One new triterpcnoid saponin, quinquenoside L17 （1）, was isolated from the leaves and stems of Panax quinquefolium L., and its structure was elucidated as 20-O-[（β-D-xylopyranosyl-（1-6）-O-β-D-glucopyranosy）]-6...One new triterpcnoid saponin, quinquenoside L17 （1）, was isolated from the leaves and stems of Panax quinquefolium L., and its structure was elucidated as 20-O-[（β-D-xylopyranosyl-（1-6）-O-β-D-glucopyranosy）]-6-O-β-D-glucopyranosy1-dammar-24-ene- 3,6,12,20-tetraol, by the combination analysis of one-dimensional NMR and two-dimensional NMR, mass spectrometry, CD spectrum and chemical evidences.展开更多
From the radix of Pueraria peduncularis Grah., two new oleanene-type triterpenoid saponins named pedunsaponins B (2) and C (3) were isolated. Their structures were determined as 3-O-(6-O-methyl)-beta-D-glucuronopyrano...From the radix of Pueraria peduncularis Grah., two new oleanene-type triterpenoid saponins named pedunsaponins B (2) and C (3) were isolated. Their structures were determined as 3-O-(6-O-methyl)-beta-D-glucuronopyranosyl-3 beta.15 alpha-diol-12-oleanene-16-one (2) and 3-O-beta-D-glucopyranosyl-( 1 --> 3)-beta-D-glucuronopyranosyl-3 beta, 15 alpha-diol-12-oleanene-16-one (3) on the basis of spectroscopic evidence and chemical reactions.展开更多
A new triterpenoid saponin, 3-O-{ β-D-xylopyranosyl-（1 → 2）-β-D-glucopyranosyl-（1 → 4）-[β-D-glucopyranosyl-（1 → 2）]-α- L-arabinopyranosyl}-3β,16α,28α-trihydroxy-13β,28-epoxy-oleanan-30-al （ardipusill...A new triterpenoid saponin, 3-O-{ β-D-xylopyranosyl-（1 → 2）-β-D-glucopyranosyl-（1 → 4）-[β-D-glucopyranosyl-（1 → 2）]-α- L-arabinopyranosyl}-3β,16α,28α-trihydroxy-13β,28-epoxy-oleanan-30-al （ardipusilloside Ⅲ, 1）, together with two known saponins, ardisiacrispins A （2） and B （3）, were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidences. Saponins 1 and 3 exhibited significant cytotoxicity against human glioblastoma U251MG cells.展开更多
A new triterpenoid saponin, 3-O-β-D-glucopyranosyl 16-oxo-platycodigenin 28-O-β-D-apiofuranosyl-（1 → 3）-β-D-xylopyra- nosyl-（1→4）-α-L-rhamnopyranosyl-（1 → 2）-α-L-arabinopyra-nosyl ester, was isolated fro...A new triterpenoid saponin, 3-O-β-D-glucopyranosyl 16-oxo-platycodigenin 28-O-β-D-apiofuranosyl-（1 → 3）-β-D-xylopyra- nosyl-（1→4）-α-L-rhamnopyranosyl-（1 → 2）-α-L-arabinopyra-nosyl ester, was isolated from the roots of Platycodon grandiflorum, together with three known saponins, including platycodin D, deapio platycoside E and platycoside E. The structure of the new compound, named 16-oxo-platycodin D, was elucidated on the basis of spectroscopic data.展开更多
A new triterpenoid saponin, named codonolaside （1） was isolated from the root of Codonopsis lanceolata. Its structure was determined by analysis of its spectral and chemical data.
