Remarkably different results between two studies from North America on genomic mutations and sensitivity to DNA demethylating agents for myelodysplastic syndromes

Sekeres et al. （1） conducted a multicenter randomized, controlled trial to compare whether azacitidine-based combinations with lenalidomide or vorinostat produce superior overall response rates to azacitidine in the treatment of myelodysplastic syndromes （MDS）. In that trial, 224 patients with higher-risk MDS and 53 with chronic myelomonocytic leukemia （CMML） were enrolled and randomly assigned to the ＂azacitidine＂ group, ＂azacitidine plus lenalidomide＂ group or ＂azacitidine plus vorinostat＂ group. The researchers found that patients with MDS treated with azacitidine-based combinations had similar response rate to azacitidine monotherapy. Using genomic mutation analysis, they found that the overall response rate to azacitidine-based treatment was higher for patients with mutations in DNMT3A and lower for those with mutations in SRSF2. Whereas in another study, Welch et al. enrolled 26 patients with MDS and 90 with acute myeloid leukemia （AML） who were treated with decitabine, and they found that patients with TP53 mutations had a higher response rate, but not those with DNMT3A mutations （2）. We propose that this big discrepancy in the conclusions between the two studies might have been caused by the presence of many co-interacting factors, e.g. study aims, DNA demethylating agents, treatment protocols, and patient sources.

Workout Action Recognition in Video Streams Using an Attention Driven Residual DC-GRU Network

Regular exercise is a crucial aspect of daily life, as it enables individuals to stay physically active, lowers thelikelihood of developing illnesses, and enhances life expectancy. The recognition of workout actions in videostreams holds significant importance in computer vision research, as it aims to enhance exercise adherence, enableinstant recognition, advance fitness tracking technologies, and optimize fitness routines. However, existing actiondatasets often lack diversity and specificity for workout actions, hindering the development of accurate recognitionmodels. To address this gap, the Workout Action Video dataset (WAVd) has been introduced as a significantcontribution. WAVd comprises a diverse collection of labeled workout action videos, meticulously curated toencompass various exercises performed by numerous individuals in different settings. This research proposes aninnovative framework based on the Attention driven Residual Deep Convolutional-Gated Recurrent Unit (ResDCGRU)network for workout action recognition in video streams. Unlike image-based action recognition, videoscontain spatio-temporal information, making the task more complex and challenging. While substantial progresshas been made in this area, challenges persist in detecting subtle and complex actions, handling occlusions,and managing the computational demands of deep learning approaches. The proposed ResDC-GRU Attentionmodel demonstrated exceptional classification performance with 95.81% accuracy in classifying workout actionvideos and also outperformed various state-of-the-art models. The method also yielded 81.6%, 97.2%, 95.6%, and93.2% accuracy on established benchmark datasets, namely HMDB51, Youtube Actions, UCF50, and UCF101,respectively, showcasing its superiority and robustness in action recognition. The findings suggest practicalimplications in real-world scenarios where precise video action recognition is paramount, addressing the persistingchallenges in the field. TheWAVd dataset serves as a catalyst for the development ofmore robust and effective fitnesstracking systems and ultimately promotes healthier lifestyles through improved exercise monitoring and analysis.

Abnormal Action Recognition with Lightweight Pose Estimation Network in Electric Power Training Scene

Electric power training is essential for ensuring the safety and reliability of the system.In this study,we introduce a novel Abnormal Action Recognition(AAR)system that utilizes a Lightweight Pose Estimation Network(LPEN)to efficiently and effectively detect abnormal fall-down and trespass incidents in electric power training scenarios.The LPEN network,comprising three stages—MobileNet,Initial Stage,and Refinement Stage—is employed to swiftly extract image features,detect human key points,and refine them for accurate analysis.Subsequently,a Pose-aware Action Analysis Module(PAAM)captures the positional coordinates of human skeletal points in each frame.Finally,an Abnormal Action Inference Module(AAIM)evaluates whether abnormal fall-down or unauthorized trespass behavior is occurring.For fall-down recognition,three criteria—falling speed,main angles of skeletal points,and the person’s bounding box—are considered.To identify unauthorized trespass,emphasis is placed on the position of the ankles.Extensive experiments validate the effectiveness and efficiency of the proposed system in ensuring the safety and reliability of electric power training.

