Background:Triple‐negative breast cancer(TNBC)displays high heterogeneity.The majority of TNBC cases are characterized by high Ki‐67 expression.TNBC with low Ki‐67 expression accounts for only a small fraction of c...Background:Triple‐negative breast cancer(TNBC)displays high heterogeneity.The majority of TNBC cases are characterized by high Ki‐67 expression.TNBC with low Ki‐67 expression accounts for only a small fraction of cases and has been relatively less studied.Methods:This study analyzed a large single‐center multiomics TNBC data set,combined with a single‐cell data set.The clinical,genomic,and metabolic characteristics of patients with low Ki‐67 TNBC were analyzed.Results:The clinical and pathological characteristics were analyzed in 2217 TNBC patients.Low Ki‐67 TNBC was associated with a higher patient age at diagnosis,a lower proportion of invasive ductal carcinoma,increased alterations in the PI3K‐AKT‐mTOR pathway,upregulated lipid metabolism pathways,and enhanced infiltration of M2 macrophages.High Ki‐67 TNBC exhibited a higher prevalence of TP53 gene mutations,elevated nucleotide metabolism,and increased infiltration of M1 macrophages.Conclusions:We identified specific genomic and metabolic characteristics unique to low Ki‐67 TNBC,which have implications for the development of precision therapies and patient stratification strategies.展开更多
Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cel...Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.展开更多
Due to the presence of a large amount of personal sensitive information in social networks,privacy preservation issues in social networks have attracted the attention of many scholars.Inspired by the self-nonself disc...Due to the presence of a large amount of personal sensitive information in social networks,privacy preservation issues in social networks have attracted the attention of many scholars.Inspired by the self-nonself discrimination paradigmin the biological immune system,the negative representation of information indicates features such as simplicity and efficiency,which is very suitable for preserving social network privacy.Therefore,we suggest a method to preserve the topology privacy and node attribute privacy of attribute social networks,called AttNetNRI.Specifically,a negative survey-based method is developed to disturb the relationship between nodes in the social network so that the topology structure can be kept private.Moreover,a negative database-based method is proposed to hide node attributes,so that the privacy of node attributes can be preserved while supporting the similarity estimation between different node attributes,which is crucial to the analysis of social networks.To evaluate the performance of the AttNetNRI,empirical studies have been conducted on various attribute social networks and compared with several state-of-the-art methods tailored to preserve the privacy of social networks.The experimental results show the superiority of the developed method in preserving the privacy of attribute social networks and demonstrate the effectiveness of the topology disturbing and attribute hiding parts.The experimental results show the superiority of the developed methods in preserving the privacy of attribute social networks and demonstrate the effectiveness of the topological interference and attribute-hiding components.展开更多
By considering the negative cosmological constant Λ as a thermodynamic pressure, we study the thermodynamics and phase transitions of the D-dimensional dyonic Ad S black holes(BHs) with quasitopological electromagnet...By considering the negative cosmological constant Λ as a thermodynamic pressure, we study the thermodynamics and phase transitions of the D-dimensional dyonic Ad S black holes(BHs) with quasitopological electromagnetism in Einstein–Gauss–Bonnet(EGB) gravity. The results indicate that the small/large BH phase transition that is similar to the van der Waals(vdW) liquid/gas phase transition always exists for any spacetime dimensions. Interestingly, we then find that this BH system exhibits a more complex phase structure in 6-dimensional case that is missed in other dimensions.Specifically, it shows for D = 6 that we observed the small/intermediate/large BH phase transitions in a specific parameter region with the triple point naturally appeared. Moreover, when the magnetic charge turned off, we still observed the small/intermediate/large BH phase transitions and triple point only in 6-dimensional spacetime, which is consistent with the previous results. However, for the dyonic Ad S BHs with quasitopological electromagnetism in Einstein–Born–Infeld(EBI) gravity, the novel phase structure composed of two separate coexistence curves observed by Li et al. [Phys. Rev. D105 104048(2022)] disappeared in EGB gravity. This implies that this novel phase structure is closely related to gravity theories, and seems to have nothing to do with the effect of quasitopological electromagnetism. In addition, it is also true that the critical exponents calculated near the critical points possess identical values as mean field theory. Finally, we conclude that these findings shall provide some deep insights into the intriguing thermodynamic properties of the dyonic Ad S BHs with quasitopological electromagnetism in EGB gravity.展开更多
