期刊文献+
共找到3,294篇文章
< 1 2 165 >
每页显示 20 50 100
Continuity of truncated Hardy-Littlewood maximal function
1
作者 WANG Yidong WU Jia YAN Dunyan 《中国科学院大学学报(中英文)》 CAS CSCD 北大核心 2024年第6期721-727,共7页
This paper focuses on the continuity of the truncated Hardy-Littlewood maximal function.We first show that the truncated Hardy-Littlewood maximal function is lower semi-continuous.Then by investigating the behavior of... This paper focuses on the continuity of the truncated Hardy-Littlewood maximal function.We first show that the truncated Hardy-Littlewood maximal function is lower semi-continuous.Then by investigating the behavior of the truncated Hardy-Littlewood maximal function when the truncated parameterγchanges,we obtain an equivalent condition of the continuity of the truncated Hardy-Littlewood maximal function. 展开更多
关键词 Hardy-Littlewood maximal function truncatION CONTINUITY truncated parameter
下载PDF
Analytical Solution and Simplified Formula for Added Mass of Horizontal and Vertical Motions of Truncated Cylinders Under Earthquake Action
2
作者 WANG Pi-guang LYU Si-yu +2 位作者 QU Yang ZHAO Mi DU Xiu-li 《China Ocean Engineering》 SCIE EI CSCD 2024年第1期54-67,共14页
This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water depth.The governing equation of the... This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water depth.The governing equation of the hydrodynamic pressure acting on the cylinder is derived based on the radiation theory with the inviscid and incompressible assumptions.The governing equation is solved by using the method of separating variables and analytical solutions are obtained by assigning reasonable boundary conditions.The analytical result is validated by a numerical model using the exact artificial boundary simulation of the infinite water.The main variation and distribution characteristics of the hydrodynamic pressure acting on the side and bottom of the cylinder are analyzed for different combinations of wide-height and immersion ratios.The added mass coefficient of the cylinder is calculated by integrating the hydrodynamic pressure and simplified formulas are proposed for engineering applications.The calculation results show that the simplified formulas are in good agreement with the analytical solutions. 展开更多
关键词 EARTHQUAKE hydrodynamic pressure truncated cylinder added mass simplified formula
下载PDF
CRISPR/Cas9-mediated NlInR2 mutants:Analyses of residual mRNA and truncated proteins
3
作者 Jun Lü Jingxiang Chen +4 位作者 Yutao Hu Lin Chen Shihui Li Yibing Zhang Wenqing Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第6期2006-2017,共12页
CRISPR/Cas9 technology is a powerful genome manipulation tool in insects.However,little is known about whether mRNA and protein of a target gene are completely cleared in homozygous mutants.This study generated homozy... CRISPR/Cas9 technology is a powerful genome manipulation tool in insects.However,little is known about whether mRNA and protein of a target gene are completely cleared in homozygous mutants.This study generated homozygous mutants of the insulin receptor gene 2(NlInR2)in the brown planthopper(Nilaparvata lugens)using CRISPR/Cas9 genome editing.Both frameshift mutants,E5_D17 and E6_I7,differentiated towards long wings,but there were differences in wing morphology,with E5_D17 showing wing deformities.Subsequent investigations revealed the presence of residual expression of NlInR2 mRNA in both mutants,as well as the occurrence of spliceosomes featuring exon skipping splicing in E5_D17.Additionally,the E5_D17 exhibited the detection of N-terminally truncated NlInR2 protein.RNA interference experiments indicated that the knockdown of NlInR2 expression in the E5_D17 mutant line increased the proportion of wing deformities from 11.1 to 65.6%,suggesting that the residual NlInR2 mRNA of the E5_D17 mutant might have retained some genetic functions.Our results imply that systematic characterization of residual protein expression or function in CRISPR/Cas9-generated mutant lines is necessary for phenotypic interpretation. 展开更多
关键词 CRISPR/Cas9 Nilaparvata lugens residual mRNA skipping exon truncated protein
下载PDF
Modified DS np Chart Using Generalized Multiple Dependent State Sampling under Time Truncated Life Test
4
作者 Wimonmas Bamrungsetthapong Pramote Charongrattanasakul 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2471-2495,共25页
