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Stem cells tropism for malignant gliomas
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作者 徐锋 朱剑虹 《Neuroscience Bulletin》 SCIE CAS CSCD 2007年第6期363-369,共7页
Various studies have demonstrated the tremendous tropism of stem cells for malignant gliomas,making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells.However,little is know... Various studies have demonstrated the tremendous tropism of stem cells for malignant gliomas,making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells.However,little is known about the mechanisms underlying the glioma-induced tropism of stem cells.Soluble factors including chemokines or growth factors released and expressed by glioma cells at least mediate the tropism of stem cells for gliomas.Here we review the possible mechanisms of stem cells tropism for malignant gliomas. 展开更多
关键词 stem cell tropism GLIOMA
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Selective tropism of liver stem cells to hepatocellular carcinoma in vivo 被引量:10
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作者 Xiao-Gang Zhong Sheng He +2 位作者 Wu Yin Jing-Yu Deng Bo Cheng 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第28期3886-3891,共6页
AIM: To investigate the selective tropism of liver stem cells to hepatocellular carcinoma (HCC) in an animal model and its feasibility as a vector to deliver therapeutic genes for targeted therapy of HCC.METHODS: ... AIM: To investigate the selective tropism of liver stem cells to hepatocellular carcinoma (HCC) in an animal model and its feasibility as a vector to deliver therapeutic genes for targeted therapy of HCC.METHODS: WB-F344, a kind of rat liver stem cell, was infected with recombinant virus to establish a cell line with stable, high-level expressing enhanced green fluorescent protein (EGFP). An animal model of HCC in Wistar rats was established by implanting HCC cells (CBRH7919) combined with an immunosuppressive drug. EGFP labeled liver stern cells were injected into caudal veins of the animals and distribution was observed at different time points after injection. SDF-1 and c-kit expression in non-tumor liver and tumor tissue were analysed by immunohistochemistry for the relationshiop between the expression and migration of liver stem cells. Furthermore, hepatic stern cells were injected via the portal vein, hepatic artery, caudal vein, or directly into the pericancerous liver tissue, respectively, and effects on migration, localization, and proliferation of the hepatic stern cells within the tumor tissue were observed and analyzed.RESULTS: Recombinant adenovirus could deliver the EGFP gene to hepatic stem cells. A new stem cell line, named WB-EGFP, was established that stably expressed EGFP. WB-EGFP cells still showed selective tropism towards HCC and EGFP expression was stable in vivo. According to immunohistochemistry results, SDF-1 may not be related to the mechanisms of tropism of hepatic stem cells. Different application sites affected the distribution of liver stem cells. Injection via the portal vein was superior with regard to selective migration, localization, and proliferation of the hepatic stem cells within the tumor tissue.CONCLUSION: Liver stem cells have the biological behavior of selective migration to HCC in vivo and they could localize and proliferate within HCC tissue stably expressing the target gene. Liver stem cells are a potential tool for a targeted gene therapy of HCC. 展开更多
关键词 LIVER Stem cells Hepatocellular carcinoma VECTOR tropism Gene therapy
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Tissue tropism and parasite burden of Toxoplasma gondii RH strain in experimentally infected mice 被引量:3
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作者 Yousef Dadimoghaddam Ahmad Daryani +2 位作者 Mehdi Sharif Ehsan Ahmadpour Zahra Hossienikhah 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第7期521-524,共4页
Objective:To evaluate parasite distribution and tissue tropism of Toxoplasma gondii tachyzoites in experimentally infected mice using real time QPCR.Methods:In this survey 16 Balb/c mice were inoculated with 1×10... Objective:To evaluate parasite distribution and tissue tropism of Toxoplasma gondii tachyzoites in experimentally infected mice using real time QPCR.Methods:In this survey 16 Balb/c mice were inoculated with 1×10~4 alive tachyzoites of Toxoplasma gondii RH strain.After 1,2,3 days post infection and the last day(before death),different tissues of mice including blood,brain,eye,liver,spleen,kidney,heart and muscle were harvested.Following tissues DNA extraction,the parasite burden was quantified using real time QPCR targeting the B1 gene(451 bp).Results:It showed that Toxoplasma after intraperitoneal injection was able to movement to various tissues in24 hours.Parasite burden was high in all tissues but the most number of parasites were observed in kidney,heart and liver,respectively.Conclusions:These data provide significant baseline information about Toxoplasma pathogenesis,vaccine monitoring and drug efficiency. 展开更多
