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Fiber Migration and Distribution of Twist at Different Radial Positions of Rotor Yarn-by Hi-Scope Video Microscope System 被引量:5
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作者 王善元 CHEUNG H.W. +2 位作者 张宏伟 LO M.T. 卢明德 《Journal of Donghua University(English Edition)》 EI CAS 2002年第3期45-47,共3页
This paper describes systematic measurement of fiber migration and distribution pattern of twist at different radial positions of rotor spun yarn mixed tracer fiber by Hi-Scope Video Microscope System. The positions o... This paper describes systematic measurement of fiber migration and distribution pattern of twist at different radial positions of rotor spun yarn mixed tracer fiber by Hi-Scope Video Microscope System. The positions of tracer fibers were measured in three dimensions accurately, and the migration index and the twist distribution at different radial positions of rotor yarn were calculated and analyzed. This research result serves to provide useful references for further study on the structural mechanics of rotor spun yarn. 展开更多
关键词 rotor yarn fiber migration twist distribution at different radial positions.
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Additional Twists of Yarn Produced by System of Compact Spinning with Lattice Apron 被引量:3
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作者 薛文良 魏孟媛 +1 位作者 程隆棣 钱竞芳 《Journal of Donghua University(English Edition)》 EI CAS 2011年第5期507-510,共4页
Based on the flow simulation in the condensing zone of compact spinning with lattice apron and a bead-elastic rod dynamic model of the flexible fiber,trajectories of fibers with different negative pressure are simulat... Based on the flow simulation in the condensing zone of compact spinning with lattice apron and a bead-elastic rod dynamic model of the flexible fiber,trajectories of fibers with different negative pressure are simulated by specially designed Matlab procedure.Then displacement components of fibers at YZ profile under different negative pressure conditions are extracted and compared.The results show that the fibers of different initial positions gradually converge,and are interlaced for position change in yarn cross-section,caused by the airflow in the condensing zone.Finally,compact-spun yarn with different negative pressure and conventional ring spun yarn are produced and their twists are tested.Both the results of simulation and experiments illustrate the existence of additional twists.Also the relationship between additional twists and negative pressure is verified. 展开更多
关键词 compact spinning with lattice apron SIMULATION dynamical model TRAJECTORY additional twists
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Adaptive Neural Observer-Based Nonsingular Super-Twisting Terminal Sliding-Mode Controller Design for a Class of Hovercraft Nonlinear Systems 被引量:1
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作者 Hamede Karami Reza Ghasemi 《Journal of Marine Science and Application》 CSCD 2021年第2期325-332,共8页
Designing a controller to stabilize maneuvering hovercrafts is an important challenge in amphibious vehicles.Hovercrafts are implemented in several applications,such as military missions,transportation,and scientific ... Designing a controller to stabilize maneuvering hovercrafts is an important challenge in amphibious vehicles.Hovercrafts are implemented in several applications,such as military missions,transportation,and scientific tasks.Thus.to improve their performance,it is crucial to control the system and compensate uncertainties and disruptions.In this paper,both classic and intelligent approaches are combined to design an observer-based controller.The system is assumed to be both controllable and observable.An adaptive neural network observer with guaranteed stability is derived for the nonlinear dynamics of a hovercraft,which is controlled via a nonsingular super-twisting terminal sliding-mode method.The main merits of the proposed method are as follows:(1) the Lyapunov stability of the overall closed-loop system,(2) the convergence of the tracking and observer errors to zero,(3) the robustness against uncertainties and disturbances,and(4) the reduction of the chattering phenomena.The simulation results validate the excellent performance of the derived method. 展开更多