This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of t... This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of the product based on the time truncated life test employing theWeibull distribution.The control chart developed supports the examination of the mean lifespan variation for a particular product in the process of manufacturing.Three control limit levels are used:the warning control limit,inner control limit,and outer control limit.Together,they enhance the capability for variation detection.A genetic algorithm can be used for optimization during the in-control process,whereby the optimal parameters can be established for the proposed control chart.The control chart performance is assessed using the average run length,while the influence of the model parameters upon the control chart solution is assessed via sensitivity analysis based on an orthogonal experimental design withmultiple linear regression.A comparative study was conducted based on the out-of-control average run length,in which the developed control chart offered greater sensitivity in the detection of process shifts while making use of smaller samples on average than is the case for existing control charts.Finally,to exhibit the utility of the developed control chart,this paper presents its application using simulated data with parameters drawn from the real set of data. 展开更多
关键词 Modified DS np chart generalizedmultiple dependent state sampling time truncated life test Weibull distribution average run length average sample size
下载PDF
Quercetin inhibits truncated isoform of dopamine-and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer
5
作者 Han-Sheng Chang Tzu-Chun Cheng +6 位作者 Shih-Hsin Tu Chih-Hsiung Wu You-Cheng Liao Jungshan Chang Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2653-2667,共15页
Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2(HER2)-positive(HER2+)breast cancer(BC).The truncated isoform of dopamine-and cAMPregulated phosph... Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2(HER2)-positive(HER2+)breast cancer(BC).The truncated isoform of dopamine-and cAMPregulated phosphoprotein(t-DARPP)has been reported to be involved in trastuzumab therapy resistance and promoting tumor progression.To evaluate the t-DARPP expression in BC,paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+BC tumor tissues.We established 2 patient-derived xenografts(PDX)mice models to test the efficacy of trastuzumab,named model 1(non-responder)and model 2(responder).t-DARPP and p95-HER2 protein-protein interactions were detected in PDX tumor tissue from non-responders using Förster resonance energy transfer assays.Instead,there is no response from the responder.Furthermore,mechanistic studies using transwell and western blot assays demonstrated that t-DARPP could upregulate epithelial-mesenchymal transition signaling proteins,enhance p95-HER2 expression and promote cell migration.We found that quercetin effectively reduced t-DARPP expression in HER2+BC cells.In t-DARPP ShRNA-suppressed cells,quercetin synergistically enhanced trastuzumab-induced apoptotic cell death and G2/M phase arrest.In conclusion,the combination of quercetin and trastuzumab treatment by targeting t-DARPP in HER2+BC patients has the potential as a biomarker for mitigating drug resistance. 展开更多
关键词 p95-Human epidermal growth factor receptor 2 (HER2) HER2-positive breast cancer QUERCETIN Trastuzumab resistance truncated isoform of dopamine-and cAMPregulated PHOSPHOPROTEIN
下载PDF
Explicit Isogeometric Topology Optimization Method with Suitably Graded Truncated Hierarchical B-Spline 被引量:1
6
作者 Haoran Zhu Xinhao Gao +3 位作者 Aodi Yang Shuting Wang Xianda Xie Tifan Xiong 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第5期1435-1456,共22页
This work puts forward an explicit isogeometric topology optimization(ITO)method using moving morphable components(MMC),which takes the suitably graded truncated hierarchical B-Spline based isogeometric analysis as th... This work puts forward an explicit isogeometric topology optimization(ITO)method using moving morphable components(MMC),which takes the suitably graded truncated hierarchical B-Spline based isogeometric analysis as the solver of physical unknown(SGTHB-ITO-MMC).By applying properly basis graded constraints to the hierarchical mesh of truncated hierarchical B-splines(THB),the convergence and robustness of the SGTHB-ITOMMC are simultaneously improved and the tiny holes occurred in optimized structure are eliminated,due to the improved accuracy around the explicit structural boundaries.Moreover,an efficient computational method is developed for the topological description functions(TDF)ofMMC under the admissible hierarchicalmesh,which consists of reducing the dimensionality strategy for design space and the locally computing strategy for hierarchical mesh.We apply the above SGTHB-ITO-MMC with improved efficiency to a series of 2D and 3Dcompliance design problems.The numerical results show that the proposed SGTHB-ITO-MMC method outperforms the traditional THB-ITO-MMCmethod in terms of convergence rate and efficiency.Therefore,the proposed SGTHB-ITO-MMC is an effective way of solving topology optimization(TO)problems. 展开更多