关键词 PARASITE BURDEN TOXOPLASMA GONDII Tissue tropism Quantitative PCR MURINE model
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Influence of Tourists′ Environmental Tropisms on Their Attitudes to Tourism and Nature Conservation in Natural Tourist Destinations: A Case Study of Jiuzhaigou National Park in China 被引量:5
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作者 CHENG Shaowen ZHANG Jie +2 位作者 LU Shaojing XU Feifei ZHANG Honglei 《Chinese Geographical Science》 SCIE CSCD 2011年第3期377-384,共8页
People′s environmental tropism has an effect on their understanding of tourism-nature relationship,and also influences their attitudes to natural resources utilization and environmental protection.Taking Jiuzhaigou N... People′s environmental tropism has an effect on their understanding of tourism-nature relationship,and also influences their attitudes to natural resources utilization and environmental protection.Taking Jiuzhaigou National Park of China as a study case,the authors conducted some quantitative analyses with the tools of SPSS 16.0 and LISREL 8.7,to explore the influence of tourists′ environmental tropism on their attitudes to tourism and nature conservation in the natural tourist destination.Three hypotheses and the theoretic model of influences of tourists′ environmental tropism on their attitudes to tourism and nature conservation have been tested and accepted based on the Structural Equation Model analysis on survey data collected in Jiuzhaigou National Park of China.Some conclusions were drawn as follows: 1) tourists′ human-prioritized concept influences their cognition to tourism-nature relationship.This concept has a positive influence on their supportive attitudes to tourism,but a negative influence on their attitudes to nature conservation;2) tourists′ human-nature coordination concept has a positive influence on their supportive attitudes to both tourism and nature conservation,especially to the latter.This paper generally proves that human′s environmental tropism does have an influence on their attitudes to tourism and nature conservation in natural tourist destinations. 展开更多
关键词 environmental tropism nature conservation natural tourist destination tourism-nature relationship Jiuz- haigou National Park
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Analysis of the Tropism and Anti-Bacterial Potential of a Type of Clay
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作者 Cassio Ilan Soares Medeiros Erica Renata Nogueira Sa +3 位作者 Juliana Raquel de Morais Santos Oliveira Lis Magalhaes Geraldo Goncalves de Almeida Filho Hilzeth de Luna Freire Pessoa 《Open Journal of Medical Microbiology》 2014年第2期140-145,共6页
Natural clays have been used by man in infections of bacterial etiology, since the first historical registers. Our attention turned to a red-colored clay, known in the northeast of Brazil as “barro de lou&#231a”... Natural clays have been used by man in infections of bacterial etiology, since the first historical registers. Our attention turned to a red-colored clay, known in the northeast of Brazil as “barro de lou&#231a” (dish clay). These clays and other natural earth materials seem interesting to us, as the blockage of the liberation of toxins or inactivation, may be related to the interruption of infection cycles in the skin and mucous membranes. The adsorptive and absorptive properties of the mineral clays are well documented in the cure process of skin and gastrointestinal diseases. Susceptibility and bacterial tropism tests were carried out. The results were analyzed and interpreted according to the conventional microbiological protocol. The bacterial strains, Staphylococcus aureus, Escherichia coli e Pseudomonas aeruginosa, did not present a susceptibility profile to an isotonic solution of clay, but there was an increase of the bacterial tropism as the concentration of the isotonic solution was increased, being the minimal observed concentration of 100 mg/mL. Our aim is to document a type of red clay from the northeast of Brazil with possible attraction properties (Tropism) to bacteria and their toxins. 展开更多
