Two New Tirucallane-Type Triterpenoid Saponins from Sapindus mukorossi

Two new tirucallane-type triterpenoid saponins, Sapimukoside A (1) and Sapimukoside B (2), were isolated from the roots of Sapindus mukorossi Gaertn. On the basis of spectroscopic and chemical evidence, their structures were elucidated to be 3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-arabinopyranosyl-(1-->3)]-beta-D-glucopyranosyl-21, 23R-epoxyl tirucall-7, 24R-diene-3beta, 21-diol (1) and 3-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranosyl-21, 23R-epoxyl tirucall-7, 24R-diene-3beta, 21-diol (2).

A New Triterpenoid Saponin from Rhaponticum uniflorum (Compositae)

A new triterpenoid saponin, namely unifloroside, together with five known compounds, was isolated from Rhaponticum uniflorum (L.) DC. The structure of the new triterpenoid saponin was elucidated as 3_O_ α_L_arabinopyranosyl_urs_9(11),12_dien_28_oic acid β_D_glucopyranosyl ester mainly by using 1D, 2D_NMR techniques and chemical methods.

New Triterpenoid Saponins from Polycarpon prostratum (Caryophyllaceae)

Three new triterpenoid saponins, namely prostratosides A-C (1-3), were isolated from the whole plant of Polycarpon prostratum (Forssk.) Aschers. et Schwein. ex Aschers. By spectroscopic methods, their structures were determined as 3_O_{β_D_xylopyranosyl_(1→2)_β_D_glucopyranosyl_(1→4)_[β_D_glucopyranosyl_(1→2)]_α_L_arabinopyranoside}_22α_acetoxy_saikogenin G, 3_O_{β_D_xylopyranosyl_(1→2)_β_D_glucopyranosyl_(1→4)_[β_D_glucopyranosyl_(1→2)]_α_L_arabinopyranoside}_16α_hydroxy_22α_acetoxy_saikogenin E and 3_O_{β_D_xylopyranosyl_(1→2)_β_D_glucopyranosyl_(1→4)_[β_D_glucopyranosyl_(1→2)]_α_L_arabinopyranoside}_21β_acetoxy_saikogenin G, respectively.

A new triterpenoid saponin from the leaves and stems of Panax quinquefolium L.

One new triterpcnoid saponin, quinquenoside L17 （1）, was isolated from the leaves and stems of Panax quinquefolium L., and its structure was elucidated as 20-O-[（β-D-xylopyranosyl-（1-6）-O-β-D-glucopyranosy）]-6-O-β-D-glucopyranosy1-dammar-24-ene- 3,6,12,20-tetraol, by the combination analysis of one-dimensional NMR and two-dimensional NMR, mass spectrometry, CD spectrum and chemical evidences.

A new triterpenoid saponin from the roots of Platycodon grandiflorum

A new triterpenoid saponin, 3-O-β-D-glucopyranosyl 16-oxo-platycodigenin 28-O-β-D-apiofuranosyl-（1 → 3）-β-D-xylopyra- nosyl-（1→4）-α-L-rhamnopyranosyl-（1 → 2）-α-L-arabinopyra-nosyl ester, was isolated from the roots of Platycodon grandiflorum, together with three known saponins, including platycodin D, deapio platycoside E and platycoside E. The structure of the new compound, named 16-oxo-platycodin D, was elucidated on the basis of spectroscopic data.

Two New Oleanene-Type Triterpenoid Saponins from Pueraria peduncularis

From the radix of Pueraria peduncularis Grah., two new oleanene-type triterpenoid saponins named pedunsaponins B (2) and C (3) were isolated. Their structures were determined as 3-O-(6-O-methyl)-beta-D-glucuronopyranosyl-3 beta.15 alpha-diol-12-oleanene-16-one (2) and 3-O-beta-D-glucopyranosyl-( 1 --> 3)-beta-D-glucuronopyranosyl-3 beta, 15 alpha-diol-12-oleanene-16-one (3) on the basis of spectroscopic evidence and chemical reactions.

Cytotoxic triterpenoid saponins from Ardisia pusilla

A new triterpenoid saponin, 3-O-{ β-D-xylopyranosyl-（1 → 2）-β-D-glucopyranosyl-（1 → 4）-[β-D-glucopyranosyl-（1 → 2）]-α- L-arabinopyranosyl}-3β,16α,28α-trihydroxy-13β,28-epoxy-oleanan-30-al （ardipusilloside Ⅲ, 1）, together with two known saponins, ardisiacrispins A （2） and B （3）, were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidences. Saponins 1 and 3 exhibited significant cytotoxicity against human glioblastoma U251MG cells.

A New Triterpenoid Saponin from Codonopsis lanceolata

A new triterpenoid saponin, named codonolaside （1） was isolated from the root of Codonopsis lanceolata. Its structure was determined by analysis of its spectral and chemical data.

