The Synthesis of Tertiary Amides by theReaction of Adducts of Schiff Bases andAcyl Chlorides with Allylsamarium Bromide

Adducts of Schiff bases and acyl chlorides react with allylsamarium bromide to afford the corresponding tertiary amides.

Synthesis and Crystal Structures of Schiff Bases Bearing Ferrocenylphenyl Groups

The Schiff bases bearing ferrocenylphenyl and diferrocenylphenyl groups were synthesized by the reactions of m-ferrocenylaniline with salicylaldehyde or 1, 4-bis (2′-formyl- phenyl)-1, 4-dioxabutane. The title compounds were characterized by elemental analysis, IR, 1H NMR and X-ray structural determination.

Synthesis, characterization and biological applications of novel Schiff bases of 2-(trifluoromethoxy) aniline

A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods. Crystal structure of one new compound was also reported. The pharmacological properties, including antibacterial(14 bacterial species), antifungal(7 strains), antimalarial, anti-trypanosomal and anti-HIV activities of the compounds, were investigated. Cytotoxicity of the tested compounds was evaluated against human cervix adernocarcinoma cells(He La). Bacterial minimum inhibitory concentration(MIC) results by broth microdilution method showed that Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella oxytoc and Klebsiella pneumonia were more sensitive in the presence of tested compounds with an MIC value of 15.6 μg/m L. All the tested compounds showed good to moderate activity against fungi. The sensitivity of Aspergillus fumigatus was higher than other strains with a minimum cell death concentration(MFC) of 15.6 μg/m L. Compound 1 showed greater antimalarial and anti-trypanosomal properties with very low to no cytotoxic effects against He La cells as compared with compound 5, while other compounds exhibited poor activity. Compounds 1–5 demonstrated good activity against HIV type-1. These Schiff base compounds could be used as good antimicrobial agents.

Synthesis and Crystal Structure of Complex of Zinc(Ⅱ) with Schiff Base {Zn[CH_3O(O)-C_6H_3CH_3=NN=C(S)NH_2](DMF)}_2

The title complex is a new binuclear Zn(Ⅱ) with chelate ligand of Schiff base containing S and N atom.The complex crystallizes in the orthorhombicspace group Pccn,with a=12.338(9),b=16.666(8),c=17.503(6),V=3599(6),Mr=723.52,Z=4,Dx=1.34 g/cm3,μ=15.22 cm-1,F(000)=1488.The structure was solved by direct methods and the final R=0.078.The crystal consists of discrete molecules with symmetric center at the center of the fourmembered ring consisting of two Zn atoms and two O atoms.

Synthesis and characterization of lanthanide complexes containing a bulky tridentate [N,N,O] Schiff base ligand

The lanthanide complexes containing a bulky tridentate [N,N,O] Schiff base ligand 3,5-But2-2-（OH）C6H2CH=N-8-C9H6N （HL） were synthesized and characterized. The reaction of anhydrous LnCl3 with NaL formed in situ in a 1：1 molar ratio in THF at room temperature afforded the lanthanide Schiff base dichloride complexes LnLCl2（DME） （Ln=Eu （1）; Sm （2））. Complexes 1 and 2 can be used as precursors for the synthesis of the lanthanide cyclopentadienyl Schiff base derivatives. The reactions of complexes 1 and 2 with one equiv of NaCH3C5H4 in THF provided the desired products LnL（CH3C5H4）CI（THF）.THF （Ln=Eu （3）; Sm （4）） in good isolated yields. These complexes were characterized by elemental analysis, IR spectra, and X-ray structural determination, in the case of complexes 3 and 4. The crystal data of complex 3 are monoclinic, P21/C space group, a=1.3370（2） nm, b=1.5190（2） nm, c=1.8910（3） nm, β=109.846（4）°, V=3.6125（8） nm^3, Z=4, Dc=1.416 mg/m^3,μ=1.847 mm^-1, F（000）=1584, R=0.0707, wR=0.1350. The crystal data of complex 4 are monoclinic, P21/c space group, a=1.3383（1） nm, b=1.5210（2） nm, c=1.8960（2） nm, β =109.878（3）°, V=3.6293（7） nm^3, Z=4, Dc=1.407 mg/m^3, μ=1.728 mm^-1, F（000）= 1580, R=0.0670, wR=0.1385.

Synthesis, Structure and Antibacterial Activities of 4-BBTS Schiff Base and Its Complexes

4-Bromobenzaldehyde thiosemicarbazone Schiff base （4-BBTS） and its Cu（Ⅱ）, Zn（Ⅱ）, Co（Ⅱ） and Ni（Ⅱ） complexes were synthesized and characterized by elemental analysis, UV, IR, MS, ^1H NMR, and molar conductivity. Using disc diffusion method, the antibacterial activity tests were conducted. The results revealed that the ligand as well as all the complexes exhibits good antibacterial activities against E. Coli. and S. Aureus. Moreover, Cu（Ⅱ） complex shows the best antibacterial activity, which provides beneficial reference for studying the relationship between the structures and performances.