关键词 Red Clay Bacterial tropism Bacterial Resistance
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Investigation of the differences between the “COLD” and “HOT” nature of Coptis chinensis Franch and its processed materials based on animal’s temperature tropism 被引量:11
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作者 ZHOU CanPing1,2, WANG JiaBo1, ZHANG XueRu1,2, ZHAO YanLing1, XIA XinHua2, ZHAO HaiPing1, REN YongShen1 & XIAO XiaoHe1 1 China Military Institute of Chinese Meteria Medica, 302 Military Hospital of China, Beijing 100039, China 2 College of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China 《Science China(Life Sciences)》 SCIE CAS 2009年第11期1073-1080,共8页
The description and differentiation of the so-called "Cold" and "Hot" natures, the primary "Drug Naure" of Chinese medicine, is the focus of theoretical research. In this study, the diver... The description and differentiation of the so-called "Cold" and "Hot" natures, the primary "Drug Naure" of Chinese medicine, is the focus of theoretical research. In this study, the divergency between the "Cold" and the "Hot" natures was investigated through examining the temperature tropism of mice affected by Coptis chinensis Franch and its processed materials by using a cold/hot plate differentiating technology. After exposure to C. chinensis Franch, the macroscopic behavioral index of the remaining rate (RR) on a warm pad (40℃ ) significantly increased (P<0.05), suggesting the enhancement of Hot tropism. The internal indexes of adenosine triphosphatase (ATPase) activity and oxygen consuming volume decreased significantly (P<0.05), suggesting the decapability of energy metabolism. This external behavior of Hot tropism might reflect the internal Cold nature of C. chinensis Franch. However, the processed materials of C. chinensis Franch exhibited a different Cold nature in temperature tropism compared with crude C. chinensis Franch (CC): the Cold nature of bile-processed C. chinensis Franch (BC) enhanced while the ginger-processed C. chinensis Franch (GC) changed inversely. The changing sequence was consistent with the theoretical prognostication. It is indicated that the external Cold & Hot natures of Chinese medicine may possibly reflect in an ethological way for the changes of animal’s temperature tropism which might be internally regulated by the body’s energy metabolism. 展开更多
关键词 "Cold" and "Hot" natures of Chinese medicine evaluation TEMPERATURE tropism ETHOLOGY DRUG process Coptis CHINENSIS Franch
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Tissue and host tropism of influenza viruses:Importance of quantitative analysis 被引量:7
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作者 ZHANG Hong1,2 1 Z-BioMed, Inc., Rockville, MD 20855, USA 2 Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China 《Science China(Life Sciences)》 SCIE CAS 2009年第12期1101-1110,共10页
It is generally accepted that human influenza viruses preferentially bind to cell-surface glycoproteins/ glycolipids containing sialic acids in α2,6-linkage; while avian and equine influenza viruses preferentially bi... It is generally accepted that human influenza viruses preferentially bind to cell-surface glycoproteins/ glycolipids containing sialic acids in α2,6-linkage; while avian and equine influenza viruses preferentially bind to those containing sialic acids in α2,3-linkage. Even though this generalized view is accurate for H3 subtype isolates, it may not be accurate and absolute for all subtypes of influenza A viruses and, therefore, needs to be reevaluated carefully and realistically. Some of the studies published in major scientific journals on the subject of tissue tropism of influenza viruses are inconsistent and caused confusion in the scientific community. One of the reasons for the inconsistency is that most studies were quantitative descriptions of sialic acid receptor distributions based on lectin or influenza virus immunohistochemistry results with limited numbers of stained cells. In addition, recent studies indicate that α2,3- and α2,6-linked sialic acids are not the sole receptors determining tissue and host tropism of influenza viruses. In fact, determinants for tissue and host tropism of human, avian and animal influenza viruses are more complex than what has been generally accepted. Other factors, such as glycan topology, concentration of invading viruses, local density of receptors, lipid raft microdomains, coreceptors or sialic acid-independent receptors, may also be important. To more efficiently control the global spread of pandemic influenza such as the current circulating influenza A H1N1, it is crucial to clarify the determinants for tissue and host tropism of influenza viruses through quantitative analysis of experimental results. In this review, I will comment on some conflicting issues related to tissue and host tropism of influenza viruses, discuss the importance of quantitative analysis of lectin and influenza virus immunohistochemistry results and point out directions for future studies in this area, which should lead to a better understanding of tissue and host tropism of influenza viruses. 展开更多
