The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constru...The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced autoimmune response, high anatomical accuracy, long-term patency and growth potential. The advent of 3D bioprinting technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field. In this review, we highlight the challenges facing those seeking to create artificial tubular tissue with its associated complex macro- and microscopic architecture. Current biofabrication approaches, including 3D printing techniques, are reviewed and future directions suggested.展开更多
Hollow tubular tissues and organs of our body have various functions: gastrointestinal (esophagus), respiratory (trachea), and vascular (veins, arteries). A panel of pathologies is associated with each of these tissue...Hollow tubular tissues and organs of our body have various functions: gastrointestinal (esophagus), respiratory (trachea), and vascular (veins, arteries). A panel of pathologies is associated with each of these tissues and therapeutic interventions, surgery or replacement may be necessary. A precise knowledge of the mechanical properties of these tissues is thus required in order to understand their functioning in native conditions, to be able to elaborate some prostheses, or to design appropriate surgical training tools. These tissues may undergo expansions or contractions (peristalsis) and are exposed to internal pressures. The wall of tubular organs is organized in different layers, and each layer consists of various cell types and extra-cellular matrix, depending on the physiological functions that the organ has to fulfil. This yields anisotropic and compliant structures. In inflation experiments, the linear elasticity approach is acceptable as long as the organ’s inflation remains moderate. In this paper, elasticity laws are revisited and supplemented in order to show that, coupled with modern experimental characterization tools, they provide useful information (compliances, directional Young moduli, Poisson ratios) for the design of artificial tubular organs. The importance of a precise determination of the wall thickness and its evolution during inflation is pointed out.展开更多
基金We acknowledge the funding support from UK Engineering and Physical Sciences Research Council （EPSRC） on the Doctoral Prize Fellowship （Grant No. EP/N509760/1） for IH and the EngD studentship （Grant No. EP/L015595/1） for JL. JZS is funded by Overseas Scholarship Council and Ministry of Education in China. We also acknowledge the funding support from China-UK Research and Innovation Partnership Fund： Newton Fund Ph.D. placement programme. We thank the National Natural Science Foundation of China （No. 21534007）, and the Beijing Municipal Science ＆ Technology Commission for their financial support.
文摘The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced autoimmune response, high anatomical accuracy, long-term patency and growth potential. The advent of 3D bioprinting technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field. In this review, we highlight the challenges facing those seeking to create artificial tubular tissue with its associated complex macro- and microscopic architecture. Current biofabrication approaches, including 3D printing techniques, are reviewed and future directions suggested.
文摘Hollow tubular tissues and organs of our body have various functions: gastrointestinal (esophagus), respiratory (trachea), and vascular (veins, arteries). A panel of pathologies is associated with each of these tissues and therapeutic interventions, surgery or replacement may be necessary. A precise knowledge of the mechanical properties of these tissues is thus required in order to understand their functioning in native conditions, to be able to elaborate some prostheses, or to design appropriate surgical training tools. These tissues may undergo expansions or contractions (peristalsis) and are exposed to internal pressures. The wall of tubular organs is organized in different layers, and each layer consists of various cell types and extra-cellular matrix, depending on the physiological functions that the organ has to fulfil. This yields anisotropic and compliant structures. In inflation experiments, the linear elasticity approach is acceptable as long as the organ’s inflation remains moderate. In this paper, elasticity laws are revisited and supplemented in order to show that, coupled with modern experimental characterization tools, they provide useful information (compliances, directional Young moduli, Poisson ratios) for the design of artificial tubular organs. The importance of a precise determination of the wall thickness and its evolution during inflation is pointed out.