Synthesis and Purification of Porphyrin-Schiff Base Using Ethyl Vanillin

A novel porphyrin-Schiff base was synthesized via the condensation of 5-（4-aminophenyl） -10,15,20-triphenylperphyrin and ethyl vanillin. After analyzing the level of purification of the perphyrin-Schiff base, it was successfully separated. This perphyrin-Schiff base was characterized by using UV-Vis, IR,^1H NMR and MS spectroscopy.

Synthesis and Crystal Structure of a Salicylaldehyde Ethylene Diamine Schiff Base Manganese (Ⅲ) Complex

The title compound, [Mn(salen)(salicyl)]?.5H2O ( H2salen = N, N?ethylenebis- (salicylideneaminato), Hsalicyl = salicylaldehyde), has been obtained from the reaction system containing (o-HOC6H4CH=NCH2)2, o-HOC6H4CHO and Mn(ClO4)2?H2O in EtOH solvent and structurally characterized. It crystallizes in the monoclinic, space group P21/c with a = 13.0548(4), b = 13.9254(4), c = 11.6630(1) ? b = 105.199(2)? V = 2046.09(9) ?, Z = 4, C23H22MnN2O5.5, Mr = 469.37, Dc = 1.524 g/cm3, F(000) = 972, m = 0.687mm-1 . R = 0.0630 and wR = 0.1142 for 1901 observed reflections with I >2(I). The Mn(Ⅲ) is coordinated by N(1), N(2), O(1) and O(2) of the Schiff base ligand and phenolate O atom of salicylaldehyde with O(3)Mn distance of 2.050(4) , forming a relatively rare five-coordinate square-pyramidal structure.

Synthesis and mesomorphic properties of fluorinated Schiff's base liquid crystals containing vinyl end groups

Three kinds of fluorinated Schiff＇s base esters, 4-allyloxy-2-X-6-X-benzoic acid 4-[（2, 3, 4-trifluorophenylimino）methyl]phenyl ester, where X=H or F, were synthesized and characterized. Their chemical structures were identified by Fourier transform infrared spectroscopy （FTIR） and ^1H nuclear magnetic resonance （^1H NMR）. Their mesomorphic properties were studied by polarized optical microscopy （POM） and differential scanning calorimetry （DSC）. It was found that all the three compounds exhibited enantiotropic nematic phases only. And their cleating point temperature and thermal range of mesophase decreased with the number of fluorine atoms on the rigid core of the compounds; while their melting point temperature showed no distinct regularity.

Synthesis, Characterization and Antibacterial Activity of New Ln(Ⅲ) Complexes with an Unsymmetrical Schiff Base Ligand

A new unsymmetrical Schiff base ligand (H2LLi) was synthesized using L-lysine, salicylaldehyde and 2-hydroxy-1-naphthaldehyde. Three solid metal complexes of this ligand \[Ln(H2L)(NO3)\] NO3·2H2O (Ln=La, Sm, Ho) have been prepared and characterized by elemental analyses, IR spectra, UV spectra, TG-DTG and molar conductance. The antibacterial activities of the ligand and its complexes are also studied. The antibacterial experiments indicate that the ligand and its complexes possess antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis and that the complexes have higher activity than those of the ligand.

Synthesis of Schiff Base Type Macrocycles Containing Naphthalene Ring

A series of new Schiff base type macrocyclic crown ethers containing naphthalene ring were synthesized from 2,2'-di(o-formylnaphthoxy) ethyl ether or 1,2-di(o-formylnaphthoxy) ethane and four appropriate diamines. The chemical structures of the new compounds were characterized by elemental analysis, infrared spectra, nuclear magnetic resonance spectra and mass spectrometry.

Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1–4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P2_1/c. The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.

Synthesis and Crystal Structure of a New 2D O-bridged Copper(Ⅱ) Coordination Polymer Constructed from Sulfonate-derived Schiff Base

A new chain-like coordination polymer, namely, [CuL]n （1, Na2L = 2-[（2-hydroxy- benzylidene）-amino]-benzenesulfonic acid sodium salt）, has been synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy and elemental analysis. Complex 1 crystallizes in monoclinic system, space group P21/c with a = 9.2296（16）, b = 10.4754（18）, c = 12.200（2） A, β = 102.392（2）°, V = 1152.0（3）A3, CI3H9CuNOaN, Mr = 338.83, Dc = 1.953 g/cm3, Z = 4, F（000） = 684, p = 2.089 mm-1, the final R = 0.0376 and wR = 0.0956. X-ray diffraction analyses indicate that 1 displays a square-pyramidal metal center with NO4 donor sets. The sulfonate-derived Schiff base serves as a common N,O,O＇-tridentate and a unique O-bridged ligand connecting the metals. Dinuclear copper complexes serve as secondary building blocks （SBUs） to construct an unusual 2D coordination network. In the crystal, the components form a stable 3D supramolecular architecture by C-H...O interactions and to-stacking

Synthesis and Self-Assembly Properties of Single-Chain Amphiphiles Containing Schiff Base Chromophore

A series of single-chain amphiphiles containing Schiff base moiety(CnSchC4N+ , n=4, 7, 10, 12, 16) were synthesized. The self-assembly properties were investigated by 1H NMR spectra, DSC and EM for aqueous solutions of these samples. The aggregates, vesi-cles, were formed when n=7. The influence of additional group-O-is discussed.