Background: In Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HIV prevalence of 3.5%. The AYP living with HIV enrolled at the 68 NARHY, Lagos reflects the national ...Background: In Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HIV prevalence of 3.5%. The AYP living with HIV enrolled at the 68 NARHY, Lagos reflects the national challenges with poor viral suppression. The OTZ program aligns with the UNAIDS 95-95-95 goals. It seeks to empower AYPLHIV to be in charge of their treatment and commit to triple zero outcomeszero missed appointments, zero missed drugs, and zero viral loads. The purpose of the study was to assess the impact of the OTZ program on viral load suppression among members of the adolescent club in 68 NARHY, Lagos. Method: A cross-sectional retrospective study to evaluate the impact of the OTZ program on the viral load of 53 AYP enrolled in the OTZ program between March 2019 to December 2019 was analyzed. The Percentage of viral load suppression before enrollment compared with 6 and 12 months after enrollment into the OTZ program. The AYP is grouped into 10 - 14, 15 - 19, and 20 - 24 years. Activities conducted were peer driven monthly meetings with the AYP during which the adolescents interacted on issues relating to improving their treatment outcomes, healthcare workers reviewed their clinical status, viral load result, provider peer counseling, and caregivers engagement to support adherence to medication and ARV refills. Results: Before OTZ, 81% aged 10 - 14 years, 75% aged 15 - 19 years, and 25% aged 20 - 24 years were virally suppressed (VL less than 1000 copies/ml). Six months after enrollment, 94% were virally suppressed95% aged 10 - 14 years, 96% aged 15 - 19 years, and 66% aged 20-24 years. Twelve months after enrollment, 96% of AYP were virally suppressed100% aged 10-14 years, 93% aged 15 - 19 years, and 100% aged 20 - 24 years. Males viral load (VL) suppression improved from 79% to 96% and 92%, while females VL suppression improved from 69% to 93% and 100% at 6 and 12 months respectively. Conclusion: The OTZ activities contributed to improved viral load suppression in the AYP of the facility.展开更多
Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the foreign.At the level of each layer,the relationships and t...Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the foreign.At the level of each layer,the relationships and the actors involved constitute a Triple Helix game.The paper distinguished three levels of analysis:the global grouping together all actors,the domestic grouping together domestic actors,and the foreign related to only actors from partner countries.Design/methodology/approach:Bibliographic records data from the Web of Science for South Korea and West Africa breakdown per innovation actors and distinguishing domestic and international collaboration are analyzed with game theory.The core,the Shapley value,and the nucleolus are computed at the three levels to measure the synergy between actors.Findings:The synergy operates more in South Korea than in West Africa;the government is more present in West Africa than in South Korea;domestic actors create more synergy in South Korea,but foreign more in West Africa;South Korea can consume all the foreign synergy,which is not the case of West Africa.Research limitations:Research data are limited to publication records;techniques and methods used may be extended to other research outputs.Practical implications:West African governments should increase their investment in science,technology,and innovation to benefit more from the synergy their innovation actors contributed at the foreign level.However,the results of the current study may not be sufficient to prove that greater investment will yield benefits from foreign synergies.Originality/value:This paper uses game theory to assess innovation systems by computing the contribution of foreign actors to knowledge production at an area level.It proposes an indicator to this end.展开更多
The corona discharge from transmission lines in high-altitude areas is more severe than at lower altitudes. The radio interference caused thereby is a key factor to be considered when designing transmission lines. To ...The corona discharge from transmission lines in high-altitude areas is more severe than at lower altitudes. The radio interference caused thereby is a key factor to be considered when designing transmission lines. To study the influence of altitude on negative corona characteristics, an experimental platform comprising a movable small corona cage was established: experiments were conducted at four altitudes in the range of 1120-4320 m, and data on the corona current pulse and radio interference level of 0.8-mm diameter fine copper wire under different negative voltages were collected. The experimental results show that the average amplitude, repetition frequency and average current of the corona current pulse increase with increasing altitude. The dispersion of pulse amplitude increases with increase in altitude, while the randomness of the pulse interval decreases continuously. Taking the average current as an intermediate variable,the relationship between radio interference level and altitude is obtained. The result of this research has some significance for understanding the corona discharge characteristics of ultra-highvoltage lines.展开更多
Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has...Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has become a research hotspot. In this paper, a scheme of realizing negative ARF based on the multiple-layered spherical structure design is proposed. The specific structure and design idea are presented. Detailed theoretical calculation analysis is carried out.Numerical simulations have been performed to verify the correctness of this prediction. The conjecture that the suppression of backscattering can achieve negative ARF is verified concretely, which greatly expands the application prospect and design ideas of the ARF. This work has laid a theoretical foundation for realizing precise control of the structure.展开更多
Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In...Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon plasma.The triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.展开更多
