In the presence of Cu（OAc）2·H2O, a variety of 5-trifluoromethyl-2,4-disubstituted oxazoles were easily synthesized via t-BuOOH （TBHP）/I2-mediated tandem oxidative cyclization from readily available starting m...In the presence of Cu（OAc）2·H2O, a variety of 5-trifluoromethyl-2,4-disubstituted oxazoles were easily synthesized via t-BuOOH （TBHP）/I2-mediated tandem oxidative cyclization from readily available starting materials aryl methanamines and α-trifluoroacetyl-substituted ketones or esters under mild conditions, The mechanism was proposed.展开更多
基金Project supported by the National Natural Science Foundation of China （Nos. 20872088, 21072126）, the Leading Academic Discipline Projects of Shanghai Municipal Education Commission （No. J50102） and the Graduated Student Innovation Fund of Shanghai University （No. SHUCX 112034）
文摘In the presence of Cu（OAc）2·H2O, a variety of 5-trifluoromethyl-2,4-disubstituted oxazoles were easily synthesized via t-BuOOH （TBHP）/I2-mediated tandem oxidative cyclization from readily available starting materials aryl methanamines and α-trifluoroacetyl-substituted ketones or esters under mild conditions, The mechanism was proposed.
基金supported by the National Natural Science Foundation of China(Nos.J1030412,20932002,20972144,21172205 and 21272222)the Chinese Ministry of Science and Technology(No.2010CB912103)~~