关键词 HOVERCRAFT Neural network OBSERVER Terminal sliding mode Nonlinear system NONSINGULAR Super twisting
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TFF3依赖TWIST1上调TRIB3促结直肠癌转移的机制
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作者 陈佳乐 帕尔哈提·沙依木 +2 位作者 舒垠 苏比依努尔·苏拉依曼 艾克热木·玉苏甫 《肿瘤防治研究》 CAS 2024年第2期85-90,共6页
目的探讨TFF3基因过表达对结直肠癌HT29细胞增殖、迁移和侵袭能力的影响,以及与癌转移相关的机制。方法构建TFF3过表达的HT29细胞系,qRT-PCR和Western blot法检测TFF3、TWIST1/TRIB3信号通路及上皮间质转化过程中相关mRNA和蛋白的表达,C... 目的探讨TFF3基因过表达对结直肠癌HT29细胞增殖、迁移和侵袭能力的影响,以及与癌转移相关的机制。方法构建TFF3过表达的HT29细胞系,qRT-PCR和Western blot法检测TFF3、TWIST1/TRIB3信号通路及上皮间质转化过程中相关mRNA和蛋白的表达,CCK-8法检测HT29细胞增殖能力,细胞划痕实验和Transwell实验评估细胞迁移和侵袭能力,透射电子显微镜观察TFF3过表达前后细胞形态的变化。结果pIRES2-TFF3质粒转染HT29细胞后,相较于对照组,TFF3 mRNA和蛋白表达水平显著升高(P<0.01),细胞增殖、迁移和侵袭能力显著增强(P<0.01),且TWIST1、TRIB3、Vimentin、Snail的表达也显著上升,而E-cadherin的表达则明显下降(P<0.05)。TFF3过表达后的HT29细胞出现了多种变化,如细胞间连接减少、绒毛脱落、伪足形成,以及形态上梭形细胞增多等。结论TFF3过表达可能通过Twist1/TRIB3信号通路促进结直肠癌细胞的EMT过程,从而提高其转移潜力,加速癌症的恶性进展。 展开更多
关键词 TFF3 结直肠癌 twist1/TRIB3信号通路 上皮间质转化 肿瘤转移
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Twisted Yangian Y(sp_(2))的单权模 被引量:2
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作者 刘晓华 谭易兰 夏利猛 《东北师大学报(自然科学版)》 CAS 北大核心 2024年第1期1-7,共7页
讨论了Twisted Yangian Y(sp_(N))的权模问题,构造了Y(sp_(2))的一类无限维单权模,分类了具有一个一维权空间的Y(sp_(2))单权模.
关键词 twisted Yangian 权模 单模 Dense模 Pointed模
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Observation and Research on the Twisting Characteristics of Flare Loop System
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作者 Li Rufeng, Bi Shaolan, Dun Jinping (Yunnan Observatory, The Chinese Academy of Sciences, Kunming 650011, China)$$$$ 《天文研究与技术》 CSCD 1999年第S1期438-441,共4页
We analyze the evolution of Hβ monochromatic images and Hβ velocity fields of the flare loops system on June 4, 1991. It is the first time to demonstrate directly the dynamic process of the energy storage, transport... We analyze the evolution of Hβ monochromatic images and Hβ velocity fields of the flare loops system on June 4, 1991. It is the first time to demonstrate directly the dynamic process of the energy storage, transportation and release of the twisting magnetic fields in the flare process. 展开更多
关键词 FLARE LOOP system twistING ENERGY STORAGE
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Twisting Sliding Mode Control of an Electrostatic MEMS Micromirror for a Laser Scanning System
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作者 Hui Chen Zhendong Sun +1 位作者 Weijie Sun John Tze Wei Yeow 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2019年第4期1060-1067,共8页
In this paper,we present a twisting control scheme with proportional-integral-derivative(PID)sliding surface for a two-axis electrostatic torsional micromirror,and the utilization of the proposed scheme in a laser sca... In this paper,we present a twisting control scheme with proportional-integral-derivative(PID)sliding surface for a two-axis electrostatic torsional micromirror,and the utilization of the proposed scheme in a laser scanning system.The experimental results of set-point regulation verify that the proposed scheme provides enhanced transient response and positioning performance as compared to traditional sliding mode control.To evaluate the tracking performance of the closed-loop system,triangular waves with different frequencies are used as desired traces.With the proposed scheme the experimental results verified that the closed-loop controlled micromirror follows the given triangular trajectories precisely.A micromirror-based laser scanning system is developed to obtain images.When compared with open-loop control,the experimental results demonstrated that the proposed scheme is able to reduce the distortion of the raster scan,and improve the imaging performance in the presence of cross-coupling effect. 展开更多
关键词 Electrostatic micromirror IMAGING microelectromechanical system(MEMS) twisting algorithm
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Large valley Nernst effect in twisted multilayer graphene systems
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作者 简冠林 朱振刚 苏刚 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第10期22-30,共9页
