The Effect of Tremella Fuciformis Spores Polysaccharides (TSP) on Immune Cellular Function of Mice in Vitro

TSP could markedly enhance the proliferative response of the murine splenocyte to LPS and induce the mitogenesis of the spleen cells.Furthermore,it was able to augment the activity of natural killer cell and ADGG;at a dosage of 25-250μg/ml,the ability of splenocytes to produce IL-2 induced by onA had been improved; at the concentration of 250μg／ml or more,TSP could inhibit the proliferative response of the murine lymphocyte to GonA and the ~3-HTdR spontaneous incorporation rate of thymocytes,and the inhibitory action ran in paralell with the increase in concentration of TSP.

Electrophoretic Analysis on RNA of Deltamethrin－resistant Culex Pipiens Pallens

TSP could markedly enhance the proliferative response of the murine splenocyte to LPS and induce the mitogenesis of the spleen cells.Furthermore,it was able to augment the activity of natural killer cell and ADGG;at a dosage of 25-250μg/ml,the ability of splenocytes to produce IL-2 induced by onA had been improved; at the concentration of 250μg/ml or more,TSP could inhibit the proliferative response of the murine lymphocyte to GonA and the ￣3-HTdR spontaneous incorporation rate of thymocytes,and the inhibitory action ran in paralell with the increase in concentration of TSP.

银耳孢糖对小鼠体内移植性肿瘤及免疫功能的影响

目的研究银耳孢糖(Tremella fuciformis spores polysaccharide,TSP)对小鼠移植性肿瘤及免疫功能的影响。方法利用小鼠肝癌H22及小鼠肉瘤S180的体内移植性肿瘤模型,腹腔连续给予TSP12d,称小鼠体重及肿瘤、脾脏和胸腺重量,测定脾淋巴细胞转化率及NK细胞杀伤活性。同时观察TSP对正常小鼠免疫器官重量和碳粒廓清的影响。结果TSP25,50,100mg·kg-1对小鼠肝癌H22及小鼠肉瘤S180有一定的抑制作用,抑瘤率分别为17.8%,27.6%,34.9%;32.8%,36.1%,44.0%;TSP50,100mg·kg-1能提高荷瘤小鼠脾NK细胞杀伤活性及淋巴细胞转化率(P<0.05)。此外,TSP50,100mg·kg-1亦能明显提高正常小鼠脾脏和胸腺的重量及网状内皮系统吞噬功能(P<0.05)。结论TSP对小鼠移植性肿瘤有一定的对抗作用,其抗肿瘤作用可能与增强机体免疫能力有关。

银耳孢糖对离体小鼠免疫细胞功能的影响

银耳孢糖在体外能明显促进ＬＰＳ对小鼠脾细胞的增殖反应，药物本身对脾细胞具有丝裂原作用，能明显增强ＮＫ细胞和ＡＤＣＣ活性。浓度为２５～２５０μｇ／ｍｌ时，能提高ＣｏｎＡ诱导脾细胞产生ＩＬ－２；当浓度大于２５μｇ／ｍｌ时，它可抑制ＣｏｎＡ诱导的Ｔ淋巴细胞增殖反应及胸腺细胞￣３Ｈ－ＴｄＲ自发掺入率，抑制程度随药量增加而更明显。