Summary:The optimal assisted reproductive treatment strategy for infertile women with unilateral tubal obstruction remains uncertain.To investigate the role of intrauterine insemination(IUI)in the treatment of inferti...Summary:The optimal assisted reproductive treatment strategy for infertile women with unilateral tubal obstruction remains uncertain.To investigate the role of intrauterine insemination(IUI)in the treatment of infertile women with unilateral tubal occlusion,the data of 148 couples were retrospectively collected and analyzed.Seventy-eight infertile women with unilateral occlusion diagnosed by hysterosalpingography(HSG)were categorized as the study group and 70 others with unexplained infertility as the control group.The study group was divided into a proximal occlusion subgroup and a mid-distal occlusion subgroup for further analysis.The main outcomes,namely the clinical pregnancy rate(CPR),ongoing pregnancy rate(OPR),and live birth rate(LBR)per cycle,were analyzed.Our results showed a tendency of lower CPR,OPR,and LBR in the study group than in the control group,without statistical significance.Further investigations revealed that the unilateral proximal occlusion subgroup had similar CPR,OPR,and LBR as the control group,while the unilateral mid-distal occlusion subgroup had significantly lower CPR(5.1%vs.20.0%,P=0.035),OPR(5.1%vs.20.0%,P=0.035),and LBR(5.1%vs.20.0%,P=0.035)than the control group.In conclusion,the clinical outcomes of IUI were worse in patients with unilateral tubal occlusion than in those with unexplained infertility.This might be primarily caused by the worse outcome of patients with unilateral mid-distal tubal occlusion instead of proximal occlusion.展开更多
Objectives: Numerous factors can cause infertility. Tubal factor accounts for approximately 30% of infertility in females. This study was conducted to evaluate the rate of asymptomatic Mycoplasma hominis and Ureaplasm...Objectives: Numerous factors can cause infertility. Tubal factor accounts for approximately 30% of infertility in females. This study was conducted to evaluate the rate of asymptomatic Mycoplasma hominis and Ureaplasma urealyticum infection in females diagnosed with tubal obstruction. Methods: This is a retrospective case-control study conducted at New Life Fertility Centre. We have identified and reviewed the health records of 167 subfertile women that had HSG and an endocervical swab for Mycoplasma hominis and Ureaplasma urealyticum done. Results: We compared the endocervical swab results of ureaplasma and mycoplasma in the patients with tubal obstruction (group 1) to the patients with normal patent tubes (group 2). Diagnosis of tubal patency was based on the HSG results. Our results show that there is a significantly higher rate of Ureaplasma urealyticum/Mycoplasma hominis infection in group 1 compared to group 2. Conclusion: Our data shows that there is a high rate of U. urealyticum and M. hominis infection in patients diagnosed with tubal factor of infertility and it can be a marker in the prediction of the tubal pathology.展开更多