Valley Nernst effect is a newly proposed and experimentally confirmed effect,which could be used to design novel thermoelectric devices.We study the valley Nernst effect in(M+N)-layer twisted multilayer graphene syste... Valley Nernst effect is a newly proposed and experimentally confirmed effect,which could be used to design novel thermoelectric devices.We study the valley Nernst effect in(M+N)-layer twisted multilayer graphene systems by a simple low-energy effective model.It is found that the total valley Nernst coefficient(VNC)is three orders of magnitude larger than that in monolayer group-Ⅵdichalcogenides.The total VNC increases with the increase of layer numbers.It is shown that the total VNC exhibits a structure with three peaks as a function of the Fermi energy.We identify that the central peak is always negative stemming from the flat band.Two shoulder peaks are positively induced by the conduction and valence bands,respectively.These predicted features can be tested experimentally.The present work would shed more light on valley caloritronics. 展开更多
关键词 valley Nernst effect twisted multilayer graphene
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Implement of the Production Monitoring and Control System for Coning,Drawing and Twisting's Workshop
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作者 邵景峰 李永刚 +2 位作者 张奎 李波 李佳 《Journal of Donghua University(English Edition)》 EI CAS 2010年第5期687-693,共7页
To achieve the production information management of the coning,drawing and twisting's workshop,and promote a good and fast development of the textile enterprise,firstly,we analyze the information technology develo... To achieve the production information management of the coning,drawing and twisting's workshop,and promote a good and fast development of the textile enterprise,firstly,we analyze the information technology development status of the textile enterprise at home and abroad,study the weaknesses of the existing computer monitoring system,introduce the system design project,and propose a system network model based on client/server(C/S)mode.Secondly,a multi-agent production monitoring and control system is developed,and the communication of the single-port-multi-protocol and a multi-thread data collection technology are studied via the multi-thread and standard template library(STL)technologies.Thirdly,the system management functions,the structure design of the database,and the technical difficulties in the process of software design are also introduced.As proved in practice,the system satisfies the production management requirements of the workshop,and implements the network management of the production information. 展开更多
关键词 monitoring system CONING drawing and twisting's workshop communication MULTI-THREAD client/server(C/S)
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Twisted Integration of Complex Oxide Magnetoelectric Heterostructures via Water‑Etching and Transfer Process
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作者 Guannan Yang Guohua Dong +4 位作者 Butong Zhang Xu Xu Yanan Zhao Zhongqiang Hu Ming Liu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期360-369,共10页
Manipulating strain mode and degree that can be applied to epitaxial complex oxide thin films have been a cornerstone of strain engineering.In recent years,lift-off and transfer technology of the epitaxial oxide thin ... Manipulating strain mode and degree that can be applied to epitaxial complex oxide thin films have been a cornerstone of strain engineering.In recent years,lift-off and transfer technology of the epitaxial oxide thin films have been developed that enabled the integration of heterostructures without the limitation of material types and crystal orientations.Moreover,twisted integration would provide a more interesting strategy in artificial magnetoelectric heterostructures.A specific twist angle between the ferroelectric and ferromagnetic oxide layers corresponds to the distinct strain regulation modes in the magnetoelectric coupling process,which could provide some insight in to the physical phenomena.In this work,the La_(0.67)Sr_(0.33)MnO_(3)(001)/0.7Pb(Mg_(1/3)Nb_(2/3))O_(3)-0.3PbTiO_(3)(011)(LSMO/PMN-PT)heterostructures with 45.and 0.twist angles were assembled via water-etching and transfer process.The transferred LSMO films exhibit a fourfold magnetic anisotropy with easy axis along LSMO<110>.A coexistence of uniaxial and fourfold magnetic anisotropy with LSMO[110]easy axis is observed for the 45°Sample by applying a 7.2 kV cm^(−1)electrical field,significantly different from a uniaxial anisotropy with LSMO[100]easy axis for the 0°Sample.The fitting of the ferromagnetic resonance field reveals that the strain coupling generated by the 45°twist angle causes different lattice distortion of LSMO,thereby enhancing both the fourfold and uniaxial anisotropy.This work confirms the twisting degrees of freedom for magnetoelectric coupling and opens opportunities for fabricating artificial magnetoelectric heterostructures. 展开更多
