BACKGROUND Femoral trochlear dysplasia(FTD)is an important risk factor for patellar instability.Dejour classification is widely used at present and relies on standard lateral X-rays,which are not common in clinical wo...BACKGROUND Femoral trochlear dysplasia(FTD)is an important risk factor for patellar instability.Dejour classification is widely used at present and relies on standard lateral X-rays,which are not common in clinical work.Therefore,magnetic resonance imaging(MRI)has become the first choice for the diagnosis of FTD.However,manually measuring is tedious,time-consuming,and easily produces great variability.AIM To use artificial intelligence(AI)to assist diagnosing FTD on MRI images and to evaluate its reliability.METHODS We searched 464 knee MRI cases between January 2019 and December 2020,including FTD(n=202)and normal trochlea(n=252).This paper adopts the heatmap regression method to detect the key points network.For the final evaluation,several metrics(accuracy,sensitivity,specificity,etc.)were calculated.RESULTS The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of the AI model ranged from 0.74-0.96.All values were superior to junior doctors and intermediate doctors,similar to senior doctors.However,diagnostic time was much lower than that of junior doctors and intermediate doctors.CONCLUSION The diagnosis of FTD on knee MRI can be aided by AI and can be achieved with a high level of accuracy.展开更多
Objective To anatomically reconstruct the oculomotor nerve, trochlear nerve, and abducent nerve by skull base surgery. Methods Seventeen cranial nerves (three oculomotor nerves, eight trochlear nerves and six abducent...Objective To anatomically reconstruct the oculomotor nerve, trochlear nerve, and abducent nerve by skull base surgery. Methods Seventeen cranial nerves (three oculomotor nerves, eight trochlear nerves and six abducent nerves) were injured and anatomically reconstructed in thirteen skull base operations during a period from 1994 to 2000. Repair techniques included end-to-end neurosuture or fibrin glue adhesion, graft neurosuture or fibrin glue adhesion. The relationships between repair techniques and functional recovery and the related factors were analyzed.Results Functional recovery began from 3 to 8 months after surgery. During a follow-up period of 4 months to 6 years, complete recovery of function was observed in 6 trochlear nerves (75%) and 4 abducent nerves (67%), while partial functional recovery was observed in the other cranial nerves including 2 trochlear nerves, 2 abducent nerves, and 3 oculomotor nerves.Conclusions Complete or partial functional recovery could be expected after anatomical neurotization of an injured oculomotor, trochlear or abducent nerve. Our study demonstrated that, in terms of functional recovery, trochlear and abducent nerves are more responsive than oculomotor nerves, and that end-to-end reconstruction is more efficient than graft reconstruction. These results encourage us to perform reconstruction for a separated cranial nerve as often as possible during skull base surgery.展开更多
【目的】探究犬脐带间充质干细胞(UC-MSCs)联合滑车沟再造术对髌骨脱位治疗的效果。【方法】将20只髌骨脱位患犬随机分为干细胞治疗组和常规手术组,每组10只。手术当天,干细胞治疗组关节腔注射0.5 mL UC-MSCs(106/kg)混悬液,常规手术组...【目的】探究犬脐带间充质干细胞(UC-MSCs)联合滑车沟再造术对髌骨脱位治疗的效果。【方法】将20只髌骨脱位患犬随机分为干细胞治疗组和常规手术组,每组10只。手术当天,干细胞治疗组关节腔注射0.5 mL UC-MSCs(106/kg)混悬液,常规手术组注入等量生理盐水,通过收集患犬基础信息、回访跟踪记录,检测血常规和血液因子含量以及影像学等方法评估犬UC-MSCs的治疗效果。【结果】与常规手术组对比,术后第1、7天干细胞治疗组白细胞介素-6(IL-6)含量极显著或显著降低(P<0.01;P<0.05),两组间转化生长因子-β1(TGF-β1)、基质金属蛋白酶13(MMP-13)及肿瘤坏死因子α(TNF-α)和白细胞总数、中性粒细胞总数均无显著差异(P>0.05)。术后第30天数字X线摄影复查结果显示,干细胞治疗组关节腔清晰,骨损位置有明显的软骨及骨组织生长,无再次脱出和关节炎等并发症。常规手术组的骨损伤处骨生长情况缓慢,2例患犬髌骨再次脱位(2/10)。【结论】滑车沟再造术后,在常规术后护理(使用抗炎、抗菌和止疼药物)条件下,关节腔内注射UC-MSCs能促进软骨和骨组织生长,降低再次脱出发生的风险。UC-MSCs联合滑车沟再造术能提升犬髌骨脱位的临床治疗效果。展开更多
Patellofemoral instability(PI)is the disruption of the patella’s relationship with the trochlear groove as a result of abnormal movement of the patella.To identify the presence of PI,conventional radiographs(anteropo...Patellofemoral instability(PI)is the disruption of the patella’s relationship with the trochlear groove as a result of abnormal movement of the patella.To identify the presence of PI,conventional radiographs(anteroposterior,lateral,and axial or skyline views),magnetic resonance imaging,and computed tomography are used.In this study,we examined four main instability factors:Trochlear dysplasia,patella alta,tibial tuberosity–trochlear groove distance,and patellar tilt.We also briefly review some of the other assessment methods used in the quantitative and qualitative assessment of the patellofemoral joint,such as patellar size and shape,lateral trochlear inclination,trochlear depth,trochlear angle,and sulcus angle,in cases of PI.In