【目的】研究不同类型沙眼衣原体蛋白在输卵管性不孕中的致病作用,预测具有临床检测价值的沙眼衣原体蛋白抗体。【方法】本研究共纳入输卵管性不孕组(TFI)58例,正常生育组(FC)41例,非输卵管性不孕组(IFC)18例。血清检测CT-IgG ELISA试...【目的】研究不同类型沙眼衣原体蛋白在输卵管性不孕中的致病作用,预测具有临床检测价值的沙眼衣原体蛋白抗体。【方法】本研究共纳入输卵管性不孕组(TFI)58例,正常生育组(FC)41例,非输卵管性不孕组(IFC)18例。血清检测CT-IgG ELISA试剂盒检测三组人群血清中CT-IgG的表达情况;利用前期获得表达、纯化的6种沙眼衣原体蛋白,建立这6种沙眼衣原体蛋白抗体的ELISA检测方法,分别检测6种沙眼衣原体蛋白抗体在TFI组、FC组和IFC组血清中的表达情况;对三组研究对象6种沙眼衣原体蛋白抗体的OD值进行统计描述,以CT-IgG的检测结果(阳/阴)为参考标准,绘制6种沙眼衣原体蛋白抗体的受试者工作特征曲线,利用约登指数确定各抗体的截断值。以TFI作为参考类,将FC、IFC分别与参考类建立两个无序多分类logistic回归模型,探究沙眼衣原体蛋白抗体、年龄预测TFI、FC和IFC的价值,并利用后退法筛选变量。【结果】各组研究对象CT376和CT443抗体OD值不全相同,CT-IgG阳性率不全相同。经两两比较发现,TFI组的CT376抗体OD值高于FC组(0.86 vs. 0.60,P=0.026)。TFI组的CT376抗体OD值高于IFC组(0.86 vs. 0.64,P=0.026)。IFC组CT443抗体OD值高于TFI组(0.59vs. 0.34,P=0.036),高于FC组(0.59 vs. 0.30,P=0.02)。经过比较,CT376抗体的阳性率在三组间不全相同(P<0.05);无序多分类logistic回归分析结果表明:TFI与FC建立的无序多分类logistic回归分析结果显示,CT-IgG [P <0.001,OR=0.084,95%CI(0.025,0.284)]、CT376抗体[P=0.068, OR=0.359,95%CI(0.120,1.078)]。CT-IgG是输卵管性不孕发生的独立危险因素,CT376抗体尚不能成为输卵管性不孕的独立危险因素;TFI与IFC建立的无序多分类logistic回归分析显示,在不孕的患者中,CT-IgG [P<0.05,OR=0.194,95%CI(0.046,0.817)]、CT376抗体[P<0.05,OR=0.176,95%CI(0.038,0.818)]和CT381抗体[P<0.05,OR=0.112,95%CI(0.016,0.796)]是输卵管性不孕发生的独立危险因素。【结论】CT376抗体在输卵管性不孕患者中的表达情况高于正常生育及非输卵管性不孕的人群,提示CT引起的输卵管性不孕或许与CT376有关。检测CT-IgG和CT376血清抗体可能对CT引起的输卵管性不孕有预测价值。展开更多
Objective To explore the association between induced abortion and tubal infertility in Chengdu, China.Methods A 1 ： 2 case-control study was designed. Infertile women with bilateral tubal occlusion in the case group ...Objective To explore the association between induced abortion and tubal infertility in Chengdu, China.Methods A 1 ： 2 case-control study was designed. Infertile women with bilateral tubal occlusion in the case group compared with two control groups： infertile control group with bilateral tubal patency and pregnant control group with currently pregnancy. Data were collected using questionnaires through face-to-face interviews, covering the subjects＇ demographic details and histories of gynecology and obstetrics. Adjusted odds ratio was calculated as a measure of the association using stepwise multiple logistic regression analysis.Results Induced abortion was not found to be associated with tubal infertility in the analysis including either the infertile controls or the pregnant controls, but other risk factors were found, such as history of acute pelvic inflammatory disease （PID）, lower abdominal surgeries, dysmenorrhea and pregnancy.Conclusion It is contended that facing an increasing trend of infertile cases with tubal occlusion in China, it is emphasized that special attention should paid to the long term impact of reproductive tract infection, especially, asymptomatic ones, rather than induced abortion.展开更多
目的:研究改进宫、腹腔镜诊治卵管性不孕症的疗效评价及对应激因子与炎症因子的影响。方法:选取2014年8月至2015年8月我院接诊的80例输卵管性不孕症患者作为本次研究对象。对照组采用传统宫、腹腔镜诊治,观察组采用改进宫、腹腔镜诊治,...目的:研究改进宫、腹腔镜诊治卵管性不孕症的疗效评价及对应激因子与炎症因子的影响。方法:选取2014年8月至2015年8月我院接诊的80例输卵管性不孕症患者作为本次研究对象。对照组采用传统宫、腹腔镜诊治,观察组采用改进宫、腹腔镜诊治,观察两组患者手术情况,治疗前后应激水平肾上腺素(E)、皮质醇(Cor)、促甲状腺激素(TSH),炎症因子白介素-2(IL-2)、白介素-6(IL-6)、白介素-8(IL-8)、C反应蛋白(CRP),治疗疗效。结果:观察组输卵管通畅率、宫内妊娠率大于对照组,再次异位妊娠率小于对照组[92.50%(37/40)vs75.00%(30/40)、95.00%(38/40)vs75.00%(30/40)、5.00%(2/40)vs22.50%(9/40)](P<0.05);观察组E、Cor小于对照组,TSH大于对照组[(96.16±10.25)ng/m L vs(152.17±16.03)ng/m L、(146.86±18.97)ng/m L vs(236.16±23.17)ng/m L、(3.10±0.50)m U/L vs(1.82±0.32)m U/L](P<0.05);观察组IL-2、IL-6、IL-8、CRP小于对照组[(17.80±2.21)pg/m L vs(29.07±4.70)pg/m L、(43.21±5.86)pg/m L vs(54.26±6.23)pg/m L、(183.25±34.20)pg/m L vs(213.97±50.65)pg/m L、(5.03±0.81)pg/m L vs(6.12±0.90)pg/m L](P<0.05);观察组总有效率优于对照组95.00%(38/40)vs75.00%(30/40)(P<0.05)。结论:改进宫、腹腔镜诊治卵管性不孕症的疗效显著,可减少应激因子与炎症因子的表达,有利于患者的预后。展开更多
基金This study was supported by grants from the Research Team of Female Reproductive Health and Fertility Preservation(No.SZSM201612065)Project for Medical Discipline Advancement of Health and Family Planning Commission of Shenzhen Municipality(No.SZXJ2017003).