关键词 Magnetoelectric heterostructures twist angle Epitaxial lift-off Magnetic anisotropy Ferromagnetic resonance
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Valley-dependent transport in a mescoscopic twisted bilayer graphene device
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作者 史文萱 刘翰林 汪军 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期61-65,共5页
We study the valley-dependent electron transport in a four-terminal mesoscopic device of the two monolayer graphene nanoribbons vertically stacked together, where the intersection forms a bilayer graphene lattice with... We study the valley-dependent electron transport in a four-terminal mesoscopic device of the two monolayer graphene nanoribbons vertically stacked together, where the intersection forms a bilayer graphene lattice with a controllable twist angle. Using a tight-binding lattice model, we show that the longitudinal and transverse conductances exhibit significant valley polarization in the low energy regime for small twist angles. As the twist angle increases, the valley polarization shifts to the high energy regime. This arises from the regrouping effect of the electron band in the twisted bilayer graphene region. But for relatively large twist angles, no significant valley polarization is observed. These results are consistent with the spectral densities of the twisted bilayer graphene. 展开更多
关键词 twisted bilayer graphene valley-dependent transport graphene nanoribbon CONDUCTANCE
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Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction
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作者 Mohamed Naguib Abouelsaad Mohammed Shaaban +1 位作者 Salah El Bagalaty Mohamed E.El Madawy 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第3期663-675,共13页
A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise buildings.In addition,the difference between the seismic perfor... A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise buildings.In addition,the difference between the seismic performance of using twisting towers over regular ones is investigated.The twisting tower is a simulation of the Evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft foundation.The soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,Egypt).The only difference between both towers is their shape in elevation.The whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in SSI.All analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some graphs.Based on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases. 展开更多
关键词 soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX
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Visualizing the Local Twist Angle Variation within and between Domains of Twisted Bilayer Graphene
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作者 户佳玮 朱诗雨 +7 位作者 胡倩颖 王云昊 申承民 杨海涛 竺晓山 郇庆 许杨 高鸿钧 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第3期146-151,共6页
Moirésuperlattices in twisted two-dimensional materials have emerged as ideal platforms for engineering quantum phenomena,which are highly sensitive to twist angles,including both the global value and the spatial... Moirésuperlattices in twisted two-dimensional materials have emerged as ideal platforms for engineering quantum phenomena,which are highly sensitive to twist angles,including both the global value and the spatial inhomogeneity.However,only a few methods provide spatial-resolved information for characterizing local twist angle distribution. 展开更多
关键词 ANGLE twist twist
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Twisted Yangian Y(sp^(2))的一类单权模
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作者 周义坤 谭易兰 徐森荣 《东北师大学报(自然科学版)》 CAS 北大核心 2024年第3期1-4,共4页
研究了Twisted Yangian Y(g_(N))的权模问题,构造了Y(sp^(2))的一类权空间维数均为2的无限维权模,给出了该权模不可约的充分条件.