addition,we reviewed the evaluation of coronal alignment,femoral anteversion,and tibial torsion.Possible causes of error that can be made when evaluating these factors are examined.PI is a multi-factorial problem.Many problems affecting bone structure and muscles morphologically and functionally can cause this condition.It is necessary to understand normal anatomy and biomechanics to make more accurate radiological measurements and to identify causes.Knowing the possible causes of measurement errors that may occur during radiological measurements and avoiding these pitfalls can provide a more reliable road map for treatment.This determines whether the disease will be treated medically and with rehabilitation or surgery without causing further complications.展开更多
Objective To study the neural, arterial and venous relationship in the middle incisural space in the region of the tentorial incisura and to determine the important clinical anatomical landmarks of these important neu...Objective To study the neural, arterial and venous relationship in the middle incisural space in the region of the tentorial incisura and to determine the important clinical anatomical landmarks of these important neurovascular structures. Methods Twenty adult cadaveric heads were examined using ×6 to ×40 magnification after perfusing the arteries and veins with colored latex and the relationship of the neural structures, arteries, veins were observed. The distances between the important neursovascular structures and landmarks were measured. Results The important cranial nerves related to the middle incisural space of the tentorial incisura are the oculomotor, the trochlear and the trigeminal nerves. And the important arteries related to the middle incisural space are posterior cerebral arteries and superior cerebellar arteries. The entrance site of oculomotor nerve to the roof of the cavernous sinus located at (11.2±4.3) mm posterior to the anterior clinoid process, (4.4±1.4) mm lateroposterior posterior to the posterior clinoid process. The entrance site of trochlear nerver located at (23.3 ± 3.0) mm posterior to anterior clinoid process, (14.5±3.9) mm lateroposterior posterior to the posterior clinoid process. The entrance site of oculomotor nerve located at (6.3±1.6) mm posterior to the supraclinoid portion of internal carotid artery, while that of the trochlear nerve at ((17.9±3.5)) mm to the supraclinoid portion of internal carotid artery. The entrance site of trochlear nerve located at (11.5±3.0) mm posterior to the entrance site of oculomotor nerve. Conclusions Anterior, posterior clinoid process and the supraclinoid portion of internal carotid artery are the important landmarks for the entrance site of the oculomotor and trochlear nerve. The superior cerebellar artery, the posterior cerebral artery and its important branches including the medial posterior choroidal artery and the long circumflex branch are all closely related to the middle incisural space, and should not be injured during operation.展开更多
Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehen...Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehensive measure of its severity. In this study, we designed the Ocular Motor Nerve Palsy Scale and investigated its validity and reliability. Six experts were invited to grade and evaluate the scale. The study recruited 106 patients with a definite diagnosis of unilateral isolated ocular motor nerve palsy. Three physicians evaluated the patients using the scale. One of the three physicians evaluated the patients again after 24 hours. The content validity index（CVI） and factor analysis were used to analyze the scale＇s construct validity. The intraclass correlation coefficient and Cronbach＇s alpha were used to evaluate the inter-rater and test-retest reliability and the internal consistency. The CVI results（I-CVI = 1.0, S-CVI = 0.9, Pc = 0.016, K＊ = 1） indicated good content validity. Factor analysis extracted two common factors that accounted for 85.2% of the variance. Furthermore, the load value of each component was above 0.8, indicating good construct validity. The Ocular Motor Nerve Palsy Scale was found to be highly reliable, with an inter-rater reliability intraclass correlation coefficient of 0.965（P 0.01）, a test-retest reliability intraclass correlation coefficient of 0.976（P 0.01）, and Cronbach＇s alpha values of 0.63–0.70. In conclusion, the Ocular Motor Nerve Palsy Scale with good validity and reliability can be used to quantify the severity of ocular motor nerve palsy. This study was registered at Chinese Clinical Trial Registry（registration number： Chi CTR-OOC-17010702）.展开更多