BCCLR:A Skeleton-Based Action Recognition with Graph Convolutional Network Combining Behavior Dependence and Context Clues

In recent years,skeleton-based action recognition has made great achievements in Computer Vision.A graph convolutional network(GCN)is effective for action recognition,modelling the human skeleton as a spatio-temporal graph.Most GCNs define the graph topology by physical relations of the human joints.However,this predefined graph ignores the spatial relationship between non-adjacent joint pairs in special actions and the behavior dependence between joint pairs,resulting in a low recognition rate for specific actions with implicit correlation between joint pairs.In addition,existing methods ignore the trend correlation between adjacent frames within an action and context clues,leading to erroneous action recognition with similar poses.Therefore,this study proposes a learnable GCN based on behavior dependence,which considers implicit joint correlation by constructing a dynamic learnable graph with extraction of specific behavior dependence of joint pairs.By using the weight relationship between the joint pairs,an adaptive model is constructed.It also designs a self-attention module to obtain their inter-frame topological relationship for exploring the context of actions.Combining the shared topology and the multi-head self-attention map,the module obtains the context-based clue topology to update the dynamic graph convolution,achieving accurate recognition of different actions with similar poses.Detailed experiments on public datasets demonstrate that the proposed method achieves better results and realizes higher quality representation of actions under various evaluation protocols compared to state-of-the-art methods.

Study on the Mechanism of Action of Glyasperin A in the Treatment of Atherosclerosis Based on Network Pharmacology and Molecular Docking

[Objectives] This study was conducted to investigate the mechanism of action of glyasperin A in the treatment of atherosclerosis using a network pharmacology approach. [Methods] Targets related to atherosclerosis were searched in GeneCards database. An active ingredient-disease-target network was constructed by Cytoscape 3.7.1. A target protein interaction network was constructed by String database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the DAVID database. [Results] Glyasperin A acted on 36 atherosclerosis-related targets, and the biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, barrier, and lipid oxidation, etc. The results showed that glyasperin A acted on 36 atherosclerosis-related targets. The biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, positive regulation of protein localization to nucleus, and hepoxilin biosynthetic process, and it played an anti-fatigue role through signal pathways such as serotonergic synapse, efferocytosis, arachidonic acid metabolism, chemical carcinogenesis-receptor activation and platelet activation. [Conclusions] Glyasperin A has multi-target and multi-pathway effects in the treatment of atherosclerosis. This study provides reference for further research on glyasperin A in the treatment of atherosclerosis.

Deep Learning-Based Action Classification Using One-Shot Object Detection

Deep learning-based action classification technology has been applied to various fields,such as social safety,medical services,and sports.Analyzing an action on a practical level requires tracking multiple human bodies in an image in real-time and simultaneously classifying their actions.There are various related studies on the real-time classification of actions in an image.However,existing deep learning-based action classification models have prolonged response speeds,so there is a limit to real-time analysis.In addition,it has low accuracy of action of each object ifmultiple objects appear in the image.Also,it needs to be improved since it has a memory overhead in processing image data.Deep learning-based action classification using one-shot object detection is proposed to overcome the limitations of multiframe-based analysis technology.The proposed method uses a one-shot object detection model and a multi-object tracking algorithm to detect and track multiple objects in the image.Then,a deep learning-based pattern classification model is used to classify the body action of the object in the image by reducing the data for each object to an action vector.Compared to the existing studies,the constructed model shows higher accuracy of 74.95%,and in terms of speed,it offered better performance than the current studies at 0.234 s per frame.The proposed model makes it possible to classify some actions only through action vector learning without additional image learning because of the vector learning feature of the posterior neural network.Therefore,it is expected to contribute significantly to commercializing realistic streaming data analysis technologies,such as CCTV.

