An operationally convenient, asymmetric synthesis of cbiral trifluoromethyl containing heterocyclic amino ac- ids has been developed via Michael addition reaction of chiral equivalent of Ni（II）-complex of glycine an...An operationally convenient, asymmetric synthesis of cbiral trifluoromethyl containing heterocyclic amino ac- ids has been developed via Michael addition reaction of chiral equivalent of Ni（II）-complex of glycine and ]Ltrifluoromethylated-α,β-unsaturated ketones. The simplicity of the experimental procedures and high stereochem- ical outcome of the presented method render these heterocyclic amino acids readily available for systematic medicinal chemistry studies and de novo peptide design.展开更多
文摘An operationally convenient, asymmetric synthesis of cbiral trifluoromethyl containing heterocyclic amino ac- ids has been developed via Michael addition reaction of chiral equivalent of Ni（II）-complex of glycine and ]Ltrifluoromethylated-α,β-unsaturated ketones. The simplicity of the experimental procedures and high stereochem- ical outcome of the presented method render these heterocyclic amino acids readily available for systematic medicinal chemistry studies and de novo peptide design.