关键词 TISSUE and HOST tropism INFLUENZA viruses sialic acid RECEPTORS quantitative analysis
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Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection 被引量:9
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作者 Rongjuan Pei Jianqi Feng +12 位作者 Yecheng Zhang Hao Sun Lian Li Xuejie Yang Jiangping He Shuqi Xiao Jin Xiong Ying Lin Kun Wen Hongwei Zhou Jiekai Chen Zhili Rong Xinwen Chen 《Protein & Cell》 SCIE CSCD 2021年第9期717-733,共17页
The coronavirus disease 2019(COVID-19)pandemic is caused by infection with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is spread primary via respiratory droplets and infects the lungs.Current... The coronavirus disease 2019(COVID-19)pandemic is caused by infection with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is spread primary via respiratory droplets and infects the lungs.Currently widely used cell lines and animals are unable to accurately mimic human physiological conditions because of the abnormal status of cell lines(transformed or cancer cells)and species differences between animals and humans.Organoids are stem cell-derived selforganized three-dimensional culture in vitro and model the physiological conditions of natural organs.Here we showed that SARS-CoV-2 infected and extensively replicated in human embryonic stem cells(hESCs)-derived lung organoids,including airway and alveolar organoids which covered the complete infection and spread route for SARS-CoV-2 within lungs.The infected ceils were ciliated,club,and alveolar type 2(AT2)cells,which were sequentially located from the proximal to the distal airway and terminal alveoli,respectively.Additionally,RNA-seq revealed early cell response to virus infection including an unexpected downregulation of the metabolic processes,especially lipid metabolism,in addition to the well-known upregulation of immune response.Further,Remdesivir and a human neutralizing antibody potently inhibited SARS-CoV-2 replication in lung organoids.Therefore,human lung organoids can serve as a pathophysiological model to investigate the underlying mechanism of SARS-CoV-2 infection and to discover and test therapeutic drugs for COVID-19. 展开更多
关键词 COVID-19 SARS-CoV-2 lung organoids cell tropism cellular metabolism drug discovery
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Complex positive selection pressures drive the evolution of HIV-1 with different co-receptor tropisms 被引量:5
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作者 ZHANG ChiYu DING Na +1 位作者 CHEN KePing YANG RongGe 《Science China(Life Sciences)》 SCIE CAS 2010年第10期1204-1214,共11页
HIV-1 co-receptor tropism is central for understanding the transmission and pathogenesis of HIV-1 infection. We performed a genome-wide comparison between the adaptive evolution of R5 and X4 variants from HIV-1 subtyp... HIV-1 co-receptor tropism is central for understanding the transmission and pathogenesis of HIV-1 infection. We performed a genome-wide comparison between the adaptive evolution of R5 and X4 variants from HIV-1 subtypes B and C. The results showed that R5 and X4 variants experienced differential evolutionary patterns and different HIV-1 genes encountered various positive selection pressures, suggesting that complex selection pressures are driving HIV-1 evolution. Compared with other hypervariable regions of Gp120, significantly more positively selected sites were detected in the V3 region of subtype B X4 variants, V2 region of subtype B R5 variants, and V1 and V4 regions of subtype C X4 variants, indicating an association of positive selection with co-receptor recognition/binding. Intriguingly, a significantly higher proportion (33.3% and 55.6%, P【0.05) of positively selected sites were identified in the C3 region than other conserved regions of Gp120 in all the analyzed HIV-1 variants, indicating that the C3 region might be more important to HIV-1 adaptation than previously thought. Approximately half of the positively selected sites identified in the env gene were identical between R5 and X4 variants. There were three common positively selected sites (96, 113 and 281) identified in Gp41 of all X4 and R5 variants from subtypes B and C. These sites might not only suggest a functional importance in viral survival and adaptation, but also imply a potential cross-immunogenicity between HIV-1 R5 and X4 variants, which has important implications for AIDS vaccine development. 展开更多