A new triterpenoid saponin, named clematiganoside A (1), was isolated from the whole plant of Clematis ganpiniana. Its structure was elucidated on the basis of 1D, 2D NMR, TOF-MS and ESI-MS techniques, and physicochem...A new triterpenoid saponin, named clematiganoside A (1), was isolated from the whole plant of Clematis ganpiniana. Its structure was elucidated on the basis of 1D, 2D NMR, TOF-MS and ESI-MS techniques, and physicochemical properties.展开更多
To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes,a phytochemical study of Cimicifuga foetida was conducted.113 g(0.17%)actein was purified by ...To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes,a phytochemical study of Cimicifuga foetida was conducted.113 g(0.17%)actein was purified by recrystallization while eight cycloartane-type triterpenes(1-8)were isolated from the mother liquid.The chemical structures of new compounds(1-4)were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses.Moreover,new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC_(50) values ranging from 4.02 to 15.80μM.展开更多
Two new triterpenoid saponins were isolated from the roots ofRhaponticum uniflorum. Their structures were elucidated as 3-O- [β-D-glucopyranosyl]-ilexolic acid-28-O-[β-D-glucopyranosyl] ester 1 and 3-O-[β-D-glucopy...Two new triterpenoid saponins were isolated from the roots ofRhaponticum uniflorum. Their structures were elucidated as 3-O- [β-D-glucopyranosyl]-ilexolic acid-28-O-[β-D-glucopyranosyl] ester 1 and 3-O-[β-D-glucopyranosyl]-urs-12, 19 （29）-dien-oic acid-28-O-[β-b-glucopyranosyl] ester 2 mainly by 1D, 2D NMR techniques and chemical methods.展开更多
A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis. On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as:olean-1...A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis. On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as:olean-12-ene-23a, 286-dioic acid 36, 16a-dihydroxy-28-O- [βD-glucopyranosyl-(1 →3)]-β-D-glucopyra-nosyl-(l →2)-β-D-glucopyranosyl-(l→6)-β-D- glucopyranoside(1).展开更多
Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by c...Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM.展开更多
A new echinocystic acid saponin, asteryunnanoside H (1), has been isolated from the roots of Astsr yunnanensis (Compositae). The structure and the unambiguous assignments of the 1H- and 13C NMR data of 1 were obtained...A new echinocystic acid saponin, asteryunnanoside H (1), has been isolated from the roots of Astsr yunnanensis (Compositae). The structure and the unambiguous assignments of the 1H- and 13C NMR data of 1 were obtained based on extensive use of 1D and 2D NMR techniques (COSY. TOCSY, ROESY, HMQC and HMBC), and chemical transformations.展开更多
Two new triterpenoid saponins, tanguticoside A and B were isolated from aerial part of Clematis tangutica. Their structures were elucidated as 3-O-beta-D-glucopyranosyl hederagenin 28 O-alpha-L-rhamnopyranosyl- (1--&g...Two new triterpenoid saponins, tanguticoside A and B were isolated from aerial part of Clematis tangutica. Their structures were elucidated as 3-O-beta-D-glucopyranosyl hederagenin 28 O-alpha-L-rhamnopyranosyl- (1-->4)-beta-D-glucopyranosyl- (1-->6)-beta-D-glucopyranosidel and 3-O-beta-D-glucopyranosyl ranosyl- (1-->2)-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl- (1-->4)-beta-D-glucopyranosyl- (1-->6)-beta-D-glucopyranoside2, respectively.展开更多
Three new triterpenoid saponins, escins IVc (1), IVd (2) and IVf (3) were isolated from the seeds of Aesculus chinensis. They were. determined as 22 alpha-tigloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyrano...Three new triterpenoid saponins, escins IVc (1), IVd (2) and IVf (3) were isolated from the seeds of Aesculus chinensis. They were. determined as 22 alpha-tigloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyranosyl (1-->4)]-beta-D-glucopyranosiduronic acid 1, 22 alpha-angeloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyrano- syl (1-->4)]-beta-D-glucopyranosiduronic acid 2 and 28-tigloyl protoaescigenin-3 beta-O- [beta-D-gluco-pyranosyl (12)] [beta-D-glucopyranosyl (1-->4)] -beta-D-glucopyranosiduronic acid 3.展开更多