文摘BACKGROUND Femoral trochlear dysplasia(FTD)is an important risk factor for patellar instability.Dejour classification is widely used at present and relies on standard lateral X-rays,which are not common in clinical work.Therefore,magnetic resonance imaging(MRI)has become the first choice for the diagnosis of FTD.However,manually measuring is tedious,time-consuming,and easily produces great variability.AIM To use artificial intelligence(AI)to assist diagnosing FTD on MRI images and to evaluate its reliability.METHODS We searched 464 knee MRI cases between January 2019 and December 2020,including FTD(n=202)and normal trochlea(n=252).This paper adopts the heatmap regression method to detect the key points network.For the final evaluation,several metrics(accuracy,sensitivity,specificity,etc.)were calculated.RESULTS The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of the AI model ranged from 0.74-0.96.All values were superior to junior doctors and intermediate doctors,similar to senior doctors.However,diagnostic time was much lower than that of junior doctors and intermediate doctors.CONCLUSION The diagnosis of FTD on knee MRI can be aided by AI and can be achieved with a high level of accuracy.
基金ThisstudywassupportedbyagrantfromtheChineseNationalNaturalScienceFoundation (No .3 0 0 0 0 170 )
文摘Objective To anatomically reconstruct the oculomotor nerve, trochlear nerve, and abducent nerve by skull base surgery. Methods Seventeen cranial nerves (three oculomotor nerves, eight trochlear nerves and six abducent nerves) were injured and anatomically reconstructed in thirteen skull base operations during a period from 1994 to 2000. Repair techniques included end-to-end neurosuture or fibrin glue adhesion, graft neurosuture or fibrin glue adhesion. The relationships between repair techniques and functional recovery and the related factors were analyzed.Results Functional recovery began from 3 to 8 months after surgery. During a follow-up period of 4 months to 6 years, complete recovery of function was observed in 6 trochlear nerves (75%) and 4 abducent nerves (67%), while partial functional recovery was observed in the other cranial nerves including 2 trochlear nerves, 2 abducent nerves, and 3 oculomotor nerves.Conclusions Complete or partial functional recovery could be expected after anatomical neurotization of an injured oculomotor, trochlear or abducent nerve. Our study demonstrated that, in terms of functional recovery, trochlear and abducent nerves are more responsive than oculomotor nerves, and that end-to-end reconstruction is more efficient than graft reconstruction. These results encourage us to perform reconstruction for a separated cranial nerve as often as possible during skull base surgery.
文摘【目的】探究犬脐带间充质干细胞(UC-MSCs)联合滑车沟再造术对髌骨脱位治疗的效果。【方法】将20只髌骨脱位患犬随机分为干细胞治疗组和常规手术组,每组10只。手术当天,干细胞治疗组关节腔注射0.5 mL UC-MSCs(106/kg)混悬液,常规手术组注入等量生理盐水,通过收集患犬基础信息、回访跟踪记录,检测血常规和血液因子含量以及影像学等方法评估犬UC-MSCs的治疗效果。【结果】与常规手术组对比,术后第1、7天干细胞治疗组白细胞介素-6(IL-6)含量极显著或显著降低(P<0.01;P<0.05),两组间转化生长因子-β1(TGF-β1)、基质金属蛋白酶13(MMP-13)及肿瘤坏死因子α(TNF-α)和白细胞总数、中性粒细胞总数均无显著差异(P>0.05)。术后第30天数字X线摄影复查结果显示,干细胞治疗组关节腔清晰,骨损位置有明显的软骨及骨组织生长,无再次脱出和关节炎等并发症。常规手术组的骨损伤处骨生长情况缓慢,2例患犬髌骨再次脱位(2/10)。【结论】滑车沟再造术后,在常规术后护理(使用抗炎、抗菌和止疼药物)条件下,关节腔内注射UC-MSCs能促进软骨和骨组织生长,降低再次脱出发生的风险。UC-MSCs联合滑车沟再造术能提升犬髌骨脱位的临床治疗效果。
文摘Patellofemoral instability(PI)is the disruption of the patella’s relationship with the trochlear groove as a result of abnormal movement of the patella.To identify the presence of PI,conventional radiographs(anteroposterior,lateral,and axial or skyline views),magnetic resonance imaging,and computed tomography are used.In this study,we examined four main instability factors:Trochlear dysplasia,patella alta,tibial tuberosity–trochlear groove distance,and patellar tilt.We also briefly review some of the other assessment methods used in the quantitative and qualitative assessment of the patellofemoral joint,such as patellar size and shape,lateral trochlear inclination,trochlear depth,trochlear angle,and sulcus angle,in cases of PI.In addition,we reviewed the evaluation of coronal alignment,femoral anteversion,and tibial torsion.Possible causes of error that can be made when evaluating these factors are examined.PI is a multi-factorial problem.Many problems affecting bone structure and muscles morphologically and functionally can cause this condition.It is necessary to understand normal anatomy and biomechanics to make more accurate radiological measurements and to identify causes.Knowing the possible causes of measurement errors that may occur during radiological measurements and avoiding these pitfalls can provide a more reliable road map for treatment.This determines whether the disease will be treated medically and with rehabilitation or surgery without causing further complications.