Fine-Grained Action Recognition Based on Temporal Pyramid Excitation Network

Mining more discriminative temporal features to enrich temporal context representation is considered the key to fine-grained action recog-nition.Previous action recognition methods utilize a fixed spatiotemporal window to learn local video representation.However,these methods failed to capture complex motion patterns due to their limited receptive field.To solve the above problems,this paper proposes a lightweight Temporal Pyramid Excitation(TPE)module to capture the short,medium,and long-term temporal context.In this method,Temporal Pyramid(TP)module can effectively expand the temporal receptive field of the network by using the multi-temporal kernel decomposition without significantly increasing the computational cost.In addition,the Multi Excitation module can emphasize temporal importance to enhance the temporal feature representation learning.TPE can be integrated into ResNet50,and building a compact video learning framework-TPENet.Extensive validation experiments on several challenging benchmark(Something-Something V1,Something-Something V2,UCF-101,and HMDB51)datasets demonstrate that our method achieves a preferable balance between computation and accuracy.

A Novel Action Transformer Network for Hybrid Multimodal Sign Language Recognition

Sign language fills the communication gap for people with hearing and speaking ailments.It includes both visual modalities,manual gestures consisting of movements of hands,and non-manual gestures incorporating body movements including head,facial expressions,eyes,shoulder shrugging,etc.Previously both gestures have been detected;identifying separately may have better accuracy,butmuch communicational information is lost.Aproper sign language mechanism is needed to detect manual and non-manual gestures to convey the appropriate detailed message to others.Our novel proposed system contributes as Sign LanguageAction Transformer Network(SLATN),localizing hand,body,and facial gestures in video sequences.Here we are expending a Transformer-style structural design as a“base network”to extract features from a spatiotemporal domain.Themodel impulsively learns to track individual persons and their action context inmultiple frames.Furthermore,a“head network”emphasizes hand movement and facial expression simultaneously,which is often crucial to understanding sign language,using its attention mechanism for creating tight bounding boxes around classified gestures.The model’s work is later compared with the traditional identification methods of activity recognition.It not only works faster but achieves better accuracy as well.Themodel achieves overall 82.66%testing accuracy with a very considerable performance of computation with 94.13 Giga-Floating Point Operations per Second(G-FLOPS).Another contribution is a newly created dataset of Pakistan Sign Language forManual and Non-Manual(PkSLMNM)gestures.

MSF-Net: A Multilevel Spatiotemporal Feature Fusion Network Combines Attention for Action Recognition

An action recognition network that combines multi-level spatiotemporal feature fusion with an attention mechanism is proposed as a solution to the issues of single spatiotemporal feature scale extraction,information redundancy,and insufficient extraction of frequency domain information in channels in 3D convolutional neural networks.Firstly,based on 3D CNN,this paper designs a new multilevel spatiotemporal feature fusion(MSF)structure,which is embedded in the network model,mainly through multilevel spatiotemporal feature separation,splicing and fusion,to achieve the fusion of spatial perceptual fields and short-medium-long time series information at different scales with reduced network parameters;In the second step,a multi-frequency channel and spatiotemporal attention module(FSAM)is introduced to assign different frequency features and spatiotemporal features in the channels are assigned corresponding weights to reduce the information redundancy of the feature maps.Finally,we embed the proposed method into the R3D model,which replaced the 2D convolutional filters in the 2D Resnet with 3D convolutional filters and conduct extensive experimental validation on the small and medium-sized dataset UCF101 and the largesized dataset Kinetics-400.The findings revealed that our model increased the recognition accuracy on both datasets.Results on the UCF101 dataset,in particular,demonstrate that our model outperforms R3D in terms of a maximum recognition accuracy improvement of 7.2%while using 34.2%fewer parameters.The MSF and FSAM are migrated to another traditional 3D action recognition model named C3D for application testing.The test results based on UCF101 show that the recognition accuracy is improved by 8.9%,proving the strong generalization ability and universality of the method in this paper.

