期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Double-edged roles of IFNγ in tumor elimination and immune escape
1
作者 Yueyue Chen Ningning Niu Jing Xue 《Journal of Pancreatology》 2023年第1期8-17,共10页
Interferon-gamma (IFNγ) is a pleiotropic cytokine implicated in tumor immune surveillance, with its antiproliferative, pro-apoptotic, and immune-provoking effects. Regarding the antitumor effects of IFNγ, IFNγ-depe... Interferon-gamma (IFNγ) is a pleiotropic cytokine implicated in tumor immune surveillance, with its antiproliferative, pro-apoptotic, and immune-provoking effects. Regarding the antitumor effects of IFNγ, IFNγ-dependent therapies have been proposed and have undergone many clinical trials for various cancer types but the outcomes were not satisfactory. Recent studies have suggested that cancer cells develop immune evasion strategies to escape from IFNγ-dependent immunosurveillance by various mechanisms. In this review, we summarize recent advances in the effects and molecular mechanisms of IFNγ on target cells, as well as potential immune escape mechanisms of tumor cells. Furthermore, we discuss how to target IFNγ signaling and overcome immune evasion to provide promising therapeutic strategies for the treatment of patients with cancer. 展开更多
关键词 IFNΓ Immune evasion Immune therapy tumor immunosurveillance
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部