 30℃ and 40℃for short-term heat shock experiment and 20℃, 25℃ and 35℃ for long-term experiment. The contents of vindoline, catharanthine, vinblastine and vincristine in C. roseus leaves and root were checked at different temperatures in short term （1-6 h） and long term （1-16 d）. Results showed that under short-term heat shock, the contents of vindoline, catharanthine and vinblastine in leaves of the seedlings were higher at 40℃ than at 30℃, but after 6 h treatment, the contents of vindoline and catharanthine under the two temperatures came to the same level. Catharanthine was exclusively distributed in C. roseus roots and its content was increased by 40% after two hours incubation at 40℃, while increased slowly at 30℃ incubation and reached the highest value at 6 h. In the Long-term experiment, concentrations of monomeric alkaloids catharanthine and vindoline were higher at 20℃ than at 25℃ and had a sharp increase under the condition of 35℃. While for dimeric alkaloid, it showed that the higher the temperature, the earlier the peak value of vinblastine content appears. Vincristine had a continuous enhancement and attained 0.027 mg.g^-1 at 16th day under 35℃ condition which was higher than those in the other conditions. It was concluded that high temperature could promote the accumulation of different alkaloids in C. roseus and the accumulation characteristic is highly related to treatment time.

Research on viral dynamic models of hepatitis B virus infection

A mathematical model with cytotoxic cells of hepatitis B virus (HBV)infection is set up based on a basic model of virus dynamics without cytotoxic cells andexperimental observation of anti-viral drag therapy for HBV infection patients. A quantitativeanalysis of dynamic behaviors shows that the model has three kinds of equilibrium points, whichrepresent the patient's complete recovery without immune ability, complete recovery with immuneability, and HBV persistent infection at the end of the treatment with drag lamivudine,respectively. Our model may provide possible quantitative interpretations for the treatments ofchronic HBV infections with the drag lamivudine, in particularly explain why the plasma virus ofNowak et al. 's patients turnover the original level after stopping the lamivudine treatment.

Effect of Solid Retention and Hydraulic Retention Times on Membrane Fouling in Membrane Bioreactor

In this bench scale submerged membrane bioreactor, effect of solid retention time and hydraulic retention time on membrane fouling propensity has been studied. This experiment is carried out at different solid retention time of 5, 10, 30, 70 and 98 days; and fouling behavior of membrane bioreactor is investigated. Average effluent quality is found to be 88.14%-94.38%. The experiment with different hydraulic retention is carried for 3 to 4 days and fouling behavior has been investigated. The effluent quality at different hydraulic retention time of 1, 2, 3, 5, 10 and 24 hours has been investigated. This paper aims to search optimal values of solid and hydraulic retention times at which lower fouling and higher organic removal efficiency can be obtained. This study has been mainly focused on operating parameters rather than microbial structure, effect and analysis of activated sludge to membrane fouling.

Investigating the potential of using acoustic frequency on the degradation of linear alkylbenzen sulfonates from aqueous solution

The effectiveness of using acoustical （sonochemical） reactor for degradation of linear alkylbenzen sulfonate （LAS） from aqueous solution was investigated. LASs are anionic surfactants, found in relatively high amounts in domestic and industrial wastewaters. In this study, experiments on LAS solution were performed using methylene blue active substances （MBAS） method. The effectiveness of acoustical processor reactor for LAS degradation is evaluated with emphasis on the effect of treatment time and initial LAS concentration. Experiments were performed at initial concentrations of 0.2, 0.5, 0.8 and 1.0 mg/L, acoustic frequency of 130 kHz, applied power of 500 W and temperature of 18℃-20℃. At the conditions involved, LAS degradation was found to increase with increasing sonochemical time. In addition, as the concentration increased, the LAS degradation rate decreased in the acoustical processor reactor.