Using BlazePose on Spatial Temporal Graph Convolutional Networks for Action Recognition

The ever-growing available visual data(i.e.,uploaded videos and pictures by internet users)has attracted the research community’s attention in the computer vision field.Therefore,finding efficient solutions to extract knowledge from these sources is imperative.Recently,the BlazePose system has been released for skeleton extraction from images oriented to mobile devices.With this skeleton graph representation in place,a Spatial-Temporal Graph Convolutional Network can be implemented to predict the action.We hypothesize that just by changing the skeleton input data for a different set of joints that offers more information about the action of interest,it is possible to increase the performance of the Spatial-Temporal Graph Convolutional Network for HAR tasks.Hence,in this study,we present the first implementation of the BlazePose skeleton topology upon this architecture for action recognition.Moreover,we propose the Enhanced-BlazePose topology that can achieve better results than its predecessor.Additionally,we propose different skeleton detection thresholds that can improve the accuracy performance even further.We reached a top-1 accuracy performance of 40.1%on the Kinetics dataset.For the NTU-RGB+D dataset,we achieved 87.59%and 92.1%accuracy for Cross-Subject and Cross-View evaluation criteria,respectively.

Feature Fusion-Based Deep Learning Network to Recognize Table Tennis Actions

A system for classifying four basic table tennis strokes using wearable devices and deep learning networks is proposed in this study.The wearable device consisted of a six-axis sensor,Raspberry Pi 3,and a power bank.Multiple kernel sizes were used in convolutional neural network(CNN)to evaluate their performance for extracting features.Moreover,a multiscale CNN with two kernel sizes was used to perform feature fusion at different scales in a concatenated manner.The CNN achieved recognition of the four table tennis strokes.Experimental data were obtained from20 research participants who wore sensors on the back of their hands while performing the four table tennis strokes in a laboratory environment.The data were collected to verify the performance of the proposed models for wearable devices.Finally,the sensor and multi-scale CNN designed in this study achieved accuracy and F1 scores of 99.58%and 99.16%,respectively,for the four strokes.The accuracy for five-fold cross validation was 99.87%.This result also shows that the multi-scale convolutional neural network has better robustness after fivefold cross validation.

Two-Stream Deep Learning Architecture-Based Human Action Recognition

Human action recognition(HAR)based on Artificial intelligence reasoning is the most important research area in computer vision.Big breakthroughs in this field have been observed in the last few years;additionally,the interest in research in this field is evolving,such as understanding of actions and scenes,studying human joints,and human posture recognition.Many HAR techniques are introduced in the literature.Nonetheless,the challenge of redundant and irrelevant features reduces recognition accuracy.They also faced a few other challenges,such as differing perspectives,environmental conditions,and temporal variations,among others.In this work,a deep learning and improved whale optimization algorithm based framework is proposed for HAR.The proposed framework consists of a few core stages i.e.,frames initial preprocessing,fine-tuned pre-trained deep learning models through transfer learning(TL),features fusion using modified serial based approach,and improved whale optimization based best features selection for final classification.Two pre-trained deep learning models such as InceptionV3 and Resnet101 are fine-tuned and TL is employed to train on action recognition datasets.The fusion process increases the length of feature vectors;therefore,improved whale optimization algorithm is proposed and selects the best features.The best selected features are finally classified usingmachine learning(ML)classifiers.Four publicly accessible datasets such as Ut-interaction,Hollywood,Free Viewpoint Action Recognition usingMotion History Volumes(IXMAS),and centre of computer vision(UCF)Sports,are employed and achieved the testing accuracy of 100%,99.9%,99.1%,and 100%respectively.Comparison with state of the art techniques(SOTA),the proposed method showed the improved accuracy.

Pharmacological Action and Molecular Mechanism of Amentoflavone

Amentoflavone(AMF)is a natural active substance extracted from Chinese herbal medicine Selaginella tamariscina,and has good anti-inflammatory,antitumor,hypoglycemic and neuroprotective pharmacological effects.This paper reviews the pharmacological action and mechanism of AMF,in order to lay a theoretical foundation for in-depth research and drug development of AMF.