Nanofluidic devices have turned out to be exemplary systems for investigating fluidic transport properties in a highly restricted area, where the electrostatic interactions or chemical reactions between nanochannel an...Nanofluidic devices have turned out to be exemplary systems for investigating fluidic transport properties in a highly restricted area, where the electrostatic interactions or chemical reactions between nanochannel and flowing species strongly dominate the ions and flow transport. Numerous nanofluidic devices have recently been explored to manipulate ion currents and construct electronic devices. Enlightened by electronic field effect transistors, utilizing the electric field effect of nanopore nanochannels has also been adopted to develop versatile nanofluidic devices. Here, we report a nanopore-based nanofluidic unijunction transistor composed of a conical glass nanopipette with the biomaterial polydopamine (PDA) coated at its outer surface. The asfabricated nanofluidic device exhibited negative differential resistance (NDR) and ion current oscillation (ICO) in ionic transport. The pre-doped copper ions in the PDA moved toward the tip as increasing the potential, having a robust shielding effect on the charge of the tip, thus affecting the surface charge density of the nanopore in the working zone. Finite element simulation based on a continuum model coupled with Stokes-Brinkman and Poisson-Nernst-Planck (PNP) equations revealed that the fluctuations in charge density remarkably affect the transport of ionic current in the nanofluidic device. The as-prepared nanofluidic semiconductor device was a ready-to-use equipment that required no additional external conditions. Our work provides a versatile and convenient way to construct nanofluidic electronic components;we believe by taking advantage of advanced surface modification methods, the oscillation frequency of the unijunction transistors could be controlled on demand, and more nanofluidic devices with resourceful functions would be exploited.展开更多
In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple e...In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple extraction models facemultiple challenges when processing domain-specific data,including insufficient utilization of semantic interaction information between entities and relations,difficulties in handling challenging samples,and the scarcity of domain-specific datasets.To address these issues,our study introduces three innovative components:Relation semantic enhancement,data augmentation,and a voting strategy,all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks.We first propose an innovative attention interaction module.This method significantly enhances the semantic interaction capabilities between entities and relations by integrating semantic information fromrelation labels.Second,we propose a voting strategy that effectively combines the strengths of large languagemodels(LLMs)and fine-tuned small pre-trained language models(SLMs)to reevaluate challenging samples,thereby improving the model’s adaptability in specific domains.Additionally,we explore the use of LLMs for data augmentation,aiming to generate domain-specific datasets to alleviate the scarcity of domain data.Experiments conducted on three domain-specific datasets demonstrate that our model outperforms existing comparative models in several aspects,with F1 scores exceeding the State of the Art models by 2%,1.6%,and 0.6%,respectively,validating the effectiveness and generalizability of our approach.展开更多
A novel negative thermal expansion(NTE) material NdMnO_(3) was synthesized by solid-state method at 1 523 K. The crystal structure, phase transition, pores effect and negative expansion properties of NdMnO_(3) were in...A novel negative thermal expansion(NTE) material NdMnO_(3) was synthesized by solid-state method at 1 523 K. The crystal structure, phase transition, pores effect and negative expansion properties of NdMnO_(3) were investigated by variable temperature X-ray diffraction(XRD), scanning electron microscope(SEM) and variable temperature Raman spectra. The compound exhibits NTE properties in the orderly O' phase crystal structure. When the temperature is from 293 to 759 K, the ceramic NdMnO_(3) shows negative thermal expansion of-4.7×10^(-6)/K. As temperature increases, the ceramic NdMnO_(3) presents NTE property range from 759 to 1 007 K. The average linear expansion coefficient is-18.88×10^(-6)/K. The physical mechanism of NTE is discussed and clarified through experiments.展开更多
Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave conditions.These can potentia...Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave conditions.These can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow model.The model was initially validated by comparing it with published experimental and numerical computational fluid dynamics results.The current results were in good agreement with the published results.It was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular waves.Under irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately 0.8MWh.The findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.展开更多
Owing to rapid developments in spintronics,spin-based logic devices have emerged as promising tools for next-generation computing technologies.This paper provides a comprehensive review of recent advancements in spin ...Owing to rapid developments in spintronics,spin-based logic devices have emerged as promising tools for next-generation computing technologies.This paper provides a comprehensive review of recent advancements in spin logic devices,particularly focusing on fundamental device concepts rooted in nanomagnets,magnetoresistive random access memory,spin–orbit torques,electric-field modu-lation,and magnetic domain walls.The operation principles of these devices are comprehensively analyzed,and recent progress in spin logic devices based on negative differential resistance-enhanced anomalous Hall effect is summarized.These devices exhibit reconfigur-able logic capabilities and integrate nonvolatile data storage and computing functionalities.For current-driven spin logic devices,negative differential resistance elements are employed to nonlinearly enhance anomalous Hall effect signals from magnetic bits,enabling reconfig-urable Boolean logic operations.Besides,voltage-driven spin logic devices employ another type of negative differential resistance ele-ment to achieve logic functionalities with excellent cascading ability.By cascading several elementary logic gates,the logic circuit of a full adder can be obtained,and the potential of voltage-driven spin logic devices for implementing complex logic functions can be veri-fied.This review contributes to the understanding of the evolving landscape of spin logic devices and underscores the promising pro-spects they offer for the future of emerging computing schemes.展开更多