Preparation and characterization of Sr0.5Ba0.5Nb2O6 glass-ceramic on piezoelectric properties

We studied the influence of heat treatment time on the optical, thermal, electrical, and mechanical properties of stron- tium barium niobate （Srl-xBaxNb206; hereafter SBN） piezoelectric glass-ceramics with tungsten bronze-type structure, which have good piezoelectric properties and are important lead-free piezoelectric materials. We found that the best heat treatment time is 4 h. The properties of the prepared materials are better than that of SBN ceramics and the glass-ceramic growth is faster than the SBN crystal when the heat treatment time of the SBN piezoelectric glass-ceramic is controlled, reducing the preparation costs greatly.

Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study

Background:This study aimed to investigate the changes in the clinical indicators and influencing factors of treatment duration among human immunodeficiency virus(HIV)patients in whom antiretroviral therapy(ART)was unsuccessful.Methods:In this retrospective study,a total of 9,418 HIV patients who failed in ART during 2004–2016 were included and divided into two treatment groups—Group 1(treatment time≤3 years,n1=5,218)and Group 2(treatment time>3 years,n2=4,200).Patient follow-up data,including age,cluster of differentiation 4(CD4)count,and viral load,glucose,creatinine,and triglyceride levels,were extracted from electronic health record databases.Covariance analysis for repeated measures was used to analyze the biochemical indicators,and multiple logistic regression modeling was used to compare relevant data extracted from the Group 1 and Group 2 HIV patient cohorts with different treatment time.Results:The median initial CD4 count was 175.0 cells/μl(interquartile range,77.0–282.0),while the initial CD4 counts for Group 1 were lower than those for Group 2(P<0.05).A significant interaction between group and time effects was observed(P<0.05)in total cholesterol(TC).Changes in hemoglobin level among HIV patients were also significantly associated with treatment time(P=0.001).The initial CD4 count(odds ratio[OR]=0.756),female sex(OR=0.713),Zerit(d4T)(OR=1.443),TC(OR=1.285),and aspartate aminotransferase level(OR=1.002)were significantly associated with the survival time of dead patients with HIV(P<0.05).Additionally,the initial CD4 count(OR=1.456),age(OR=1.022),time interval(OR=0.903),patient’s living status(OR=0.597),d4T(OR=2.256),and triglyceride(OR=0.930)and hemoglobin levels(OR=0.997)were significantly associated with the treatment time of HIV patients with drug withdrawal(P<0.05).Conclusion:The initial biochemical parameters can affect the survival and treatment time of HIV patients.With a comprehensive understanding of the physiological and biochemical indicators of patients,we can reduce the probability of drug withdrawal and prolong the survival time of HIV patients.

CLINICAL STUDY ON THE TIME OF TREATING CHEMOTHERAPY INDUCED TOXIC AND SIDE EFFECTS IN MALIGNANT TUMOR PATIENTS BY ACUPOINT INJECTION OF ASTRAGALUS ROOT INJECTION

Objective: To investigate the suitable time of treating virulent and side effects of chemotherapy for malignant tumor by acupoint injection of Astragalus Root injection. Methods: Sixty three patients with malignant tumor were divided into three groups: prevention treatment (PT) group (n=23 cases),post chemotherapy treatment (PCT) group( n=22 cases), Western medicine (WM) group ( n=18 cases). The patients in PT, PCT and WM groups were treated respectively from the fifth day on before chemotherapy and from the first day on after chemotherapy, 18 days in all. The patients in WM group were administered Batilol and Leucogen from the first day on after chemotherapy. Changes of leukocytes and immunoglobulin before and after treatment were observed. Results: 1) Acupoint injection of Astragalus Root injectio could increase the number of leukocytes and immunoglobulin content and its effect was better than that of Western medicine (P<0.05); 2) The effect of PT group was better than that of PCT group in preventing and treating virulent and side effects of chemotherapy (P<0.05). Conclusion: It should be stressed on prevention of malignant tumor by using acupoint injection of Astragalus Root for relieving virulent and side effects of chemotherapy.