基于LDA主题模型的GitHub Actions工作流项目推荐算法

在CI/CD实践中,自动化已成为软件开发实践中的一种规范。GitHub引入GitHub Actions为软件维护者提供自动化的持续集成工作流方案,尽管其为开发者提供了诸多便利,GitHub社区也提供了许多第三方的GitHub Actions服务,但仍然只有极少的项目在使用。为了满足开发人员对工作流自动化的需求,减少非开发任务工作量,提出一种基于隐含狄利克雷分布(LDA)主题模型和Jensen-Shannon距离的GitHub Actions工作流项目推荐算法。通过对GitHub Actions存储库的README文件进行主题建模,将GitHub的事件描述文本和用户输入作为模型输入,为正在开发的代码仓库推荐GitHub Actions服务。将该推荐模型与标准的基于余弦相似度的方法进行比较的实验结果表明,该方法能有效改善开源软件仓库的推荐精度。

Network pharmacology and preliminary cell screening studies on the anti-liver cancer activity of Nauclea Officinalis

Objective:To explore the mechanism of Nauclea Officinalis of anti-liver cancer effect based on network pharmacology,and to preliminarily verify anti-liver cancer activity of Nauclea Officinalis through cell screening.Methods:Network pharmacology was used to screen for common targets of Nauclea Officinalis and liver cancer,protein-protein interaction(PPI)network was constructed,and enrichment analysis and mechanism prediction were conductd.Molecular docking of main active ingredients of Nauclea Officinalis with core targets was made.Preliminary verification was performed by in vitro cell experiments such as CCK8,cell apoptosis,and PCR.Results:After the screening,14 active ingredients of Nauclea Officinalis were obtained,with 587 related targets.After mapping with liver cancer targets,there were 288 common targets,mainly including TP53,SRC,STAT3,and other core targets.Among them,compounds such as strictosamide,pumiloside and vincosamide may be potential active ingredients of Nauclea Officinalis of anti-liver cancer effect.They may participate in protein phosphorylation and negative regulation of the apoptosis process by mediating cancer pathways,PI3K/Akt and EGFR tyrosine kinase inhibitors resistance signaling pathways to play an anti-liver cancer role;molecular docking results showd that active ingredients of Nauclea Officinalis had a stable binding with liver cancer core targets;in vitro cell experiments showd that main ingredient strictosamide of Nauclea Officinalis had cytotoxicity against liver cancer cells,inhibited liver cancer cell proliferation(P<0.001),down-regulated gene expression of liver cancer HepG2 cells SRC,STAT3,MAPK3(P<0.05),and induced liver cancer cell apoptosis(P<0.001).Conclusion:This study preliminarily explores the potential mechanism of active ingredients of Nauclea Officinalis against liver cancer and its preliminary pharmacological effects,providing a theoretical basis for the study of Nauclea Officinalis of anti-liver cancer mechanism.

Combining ability and gene action studies for yield and fibre traits in Gossypium arboreum using Griffings numerical and Haymans graphical approach

Background For the purpose of utilising hybrid vigour to produce possible hybrids with a suitable level of stability,the knowledge of gene activity and combining ability is a crucial prerequisite before choosing desirable parents.The present study was carried out with six parents crossed in full diallel fashion and generated 30 F1 hybrids.These hybrids were evaluated in two replications in Randomized Block Design at Department of Cotton,TNAU for combining ability and gene action.Diallel analysis was carried out according to Griffing’s method-I(parents + F_(1) + reciprocals) and model-I and Hayman’s graphical approach by using INDOSTAT software.Results Analysis of variance for combining ability indicated that mean square values of GCA,SCA and reciprocals were highly significant for all the traits except for the uniformity index.RG763 and K12 showed highly positively significant GCA effects for most of the yield traits while PA838 and K12 for fibre quality traits,so they were found as best general combiners.PAIG379 × K12 and PDB29 × K12 for yield traits,and PDB29 × PA838,RG763 × PA838,and CNA1007 × RG763 cross combinations for fibre quality traits could be recommended for future breeding programms.Conclusion The results of both Griffing’s and Hayman’s approaches showed that non-additive gene action predominates as SCA variance was bigger than GCA variance,so heterosis breeding is thought to be a more fruitful option for enhancing GCA of many traits.