Negative Poisson’s ratio(NPR)metamaterials are attractive for their unique mechanical behaviors and potential applications in deformation control and energy absorption.However,when subjected to significant stretching...Negative Poisson’s ratio(NPR)metamaterials are attractive for their unique mechanical behaviors and potential applications in deformation control and energy absorption.However,when subjected to significant stretching,NPR metamaterials designed under small strain assumption may experience a rapid degradation in NPR performance.To address this issue,this study aims to design metamaterials maintaining a targeted NPR under large deformation by taking advantage of the geometry nonlinearity mechanism.A representative periodic unit cell is modeled considering geometry nonlinearity,and its topology is designed using a gradient-free method.The unit cell microstructural topologies are described with the material-field series-expansion(MFSE)method.The MFSE method assumes spatial correlation of the material distribution,which greatly reduces the number of required design variables.To conveniently design metamaterials with desired NPR under large deformation,we propose a two-stage gradient-free metamaterial topology optimization method,which fully takes advantage of the dimension reduction benefits of the MFSE method and the Kriging surrogate model technique.Initially,we use homogenization to find a preliminary NPR design under a small deformation assumption.In the second stage,we begin with this preliminary design and minimize deviations in NPR from a targeted value under large deformation.Using this strategy and solution technique,we successfully obtain a group of NPR metamaterials that can sustain different desired NPRs in the range of[−0.8,−0.1]under uniaxial stretching up to 20% strain.Furthermore,typical microstructure designs are fabricated and tested through experiments.The experimental results show good consistency with our numerical results,demonstrating the effectiveness of the present gradientfree NPR metamaterial design strategy.展开更多
Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning al...Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent,which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without interference.Therefore,in this study,the interval robustness(embodied as the interval stability)of theα-UTI method is explored in the interval-valued fuzzy environment.To begin with,the stability of theα-UTI method is explored for the case of an individual rule,and the upper and lower bounds of its results are estimated,using four kinds of unified interval implications(including the R-interval implication,the S-interval implication,the QL-interval implication and the interval t-norm implication).Through analysis,it is found that theα-UTI method exhibits good interval stability for an individual rule.Moreover,the stability of theα-UTI method is revealed in the case of multiple rules,and the upper and lower bounds of its outcomes are estimated.The results show that theα-UTI method is stable for multiple rules when four kinds of unified interval implications are used,respectively.Lastly,theα-UTI reasoning chain method is presented,which contains a chain structure with multiple layers.The corresponding solutions and their interval perturbations are investigated.It is found that theα-UTI reasoning chain method is stable in the case of chain reasoning.Two application examples in affective computing are given to verify the stability of theα-UTImethod.In summary,through theoretical proof and example verification,it is found that theα-UTImethod has good interval robustness with four kinds of unified interval implications aiming at the situations of an individual rule,multi-rule and reasoning chain.展开更多
基金National Natural Science Foundation of China,Grant/Award Numbers:81872137,82072917,82272957Shanghai Science and Technology Innovation Action Plan,Grant/Award Number:22DZ2204400。
文摘Background:Triple‐negative breast cancer(TNBC)displays high heterogeneity.The majority of TNBC cases are characterized by high Ki‐67 expression.TNBC with low Ki‐67 expression accounts for only a small fraction of cases and has been relatively less studied.Methods:This study analyzed a large single‐center multiomics TNBC data set,combined with a single‐cell data set.The clinical,genomic,and metabolic characteristics of patients with low Ki‐67 TNBC were analyzed.Results:The clinical and pathological characteristics were analyzed in 2217 TNBC patients.Low Ki‐67 TNBC was associated with a higher patient age at diagnosis,a lower proportion of invasive ductal carcinoma,increased alterations in the PI3K‐AKT‐mTOR pathway,upregulated lipid metabolism pathways,and enhanced infiltration of M2 macrophages.High Ki‐67 TNBC exhibited a higher prevalence of TP53 gene mutations,elevated nucleotide metabolism,and increased infiltration of M1 macrophages.Conclusions:We identified specific genomic and metabolic characteristics unique to low Ki‐67 TNBC,which have implications for the development of precision therapies and patient stratification strategies.
