Some reactions of the title anion were studied.By these reactions six molybdenum complexes were prepared.On reac- tion with 1,3-dibromopropane the anion yielded the cyclic carbene complex(η-C_5H_4Si_2Me_5)MoBr(CO)_2C...Some reactions of the title anion were studied.By these reactions six molybdenum complexes were prepared.On reac- tion with 1,3-dibromopropane the anion yielded the cyclic carbene complex(η-C_5H_4Si_2Me_5)MoBr(CO)_2CO(CH_2)_2CH_2.The crystal and mole- cular structures of (η-C_5H_4Si_2Me_5)MoBr(CO)_3 and 〔(η-C_5H_4Si_2Me_5)Mo- (CO)_3〕_2 Were determined by X-ray crystallography.展开更多
The structures of several recently reported organometallic NLO chromophores, (thio-phene) manganese tricarbonyl cations, were fully optimized at the DFT non-local (GGA) level. The calculated results show that the fra...The structures of several recently reported organometallic NLO chromophores, (thio-phene) manganese tricarbonyl cations, were fully optimized at the DFT non-local (GGA) level. The calculated results show that the fragments 2-SC4H3CH=CHC6H4-R in these organometallic chromophores are not planar with dihedral angles of 42.2~59.8 between two aromatic rings, which are different from those of uncoordinated counterparts. Based on the DFT geometry opti-mization, the second-order nonlinear optical polarizabilities were calculated by using RPA method. The calculated results indicate that incorporation of +3Mn(CO) unit with thiophene leads to a sub-stantial increase in the second-order polarizability (b).展开更多
Carbon monoxide(CO)gas therapy,a novel anti-tumor technique based on the cytotoxicity from the CO released in situ,has become one of the hot topics in cancer treatment.Since the technique is oxygenindependent,it displ...Carbon monoxide(CO)gas therapy,a novel anti-tumor technique based on the cytotoxicity from the CO released in situ,has become one of the hot topics in cancer treatment.Since the technique is oxygenindependent,it displays promising therapeutic effect for hypoxic tumor where traditional photodynamic therapy shows limited efficacy and insufficient penetration depth.To fully address these limitations of PDT,we propose a synergetic sonodynamic-CO gas releasing strategy for the therapy of hypoxic tumor.In this work,two rhenium(Ⅰ)tricarbonyl complexes with different substituted ligands are investigated for US-triggered ROS generation and CO release.Our results indicated that the electron-donating NMe2-substituted complex(Re-NMe2)exhibits stronger luminescence intensity and generates more singlet oxygen(1O2)than the electron-withdrawing NO2-substituted complex(Re-NO2).In addition,Re-NMe2displays release of CO triggered by US,thus showing high sono-cytotoxicity to tumor cells in-vitro and in-vivo.The strong ROS-generating capability combined with rapid CO-releasing feature from Re-NMe2has made it a powerful tool for the efficient treatment of hypoxic tumor.展开更多
文摘Some reactions of the title anion were studied.By these reactions six molybdenum complexes were prepared.On reac- tion with 1,3-dibromopropane the anion yielded the cyclic carbene complex(η-C_5H_4Si_2Me_5)MoBr(CO)_2CO(CH_2)_2CH_2.The crystal and mole- cular structures of (η-C_5H_4Si_2Me_5)MoBr(CO)_3 and 〔(η-C_5H_4Si_2Me_5)Mo- (CO)_3〕_2 Were determined by X-ray crystallography.
文摘The structures of several recently reported organometallic NLO chromophores, (thio-phene) manganese tricarbonyl cations, were fully optimized at the DFT non-local (GGA) level. The calculated results show that the fragments 2-SC4H3CH=CHC6H4-R in these organometallic chromophores are not planar with dihedral angles of 42.2~59.8 between two aromatic rings, which are different from those of uncoordinated counterparts. Based on the DFT geometry opti-mization, the second-order nonlinear optical polarizabilities were calculated by using RPA method. The calculated results indicate that incorporation of +3Mn(CO) unit with thiophene leads to a sub-stantial increase in the second-order polarizability (b).
基金the financial support of the National Natural Science Foundation of China(NSFC,No.22077085)the Science and Technology Foundation of Shenzhen(Nos.JCYJ20210324095200002,JCYJ20190808153209537)。
文摘Carbon monoxide(CO)gas therapy,a novel anti-tumor technique based on the cytotoxicity from the CO released in situ,has become one of the hot topics in cancer treatment.Since the technique is oxygenindependent,it displays promising therapeutic effect for hypoxic tumor where traditional photodynamic therapy shows limited efficacy and insufficient penetration depth.To fully address these limitations of PDT,we propose a synergetic sonodynamic-CO gas releasing strategy for the therapy of hypoxic tumor.In this work,two rhenium(Ⅰ)tricarbonyl complexes with different substituted ligands are investigated for US-triggered ROS generation and CO release.Our results indicated that the electron-donating NMe2-substituted complex(Re-NMe2)exhibits stronger luminescence intensity and generates more singlet oxygen(1O2)than the electron-withdrawing NO2-substituted complex(Re-NO2).In addition,Re-NMe2displays release of CO triggered by US,thus showing high sono-cytotoxicity to tumor cells in-vitro and in-vivo.The strong ROS-generating capability combined with rapid CO-releasing feature from Re-NMe2has made it a powerful tool for the efficient treatment of hypoxic tumor.