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes,a phytochemical study of Cimicifuga foetida was conducted.113 g(0.17%)actein was purified by recrystallization while eight cycloartane-type triterpenes(1-8)were isolated from the mother liquid.The chemical structures of new compounds(1-4)were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses.Moreover,new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC_(50) values ranging from 4.02 to 15.80μM.

A new triterpenoid saponin from Clematis ganpiniana

A new triterpenoid saponin, named clematiganoside A (1), was isolated from the whole plant of Clematis ganpiniana. Its structure was elucidated on the basis of 1D, 2D NMR, TOF-MS and ESI-MS techniques, and physicochemical properties.

A new bidesmoside triterpenoid saponin from Stauntonia chinensis

A new bidesmoside triterpenoid saponin, named stauntoside C1 （1） has been isolated from Stauntonia chinensis. Its structure was established by means of spectral and chemical methods. C 2009 Guo Ping Zhou. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM.

Two new triterpenoid saponins from Rhaponticum uniflorum

Two new triterpenoid saponins were isolated from the roots ofRhaponticum uniflorum. Their structures were elucidated as 3-O- [β-D-glucopyranosyl]-ilexolic acid-28-O-[β-D-glucopyranosyl] ester 1 and 3-O-[β-D-glucopyranosyl]-urs-12, 19 （29）-dien-oic acid-28-O-[β-b-glucopyranosyl] ester 2 mainly by 1D, 2D NMR techniques and chemical methods.

A New Triterpenoid Saponin from the Seeds of Deccaria segetalis

A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis. On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as:olean-12-ene-23a, 286-dioic acid 36, 16a-dihydroxy-28-O- [βD-glucopyranosyl-(1 →3)]-β-D-glucopyra-nosyl-(l →2)-β-D-glucopyranosyl-(l→6)-β-D- glucopyranoside(1).

Triterpenoid Saponins from Clematis tangutica

Two new triterpenoid saponins, tanguticoside A and B were isolated from aerial part of Clematis tangutica. Their structures were elucidated as 3-O-beta-D-glucopyranosyl hederagenin 28 O-alpha-L-rhamnopyranosyl- (1-->4)-beta-D-glucopyranosyl- (1-->6)-beta-D-glucopyranosidel and 3-O-beta-D-glucopyranosyl ranosyl- (1-->2)-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl- (1-->4)-beta-D-glucopyranosyl- (1-->6)-beta-D-glucopyranoside2, respectively.

A NEW TRITERPENOID SAPONIN, ASTERYUNNANOSIDE H, FROM ASTER YUNNANENSIS

A new echinocystic acid saponin, asteryunnanoside H (1), has been isolated from the roots of Astsr yunnanensis (Compositae). The structure and the unambiguous assignments of the 1H- and 13C NMR data of 1 were obtained based on extensive use of 1D and 2D NMR techniques (COSY. TOCSY, ROESY, HMQC and HMBC), and chemical transformations.

Three New Triterpenoid Saponins from the Seeds of Aesculus chinensis

Three new triterpenoid saponins, escins IVc (1), IVd (2) and IVf (3) were isolated from the seeds of Aesculus chinensis. They were. determined as 22 alpha-tigloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyranosyl (1-->4)]-beta-D-glucopyranosiduronic acid 1, 22 alpha-angeloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyrano- syl (1-->4)]-beta-D-glucopyranosiduronic acid 2 and 28-tigloyl protoaescigenin-3 beta-O- [beta-D-gluco-pyranosyl (12)] [beta-D-glucopyranosyl (1-->4)] -beta-D-glucopyranosiduronic acid 3.

ASTERYUNNANOSIDE E,A NEW TRITERPENOID SAPONIN FROM ASTER YUNNANENSIS FRANCH

A new oleanane-type triterpene saponin. asteryunnanoside E. has been isolated from the roots of Astir yunnanensis Franch. and its structure elucidated as 3-O-β-D-glucopyranosyl-bayogenin-28-O-β-glucopyranoside by means of spectral data particularly 2D NMR including COSY. HETCOR, HOHAHA and ROESY techniques and chemical transformation.

A Triterpenoid Saponin from Polycarpon prostratum

A new triterpenoid saponin, named prostratoside A. was isolated from the whole plants of Polycarpon prostratum. Its structure nas determined to be 3-O-{beta-D-xylopyranosyl- (1-->2)- beta-D-glucopranosyl-(1-->4)-[ beta- D-plucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl}- 22 alpha- acetoxy saikogenin G by spectroscopic methods..

A New Triterpenoid Saponin: Se-saponin A

A new triterpenoid saponin, se-saponin A, was isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Its structure was determined by spectral and chemical methods. Only one triterpenoid saponin has been isolated from Clerodendrum genus before. Se-saponin A is the second instance.