关键词 HIV-1 co-receptor tropism adaptive evolution positively selected site R5 and X4 GP120 EPITOPES
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Different meridian tropism in three Chinese medicines: Tinglizi(Semen Lepidii Apetali), Yiyiren(Semen Coicis), Cheqianzi(Semen Plantaginis) 被引量:4
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作者 Zeng Mengnan Li Miao +4 位作者 Zhang Li Zhang Beibei Wu Guangcao Feng Weisheng Zheng Xiaoke 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2019年第2期213-220,共8页
OBJECTIVE: To study the meridian tropism(MT) for three Chinese medicines: Tinglizi(Semen Lepidii Apetali, TLZ), Yiyiren(Semen Coicis, YYR), Cheqianzi(Semen Plantaginis, CQZ) in vivo experiments.METHODS: The extracts o... OBJECTIVE: To study the meridian tropism(MT) for three Chinese medicines: Tinglizi(Semen Lepidii Apetali, TLZ), Yiyiren(Semen Coicis, YYR), Cheqianzi(Semen Plantaginis, CQZ) in vivo experiments.METHODS: The extracts of TLZ,YYR, CQZ were orally administered to rats at a dose 234, 700 and 350 mg/kg, respectively. The urinary excretion rate, loss in weight of rats and the electrolyte levels in the plasma were measured, in order to assess the mechanisms of the three traditional Chinese diuretic medicines.RESULTS: TLZ, YYR and CQZ exhibited obvious diuretic effect and reduced the weight of saline-loaded animals. All the three diuretic medicines differentially reduced various serum, urinary, lung, stomach, kidney and hormonal markers, thus indicating the different mechanisms of action and a close resemblance with their different meridian as per the MT theory.CONCLUSION: Our findings suggest that the three Traditional Chinese Medicine(TCM) medicines-TLZ,YYR and CQZ-possess different Shamisen meridian.This can support the regimen of treating the same disease with different therapies in TCM theory. 展开更多
关键词 Medicine Chinese traditional DIURETICS MERIDIAN tropism
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Understanding channel tropism in traditional Chinese medicine in the context of systems biology 被引量:2
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作者 Ping Liu Songlin Liu +1 位作者 Gang Chen Ping Wang 《Frontiers of Medicine》 SCIE CSCD 2013年第3期277-279,共3页
Channel tropism is investigated and developed through long-term clinical practice.In recent years,the development of channel tropism theory has attracted increasing attention.This study analyzed channel tropism theory... Channel tropism is investigated and developed through long-term clinical practice.In recent years,the development of channel tropism theory has attracted increasing attention.This study analyzed channel tropism theory and the problems associated with it.Results showed that this theory and systems biology have a similar holistic viewpoint.Systems biology could provide novel insights and platform in the study of channel tropism.Some problems in channel tropism theory,including pharmacology and action mechanism,were investigated. 展开更多
关键词 systems biology channel tropism theory traditional Chinese medicine APPLICATION
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Meridian Tropism of Polygoni Avicularis Herba by Tissue Distribution of Avicularin in Rats 被引量:1
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作者 Fu-quan XU Hua-shi GUAN +1 位作者 Yuan-yuan FENG Bin-lun YAN 《Chinese Herbal Medicines》 CAS 2012年第3期201-204,共4页
Objective To observe the meridian tropism of Polygoni Avicularis Herba by tissue distribution of avicularin in rats. Methods Tissue distribution of avicularin in rat following a single iv administration was appointed ... Objective To observe the meridian tropism of Polygoni Avicularis Herba by tissue distribution of avicularin in rats. Methods Tissue distribution of avicularin in rat following a single iv administration was appointed and observed. HPLC method was established and validated for the determination of avicularin in rat tissues. Results Kidney and bladder were the most important target tissue of avicularin. Conclusion HPLC method is successfully applied to tissues distribution study of avicularin after iv administration to rats, and the results explain Polygoni Avicularis Herba on bladder tropism reasonably. 展开更多