关键词 Isogeometric topology optimization moving morphable components truncated hierarchical B-spline suitably graded hierarchical mesh
下载PDF
Tau truncation in the pathogenesis of Alzheimer's disease:a narrative review 被引量:3
7
作者 Dandan Chu Xingyue Yang +5 位作者 Jing Wang Yan Zhou Jin-Hua Gu Jin Miao Feng Wu Fei Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1221-1232,共12页
Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau pro... Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein.Recent studies suggest that dysregulation of the microtubuleassociated protein Tau,especially specific proteolysis,could be a driving force for Alzheimer's disease neurodegeneration.Tau physiologically promotes the assembly and stabilization of microtubules,whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers,resulting in them gaining prion-like characteristics.In addition,Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent manner.This review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments,investigates the role of specific truncations in physiological and pathological states of Alzheimer's disease,and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer's disease. 展开更多
关键词 Alzheimer's disease cleavage site diagnosis MARKER neurofibrillary tangles PHOSPHORYLATION TAU Tau aggregation therapy truncatION
下载PDF
Evolutionary Plasmonic Properties of Single Truncated Ag Nanowire-on-Au Film Nanocavity
8
作者 朱鑫 张静云 +2 位作者 杨翠红 李莹 陈云云 《Chinese Physics Letters》 SCIE EI CAS CSCD 2023年第5期104-108,共5页
Noble metal nanocavities have been widely demonstrated to possess great potential applications in nanooptics and nanophotonics due to their extraordinary localized surface plasmon resonance.However,most metal nanocrys... Noble metal nanocavities have been widely demonstrated to possess great potential applications in nanooptics and nanophotonics due to their extraordinary localized surface plasmon resonance.However,most metal nanocrystals synthesized by chemical methods often suffer from truncation with different degrees due to oxidation and dissolution of metal atoms at corner and edges.We investigate the influence of shape truncation on the plasmonic properties of single Ag nanowire on Au film nanocavity using the finite difference time domain method.When the Ag nanowire(the circumradius R_(2)=50 nm)is gradually truncated from pentagonal to circular geometry,the scattering peak position of the nanocavity shows prominent blue shift from 962 nm to 608 nm,suggesting a nonnegligible role of truncation on plasmonic properties.The electric field strength and charge distribution of the structure reveal the evolution from dipole mode to quadrupole mode.It is also found that the plasmon resonance wavelength is linearly dependent on the truncation ratio R_(1)/R_(2)(R_(1) is the inradius)and the modulation slope is also reliable to the size of Ag nanowire.Our observations could shed light on developing high-performance tunable optical nano-devices in future. 展开更多
关键词 cavity truncatION RADIUS
下载PDF
The Doubly Truncated Generalized Log-Lindley Distribution
9
作者 Abd-Elmoneim A. M. Teamah Hussin M. Elmenify 《Applied Mathematics》 2023年第7期481-495,共15页
The aim of this paper is to present generalized log-Lindely (GLL) distribution, as a new model, and find doubly truncated generalized log-Lindely (DTGLL) distribution, truncation in probability distributions may occur... The aim of this paper is to present generalized log-Lindely (GLL) distribution, as a new model, and find doubly truncated generalized log-Lindely (DTGLL) distribution, truncation in probability distributions may occur in many studies such as life testing, and reliability. We illustrate the applicability of GLL and DTGLL distributions by Real data application. The GLL distribution can handle the risk rate functions in the form of panich and increase. This property makes GLL useful in survival analysis. Various statistical and reliability measures are obtained for the model, including hazard rate function, moments, moment generating function, mean and variance, quantiles function, Skewness and kurtosis, mean deviations, mean inactivity time and strong mean inactivity time. The estimation of model parameters is justified by the maximum Likelihood method. An application to real data shows that DTGLL distribution can provide better suitability than GLL and some other known distributions. 展开更多