A new oleanane-type triterpene saponin. asteryunnanoside E. has been isolated from the roots of Astir yunnanensis Franch. and its structure elucidated as 3-O-β-D-glucopyranosyl-bayogenin-28-O-β-glucopyranoside by me...A new oleanane-type triterpene saponin. asteryunnanoside E. has been isolated from the roots of Astir yunnanensis Franch. and its structure elucidated as 3-O-β-D-glucopyranosyl-bayogenin-28-O-β-glucopyranoside by means of spectral data particularly 2D NMR including COSY. HETCOR, HOHAHA and ROESY techniques and chemical transformation.展开更多
A new triterpenoid saponin, named prostratoside A. was isolated from the whole plants of Polycarpon prostratum. Its structure nas determined to be 3-O-{beta-D-xylopyranosyl- (1-->2)- beta-D-glucopranosyl-(1-->4)...A new triterpenoid saponin, named prostratoside A. was isolated from the whole plants of Polycarpon prostratum. Its structure nas determined to be 3-O-{beta-D-xylopyranosyl- (1-->2)- beta-D-glucopranosyl-(1-->4)-[ beta- D-plucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl}- 22 alpha- acetoxy saikogenin G by spectroscopic methods..展开更多
A new triterpenoid saponin, se-saponin A, was isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Its structure was determined by spectral and chemical methods. Only one triterpenoid s...A new triterpenoid saponin, se-saponin A, was isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Its structure was determined by spectral and chemical methods. Only one triterpenoid saponin has been isolated from Clerodendrum genus before. Se-saponin A is the second instance.展开更多
A new triterpenoid bisglycoside, named raddeanoside R19, was isolated from the roots of Anemone raddeana. Its structure was elucidated on the basis of ESI-MS, ^13C NMR, and chemical methods.
A new triterpenoid saponin, tomentoside (5), together with prosapogenin CP 4 (1),huzhangoside B (2), C (3) and D (4) was isolated from the ethanolic extract of Anemone tomentosa.its structure was established by spectr...A new triterpenoid saponin, tomentoside (5), together with prosapogenin CP 4 (1),huzhangoside B (2), C (3) and D (4) was isolated from the ethanolic extract of Anemone tomentosa.its structure was established by spectroscopic and chemical evidence.展开更多
The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China.As a part of our continuous effort to search for bioactive molecules from the plant,the fruits of A.marina were investigate...The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China.As a part of our continuous effort to search for bioactive molecules from the plant,the fruits of A.marina were investigated,which has led to one new triterpenoid saponin(1)and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data.The new triterpenoid saponin showed cytotoxicity against GSC3#and GSC-18# with the IC50 values were 12.21 and 5.53 μg/mL respectively,and most of the known compounds had significant antioxidant capacity with the IC_(50) values ranging from 0.36 to 13.07 μg/mL.展开更多
Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill.(Cardiopteridaceae)led to the isolation of ethyl esters of three new triterpenoid sapon...Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill.(Cardiopteridaceae)led to the isolation of ethyl esters of three new triterpenoid saponins(1–3)and the known sesquiterpenoid cinnamosmolide(4).The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry.Compounds 1,2,and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8,10.2 and 2.0 lM,respectively.展开更多
基金supported by 973 Program(No.2006CB708517)Program for New Century Excellent Talents in University of Peoples Republic of China(No.NCET-04-0289)
文摘One new triterpcnoid saponin, quinquenoside L17 （1）, was isolated from the leaves and stems of Panax quinquefolium L., and its structure was elucidated as 20-O-[（β-D-xylopyranosyl-（1-6）-O-β-D-glucopyranosy）]-6-O-β-D-glucopyranosy1-dammar-24-ene- 3,6,12,20-tetraol, by the combination analysis of one-dimensional NMR and two-dimensional NMR, mass spectrometry, CD spectrum and chemical evidences.