文摘Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.
基金supported by the National Natural Science Foundation of China(Nos.62006001,62372001)the Natural Science Foundation of Chongqing City(Grant No.CSTC2021JCYJ-MSXMX0002).
文摘Due to the presence of a large amount of personal sensitive information in social networks,privacy preservation issues in social networks have attracted the attention of many scholars.Inspired by the self-nonself discrimination paradigmin the biological immune system,the negative representation of information indicates features such as simplicity and efficiency,which is very suitable for preserving social network privacy.Therefore,we suggest a method to preserve the topology privacy and node attribute privacy of attribute social networks,called AttNetNRI.Specifically,a negative survey-based method is developed to disturb the relationship between nodes in the social network so that the topology structure can be kept private.Moreover,a negative database-based method is proposed to hide node attributes,so that the privacy of node attributes can be preserved while supporting the similarity estimation between different node attributes,which is crucial to the analysis of social networks.To evaluate the performance of the AttNetNRI,empirical studies have been conducted on various attribute social networks and compared with several state-of-the-art methods tailored to preserve the privacy of social networks.The experimental results show the superiority of the developed method in preserving the privacy of attribute social networks and demonstrate the effectiveness of the topology disturbing and attribute hiding parts.The experimental results show the superiority of the developed methods in preserving the privacy of attribute social networks and demonstrate the effectiveness of the topological interference and attribute-hiding components.
基金supported by the National Natural Science Foundation of China (Grant No. 11903025)the Starting Fund of China West Normal University (Grant No. 18Q062)+2 种基金the Sichuan Science and Technology Program (Grant No. 2023ZYD0023)the Sichuan Youth Science and Technology Innovation Research Team (Grant No. 21CXTD0038)the Natural Science Foundation of Sichuan Province (Grant No. 2022NSFSC1833)。
文摘By considering the negative cosmological constant Λ as a thermodynamic pressure, we study the thermodynamics and phase transitions of the D-dimensional dyonic Ad S black holes(BHs) with quasitopological electromagnetism in Einstein–Gauss–Bonnet(EGB) gravity. The results indicate that the small/large BH phase transition that is similar to the van der Waals(vdW) liquid/gas phase transition always exists for any spacetime dimensions. Interestingly, we then find that this BH system exhibits a more complex phase structure in 6-dimensional case that is missed in other dimensions.Specifically, it shows for D = 6 that we observed the small/intermediate/large BH phase transitions in a specific parameter region with the triple point naturally appeared. Moreover, when the magnetic charge turned off, we still observed the small/intermediate/large BH phase transitions and triple point only in 6-dimensional spacetime, which is consistent with the previous results. However, for the dyonic Ad S BHs with quasitopological electromagnetism in Einstein–Born–Infeld(EBI) gravity, the novel phase structure composed of two separate coexistence curves observed by Li et al. [Phys. Rev. D105 104048(2022)] disappeared in EGB gravity. This implies that this novel phase structure is closely related to gravity theories, and seems to have nothing to do with the effect of quasitopological electromagnetism. In addition, it is also true that the critical exponents calculated near the critical points possess identical values as mean field theory. Finally, we conclude that these findings shall provide some deep insights into the intriguing thermodynamic properties of the dyonic Ad S BHs with quasitopological electromagnetism in EGB gravity.