文摘Summary:The optimal assisted reproductive treatment strategy for infertile women with unilateral tubal obstruction remains uncertain.To investigate the role of intrauterine insemination(IUI)in the treatment of infertile women with unilateral tubal occlusion,the data of 148 couples were retrospectively collected and analyzed.Seventy-eight infertile women with unilateral occlusion diagnosed by hysterosalpingography(HSG)were categorized as the study group and 70 others with unexplained infertility as the control group.The study group was divided into a proximal occlusion subgroup and a mid-distal occlusion subgroup for further analysis.The main outcomes,namely the clinical pregnancy rate(CPR),ongoing pregnancy rate(OPR),and live birth rate(LBR)per cycle,were analyzed.Our results showed a tendency of lower CPR,OPR,and LBR in the study group than in the control group,without statistical significance.Further investigations revealed that the unilateral proximal occlusion subgroup had similar CPR,OPR,and LBR as the control group,while the unilateral mid-distal occlusion subgroup had significantly lower CPR(5.1%vs.20.0%,P=0.035),OPR(5.1%vs.20.0%,P=0.035),and LBR(5.1%vs.20.0%,P=0.035)than the control group.In conclusion,the clinical outcomes of IUI were worse in patients with unilateral tubal occlusion than in those with unexplained infertility.This might be primarily caused by the worse outcome of patients with unilateral mid-distal tubal occlusion instead of proximal occlusion.
文摘Objectives: Numerous factors can cause infertility. Tubal factor accounts for approximately 30% of infertility in females. This study was conducted to evaluate the rate of asymptomatic Mycoplasma hominis and Ureaplasma urealyticum infection in females diagnosed with tubal obstruction. Methods: This is a retrospective case-control study conducted at New Life Fertility Centre. We have identified and reviewed the health records of 167 subfertile women that had HSG and an endocervical swab for Mycoplasma hominis and Ureaplasma urealyticum done. Results: We compared the endocervical swab results of ureaplasma and mycoplasma in the patients with tubal obstruction (group 1) to the patients with normal patent tubes (group 2). Diagnosis of tubal patency was based on the HSG results. Our results show that there is a significantly higher rate of Ureaplasma urealyticum/Mycoplasma hominis infection in group 1 compared to group 2. Conclusion: Our data shows that there is a high rate of U. urealyticum and M. hominis infection in patients diagnosed with tubal factor of infertility and it can be a marker in the prediction of the tubal pathology.
