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A new route to the synthesis of thieno[2,3-d]pyrimidin-4(3H)-one derivatives catalyzed by 12-tungstophosphoric acid (H_3PW_(12)O_(40))
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作者 A.Davoodnia M.Bakavoli +1 位作者 Gh.Barakouhi N.Tavakoli-Hoseini 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第12期1483-1486,共4页
Heteropoly acid H3PW12040 (PW) has been used as an effective catalyst for the synthesis of thieno[2,3-d]pyrimidin-4(3H)-one derivatives. The present methodology offers several advantages, such as high yields, shor... Heteropoly acid H3PW12040 (PW) has been used as an effective catalyst for the synthesis of thieno[2,3-d]pyrimidin-4(3H)-one derivatives. The present methodology offers several advantages, such as high yields, short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up. 展开更多
关键词 Thieno[2 3-d]pyrimidin-4(3H)-one Heteropoly acid 12-Tungstophosphoric acid Orthoesters
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H_3PMo_(12)O_(40) catalyzed three-component one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones under solvent-free conditions
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作者 Zeinab Pourghobadi Fatemeh Derikvand 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第3期269-272,共4页
4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component one-pot condensation of acetophe-none derivatives,aldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amou... 4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component one-pot condensation of acetophe-none derivatives,aldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of HPMoOunder solvent-free conditions. 展开更多
关键词 4 6-Diarylpyrimidin-2(1H)-ones H_3PMo_(12)O_(40) Solvent-less reactions Biginelli like reactions HETEROPOLYACIDS
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京大戟化学成分的研究 被引量:9
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作者 陈海鹰 陶伟伟 +2 位作者 曹雨诞 陈佩东 丁安伟 《中成药》 CAS CSCD 北大核心 2013年第4期745-748,共4页
目的研究京大戟的化学成分。方法利用硅胶柱色谱、制备薄层等手段进行分离纯化,通过波谱数据分析和理化性质鉴定化合物结构。结果从京大戟中分离并鉴定了10个化合物,分别为二十四烷醇(1)、正十八烷醇(2)、十四烷酸(3)、大戟醇(4)、阿魏... 目的研究京大戟的化学成分。方法利用硅胶柱色谱、制备薄层等手段进行分离纯化,通过波谱数据分析和理化性质鉴定化合物结构。结果从京大戟中分离并鉴定了10个化合物,分别为二十四烷醇(1)、正十八烷醇(2)、十四烷酸(3)、大戟醇(4)、阿魏酸二十八酯(5)、β-谷甾醇(6)、(3β,12α,13α)-3,12-dihydroxypimara-7,15-dien-2-one(7)、pekinenal(8)、neomotiol(9)、3,3'-二甲氧基鞣花酸(10)。化合物7和8对人正常肝细胞LO2和人胃上皮GES-1细胞增殖具有抑制作用,化合物7对两种细胞的IC50为51.196μg/mL和21.223μg/mL;化合物8对两种细胞的IC50分别为15.722μg/mL和13.294μg/mL。结论化合物1、3、7、9为首次从该植物中发现。 展开更多
关键词 京大戟 (3β 12α 13α)-3 12-dihydroxypimara-7 15-dien-2-one neomotiol
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Vitamin B12: An efficient type catalyst for the one-pot synthesis of 3,4,5-trisubstituted furan-2(5H)-ones and N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates 被引量:2
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作者 Mehrnoosh Kangani Malek-Taher Maghsoodlou Nourallah Hazeri 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第1期66-70,共5页
Vitamin B12 was applied as catalyst for the one-pot three-component synthesis of 3,4,5-trisubstituted furan-2(5H)-ones from the condensation between aldehydes, amines and dialkylacetylendicarboxylates at ambient tem... Vitamin B12 was applied as catalyst for the one-pot three-component synthesis of 3,4,5-trisubstituted furan-2(5H)-ones from the condensation between aldehydes, amines and dialkylacetylendicarboxylates at ambient temperature in Et OH. In addition, N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates were synthesised using mentioned catalyst at ambient temperature in Et OH from condensation between formaldehyde, amines, and dialkylacetylenedicarboxylates. This methodology has number of advantages such as: use of green and nonhazardous catalyst, clean work up, short reaction times,high yields and no need to column chromatography. 展开更多
关键词 Vitamin B12 3 4 5-Trisubstituted furan-2(5H)-ones N-aryl-3-aminodihydropyrrol-2-one-4- CARBOXYLATES