Effect of Heat Treatment Time on Dy–Cu Alloy Diffusion Process in Dy-Containing Commercial Nd–Fe–B Sintered Magnets

In this paper, the grain boundary diffusion process（GBDP） using a Dy70Cu30（at.%） alloy as the diffusion source was performed in a commercial sintered Nd–Fe–B magnet, and the effect of heat treatment time on the microstructure and magnetic properties of the magnet was investigated in detail. For the processed magnets heat-treated at 860℃, as heat treatment time increased, the coercivity and the depth of（Nd,Dy）2Fe14B core–shell structure increased first and then decreased. However, when the heat treatment time was more than 2 h, the diffusion path of Dy from the Dy-rich shell phase into the Nd2Fe14B grains was revealed, and a nearly homogeneous（Nd,Dy）2Fe14B phase was formed, which brought on the decrease in both the depth of visible core–shell structure and the coercivity of Nd–Fe–B magnet.

Occurrence,distribution,and potential influencing factors of sewage sludge components derived from nine full-scale wastewater treatment plants of Beijing,China

Millions of tons of waste activated sludge（WAS） produced from biological wastewater treatment processes cause severe adverse environmental consequences. A better understanding of WAS composition is thus very critical for sustainable sludge management. In this work, the occurrence and distribution of several fundamental sludge constituents were explored in WAS samples from nine full-scale wastewater treatment plants（WWTPs） of Beijing, China. Among all the components investigated, active heterotrophic biomass was dominant in the samples（up to 9478 mg/L）, followed by endogenous residues（6736 mg/L）,extracellular polymeric substances（2088 mg/L）, and intracellular storage products（464 mg/L）among others. Moreover, significant differences（p 〈 0.05） were observed in composition profiles of sludge samples among the studied WWTPs. To identify the potential parameters affecting the variable fractions of sludge components, wastewater source as well as design and operational parameters of WWTPs were studied using statistical methods. The findings indicated that the component fraction of sewage sludge depends more on wastewater treatment alternatives than on wastewater characteristics among other parameters. A principal component analysis was conducted, which further indicated that there was a greater proportion of residual inert biomass in the sludge produced by the combined system of the conventional anaerobic/anoxic/oxic process and a membrane bioreactor. Additionally, a much longer solids retention time was also found to influence the sludge composition and induce an increase in both endogenous inert residues and extracellular polymeric substances in the sludge.

The effect of treatment package time in head and neck cancer patients treated with adjuvant radiotherapy and concurrent systemic therapy

Objectives:In patients with head and neck carcinoma,“treatment package time”(TPT)was proven to impact outcomes in cases receiving adjuvant radiotherapy alone.Its impact in patients receiving radiotherapy with concurrent systemic therapy has not been studied previously.The TPT influence on survival endpoints for patients treated with surgery followed by radiation and concurrent systemic therapy was analyzed.Methods:Institutional database to identify head and neck carcinoma cases treated with definitive surgery followed by concomitant chemo(bio)radiotherapy(CRT)was used.TPT was the number of days elapsed between surgery and the last day of radiation.%FINDCUT SAS macro tool was used to search for the cutoff TPT that was associated with significant survival benefit.Kaplan-Meier curves,log-rank tests as well as univariate and multivariate analyses were used to assess overall survival(OS)and recurrence free survival(RFS).Results:One hundred and three cases with a median follow up of 37 months were included in the study.Oropharyngeal tumors were 43%,oral cavity 40%and laryngeal 17%of cases.Concurrent systemic therapy included platinum and cetuximab in 72%and 28%,respectively.Optimal TPT was found to be<100 days with significantly better OS(P=0.002)and RFS(P=0.043)compared to TPT≥100 days.On multivariate analysis;TPT<100 days,extracapsular nodal extension,high-risk score,iymphovascular space and perineural invasion were independent predictors for worse OS(P<0.05).T4,extracapsular nodal extension and high-risk score were all significantly detrimental to RFS(P<0.05).Conclusions:Addition of concomitant systemic therapy to adjuvant radiotherapy did not compensate for longer TPT in head and neck squamous cell carcinoma.Multidisciplinary coordinated care must be provided to ensure the early start of CRT with minimal treatment breaks.