关键词 Log-Lindley Distribution Quantile Function Maximum Likelihood Estimation Doubly truncated
下载PDF
Different wave patterns for two-coupled Maccari's system with complex structure via truncated Painlevéapproach
10
作者 马红彩 戚心茹 邓爱平 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第12期293-298,共6页
We focused on the two-coupled Maccari's system.With the help of truncated Painlevéapproach(TPA),we express local solution in the form of arbitrary functions.From the solution obtained,using its appropriate ar... We focused on the two-coupled Maccari's system.With the help of truncated Painlevéapproach(TPA),we express local solution in the form of arbitrary functions.From the solution obtained,using its appropriate arbitrary functions,we have generated the rogue wave pattern solutions,rogue wave solutions,and lump solutions.In addition,by controlling the values of the parameters in the solutions,we show the dynamic behaviors of the rogue wave pattern solutions,rogue wave solutions,and lump solutions with the aid of Maple tool.The results of this study will contribute to the understanding of nonlinear wave dynamics in higher dimensional Maccari's systems. 展开更多
关键词 two-coupled Maccari's system rogue wave lump wave truncated Painlevéapproach
下载PDF
Numerical simulation of a truncated cladding negative curvature fiber sensor based on the surface plasmon resonance effect
11
作者 张志超 苑金辉 +6 位作者 邱石 周桂耀 周娴 颜玢玢 吴强 王葵如 桑新柱 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第3期262-269,共8页
A refractive index(RI)sensor based on the surface plasmon resonance effect is proposed using a truncated cladding negative curvature fiber(TC-NCF).The influences of the TC-NCF structure parameters on the sensing perfo... A refractive index(RI)sensor based on the surface plasmon resonance effect is proposed using a truncated cladding negative curvature fiber(TC-NCF).The influences of the TC-NCF structure parameters on the sensing performances are investigated and compared with the traditional NCF.The simulation results show that the proposed TC-NCF RI sensor has an ultra-wide detection range from 1.16 to 1.43.The maximum wavelength sensitivity reaches 12400 nm/RIU,and the corresponding R^(2)of the polynomial fitting equation is 0.9999.The maximum and minimum resolutions are 2.56×10^(-5)and 8.06×10^(-6),respectively.In addition,the maximum amplitude sensitivity can reach-379.1 RIU^(-1)when the RI is chosen as 1.43.The proposed TC-NCF RI sensor could be useful in biochemical medicine,environmental monitoring,and food safety. 展开更多
关键词 truncated cladding negative curvature fiber refractive index sensor surface plasmon resonance
下载PDF
Pricing European Options Based on a Logarithmic Truncated t-Distribution
12
作者 Yingying Cao Xueping Liu +1 位作者 Yiqian Zhao Xuege Han 《Journal of Applied Mathematics and Physics》 2023年第5期1349-1358,共10页
The t-distribution has a “fat tail” feature, which is more suitable than the normal probability density function to describe the distribution characteristics of return on assets. The difficulty of using t-distributi... The t-distribution has a “fat tail” feature, which is more suitable than the normal probability density function to describe the distribution characteristics of return on assets. The difficulty of using t-distribution to price European options is that a fat tail can lead to a deviation in one integral required for option pricing. We use a distribution called logarithmic truncated t-distribution to price European options. A risk neutral valuation method was used to obtain a European option pricing model with logarithmic truncated t-distribution. 展开更多
关键词 Option Pricing Logarithmic truncated t-Distribution Asset Returns Risk-Neutral Valuation Approach
下载PDF
A truncated implicit high-order finite-difference scheme combined with boundary conditions 被引量:2
13
作者 常锁亮 刘洋 《Applied Geophysics》 SCIE CSCD 2013年第1期53-62,118,共11页
In this paper, first we calculate finite-difference coefficients of implicit finite- difference methods (IFDM) for the first and second-order derivatives on normal grids and first- order derivatives on staggered gri... In this paper, first we calculate finite-difference coefficients of implicit finite- difference methods (IFDM) for the first and second-order derivatives on normal grids and first- order derivatives on staggered grids and find that small coefficients of high-order IFDMs exist. Dispersion analysis demonstrates that omitting these small coefficients can retain approximately the same order accuracy but greatly reduce computational costs. Then, we introduce a mirrorimage symmetric boundary condition to improve IFDMs accuracy and stability and adopt the hybrid absorbing boundary condition (ABC) to reduce unwanted reflections from the model boundary. Last, we give elastic wave modeling examples for homogeneous and heterogeneous models to demonstrate the advantages of the proposed scheme. 展开更多