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Synthesis,Urease Inhibition and Molecular Modelling Studies of Novel Derivatives of the Naturally Occurring b-Amyrenone
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作者 Jean J.K.Bankeu Hira Sattar +9 位作者 Yannick S.F.Fongang Syeda W.Muhammadi Conrad V.Simoben Fidele Ntie-Kang Guy R.T.Feuya Marthe A.T.Tchuenmogne Mehreen Lateef Bruno N.Lenta Muhammad S.Ali Augustin S.Ngouela 《Natural Products and Bioprospecting》 CAS 2019年第1期49-59,共11页
Urease enzyme(UE)has been reported to be a potent virulence factor for Helicobacter pylori(HP)bacteria indicated to be responsible for various gastrointestinal diseases.Therefore,the spread of HP,currently regarded by... Urease enzyme(UE)has been reported to be a potent virulence factor for Helicobacter pylori(HP)bacteria indicated to be responsible for various gastrointestinal diseases.Therefore,the spread of HP,currently regarded by the World Health Organization as a class 1 carcinogen,could be better controlled by targeting UE.It is in this line that we have synthesized three new derivatives(2–4)of the naturally occurring olean-12-en-3-one(1),which was previously isolated from the figs of Ficus vallis-choudae Delile(Moraceae).Among the synthesized compounds,3 and 4 contain an indole moiety.Their structures were unambiguously assigned by spectroscopic and spectrometric techniques(1D-NMR,2D-NMR and MS).The starting material and the synthesized compounds were screened for UE inhibition activity,and showed significant activities with IC50 values ranging from 14.5 to 24.6 lM,with compound(1)being the most potent as compared to the positive control thiourea(IC50=21.6 lM).Amongst the synthetic derivatives,compound 4 was the most potent(IC50-=17.9 lM),while the others showed activities close to that of the control.In addition,molecular docking study of target compounds 2–4 was performed in an attempt to explore their binding mode for the design of more potent UE inhibitors. 展开更多
关键词 Helicobacter pylori Urease inhibition DOCKING Olean-12-en-3-one derivatives
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雷山石杉的化学成分研究 被引量:2
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作者 李齐激 王冲 +3 位作者 李继新 张敬杰 刘亚华 潘炉台 《中国药学杂志》 CAS CSCD 北大核心 2014年第7期550-553,共4页
目的研究雷山石杉的化学成分。方法使用制备薄层、硅胶柱色谱、SephadexLH-20及半制备高效液相色谱法等手段进行分离、纯化,结合文献资料、理化性质、1H—NMR及13C-NMR数据进行结构鉴定。结果分离得到10个化合物,分别鉴定为(15R)-12... 目的研究雷山石杉的化学成分。方法使用制备薄层、硅胶柱色谱、SephadexLH-20及半制备高效液相色谱法等手段进行分离、纯化,结合文献资料、理化性质、1H—NMR及13C-NMR数据进行结构鉴定。结果分离得到10个化合物,分别鉴定为(15R)-12,16-epoxy-11,14-dihydroxy-8,11,13-abietatrien-7-one(Ⅰ),21-epi—serratenediol-3,21-acetate(Ⅱ),setTatene—diol-3-acetate(Ⅲ),21-epi—serratenediol-3-acetate(Ⅳ),21a—hydroxy—serrat-14-en-3β-ol(Ⅴ),21β-hydroxy—serrat-14-en-3β-ol(Ⅵ),石杉碱甲(huperzineA,Ⅶ),蔗糖(Ⅷ),β-谷甾醇(Ⅸ),胡萝卜串(Ⅹ)。结论化合物Ⅰ~Ⅹ均首次从该植物中分离到。 展开更多
关键词 雷山石杉 化学成分 (15R)-12 16-epoxy—11 14-dihydroxy-8 11 13-abietatrien-7-one 21-epi—serratenediol-3 21-acetate serratene-diol-3-acetate
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新鲜烟叶中的1个新二萜类成分 被引量:1
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作者 郑庆霞 刘萍萍 +4 位作者 翟妞 陈千思 金立锋 陈霞 周会娜 《中草药》 CAS CSCD 北大核心 2017年第13期2597-2600,共4页
目的研究烟草Nicotiana tabacum叶中的西松烷二萜类化学成分。方法采用柱色谱技术对烟草的95%乙醇提取物进行分离纯化,采用波谱技术结合化学方法进行结构鉴定。结果从烟草提取物中分离得到了5个西松烷二萜类成分,分别鉴定为(1R,3E,7E,10... 目的研究烟草Nicotiana tabacum叶中的西松烷二萜类化学成分。方法采用柱色谱技术对烟草的95%乙醇提取物进行分离纯化,采用波谱技术结合化学方法进行结构鉴定。结果从烟草提取物中分离得到了5个西松烷二萜类成分,分别鉴定为(1R,3E,7E,10S,11E)-3,7,11-cem-bratriene-10,15-diols(1)、(1S,2E,4S,6R,7E,10E,12S)-2,7,10-cembratriene-4,6,11-triol(2)、(1S,2E,4R,6R,7E,10E,12S)-2,7,10-cembratriene-4,6,11-triol(3)、(1S,2E,4S,6R,7E)-4,6,11-trihydroxy-1-isopropyl-4,8-dimethylpentadeca-2,7-dien-12-one(4)、(1S,2E,4R,6R,7E,11S,12S)-11,12-epoxy-2,7-cembradiene-4,6-diol(5)。结论化合物1为1个新化合物,命名为烟叶二萜B;化合物4首次在植物中发现,为1个新的天然产物。 展开更多
关键词 烟草属 烟叶 西松烷二萜 烟叶二萜B (1S 2E 4S 6R 7E)-4 6 11-trihydroxy-1-isopropyl-4 8-dimethylpentadeca-2 7-dien-12-one
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