文摘Background: In Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HIV prevalence of 3.5%. The AYP living with HIV enrolled at the 68 NARHY, Lagos reflects the national challenges with poor viral suppression. The OTZ program aligns with the UNAIDS 95-95-95 goals. It seeks to empower AYPLHIV to be in charge of their treatment and commit to triple zero outcomeszero missed appointments, zero missed drugs, and zero viral loads. The purpose of the study was to assess the impact of the OTZ program on viral load suppression among members of the adolescent club in 68 NARHY, Lagos. Method: A cross-sectional retrospective study to evaluate the impact of the OTZ program on the viral load of 53 AYP enrolled in the OTZ program between March 2019 to December 2019 was analyzed. The Percentage of viral load suppression before enrollment compared with 6 and 12 months after enrollment into the OTZ program. The AYP is grouped into 10 - 14, 15 - 19, and 20 - 24 years. Activities conducted were peer driven monthly meetings with the AYP during which the adolescents interacted on issues relating to improving their treatment outcomes, healthcare workers reviewed their clinical status, viral load result, provider peer counseling, and caregivers engagement to support adherence to medication and ARV refills. Results: Before OTZ, 81% aged 10 - 14 years, 75% aged 15 - 19 years, and 25% aged 20 - 24 years were virally suppressed (VL less than 1000 copies/ml). Six months after enrollment, 94% were virally suppressed95% aged 10 - 14 years, 96% aged 15 - 19 years, and 66% aged 20-24 years. Twelve months after enrollment, 96% of AYP were virally suppressed100% aged 10-14 years, 93% aged 15 - 19 years, and 100% aged 20 - 24 years. Males viral load (VL) suppression improved from 79% to 96% and 92%, while females VL suppression improved from 69% to 93% and 100% at 6 and 12 months respectively. Conclusion: The OTZ activities contributed to improved viral load suppression in the AYP of the facility.
文摘Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the foreign.At the level of each layer,the relationships and the actors involved constitute a Triple Helix game.The paper distinguished three levels of analysis:the global grouping together all actors,the domestic grouping together domestic actors,and the foreign related to only actors from partner countries.Design/methodology/approach:Bibliographic records data from the Web of Science for South Korea and West Africa breakdown per innovation actors and distinguishing domestic and international collaboration are analyzed with game theory.The core,the Shapley value,and the nucleolus are computed at the three levels to measure the synergy between actors.Findings:The synergy operates more in South Korea than in West Africa;the government is more present in West Africa than in South Korea;domestic actors create more synergy in South Korea,but foreign more in West Africa;South Korea can consume all the foreign synergy,which is not the case of West Africa.Research limitations:Research data are limited to publication records;techniques and methods used may be extended to other research outputs.Practical implications:West African governments should increase their investment in science,technology,and innovation to benefit more from the synergy their innovation actors contributed at the foreign level.However,the results of the current study may not be sufficient to prove that greater investment will yield benefits from foreign synergies.Originality/value:This paper uses game theory to assess innovation systems by computing the contribution of foreign actors to knowledge production at an area level.It proposes an indicator to this end.
基金supported by the Science and Technology Project of State Grid Corporation of China (No.5200202155587A-0-5-GC)。
文摘The corona discharge from transmission lines in high-altitude areas is more severe than at lower altitudes. The radio interference caused thereby is a key factor to be considered when designing transmission lines. To study the influence of altitude on negative corona characteristics, an experimental platform comprising a movable small corona cage was established: experiments were conducted at four altitudes in the range of 1120-4320 m, and data on the corona current pulse and radio interference level of 0.8-mm diameter fine copper wire under different negative voltages were collected. The experimental results show that the average amplitude, repetition frequency and average current of the corona current pulse increase with increasing altitude. The dispersion of pulse amplitude increases with increase in altitude, while the randomness of the pulse interval decreases continuously. Taking the average current as an intermediate variable,the relationship between radio interference level and altitude is obtained. The result of this research has some significance for understanding the corona discharge characteristics of ultra-highvoltage lines.
基金Project supported by the National Key Research and Development Program of China (Grant No.2020YFA0211400)the State Key Program of the National Natural Science Foundation of China (Grant No.11834008)+3 种基金the National Natural Science Foundation of China (Grant Nos.12174192 and 12204119)the Fund from the State Key Laboratory of Acoustics,Chinese Academy of Sciences (Grant No.SKLA202210)the Fund from the Key Laboratory of Underwater Acoustic Environment,Chinese Academy of Sciences (Grant No.SSHJ-KFKT-1701)the Science and Technology Foundation of Guizhou Province,China (Grant No.ZK[2023]249)。
文摘Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has become a research hotspot. In this paper, a scheme of realizing negative ARF based on the multiple-layered spherical structure design is proposed. The specific structure and design idea are presented. Detailed theoretical calculation analysis is carried out.Numerical simulations have been performed to verify the correctness of this prediction. The conjecture that the suppression of backscattering can achieve negative ARF is verified concretely, which greatly expands the application prospect and design ideas of the ARF. This work has laid a theoretical foundation for realizing precise control of the structure.