Synthesis of Two Blue-light emitting Complexes with Schiff Base Calixarene as the Ligand

Two new blue luminescent zinc and beryllium complexes with Schiff base calixarene derivative as the ligand were prepared. Their luminescent properties were determined, which indicated that they had strong blue fluorescent properties. They also had good solubility and film formation. These new complexes can be used as blue organic electroluminescent materials (OELMs) in organic electroluminescent devices.

Synthesis, Crystal Structure and Biological Activity of 4-Amino-2,4-dihydro-5-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-3H-1,2,4-triazole-3-thione Schiff Base

The target compound 1,2,4-triazole Schiff base containing pyrazole ring was synthesized by 4-amino-2,4-dihydro-5-（（3,5-dimethyl- lH-pyrazol-1-yl）methyl）-3H-1,2,4-triazole-3-thione and 3,4,5-trimethoxy benzaldehyde.The structure was confirmed by IR,~1H NMR,H RMS,elemental analysis and single-crystal X-ray diffraction.The crystal belongs to the triclinic system,space group P1 with a = 7.8772（17）,b = 8.2986（18）,c = 15.392（3） A,α= 93.360（4）,β= 94.609（4）,γ= 93.584（4）°,C（18）H（22）N6O3S,Mr= 402.47,V= 998.9（4） A^3,Z= 2,F（000） = 422,Dc =1.335 g/cm^3,μ= 0.194 mm^（-1）,the final R = 0.0533 and wR = 0.1329 for 3517 observed reflections with I 2σ（I）.The preliminary bioassay results indicate that the target compound has good fungicidal activity against Gibberlla nicotiancola in EC50 value and F.O.f.sp.niveum in EC（95） value.

Synthesis and Characterization of Lanthanum Complexes with Amino Acid Schiff Base

Six new complexes of lanthanum with amino acid Schiff base ligands, A-F, were prepared in methanol-aqueous solution. The composition and properties of the title complexes were characterized by elemental analysis, molar conductance, infrared, electronic spectra, H-1 NMR, thermogravimetric and differential thermal analysis.

Crystal Structure of C 19 H 22 N 2O 3 and Synthesis of Two Potential Schiff base Ligands ①

Two new Schiff base compounds, as potential ligands, 3, 3’ dimethyl 4, 4’ di(acetylacetonylideneimino)biphenyl C 19 H 22 N 2O 3(1) and 3, 3’ dimethyl 4 acetylacetonylideneimino 4’ aminobiphenyl C 24 H 28 N 2O 4(2), were synthesized and characterized by elemental analyses, IR, UV and 1H NMR spectra. The crystal structure of 1 has been determined by X ray diffraction technique. The crystal is monoclinic, space group P2 1/c , with a=14.871(3), b=7.290(1), c=16.787(3) , β =106.97(3)°, V=1741(1) 3, D x =1.246 g/cm 3, Z=4, M r=326.40, λ =0 71073 , μ (Mo Kα) =0.792 cm -1 , F(000) =696. The final refinement is converged with R =0.057 and R w =0.058 for 1615 observed reflections I≥3σ(I) . The result of structure analysis indicates that atoms N(1), O(2) and O(3) are included in a conjugate system.

Synthesis and Phase Behavior Studies of Two New Chiral Liquid Crystals of Schiff Base——The Influence of Intramolecular Hydrogen Bond on the Phase Behavior

Two new chiral liquid crystals of schiff-base type have been synthesized.This series of compounds contain α-chloro acidic ester chain prepared from commercially available L-valine.Both of the compounds exhibit tilted smectic phases;their phase transitions were studied using DSC and polarized optical microscopy;the influence of intramolecular hydrogen bonds on the phase behavior was studied as well.

Synthesis and Electrical Conductivities of Fully Conjugated Schiff Base Macrocycles Containing 1,3,4-Oxadiazole

Conjugated Schiff base macrocycles containing 1,3,3-oxadiazole were prepared by [2 + 2] cyclic condensation of phenylenediamine with 2,5-bis(m-formyl-phenyl)-1,3,4-oxadiazole. These macrocycles with iodine or TCNQ produced stable charge-transfer complexes. The formation of complexes were identified by UV-Vis and FT-IR spectra.