关键词 Implicit finite difference symmetric boundary condition high-order accuracy truncatION absorbing boundary condition staggered grid numerical modeling
下载PDF
Acquisition of Insect-Resistant Transgenic Maize Harboring a Truncated cry1Ah Gene via Agrobacterium-Mediated Transformation 被引量:5
14
作者 LI Xiu-ying LANG Zhi-hong +3 位作者 ZHANG Jie HE Kang-lai ZHU Li HUANG Da-fang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2014年第5期937-944,共8页
A novel insecticidal gene crylAh was cloned from Bacillus thuringiensis isolate BT8 previously for plant genetic engineering improvement. Truncated active CrylAh toxin has a toxicity level similar to that of the full-... A novel insecticidal gene crylAh was cloned from Bacillus thuringiensis isolate BT8 previously for plant genetic engineering improvement. Truncated active CrylAh toxin has a toxicity level similar to that of the full-length CrylAh toxin. In this study, plant expression vector pMhGM harboring truncated crylAh gene was transformed into maize (Zea mays L.) immature embryos by Agrobacterium tumefaciens-mediated transformation at which maize alcohol dehydrogenase matrix attachment regions (madMARs) were incorporated on both sides of the gene expression cassette to improve gene expression. A total of 23 PCR positive events were obtained with a transformation efficiency of 5% around. Bioassay results showed that events 1-4 and 1-5 exhibited enhanced resistance to the Asian corn borer (Ostriniafurnacalis). These two events were further confirmed by molecular analysis. Southern blot suggested that a single copy of the crylAh gene was successfully integrated into the maize genome. Western blot and ELISA showed that the foreign gene crylAh was expressed stably at high level in maize and could be inherited stably over generations. The results of a bioassay of T l-T4 transgenic maize plants indicated that the transgenic plants were highly toxic to the Asian corn borer and their resistance could be inherited stably from generation to generation. Thus, events 1-4 and 1-5 are good candidates for the breeding of insect-resistant maize. 展开更多
关键词 Bacillus thuringiensis truncated crylAh gene insectresistant maize stable inheritance
下载PDF
Numerical modeling of wave equation by a truncated high-order finite-difference method 被引量:4
15
作者 Yang Liu Mrinal K. Sen 《Earthquake Science》 CSCD 2009年第2期205-213,共9页
Finite-difference methods with high-order accuracy have been utilized to improve the precision of numerical solution for partial differential equations. However, the computation cost generally increases linearly with ... Finite-difference methods with high-order accuracy have been utilized to improve the precision of numerical solution for partial differential equations. However, the computation cost generally increases linearly with increased order of accuracy. Upon examination of the finite-difference formulas for the first-order and second-order derivatives, and the staggered finite-difference formulas for the first-order derivative, we examine the variation of finite-difference coefficients with accuracy order and note that there exist some very small coefficients. With the order increasing, the number of these small coefficients increases, however, the values decrease sharply. An error analysis demonstrates that omitting these small coefficients not only maintain approximately the same level of accuracy of finite difference but also reduce computational cost significantly. Moreover, it is easier to truncate for the high-order finite-difference formulas than for the pseudospectral for- mulas. Thus this study proposes a truncated high-order finite-difference method, and then demonstrates the efficiency and applicability of the method with some numerical examples. 展开更多
关键词 finite difference high-order accuracy truncatION EFFICIENCY numerical modeling
下载PDF
UNIQUENESS PROBLEM FOR MEROMORPHIC MAPPINGS IN SEVERAL COMPLEX VARIABLES INTO P^N(C) WITH TRUNCATED MULTIPLICITIES 被引量:4
16
作者 涂振汉 王中华 《Acta Mathematica Scientia》 SCIE CSCD 2013年第1期122-130,共9页
This paper proves some uniqueness theorems for meromorphic mappings in several complex variables into the complex projective space p^N(C) with truncated multiplicities, and our results improve some earlier work.