关键词 twisted Yangian 权模 单模
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Retraction:miR-203 suppresses bladder cancer cell growth and targets twist1
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作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2024年第10期1693-1693,共1页
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ... Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases. 展开更多
关键词 BLADDER twist shaped
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Twist2表达与卵巢癌脉管浸润及预后的相关研究
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作者 蒋婧婧 张红玲 +1 位作者 付方方 王恬 《实用妇产科杂志》 CAS CSCD 北大核心 2024年第5期369-373,共5页
目的:分析Twist2与卵巢癌患者的预后及脉管浸润之间的关系,探索Twist2在卵巢癌脉管浸润中的作用及机制。方法:利用KM plotter分析卵巢癌患者中Twist2 mRNA的表达与卵巢癌总生存率(OS)、无进展生存率(PFS)、肿瘤进展后生存率(PPS)的相关... 目的:分析Twist2与卵巢癌患者的预后及脉管浸润之间的关系,探索Twist2在卵巢癌脉管浸润中的作用及机制。方法:利用KM plotter分析卵巢癌患者中Twist2 mRNA的表达与卵巢癌总生存率(OS)、无进展生存率(PFS)、肿瘤进展后生存率(PPS)的相关性。利用癌症基因组学数据库cBioportal分析卵巢癌患者中Twist2与脉管浸润的相关性。体外实验:采用Transwell检测Twist2对卵巢癌CAOV3细胞[空白组、阴性对照组(siNC组)、siTwist2组]侵袭、迁移能力的影响,并利用实时荧光定量多聚核苷酸链式反应(realtime-PCR)及蛋白免疫印迹(Western blot)检测分别从RNA水平及蛋白水平检测下调Twist2表达后CAOV3细胞中Twist2、血管内皮生长因子C(VEGFC)表达的变化。结果:①KM plotter在线数据分析结果示,Twist2高表达的卵巢癌患者与不良预后有关,OS(HR 1.24,95%CI 1.01~1.52)、PFS(HR 1.39,95%CI 1.14~1.70)及PPS(HR 1.37,95%CI 1.08~1.74)差异均有统计学意义(P<0.05);cBioportal分析示,Twist2 mRNA表达与卵巢癌血管浸润(r=0.93,P=0.001)及淋巴管浸润(r=0.89,P=0.009)均呈正相关。②体外实验Transwell检测示,与空白组和siNC组比较,siTwist2组卵巢癌细胞的侵袭及迁移能力显著下降(P<0.05)。Realtime-PCR及Western blot检测示,与空白组和siNC组比较,siTwist2组中Twist2 mRNA及蛋白、VEGFC mRNA及蛋白的表达均明显下降(P<0.05)。结论:卵巢癌中Twist2的表达与肿瘤预后及脉管浸润密切相关,下调Twist2后,细胞迁移及侵袭穿透的细胞数明显减少、VEGFC表达降低,Twist2可能通过VEGFC来诱导肿瘤细胞侵袭转移参与肿瘤脉管浸润,Twist2可能是未来卵巢癌评估预后及靶向治疗的指标之一。 展开更多
关键词 卵巢癌 twist2 血管内皮生长因子C 预后 脉管浸润
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Wafer-scale 30°twisted bilayer graphene epitaxially grown on Cu_(0.75)Ni_(0.25)(111)
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作者 马鹏程 张翱 +10 位作者 甄洪润 江志诚 杨逸尘 丁建阳 刘正太 刘吉山 沈大伟 于庆凯 刘丰 张学富 刘中灏 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期467-471,共5页
Twisted bilayer graphene(TBG) has been extensively studied because of its novel physical properties and potential application in electronic devices.Here we report the synthesis and characterization of 300 TBG naturall... Twisted bilayer graphene(TBG) has been extensively studied because of its novel physical properties and potential application in electronic devices.Here we report the synthesis and characterization of 300 TBG naturally grown on