基金supported by Bhabha Atomic Research Centre, Department of Atomic Energy, Government of IndiaDepartment of Atomic Energy, Government of India for financial assistance under DAE Doctoral Fellowship Scheme-2018。
文摘Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon plasma.The triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.
基金supported by the National Natural Science Foundation of China(Nos.22374145 and 21675146)the Jilin Province Science Technology Development Plan Project(No.20230508075RC)the Youth Innovation Promotion Association CAS(No.2021224).
文摘Nanofluidic devices have turned out to be exemplary systems for investigating fluidic transport properties in a highly restricted area, where the electrostatic interactions or chemical reactions between nanochannel and flowing species strongly dominate the ions and flow transport. Numerous nanofluidic devices have recently been explored to manipulate ion currents and construct electronic devices. Enlightened by electronic field effect transistors, utilizing the electric field effect of nanopore nanochannels has also been adopted to develop versatile nanofluidic devices. Here, we report a nanopore-based nanofluidic unijunction transistor composed of a conical glass nanopipette with the biomaterial polydopamine (PDA) coated at its outer surface. The asfabricated nanofluidic device exhibited negative differential resistance (NDR) and ion current oscillation (ICO) in ionic transport. The pre-doped copper ions in the PDA moved toward the tip as increasing the potential, having a robust shielding effect on the charge of the tip, thus affecting the surface charge density of the nanopore in the working zone. Finite element simulation based on a continuum model coupled with Stokes-Brinkman and Poisson-Nernst-Planck (PNP) equations revealed that the fluctuations in charge density remarkably affect the transport of ionic current in the nanofluidic device. The as-prepared nanofluidic semiconductor device was a ready-to-use equipment that required no additional external conditions. Our work provides a versatile and convenient way to construct nanofluidic electronic components;we believe by taking advantage of advanced surface modification methods, the oscillation frequency of the unijunction transistors could be controlled on demand, and more nanofluidic devices with resourceful functions would be exploited.
基金Science and Technology Innovation 2030-Major Project of“New Generation Artificial Intelligence”granted by Ministry of Science and Technology,Grant Number 2020AAA0109300.
文摘In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple extraction models facemultiple challenges when processing domain-specific data,including insufficient utilization of semantic interaction information between entities and relations,difficulties in handling challenging samples,and the scarcity of domain-specific datasets.To address these issues,our study introduces three innovative components:Relation semantic enhancement,data augmentation,and a voting strategy,all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks.We first propose an innovative attention interaction module.This method significantly enhances the semantic interaction capabilities between entities and relations by integrating semantic information fromrelation labels.Second,we propose a voting strategy that effectively combines the strengths of large languagemodels(LLMs)and fine-tuned small pre-trained language models(SLMs)to reevaluate challenging samples,thereby improving the model’s adaptability in specific domains.Additionally,we explore the use of LLMs for data augmentation,aiming to generate domain-specific datasets to alleviate the scarcity of domain data.Experiments conducted on three domain-specific datasets demonstrate that our model outperforms existing comparative models in several aspects,with F1 scores exceeding the State of the Art models by 2%,1.6%,and 0.6%,respectively,validating the effectiveness and generalizability of our approach.
文摘A novel negative thermal expansion(NTE) material NdMnO_(3) was synthesized by solid-state method at 1 523 K. The crystal structure, phase transition, pores effect and negative expansion properties of NdMnO_(3) were investigated by variable temperature X-ray diffraction(XRD), scanning electron microscope(SEM) and variable temperature Raman spectra. The compound exhibits NTE properties in the orderly O' phase crystal structure. When the temperature is from 293 to 759 K, the ceramic NdMnO_(3) shows negative thermal expansion of-4.7×10^(-6)/K. As temperature increases, the ceramic NdMnO_(3) presents NTE property range from 759 to 1 007 K. The average linear expansion coefficient is-18.88×10^(-6)/K. The physical mechanism of NTE is discussed and clarified through experiments.
基金financially supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(Grant No.2022R1I1A1A01069442)the 2024 Hongik University Research Fund。
文摘Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave conditions.These can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow model.The model was initially validated by comparing it with published experimental and numerical computational fluid dynamics results.The current results were in good agreement with the published results.It was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular waves.Under irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately 0.8MWh.The findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.