关键词 avicularin HPLC meridian tropism Polygoni Avicularis Herba tissues distribution
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Research on Fuzi based on animal thermotropism behavior to discover if it has fewer "hot" characteristics without Ganjiang 被引量:4
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作者 孙志勇 赵艳玲 +6 位作者 王伽伯 张琳 魏思思 江凤娟 贾雷 程丹红 肖小河 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2012年第2期208-214,共7页
OBJECTIVE:To investigate whether Fuzi(Radix Aconiti Praeparata) has fewer "hot" characteristics when administered without Ganjiang(Rhizoma Zingiberis).METHODS:Differences in the thermotropism behaviors of mi... OBJECTIVE:To investigate whether Fuzi(Radix Aconiti Praeparata) has fewer "hot" characteristics when administered without Ganjiang(Rhizoma Zingiberis).METHODS:Differences in the thermotropism behaviors of mice treated either with Fuzi(Radix Aconiti Praeparata),Ganjiang(Rhizoma Zingiberis) or the combination of the two given intragastrically were investigated using the Animal Thermotropism Behavior Surveillance System.The water intake volume,oxygen consumption volume,adenosine triphosphatase(ATPase) activity,total antioxidant capacity(T-AOC) and total superoxide dismutase(T-SOD) activity were determined during the investigation.RESULTS:When Fuzi and Ganjiang were administered together,the rate at which mice remained on a warm plate("remaining rate") and the times and distances of their movement were all significantly reduced(P<0.05).Compared with the Normal group,the reduction was 55.1%,48.3% and 44.8%,while compared with the Fuzi group,the reduction was 57.6%,34.3% and 36.0%,indicating that "cold" tropism was significantly increased.Compared with the Normal and Fuzi groups,the ATPase activity and the respiratory oxygen consumption volume of the Fuzi + Ganjiang group were significantly increased(P<0.05),suggesting an improvement in energy metabolism and showing a "hot" characteristic when Fuzi and Ganjiang are present together.Additionally,the T-AOC and T-SOD activity were significantly enhanced(P<0.05).CONCLUSION:The behavior of mice tending toward "cold" tropism can be regarded as a quantitative reflection of Fuzi having fewer characteristics consistent w ith a "hot" nature when not used with Ganjiang,the functional mechanism of which may be a change in the ATPase activity in liver tissue. 展开更多
关键词 Animal thermotropic behavior Objectivity Cold/Hot tropism Fuzi(Radix Aconiti Praeparata) Ganjiang(Rhizoma Zingiberis)
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Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription(加味五子衍宗方) in Rats and Meridian Tropism Theory 被引量:2
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作者 WANG Lin-lin LI Wei-wei +6 位作者 WU Cai-sheng ZHANG Jin-lan SONG Yi-xiang SONG Fang-jiao FU Hong LIU Geng-xin WANG Xue-mei 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2018年第2期117-124,共8页
Objective: To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription(加味五子衍宗方, MWP) in rats and meridian tropism theory. Methods: A high-performance liquid chromatogr... Objective: To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription(加味五子衍宗方, MWP) in rats and meridian tropism theory. Methods: A high-performance liquid chromatography with Fourier transform-mass spectrometry(HPLC-FT) method was used to identify the metabolites of MWP in different tissues of rats after continued oral administration of MWP for 7 days. The relationship between MWP and meridian tropism theory was studied according to the tissue distributions of the metabolites of MWP in rats and the relevant literature. Results: Nineteen metabolites, mainly flavanoid compounds, were detected in the different rat tissues and classified to each herb in MWP. Further, it was able to establish that the tissue distributions of the metabolites of MWP were consistent with the descriptions of meridian tropism of MWP available in literature, this result might be useful in clarifying the mechanism of MWP on meridian tropism. In the long run, these data might provide scientific evidence of the meridian tropism theory to further promote the reasonable, effective utilization, and modernization of Chinese medicine. Conclusion: The tissue distributions of MWP in vivo were consistent with the descriptions of meridian tropism of MWP. 展开更多
关键词 modified Wuzi Yanzong Prescription Chinese medicine tissue distributions meridian tropism high-performance liquid chromatography Fourier transform mass spectrometry