关键词 meromorphic mappings truncated multiplicities uniqueness theorems value distribution theory
下载PDF
Dynamics of Large-Truncated Mooring Systems Coupled with A Catenary Moored Semi-Submersible 被引量:2
17
作者 徐胜 嵇春艳 《China Ocean Engineering》 SCIE EI CSCD 2014年第2期149-162,共14页
With the floating structures pushing their activities to the ultra-deep water, model tests have presented a challenge due to the limitation of the existing wave basins. Therefore, the concept of truncated mooring syst... With the floating structures pushing their activities to the ultra-deep water, model tests have presented a challenge due to the limitation of the existing wave basins. Therefore, the concept of truncated mooring system is implemented to replace the full depth mooring system in the model tests, which aims to have the same dynamic responses as the full depth system. The truncated mooring system plays such a significant role that extra attention should be paid to the mooring systems with large truncation factor. Three different types of large truncation factor mooring system are being employed in the simulations, including the homogenously truncated mooring system, non-homogenously truncated mooring system and simplified truncated mooring system. A catenary moored semi-submersible operating at 1000 m water depth is presented. In addition, truncated mooring systems are proposed at the truncated water depth of 200 m. In order to explore the applicability of these truncated mooring systems, numerical simulations of the platform’s surge free decay interacting with three different styles of truncated mooring systems are studied in calm water. Furthermore, the mooring-induced damping of the truncated mooring systems is simulated in the regular wave. Finally, the platform motion responses and mooring line dynamics are simulated in irregular wave. All these simulations are implemented by employing full time domain coupled dynamic analysis, and the results are compared with those of the full depth simulations in the same cases. The results show that the mooring-induced damping plays a significant role in platform motion responses, and all truncated mooring systems are suitable for model tests with appropriate truncated mooring line diameters. However, a large diameter is needed for simplified truncated mooring lines. The suggestions are given to the selection of truncated mooring system for different situations as well as to the truncated mooring design criteria. 展开更多
关键词 CATENARY SEMI-SUBMERSIBLE truncated mooring system large truncated full coupled dynamic analysis mooring-induced damping
下载PDF
Dynamic Response Analysis of the Equivalent Water Depth Truncated Point of the Catenary Mooring Line 被引量:3
18
作者 ZHANG Huo-ming KONG Ling-bin +2 位作者 GUAN Wei-bing HUANG Sai-hua FANG Gui-sheng 《China Ocean Engineering》 SCIE EI CSCD 2017年第1期37-47,共11页
The real-time computer-controlled actuators are used to connect the truncated parts of moorings and risers in the active hybrid model testing system. This must be able to work in model-scale real time, based on feedba... The real-time computer-controlled actuators are used to connect the truncated parts of moorings and risers in the active hybrid model testing system. This must be able to work in model-scale real time, based on feedback input from the floater motions. Thus, mooring line dynamics and damping effects are artificially simulated in real time, based on a computer-based model of the problem. In consideration of the nonlinear characteristics of the sea platform catenary mooring line, the equations of the mooring line motion are formulated by using the lumped-mass method and the dynamic response of several points on the mooring line is investigated by the time and frequency domain analysis method. The dynamic response of the representative point on the mooring line is analyzed under the condition of two different corresponding upper endpoint movements namely sine wave excitation and random wave excitation. The corresponding laws of the dynamic response between the equivalent water depth truncated points at different locations and the upper endpoint are obtained, which can provide technical support for further study of the active hybrid model test. 展开更多
