A new compound was synthesized with 1,2,3 trimethoxybenzene as the starting material, followed by acylation of Friedel Crafts, bromination reaction, the nucleophilic N substitution of imidazole . For 2 bromo 1 (2,3,4 ...A new compound was synthesized with 1,2,3 trimethoxybenzene as the starting material, followed by acylation of Friedel Crafts, bromination reaction, the nucleophilic N substitution of imidazole . For 2 bromo 1 (2,3,4 trimethoxyphenyl)ethanone in DMF,2 (1H imidazol 1 yl) 1 (2,3,4 trimethoxyphenyl) ethanone was obtained in yield of 62 7%. It was obtained that the best reaction condition which the molar ratio of bromo compound to imidazole will be 1∶5 and the reaction time will be 8 h under low temperature or room temperature. The structure of the product was confirmed by elemental analysis, 1H NMR and IR spectrum analysis.展开更多
文摘A new compound was synthesized with 1,2,3 trimethoxybenzene as the starting material, followed by acylation of Friedel Crafts, bromination reaction, the nucleophilic N substitution of imidazole . For 2 bromo 1 (2,3,4 trimethoxyphenyl)ethanone in DMF,2 (1H imidazol 1 yl) 1 (2,3,4 trimethoxyphenyl) ethanone was obtained in yield of 62 7%. It was obtained that the best reaction condition which the molar ratio of bromo compound to imidazole will be 1∶5 and the reaction time will be 8 h under low temperature or room temperature. The structure of the product was confirmed by elemental analysis, 1H NMR and IR spectrum analysis.