文摘From the radix of Pueraria peduncularis Grah., two new oleanene-type triterpenoid saponins named pedunsaponins B (2) and C (3) were isolated. Their structures were determined as 3-O-(6-O-methyl)-beta-D-glucuronopyranosyl-3 beta.15 alpha-diol-12-oleanene-16-one (2) and 3-O-beta-D-glucopyranosyl-( 1 --> 3)-beta-D-glucuronopyranosyl-3 beta, 15 alpha-diol-12-oleanene-16-one (3) on the basis of spectroscopic evidence and chemical reactions.
文摘A new triterpenoid saponin, 3-O-{ β-D-xylopyranosyl-（1 → 2）-β-D-glucopyranosyl-（1 → 4）-[β-D-glucopyranosyl-（1 → 2）]-α- L-arabinopyranosyl}-3β,16α,28α-trihydroxy-13β,28-epoxy-oleanan-30-al （ardipusilloside Ⅲ, 1）, together with two known saponins, ardisiacrispins A （2） and B （3）, were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidences. Saponins 1 and 3 exhibited significant cytotoxicity against human glioblastoma U251MG cells.
文摘A new triterpenoid saponin, 3-O-β-D-glucopyranosyl 16-oxo-platycodigenin 28-O-β-D-apiofuranosyl-（1 → 3）-β-D-xylopyra- nosyl-（1→4）-α-L-rhamnopyranosyl-（1 → 2）-α-L-arabinopyra-nosyl ester, was isolated from the roots of Platycodon grandiflorum, together with three known saponins, including platycodin D, deapio platycoside E and platycoside E. The structure of the new compound, named 16-oxo-platycodin D, was elucidated on the basis of spectroscopic data.
文摘A new triterpenoid saponin, named codonolaside （1） was isolated from the root of Codonopsis lanceolata. Its structure was determined by analysis of its spectral and chemical data.
文摘A new triterpenoid saponin, named clematiganoside A (1), was isolated from the whole plant of Clematis ganpiniana. Its structure was elucidated on the basis of 1D, 2D NMR, TOF-MS and ESI-MS techniques, and physicochemical properties.
基金This research work was financial supported by Programs of National Natural Science Foundation of China(Nos.81803396 and U1132604)Autonomous Deployment Project(KIB2017010)of Kunming Institute of Botany,CAS,as well as The Major Program of CAS(No.KSZD-EW-Z-004-01).
文摘To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes,a phytochemical study of Cimicifuga foetida was conducted.113 g(0.17%)actein was purified by recrystallization while eight cycloartane-type triterpenes(1-8)were isolated from the mother liquid.The chemical structures of new compounds(1-4)were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses.Moreover,new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC_(50) values ranging from 4.02 to 15.80μM.
基金supported by the Education Bureau of Fujian Province(No.JS06025)National Natural Sciences Foundation of China(No.29772010)
文摘Two new triterpenoid saponins were isolated from the roots ofRhaponticum uniflorum. Their structures were elucidated as 3-O- [β-D-glucopyranosyl]-ilexolic acid-28-O-[β-D-glucopyranosyl] ester 1 and 3-O-[β-D-glucopyranosyl]-urs-12, 19 （29）-dien-oic acid-28-O-[β-b-glucopyranosyl] ester 2 mainly by 1D, 2D NMR techniques and chemical methods.
文摘A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis. On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as:olean-12-ene-23a, 286-dioic acid 36, 16a-dihydroxy-28-O- [βD-glucopyranosyl-(1 →3)]-β-D-glucopyra-nosyl-(l →2)-β-D-glucopyranosyl-(l→6)-β-D- glucopyranoside(1).
基金support from the independent topics supported by operational expenses for basic research of China Academy of Chinese Medical Sciences(ZXKT15032).
文摘Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM.
文摘A new echinocystic acid saponin, asteryunnanoside H (1), has been isolated from the roots of Astsr yunnanensis (Compositae). The structure and the unambiguous assignments of the 1H- and 13C NMR data of 1 were obtained based on extensive use of 1D and 2D NMR techniques (COSY. TOCSY, ROESY, HMQC and HMBC), and chemical transformations.
