Development of triple-layered tablets containing laxatives with a hydrophilic polymer

Constipation is a common functional gastrointestinal disorder which has caused much discomfort affecting the quality of life. The prevalence of constipation in the general population is approximately 20%(1)Various kinds of laxatives were introduced such as bulking agent, stool softener, stimulant, and osmotic agent (2)Fixed dose combination with bisacodyl as a stimulant and docusate sodium as a stool softener, Ducolax STM, was developed as enteric coated tablets targeting colon.

DIR:Dynamic Request Interleaving for Improving the Read Performance of Aged Solid-State Drives

Triple-level cell(TLC)NAND flash is increasingly adopted to build solid-state drives(SSDs)for modern computer systems.While TLC NAND flash effectively improves storage density,it faces severe reliability issues;in partic-ular,the pages exhibit different raw bit error rates(RBERs).Integrating strong low-density parity-check(LDPC)code helps to improve reliability but suffers from prolonged and proportional read latency due to multiple read retries for worse pages.The straightforward idea is that dispersing page-size data across several pages in different types can achieve a low-er average RBER and reduce the read latency.However,directly implementing this simple idea into flash translation lay-er(FTL)induces the read amplification issue as one logic page residing in more than one physical page brings several read operations.In this paper,we propose the Dynamic Request Interleaving(DIR)technology for improving the performance of TLC NAND flash-based SSDs,in particular,the aged ones with large RBERs.DIR exploits the observation that the la-tency of an I/O request is determined,without considering the queuing time,by the access of the slowest device page,i.e.,the page that has the highest RBER.By grouping consecutive logical pages that have high locality and interleaving their encoded data in different types of device pages that have different RBERs,DIR effectively reduces the number of read re-tries for LDPC with limited read amplification.To meet the requirement of allocating hybrid page types for interleaved data,we also design a page-interleaving friendly page allocation scheme,which splits all the planes into multi-plane re-gions for storing the interleaved data and single-plane regions for storing the normal data.The pages in the multi-plane re-gion can be read/written in parallel by the proposed multi-plane command and avoid the read amplification issue.Based on the DIR scheme and the proposed page allocation scheme,we build DIR-enable FTL,which integrates the proposed schemes into the FTL with some modifications.Our experimental results show that adopting DIR in aged SSDs exploits nearly 33%locality from I/O requests and,on average,reduces 43%read latency over conventional aged SSDs.

One-Step Synthesis of Magnetically Recyclable Au/Co/Fe Triple- Layered Core-Shell Nanoparticles as Highly Efficient Catalysts for the Hydrolytic Dehydrogenation of Ammonia Borane

Magnetically recyclable Au/Co/Fe core-shell nanoparticles （NPs） have been successfully synthesized via a one-step in situ procedure. Transmission electron microscope （TEM）, energy dispersive X-ray spectroscopic （EDS）, and electron energy-loss spectroscopic （EELS） measurements revealed that the trimetallic Au/Co/Fe NPs have a triple-layered core-shell structure composed of a Au core, a Co-rich inter-layer, and a Fe-rich shell. The Au/Co/Fe core-shell NPs exhibit much higher catalytic activities for hydrolytic dehydrogenation of ammonia borane （NHBBH3, AB） than the monometallic （Au, Co, Fe） or bimetallic （AuCo, AuFe, CoFe） counterparts.

Stability analysis and optimization of excavation method of double-arch tunnel with an extra-large span based on numerical investigation

The Xiamen Haicang double-arch tunnel has a maximum span of 45.73 m and a minimum burial depth of 5.8 m.A larger deformation or collapse of the tunnel is readily encountered during tunnel excavation.It is therefore necessary to select a construction approach that is suitable for double-arch tunnel projects with an extra-large span.In this study,three construction methods for double-arch tunnels with extra-large spans were numerically simulated.Subsequently,the deformation behavior and stress characteristics of the surrounding rock were obtained and compared.The results showed that the double-side-drift method with temporary vertical support achieves better adaptability in the construction of such tunnels,which can be observed from both the numerical results and in situ monitoring data.In addition,the improved temporary support plays a critical role in controlling the surrounding rock deformation.In addition,the disturbance resulting from the excavation of adjacent drifts was obvious,particularly the disturbance of the surrounding rock caused by the excavation of the middle drift.The present findings can serve as the initial guidelines for the construction of ultra-shallowly buried double-arch tunnels with extra-large spans.