针灸应用于糖尿病周围神经病变的Meta分析及治疗策略

目的采用Meta分析方法系统评价针灸治疗糖尿病周围神经病变的临床疗效。方法通过检索CNKI、万方、VIP、CBM及Pub Med数据库,收集针灸治疗糖尿病周围神经病变的随机对照试验,采用Rev Man 5.3软件进行Meta分析。结果共纳入文献7篇,患者累计546例。Meta分析结果显示,针灸可显著的提高糖尿病周围神经病变患者正中神经、胫神经的运动及感觉神经的传导速度。结论针灸治疗糖尿病周围神经病变的疗效确切。

再手术治疗腰椎间盘突出症临床分析

目的 探讨腰椎间盘突出症再手术原因及处理对策。方法 对31例腰椎间盘突出症再手术的病例进行回顾分析。结果 再手术原因主要为术前诊断及定位错误、椎间盘切除不彻底、对神经根管狭窄认识不足、脊柱稳定结构破坏 多节段椎间盘突出症遗漏、椎管瘢痕粘连等。结论 腰椎间盘突出症手术前诊断及定位需准确,髓核切除要干净,并松解神经根,必要时扩大神经根管,注意维持脊柱稳定结构,多节段椎间盘突出症术前应斟酌取舍。

膀胱及尿道异物的临床特点及治疗策略

目的总结膀胱及尿道异物的临床治疗经验。方法回顾性分析了2000年~2019年我院收治的28例膀胱及尿道异物的临床特点,治疗方法及疗效。共收治28例患者,其中男性19例(青少年3例),女性9例,平均年龄40.3岁,尿道内异物5例,膀胱尿道异物8例,膀胱内异物15例,异物种类繁多,根据不同情况给予了个体化治疗方式,采用内镜下取出异物19例,直接钳夹取出前尿道异物3例,膀胱镜辅助膀胱小切口切开取出异物5例,1例异物自行排出。结果所有患者均取出全部异物,术后随访1~6月,无明显并发症发生。结论治疗不同情况的异物因遵循个体化的手术方式。内镜治疗是膀胱及尿道异物治疗的主要手段,对于不适合用内镜经尿道取出的异物可采用耻骨上膀胱切开或尿道切开取出异物,应同时加强患者的健康教育和心理疏导以减少下尿路异物的发生率。

THE DYNAMICS AND THERAPEUTIC STRATEGIES OF A SEIS EPIDEMIC MODEL

Based on an epidemic model which Manvendra and Vinay [Mathematical model to simulate infections disease, VSRD-TNTJ 3（2） （2012） 60 68] have proposed, we consider the dynamics and therapeutic strategy of a SEIS epidemic model with latent patients and active patients. First, the basic reproduction number is established by applying the method of the next generation matrix. By means of appropriate Lyapunov functions, it is proven that while the basic reproduction number 0 〈 R0 〈 1, the disease-free equilibrium is globally asymptotically stable and the disease eliminates; and if the basic reproduction number R0 〉 1, the endemic equilibrium is globally asymptotically stable and therefore the disease becomes endemic. Numerical investigations of their basin of attraction indicate that the locally stable equilibria are global attractors. Second, we consider the impact of treatment on epidemic disease and analytically determine the most effective therapeutic strategy. We conclude that the most effective therapeutic strategy consists of treating both the exposed and the infectious, while treating only the exposed is the least effective therapeutic strategy. Finally, numerical simulations are given to illustrate the effectiveness of the proposed results.

New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer

With the development of proteomics and epigenetics,a large number of RNA-binding proteins(RBPs)have been discovered in recent years,and the inter-action between long non-coding RNAs(lncRNAs)and RBPs has also received increasing attention.It is extremely important to conduct in-depth research on the lncRNA-RBP interaction network,especially in the context of its role in the occurrence and development of cancer.Increasing evidence has demonstrated that lncRNA-RBP interactions play a vital role in cancer progression;there-fore,targeting these interactions could provide new insights for cancer drug discovery.In this review,we discussed how lncRNAs can interact with RBPs to regulate their localization,modification,stability,and activity and discussed the effects of RBPs on the stability,transport,transcription,and localization of lncRNAs.Moreover,we explored the regulation and influence of these inter-actions on lncRNAs,RBPs,and downstream pathways that are related to can-cer development,such as N6-methyladenosine(m6A)modification of lncRNAs.In addition,we discussed how the lncRNA-RBP interaction network regulates cancer cell phenotypes,such as proliferation,apoptosis,metastasis,drug resis-tance,immunity,tumor environment,and metabolism.Furthermore,we sum-marized the therapeutic strategies that target the lncRNA-RBP interaction net-work.Although these treatments are still in the experimental stage and various theories and processes are still being studied,we believe that these strategiesmay provide new ideas for cancer treatment.