文摘Two new triterpenoid saponins, tanguticoside A and B were isolated from aerial part of Clematis tangutica. Their structures were elucidated as 3-O-beta-D-glucopyranosyl hederagenin 28 O-alpha-L-rhamnopyranosyl- (1-->4)-beta-D-glucopyranosyl- (1-->6)-beta-D-glucopyranosidel and 3-O-beta-D-glucopyranosyl ranosyl- (1-->2)-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl- (1-->4)-beta-D-glucopyranosyl- (1-->6)-beta-D-glucopyranoside2, respectively.
文摘A new oleanane-type triterpene saponin. asteryunnanoside E. has been isolated from the roots of Astir yunnanensis Franch. and its structure elucidated as 3-O-β-D-glucopyranosyl-bayogenin-28-O-β-glucopyranoside by means of spectral data particularly 2D NMR including COSY. HETCOR, HOHAHA and ROESY techniques and chemical transformation.
文摘A new triterpenoid saponin, named prostratoside A. was isolated from the whole plants of Polycarpon prostratum. Its structure nas determined to be 3-O-{beta-D-xylopyranosyl- (1-->2)- beta-D-glucopranosyl-(1-->4)-[ beta- D-plucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl}- 22 alpha- acetoxy saikogenin G by spectroscopic methods..
基金National Natural Science Foundation of China! (Grant No. 29772039).
文摘A new triterpenoid saponin, se-saponin A, was isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Its structure was determined by spectral and chemical methods. Only one triterpenoid saponin has been isolated from Clerodendrum genus before. Se-saponin A is the second instance.
文摘A new triterpenoid bisglycoside, named raddeanoside R19, was isolated from the roots of Anemone raddeana. Its structure was elucidated on the basis of ESI-MS, ^13C NMR, and chemical methods.
文摘A new triterpenoid saponin, tomentoside (5), together with prosapogenin CP 4 (1),huzhangoside B (2), C (3) and D (4) was isolated from the ethanolic extract of Anemone tomentosa.its structure was established by spectroscopic and chemical evidence.
基金The authors are grateful to the Natural Science Foundation of China(31770388,81225024)the "Ten Thousand Plan",a National High-level Talents Special Support Plan for partial financial support.
文摘The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China.As a part of our continuous effort to search for bioactive molecules from the plant,the fruits of A.marina were investigated,which has led to one new triterpenoid saponin(1)and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data.The new triterpenoid saponin showed cytotoxicity against GSC3#and GSC-18# with the IC50 values were 12.21 and 5.53 μg/mL respectively,and most of the known compounds had significant antioxidant capacity with the IC_(50) values ranging from 0.36 to 13.07 μg/mL.
基金This project was supported by the Fogarty International Center,the National Cancer Institute,the National Institute of Allergy and Infectious Diseases,the National Institute of Mental Health,the National Institute on Drug Abuse,the National Heart Lung and Blood Institute,the National Center for Complementary and Alternative Medicine,the Office of Dietary Supplements,the National Institute of General Medical Sciences,the Biological Sciences Directorate of the National Science Foundation,and the Office of Biological and Environmental Research of the U.S.Department of Energy under Cooperative Agreement U01 TW00313 with the International Cooperative Biodiversity GroupsThis project was also supported by the National Research Initiative of the Cooperative State Research,Education and Extension Service,USDA,Grant#2008-35621-04732These supports are gratefully acknowledged.Work at Virginia Tech was supported by the National Science Foundation under Grant CHE-0722638 for the purchase of the Agilent 6220 mass spectrometer.
文摘Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill.(Cardiopteridaceae)led to the isolation of ethyl esters of three new triterpenoid saponins(1–3)and the known sesquiterpenoid cinnamosmolide(4).The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry.Compounds 1,2,and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8,10.2 and 2.0 lM,respectively.