Cu_(0.75)Ni_(0.25)(111) film and investigate the electronic structure by angle-resolved photoemission spectroscopy.Compared with other substrates,our TBG with a wafer scale is acquired with a shorter growth time.The Fermi velocity and energy gap of Dirac cones of TBG are comparable with those of a monolayer on Cu_(0.85)Ni_(0.15)(111).The signature of moré lattices has not been observed in either the low-energy electron diffraction patterns or the Fermi surface map within experimental resolution,possibly due to different Cu and Ni contents in the substrates enhancing the different couplings between the substrate and the first/second layers and hindering the formation of a quasiperiodic structure. 展开更多
关键词 twisted bilayer graphene electronic structure Cu/Ni(111)
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Tubular Heat Enhancement Using Twisted Tape Inserts with Large Holes
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作者 Ali Jaber Abdulhamed Aws Al-Akam +1 位作者 Wisam J.Khudhayer Ali Sabri Allw 《Energy Engineering》 EI 2024年第2期273-290,共18页
Heat augmentation techniques play a vital role in the heating and cooling processes in industries,including solar collectors and many applications that utilize heat exchangers.Several studies are based on inserting fi... Heat augmentation techniques play a vital role in the heating and cooling processes in industries,including solar collectors and many applications that utilize heat exchangers.Several studies are based on inserting fillers inside the tubes to enhance heat transfer.This investigation considered the effects of twisted tapes with large holes on a tubular heat exchanger’s(HX)heat transmission,pressure drop,and thermal boosting factor.In the experimental section,counter-swirl flow generators used twisted tapes with pairs of 1.0 cm-diameter holes and changes in porosity(Rp)at 1.30%and 2.70%.In the experiments,air was utilized as a working fluid in a tube with a circular cross-section.The turbulent flow was considered,with Reynolds numbers(Re)domain from 4800 to 9500,and a boundary condition with a uniform wall heat flux was constructed.The findings expound that when the number of holes rose,the Nusselt number(Nu),the factor of friction(f),and the thermal enhancement factor(η)all increased as well.Additionally,as the friction factor increased,the Nusselt number of the tape-equipped tube was noticeably higher.Additionally,it was discovered that the friction factor was between 70%and 94%lower than the values of the tube without tape,while the(Nu)was between 87%and 97%higher than the conventional tube values.The maximum value ofηis 89%.According to the experimental results,empirical correlations for Nu,f,andηwere also generated. 展开更多