文摘Objective To study the neural, arterial and venous relationship in the middle incisural space in the region of the tentorial incisura and to determine the important clinical anatomical landmarks of these important neurovascular structures. Methods Twenty adult cadaveric heads were examined using ×6 to ×40 magnification after perfusing the arteries and veins with colored latex and the relationship of the neural structures, arteries, veins were observed. The distances between the important neursovascular structures and landmarks were measured. Results The important cranial nerves related to the middle incisural space of the tentorial incisura are the oculomotor, the trochlear and the trigeminal nerves. And the important arteries related to the middle incisural space are posterior cerebral arteries and superior cerebellar arteries. The entrance site of oculomotor nerve to the roof of the cavernous sinus located at (11.2±4.3) mm posterior to the anterior clinoid process, (4.4±1.4) mm lateroposterior posterior to the posterior clinoid process. The entrance site of trochlear nerver located at (23.3 ± 3.0) mm posterior to anterior clinoid process, (14.5±3.9) mm lateroposterior posterior to the posterior clinoid process. The entrance site of oculomotor nerve located at (6.3±1.6) mm posterior to the supraclinoid portion of internal carotid artery, while that of the trochlear nerve at ((17.9±3.5)) mm to the supraclinoid portion of internal carotid artery. The entrance site of trochlear nerve located at (11.5±3.0) mm posterior to the entrance site of oculomotor nerve. Conclusions Anterior, posterior clinoid process and the supraclinoid portion of internal carotid artery are the important landmarks for the entrance site of the oculomotor and trochlear nerve. The superior cerebellar artery, the posterior cerebral artery and its important branches including the medial posterior choroidal artery and the long circumflex branch are all closely related to the middle incisural space, and should not be injured during operation.
基金supported by the National Natural Science Foundation of China,No.81674052
文摘Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehensive measure of its severity. In this study, we designed the Ocular Motor Nerve Palsy Scale and investigated its validity and reliability. Six experts were invited to grade and evaluate the scale. The study recruited 106 patients with a definite diagnosis of unilateral isolated ocular motor nerve palsy. Three physicians evaluated the patients using the scale. One of the three physicians evaluated the patients again after 24 hours. The content validity index（CVI） and factor analysis were used to analyze the scale＇s construct validity. The intraclass correlation coefficient and Cronbach＇s alpha were used to evaluate the inter-rater and test-retest reliability and the internal consistency. The CVI results（I-CVI = 1.0, S-CVI = 0.9, Pc = 0.016, K＊ = 1） indicated good content validity. Factor analysis extracted two common factors that accounted for 85.2% of the variance. Furthermore, the load value of each component was above 0.8, indicating good construct validity. The Ocular Motor Nerve Palsy Scale was found to be highly reliable, with an inter-rater reliability intraclass correlation coefficient of 0.965（P 0.01）, a test-retest reliability intraclass correlation coefficient of 0.976（P 0.01）, and Cronbach＇s alpha values of 0.63–0.70. In conclusion, the Ocular Motor Nerve Palsy Scale with good validity and reliability can be used to quantify the severity of ocular motor nerve palsy. This study was registered at Chinese Clinical Trial Registry（registration number： Chi CTR-OOC-17010702）.
