The expression of epidermal growth factor receptor （EGFR） and leucine-rich repeats and immunoglobulin-like domain 1 （LRIG-1） in human trigeminal neurinoma was investigated and their effect on the origination and d...The expression of epidermal growth factor receptor （EGFR） and leucine-rich repeats and immunoglobulin-like domain 1 （LRIG-1） in human trigeminal neurinoma was investigated and their effect on the origination and development of trigeminal neurinoma, and the relationship between them was studied. By using immunohistochemistry：with tissue chip, the expression of EGFR and LRIG-1 was detected in 23 cases of trigeminal neurinoma. It was found that in the 23 cases, the expression rate of EGFR was 21.74%, while that of the LRIG-1 was 78. 26 %. There was a negative correlation between them. It was suggested that LRIG-1 might inhibit the malignant differentiation and proliferation of the trigeminal neurinoma possibly by the negative feedback loop of EGFR.展开更多
Objective To investigate the best surgical approach for the removal of trigeminal neurinomas (TNs). Methods A retrospective analysis of 75 patients with TNs in Huashan Hospital was carried out. Results In the e...Objective To investigate the best surgical approach for the removal of trigeminal neurinomas (TNs). Methods A retrospective analysis of 75 patients with TNs in Huashan Hospital was carried out. Results In the early group (1978-1984), a series of conventional intradural approaches were used; in the late group (1985-1995), an epidural approach via the skull base craniotomy was used. Total tumor removal was achieved in 58% (20/35) of patients in the early group and 80% (32/40) in the late group (P<0.025). Temporary and permanent cranial nerve morbidity were 62.7% and 37% in the early group and 28.1% and 10% in the late group (P<0.001). Conclusion The best microsurgical approach for the removal of trigeminal neurinomas except those confined to the posterior fossa is epidural approach or epiduro transduro transtentorial approach via the skull base craniotomy.展开更多
文摘The expression of epidermal growth factor receptor （EGFR） and leucine-rich repeats and immunoglobulin-like domain 1 （LRIG-1） in human trigeminal neurinoma was investigated and their effect on the origination and development of trigeminal neurinoma, and the relationship between them was studied. By using immunohistochemistry：with tissue chip, the expression of EGFR and LRIG-1 was detected in 23 cases of trigeminal neurinoma. It was found that in the 23 cases, the expression rate of EGFR was 21.74%, while that of the LRIG-1 was 78. 26 %. There was a negative correlation between them. It was suggested that LRIG-1 might inhibit the malignant differentiation and proliferation of the trigeminal neurinoma possibly by the negative feedback loop of EGFR.
文摘Objective To investigate the best surgical approach for the removal of trigeminal neurinomas (TNs). Methods A retrospective analysis of 75 patients with TNs in Huashan Hospital was carried out. Results In the early group (1978-1984), a series of conventional intradural approaches were used; in the late group (1985-1995), an epidural approach via the skull base craniotomy was used. Total tumor removal was achieved in 58% (20/35) of patients in the early group and 80% (32/40) in the late group (P<0.025). Temporary and permanent cranial nerve morbidity were 62.7% and 37% in the early group and 28.1% and 10% in the late group (P<0.001). Conclusion The best microsurgical approach for the removal of trigeminal neurinomas except those confined to the posterior fossa is epidural approach or epiduro transduro transtentorial approach via the skull base craniotomy.