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Study on Hot Property of Aconiti Lateralis Radix Praeparata and Its Compatibility with Zingiberis Rhizoma Based on Animal Temperature Tropism
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作者 SUN Zhi-yong ZHAO Yan-ling +4 位作者 WANG Jia-bo LI Rui-sheng WEI Si-si JIANG Feng-juan XIAO Xiao-he 《Chinese Herbal Medicines》 CAS 2012年第4期294-300,共7页
Objective To establish an objective method for evaluating the intrinsic characteristics between hot and cold properties of herbal drugs and to study the hot property of Aconiti Lateralis Radix Praeparata(ALRP) and its... Objective To establish an objective method for evaluating the intrinsic characteristics between hot and cold properties of herbal drugs and to study the hot property of Aconiti Lateralis Radix Praeparata(ALRP) and its compatibility with Zingiberis Rhizoma(ZR) on animal temperature tropism.Methods The equipment with cold/hot pads was used to investigate the variety of temperature tropism among mice treated by ALRP and its compatibility with ZR.Meanwhile,the activities of adenosine triphosphatase(ATPase),total anti-oxidant capability(T-AOC),and total superoxide dismutase(T-SOD) were measured.Results Compared with the homologous ALRP group,the compatibility between ALRP and ZR(AZ) had a stronger action against the decreasing of remaining rate on hot pad(P < 0.05),suggesting an enhancement of cold tropism.Meanwhile,the internal indexes of Na+-K+-ATPase activity,Ca2+-Mg2+-ATPase activity,and oxygen consuming volume increased significantly(P < 0.05),suggesting an enhancement of energy metabolism.The changes of T-AOC and T-SOD activity suggested that AZ reinforced the anti-oxidative capability of mice.In addition,it could be inferred from cluster analysis that the activity of AZ was concretely stronger than that of homologous ALRP.Conclusion ALRP and ZR are both herbs with hot property,but AZ has an enhanced trend of hot property.This external behavior of cold tropism and the internal activity of energy metabolism and anti-oxidant might reflect the internal hot property in an intuitive and objective way.The changes of ATPase activity of liver tissue might be the mechanism of drug action. 展开更多
关键词 Aconiti Lateralis Radix Praeparata animal temperature tropism clustering analysis compatibility Zingiberis Rhizoma
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Different Effects of Mahuang Decoction and Maxing Shigan Decoction on Animal Temperature Tropism and Correlation to Differences of Cold and Hot Nature of Chinese Materia Medica
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作者 WANG Jia-bo1, ZHAO Yan-ling1, ZHANG Xue-ru1,2, ZHOU Can-ping1,2, LIU Ta-si2, ZHAO Hai-ping1, REN Yong-shen1, XIAO Xiao-he1 1. China Military Institute of Chinese Meteria Medica, 302 Military Hospital of China, Beijing 100039, China 2. College of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China 《Chinese Herbal Medicines》 CAS 2010年第3期211-215,243,共5页
Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing S... Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing Shigan decoction (MSD) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of the temperature tropism between two groups of mice treated by MHD and MSD, respectively. Meanwhile, the activities of adenosine triphosphatase (ATPase), superoxide dismutase, succinate dehydrogenase, and malondialdehyde were measured. Results After treated by MHD, the macroscopic behavioral index of remaining rate on warm pad (40 ℃ ) of mice decreased significantly (P < 0.05), suggesting the enhancement of cold tropism, meanwhile, the internal indices of ATPase activity and oxygen consuming volume increased significantly (P < 0.05), suggesting the enhancement of energy metabolism. On the other hand, the above-mentioned indices in MSD group changed on the inverse way. Conclusion The relative drug nature of MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition. It indicates that the internal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropism which might be internally regulated by body energy metabolism. 展开更多
关键词 cold/hot nature of Chinese materia medica Mahuang decoction Maxing Shigan decoction temperature tropism
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Hot Property of Aconiti Lateralis Radix Praeparata and its Compatibility with Zingiberis Rhizoma Based on Animal Temperature Tropism
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作者 SUN Zhi-yong1 《Chinese Herbal Medicines》 CAS 2012年第4期-,共7页