基金sponsored by the National Key Research and Development Program of China(Nos.2017YFA0206202 and 2022YFA1203904)the National Natural Science Foundation of China(No.52271160).
文摘Owing to rapid developments in spintronics,spin-based logic devices have emerged as promising tools for next-generation computing technologies.This paper provides a comprehensive review of recent advancements in spin logic devices,particularly focusing on fundamental device concepts rooted in nanomagnets,magnetoresistive random access memory,spin–orbit torques,electric-field modu-lation,and magnetic domain walls.The operation principles of these devices are comprehensively analyzed,and recent progress in spin logic devices based on negative differential resistance-enhanced anomalous Hall effect is summarized.These devices exhibit reconfigur-able logic capabilities and integrate nonvolatile data storage and computing functionalities.For current-driven spin logic devices,negative differential resistance elements are employed to nonlinearly enhance anomalous Hall effect signals from magnetic bits,enabling reconfig-urable Boolean logic operations.Besides,voltage-driven spin logic devices employ another type of negative differential resistance ele-ment to achieve logic functionalities with excellent cascading ability.By cascading several elementary logic gates,the logic circuit of a full adder can be obtained,and the potential of voltage-driven spin logic devices for implementing complex logic functions can be veri-fied.This review contributes to the understanding of the evolving landscape of spin logic devices and underscores the promising pro-spects they offer for the future of emerging computing schemes.
基金the support of the National Science Foundation of China(12372120,12172075)the Liaoning Revitalization Talents Program(XLYC2007027)Fundamental Research Funds for the Central Universities(DUT21RC(3)067).
文摘Negative Poisson’s ratio(NPR)metamaterials are attractive for their unique mechanical behaviors and potential applications in deformation control and energy absorption.However,when subjected to significant stretching,NPR metamaterials designed under small strain assumption may experience a rapid degradation in NPR performance.To address this issue,this study aims to design metamaterials maintaining a targeted NPR under large deformation by taking advantage of the geometry nonlinearity mechanism.A representative periodic unit cell is modeled considering geometry nonlinearity,and its topology is designed using a gradient-free method.The unit cell microstructural topologies are described with the material-field series-expansion(MFSE)method.The MFSE method assumes spatial correlation of the material distribution,which greatly reduces the number of required design variables.To conveniently design metamaterials with desired NPR under large deformation,we propose a two-stage gradient-free metamaterial topology optimization method,which fully takes advantage of the dimension reduction benefits of the MFSE method and the Kriging surrogate model technique.Initially,we use homogenization to find a preliminary NPR design under a small deformation assumption.In the second stage,we begin with this preliminary design and minimize deviations in NPR from a targeted value under large deformation.Using this strategy and solution technique,we successfully obtain a group of NPR metamaterials that can sustain different desired NPRs in the range of[−0.8,−0.1]under uniaxial stretching up to 20% strain.Furthermore,typical microstructure designs are fabricated and tested through experiments.The experimental results show good consistency with our numerical results,demonstrating the effectiveness of the present gradientfree NPR metamaterial design strategy.
基金the National Natural Science Foundation of China under Grants 62176083,62176084,61877016,and 61976078the Key Research and Development Program of Anhui Province under Grant 202004d07020004the Natural Science Foundation of Anhui Province under Grant 2108085MF203.
文摘Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent,which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without interference.Therefore,in this study,the interval robustness(embodied as the interval stability)of theα-UTI method is explored in the interval-valued fuzzy environment.To begin with,the stability of theα-UTI method is explored for the case of an individual rule,and the upper and lower bounds of its results are estimated,using four kinds of unified interval implications(including the R-interval implication,the S-interval implication,the QL-interval implication and the interval t-norm implication).Through analysis,it is found that theα-UTI method exhibits good interval stability for an individual rule.Moreover,the stability of theα-UTI method is revealed in the case of multiple rules,and the upper and lower bounds of its outcomes are estimated.The results show that theα-UTI method is stable for multiple rules when four kinds of unified interval implications are used,respectively.Lastly,theα-UTI reasoning chain method is presented,which contains a chain structure with multiple layers.The corresponding solutions and their interval perturbations are investigated.It is found that theα-UTI reasoning chain method is stable in the case of chain reasoning.Two application examples in affective computing are given to verify the stability of theα-UTImethod.In summary,through theoretical proof and example verification,it is found that theα-UTImethod has good interval robustness with four kinds of unified interval implications aiming at the situations of an individual rule,multi-rule and reasoning chain.