关键词 mooting line truncated point dynamic response lumped-mass method time domain simulation
下载PDF
THE CONSTRUCTION OF WAVELET-BASED TRUNCATED CONICAL SHELL ELEMENT USING B-SPLINE WAVELET ON THE INTERVAL 被引量:7
19
作者 Xiang Jiawei He Zhengjia Chen Xuefeng 《Acta Mechanica Solida Sinica》 SCIE EI 2006年第4期316-326,共11页
Based on B-spline wavelet on the interval (BSWI), two classes of truncated conical shell elements were constructed to solve axisymmetric problems, i.e. BSWI thin truncated conical shell element and BSWI moderately t... Based on B-spline wavelet on the interval (BSWI), two classes of truncated conical shell elements were constructed to solve axisymmetric problems, i.e. BSWI thin truncated conical shell element and BSWI moderately thick truncated conical shell element with independent slopedeformation interpolation. In the construction of wavelet-based element, instead of traditional polynomial interpolation, the scaling functions of BSWI were employed to form the shape functions through the constructed elemental transformation matrix, and then construct BSWI element via the variational principle. Unlike the process of direct wavelets adding in the wavelet Galerkin method, the elemental displacement field represented by the coefficients of wavelets expansion was transformed into edges and internal modes via the constructed transformation matrix. BSWI element combines the accuracy of B-spline function approximation and various wavelet-based elements for structural analysis. Some static and dynamic numerical examples of conical shells were studied to demonstrate the present element with higher efficiency and precision than the traditional element. 展开更多
关键词 B-spline wavelet on the interval finite element method axisymmetric problem truncated conical shell element
下载PDF
Over-expressed and truncated midkines promote proliferation of BGC823 cells in vitro and tumor growth in vivo 被引量:14
20
作者 Qing-Ling Wang Hui Wang Shu-Li Zhao Ya-Hong Huang Ya-Yi Hou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第12期1858-1865,共8页
AIM: To determine whether midkine (M/O and its truncated form (tMK) contribute to gastric tumorigenesis using in vitro and in vivo models. METHODS: Human MK and tMt( plasmids were constructed and expressed in BG... AIM: To determine whether midkine (M/O and its truncated form (tMK) contribute to gastric tumorigenesis using in vitro and in vivo models. METHODS: Human MK and tMt( plasmids were constructed and expressed in BGC823 (a gastric adenocarcinoma cell line) to investigate the effect of over-expressed MK or tMK on cell growth and turmorigenesis in nude mice. RESULTS: The growth of MK-transfected or tMK- transfected cells was significantly increased compared with that of the control cells, and tMK-transfected cells grew more rapidly than MK-transfected cells. The number of colony formation of the cells transfected with MK or tMK gene was larger than the control cells. In nude mice injected with MK-transfected or tMK-transfected cells, visible tumor was observed earlier and the tumor tissues were larger in size and weight than in control animals that were injected with cells without the transfection of either genes. CONCLUSION: Over-expressed MK or tMtC can promote human gastric cancer cell growth in vitro and in vivo, and bMK has greater effect than MK. tMK may be a more promising gene therapeutic target compared with MK for treatment of malignant tumors. 展开更多
关键词 MIDKINE truncated midkine Gastric cancer BGC823 Tumorigenisis
下载PDF
上一页 1 2 165 下一页 到第
使用帮助 返回顶部