文摘【目的】研究不同类型沙眼衣原体蛋白在输卵管性不孕中的致病作用,预测具有临床检测价值的沙眼衣原体蛋白抗体。【方法】本研究共纳入输卵管性不孕组(TFI)58例,正常生育组(FC)41例,非输卵管性不孕组(IFC)18例。血清检测CT-IgG ELISA试剂盒检测三组人群血清中CT-IgG的表达情况;利用前期获得表达、纯化的6种沙眼衣原体蛋白,建立这6种沙眼衣原体蛋白抗体的ELISA检测方法,分别检测6种沙眼衣原体蛋白抗体在TFI组、FC组和IFC组血清中的表达情况;对三组研究对象6种沙眼衣原体蛋白抗体的OD值进行统计描述,以CT-IgG的检测结果(阳/阴)为参考标准,绘制6种沙眼衣原体蛋白抗体的受试者工作特征曲线,利用约登指数确定各抗体的截断值。以TFI作为参考类,将FC、IFC分别与参考类建立两个无序多分类logistic回归模型,探究沙眼衣原体蛋白抗体、年龄预测TFI、FC和IFC的价值,并利用后退法筛选变量。【结果】各组研究对象CT376和CT443抗体OD值不全相同,CT-IgG阳性率不全相同。经两两比较发现,TFI组的CT376抗体OD值高于FC组(0.86 vs. 0.60,P=0.026)。TFI组的CT376抗体OD值高于IFC组(0.86 vs. 0.64,P=0.026)。IFC组CT443抗体OD值高于TFI组(0.59vs. 0.34,P=0.036),高于FC组(0.59 vs. 0.30,P=0.02)。经过比较,CT376抗体的阳性率在三组间不全相同(P<0.05);无序多分类logistic回归分析结果表明:TFI与FC建立的无序多分类logistic回归分析结果显示,CT-IgG [P <0.001,OR=0.084,95%CI(0.025,0.284)]、CT376抗体[P=0.068, OR=0.359,95%CI(0.120,1.078)]。CT-IgG是输卵管性不孕发生的独立危险因素,CT376抗体尚不能成为输卵管性不孕的独立危险因素;TFI与IFC建立的无序多分类logistic回归分析显示,在不孕的患者中,CT-IgG [P<0.05,OR=0.194,95%CI(0.046,0.817)]、CT376抗体[P<0.05,OR=0.176,95%CI(0.038,0.818)]和CT381抗体[P<0.05,OR=0.112,95%CI(0.016,0.796)]是输卵管性不孕发生的独立危险因素。【结论】CT376抗体在输卵管性不孕患者中的表达情况高于正常生育及非输卵管性不孕的人群,提示CT引起的输卵管性不孕或许与CT376有关。检测CT-IgG和CT376血清抗体可能对CT引起的输卵管性不孕有预测价值。
基金supported by the Special Programme of Research, Development, and Research Training in Human Reproduction, World Health Organization (Project 96809)
文摘Objective To explore the association between induced abortion and tubal infertility in Chengdu, China.Methods A 1 ： 2 case-control study was designed. Infertile women with bilateral tubal occlusion in the case group compared with two control groups： infertile control group with bilateral tubal patency and pregnant control group with currently pregnancy. Data were collected using questionnaires through face-to-face interviews, covering the subjects＇ demographic details and histories of gynecology and obstetrics. Adjusted odds ratio was calculated as a measure of the association using stepwise multiple logistic regression analysis.Results Induced abortion was not found to be associated with tubal infertility in the analysis including either the infertile controls or the pregnant controls, but other risk factors were found, such as history of acute pelvic inflammatory disease （PID）, lower abdominal surgeries, dysmenorrhea and pregnancy.Conclusion It is contended that facing an increasing trend of infertile cases with tubal occlusion in China, it is emphasized that special attention should paid to the long term impact of reproductive tract infection, especially, asymptomatic ones, rather than induced abortion.
文摘目的:研究改进宫、腹腔镜诊治卵管性不孕症的疗效评价及对应激因子与炎症因子的影响。方法:选取2014年8月至2015年8月我院接诊的80例输卵管性不孕症患者作为本次研究对象。对照组采用传统宫、腹腔镜诊治,观察组采用改进宫、腹腔镜诊治,观察两组患者手术情况,治疗前后应激水平肾上腺素(E)、皮质醇(Cor)、促甲状腺激素(TSH),炎症因子白介素-2(IL-2)、白介素-6(IL-6)、白介素-8(IL-8)、C反应蛋白(CRP),治疗疗效。结果:观察组输卵管通畅率、宫内妊娠率大于对照组,再次异位妊娠率小于对照组[92.50%(37/40)vs75.00%(30/40)、95.00%(38/40)vs75.00%(30/40)、5.00%(2/40)vs22.50%(9/40)](P<0.05);观察组E、Cor小于对照组,TSH大于对照组[(96.16±10.25)ng/m L vs(152.17±16.03)ng/m L、(146.86±18.97)ng/m L vs(236.16±23.17)ng/m L、(3.10±0.50)m U/L vs(1.82±0.32)m U/L](P<0.05);观察组IL-2、IL-6、IL-8、CRP小于对照组[(17.80±2.21)pg/m L vs(29.07±4.70)pg/m L、(43.21±5.86)pg/m L vs(54.26±6.23)pg/m L、(183.25±34.20)pg/m L vs(213.97±50.65)pg/m L、(5.03±0.81)pg/m L vs(6.12±0.90)pg/m L](P<0.05);观察组总有效率优于对照组95.00%(38/40)vs75.00%(30/40)(P<0.05)。结论:改进宫、腹腔镜诊治卵管性不孕症的疗效显著,可减少应激因子与炎症因子的表达,有利于患者的预后。