关键词 TUBULAR heat exchanger tape inserts twisted tape
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TWIST1通过激活自噬促进肺动脉高压大鼠模型肺血管重塑作用及机制的实验研究
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作者 贺红艳 晁满香 +2 位作者 翟翠 张晴 李海燕 《现代检验医学杂志》 CAS 2024年第4期45-49,共5页
目的探讨Twist相关蛋白1(Twist-related protein 1,TWIST1)对野百合碱(Monocrotaline,MCT)诱导的肺动脉高压(pulmonary arterial hypertension,PAH)大鼠肺血管重塑的影响及机制。方法将50只健康雄性SD大鼠,随机分为5组,即对照组、模型... 目的探讨Twist相关蛋白1(Twist-related protein 1,TWIST1)对野百合碱(Monocrotaline,MCT)诱导的肺动脉高压(pulmonary arterial hypertension,PAH)大鼠肺血管重塑的影响及机制。方法将50只健康雄性SD大鼠,随机分为5组,即对照组、模型组、二甲基亚砜(Dimethyl sulfoxide,DMSO)溶剂处理的模型组、TWIST1抑制剂Harmine组、自噬抑制剂羟氯喹组。检测右心室收缩压(RVSP),右心室肥厚指数(RVHI)和内膜厚度百分比(MT%)以评估大鼠PAH的发展。采用免疫印迹法检测TWIST1,自噬相关蛋白LC3B以及RND3的蛋白质水平。结果与对照组比较,MCT诱导的PAH大鼠中TWIST1和LC3B表达增加,分别为对照组的2.32±0.22倍和0.87±0.19倍,差异具有统计学意义(t=15.812,11.227,均P<0.001);同时RND3表达下调,为对照组的0.32±0.07倍,差异具有统计学意义(t=-13.003,P<0.001)。给与TWIST1抑制剂Harmine或自噬抑制剂羟氯喹可显著抑制MCT诱导的自噬激活和RND3表达下调,同时降低了MCT诱导的PAH大鼠的RVSP,RVHI和MT%,差异具有统计学意义(t=-24.277~16.636,均P<0.001)。结论TWIST1通过诱导自噬激活促进肺血管重塑,促进PAH的发生发展。 展开更多
关键词 肺动脉高压 血管重塑 twist相关蛋白1
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子宫内膜癌组织CTGF、TWIST1、NCAPH的表达与临床病理特征及预后的关系
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作者 丁其培 卢红 +3 位作者 陆月梅 薛晓玲 陈薇 章杨韦 《国际检验医学杂志》 CAS 2024年第8期981-986,共6页
目的 探讨子宫内膜癌组织中结缔组织生长因子(CTGF)、TWIST1和非平滑肌细胞凝聚素Ⅰ复合亚单位H(NCAPH)蛋白的表达,以及与肿瘤临床病理特征及患者预后的关系。方法 回顾性分析2017年1月至2019年1月于南通大学附属海安医院行全子宫切除术... 目的 探讨子宫内膜癌组织中结缔组织生长因子(CTGF)、TWIST1和非平滑肌细胞凝聚素Ⅰ复合亚单位H(NCAPH)蛋白的表达,以及与肿瘤临床病理特征及患者预后的关系。方法 回顾性分析2017年1月至2019年1月于南通大学附属海安医院行全子宫切除术140例患者的临床资料,其中术后病理证实为子宫内膜癌68例(子宫内膜癌组)、不典型增生42例(不典型增生组)和正常子宫内膜30例(正常组)。采用免疫组化染色法检测3组CTGF、TWIST1和NCAPH蛋白的阳性表达率,分析其与子宫内膜癌患者的肿瘤病理特征和预后的关系。结果 子宫内膜癌组CTGF、TWIST1和NCAPH蛋白的阳性表达率均明显高于不典型增生组和正常组,差异有统计学意义(P<0.05),而不典型增生组和正常组上述指标比较差异无统计学意义(P>0.05)。子宫内膜癌组CTGF、TWIST1和NCAPH蛋白的阳性表达率与患者年龄、肿瘤分化程度和病理类型无相关性(P>0.05),而与肿瘤临床分期、淋巴结转移和肿瘤肌层浸润深度密切相关(P<0.05)。Kaplan-Meier生存分析显示,子宫内膜癌组CTGF、TWIST1和NCAPH阳性表达患者的累积总生存率均明显低于阴性表达患者(P<0.05)。单因素和多因素COX回归分析显示,国际妇产科联盟(FIGO)分期Ⅲ~Ⅳ期、淋巴结转移阳性、CTGF、TWIST1和NCAPH阳性表达是患者死亡的独立危险因素(P<0.05)。结论 子宫内膜癌患者组织CTGF、TWIST1和NCAPH表达上调可能与肿瘤发生和发展密切相关,三者可作为预测生存预后的重要生物标志物。 展开更多
关键词 子宫内膜癌 结缔组织生长因子 twist1 非平滑肌细胞凝聚素Ⅰ复合亚单位H 病理特征 预后 危险因素
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