Abstract: Objective To establish an objective method for evaluating the intrinsic characteristics between hot and cold properties of herbal drugs and to study the hot property of Aconiti Lateralis Radix Praeparata (... Abstract: Objective To establish an objective method for evaluating the intrinsic characteristics between hot and cold properties of herbal drugs and to study the hot property of Aconiti Lateralis Radix Praeparata (ALRP) and its compatibility with Zingiberis Rhizoma (ZR) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of temperature tropism among mice treated by ALRP and its compatibility with ZR. Meanwhile, the activities of adenosine triphosphatase (ATPase), total anti-oxidant capability (T-AOC), and total superoxide dismutase (T-SOD) were measured. Results Compared with the homologous ALRP group, the compatibility between ALRP and ZR (AZ) had a stronger action against the decreasing of remaining rate on hot pad (P 【 0.05), suggesting an enhancement of cold tropism. Meanwhile, the internal indexes of Na+-K+-ATPase activity, Ca2+-Mg2+-ATPase activity, and oxygen consuming volume increased significantly (P 【 0.05), suggesting an enhancement of energy metabolism. The changes of T-AOC and T-SOD activity suggested that AZ reinforced the anti-oxidative capability of mice. In addition, it could be inferred from cluster analysis that the activity of AZ was concretely stronger than that of homologous ALRP. Conclusion ALRP and ZR are both herbs with hot property, but AZ has an enhanced trend of hot property. This external behavior of cold tropism and the internal activity of energy metabolism and anti-oxidant might reflect the internal hot property in an intuitive and objective way. The changes of ATPase activity of liver tissue might be the mechanism of drug action. 展开更多
关键词 KEY words: Aconiti Lateralis RADIX Praeparata ANIMAL TEMPERATURE tropism clustering analysis compatibility Zingiberis Rhizoma
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基于中药性味归经理论探讨祛瘀消肿汤对混合痔术后愈合的影响 被引量:1
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作者 李仲云 李昌盛 陈艳花 《中华中医药学刊》 CAS 北大核心 2024年第5期174-177,共4页
目的探究基于中药性味归经理论指导下探讨祛瘀消肿汤对混合痔术后愈合的影响。方法选取2021年1月—2022年12月收治的98例混合痔患者,以随机数字表法分为观察组与对照组进行研究。对照组(49例)采用外剥内扎手术治疗方法,观察组(49例)在... 目的探究基于中药性味归经理论指导下探讨祛瘀消肿汤对混合痔术后愈合的影响。方法选取2021年1月—2022年12月收治的98例混合痔患者,以随机数字表法分为观察组与对照组进行研究。对照组(49例)采用外剥内扎手术治疗方法,观察组(49例)在此基础上结合内服祛瘀消肿汤治疗。观察两组患者治疗前后血清炎症因子、视觉模拟疼痛评分、水肿评分、创面愈合情况、生长因子水平。观察两组患者临床疗效、症状缓解时间。结果治疗前两组患者白介素-6(interleukin-6,IL-6)、肿瘤坏死因子(tumor necrosis factor,TNF-α)及C反应蛋白(C-reactive protein,CRP)、视觉模拟疼痛评分(visual analogue scale,VAS)与水肿评分、碱性成纤维细胞生长因子(basic fibroblast growth fac⁃tor,b-FGF)及血管内皮生长因子(vascular endothelial growth factor,VEGF)水平比较(P>0.05);治疗后观察组IL-6、TNF-α和CRP水平及VAS和水肿评分均降低,且观察组低于对照组,b-FGF、VEGF水平均上升,观察组高于对照组(P<0.05)。治疗10 d后,两组患者创面出血评分、创面渗液评分比较,P>0.05;治疗14 d后观察组评分比对照组低(P<0.05)。与对照组患者肛门坠胀缓解时间及肛门水肿缓解时间、创面渗液消失时间和疼痛缓解时间比较,观察组时间均更短(P<0.05)。观察组临床总有效率95.92%(47/49),显著高于对照组的81.64%(40/49)(χ^(2)=5.018,P=0.025)。结论在中药性味归经理论指导下,祛瘀消肿汤能降低混合痔术后血清炎症因子水平、减少创面疼痛、加快愈合时间和提高临床疗效。 展开更多
关键词 性味归经 祛瘀消肿汤 混合痔 愈合情况 生长因子 临床疗效
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外来中药辣木叶的药性与功用再探索
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作者 宋明 费文婷 +6 位作者 刘金莲 陈亮 杜军 王林元 王淳 高学敏 张建军 《世界中医药》 CAS 北大核心 2024年第11期1550-1554,1562,共6页
辣木叶(Moringa spp.)是印度传统草药,因其具有降血糖、降血脂、抗氧化、利尿、改善睡眠、增强人体免疫力、延缓衰老、抗肿瘤等作用而引起人们的广泛关注。辣木叶目前合法引入中国,并因其确切的药理活性与安全无毒的药物属性,应用与研... 辣木叶(Moringa spp.)是印度传统草药,因其具有降血糖、降血脂、抗氧化、利尿、改善睡眠、增强人体免疫力、延缓衰老、抗肿瘤等作用而引起人们的广泛关注。辣木叶目前合法引入中国,并因其确切的药理活性与安全无毒的药物属性,应用与研究日益增多。但当前其暂无中药标准,仅有少量药性记载。辣木叶的中药药性亟待完善,以有利于辣木叶与中药合理配伍运用从而充分发挥其应有的价值。以“文献研究→理论探讨→药性验证→临床实践”为路径构建新外来药物“中药化”的研究策略与范式,以临床应用为依据、实验研究为参考,进行外来中药辣木叶的药性与功用的深入探讨,对规范其应用具有重要意义。 展开更多
关键词 辣木叶 外来中药 药性理论 功能主治 应用 性味归经 药用历史 药理作用
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新外来中药香蜂草的药性探讨
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作者 刘洋 王林元 +7 位作者 王淳 张建军 费文婷 叶丹妮 赵尹铭 李爱民 赵明明 陈彦 《世界中医药》 CAS 北大核心 2024年第11期1591-1598,共8页
香蜂草为唇形科植物Melissa officinalis L.的叶。原产于欧洲地中海地区,欧洲、北美、亚洲各大洲均有分布,我国的中南、西南部以及台湾也有野生种分布。香蜂草在国外有长久的应用历史,被广泛应用于治疗精神和中枢神经系统疾病、心血管... 香蜂草为唇形科植物Melissa officinalis L.的叶。原产于欧洲地中海地区,欧洲、北美、亚洲各大洲均有分布,我国的中南、西南部以及台湾也有野生种分布。香蜂草在国外有长久的应用历史,被广泛应用于治疗精神和中枢神经系统疾病、心血管疾病等。也作为抗焦虑药、睡眠辅助剂以及解毒剂。目前香蜂草在我国作为香料使用,并有多种以香蜂草为原料的专利。中医药学自古就广泛吸收外来药物不断扩大我国中药资源,如藿香、丁香、木香等源自域外的“香药”至今也是我国的常用中药。将香蜂草列入中药潜在的引入对象进行研究,以其临床研究和应用文献为基础,结合中医药理论对香蜂草的中药药性进行理论分析。结果为香蜂草药性辛、凉,归心、肝经,具有宁心安神益智、疏肝解郁、缓急止痛的功效,用于治疗心神不宁,失眠,健忘,心悸;情志抑郁,烦躁多虑;腹痛、牙痛等症状。 展开更多
关键词 香蜂草 外来中药 中药药性 新中药 药用植物 功效主治 性味归经 药用历史
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