Discontinuity development patterns and the challenges for 3D discrete fracture network modeling on complicated exposed rock surfaces

Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and rockfalls.This study presents a systematic outcrop research of fracture pattern variations in a complicated rock slope,and the qualitative and quantitative study of the complex phenomena impact on threedimensional(3D)discrete fracture network(DFN)modeling.As the studies of the outcrop fracture pattern have been so far focused on local variations,thus,we put forward a statistical analysis of global variations.The entire outcrop is partitioned into several subzones,and the subzone-scale variability of fracture geometric properties is analyzed(including the orientation,the density,and the trace length).The results reveal significant variations in fracture characteristics(such as the concentrative degree,the average orientation,the density,and the trace length)among different subzones.Moreover,the density of fracture sets,which is approximately parallel to the slope surface,exhibits a notably higher value compared to other fracture sets across all subzones.To improve the accuracy of the DFN modeling,the effects of three common phenomena resulting from vegetation and rockfalls are qualitatively analyzed and the corresponding quantitative data processing solutions are proposed.Subsequently,the 3D fracture geometric parameters are determined for different areas of the high-steep rock slope in terms of the subzone dimensions.The results show significant variations in the same set of 3D fracture parameters across different regions with density differing by up to tenfold and mean trace length exhibiting differences of 3e4 times.The study results present precise geological structural information,improve modeling accuracy,and provide practical solutions for addressing complex outcrop issues.

Unveiling health rights:A call to action for sex workers'HIV care in the Philippines

We are writing in response to the article titled“Addressing the needs and rights of sex workers for HIV healthcare services in the Philippines”[1].The article calls for attention on the significant challenges faced by sex workers in the Philippines in accessing HIV healthcare.We appreciate the article’s effort to examine these issues in depth.We would like to present a constant flow of thoughts in this letter while highlighting the positive aspects,potential obstacles,and additional points that contribute to this ongoing discussion.

Impact of Action Observation Therapy along with Usual Physiotherapy Intervention of Individual with Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairments in the initial stage, which lead to severe cognitive dysfunction in the later stage. Action observation therapy (AOT) is a multisensory cognitive rehabilitation technique where the patient initially observes the actions and then tries to perform. The study aimed to examine the impact of AOT along with usual physiotherapy interventions to reduce depression, improve cognition and balance of a patient with AD. A 67 years old patient with AD was selected for this study because the patient has been suffering from depression, dementia, and physical dysfunction along with some other health conditions like diabetes and hypertension. Before starting intervention, a baseline assessment was done through the Beck Depression Inventory (BDI) tool, the Mini-Cog Scale, and the Berg Balance Scale (BBS). The patient received 12 sessions of AOT along with usual physiotherapy interventions thrice a week for four weeks, which included 45 minutes of each session. After four weeks of intervention, the patient demonstrated significant improvement in depression, cognition, and balance, whereas the BDI score declined from moderate 21/63 to mild 15/63 level of depression. The Mini-Cog score improved from 2/5 to 4/5, and the BBS score increased from 18/56 to 37/56. It is concluded that AOT along with usual physiotherapy intervention helps to reduce depression, improve cognition and balance of people with AD.

General Optimal Trajectory Planning:Enabling Autonomous Vehicles with the Principle of Least Action

This study presents a general optimal trajectory planning(GOTP)framework for autonomous vehicles(AVs)that can effectively avoid obstacles and guide AVs to complete driving tasks safely and efficiently.Firstly,we employ the fifth-order Bezier curve to generate and smooth the reference path along the road centerline.Cartesian coordinates are then transformed to achieve the curvature continuity of the generated curve.Considering the road constraints and vehicle dynamics,limited polynomial candidate trajectories are generated and smoothed in a curvilinear coordinate system.Furthermore,in selecting the optimal trajectory,we develop a unified and auto-tune objective function based on the principle of least action by employing AVs to simulate drivers’behavior and summarizing their manipulation characteristics of“seeking benefits and avoiding losses.”Finally,by integrating the idea of receding-horizon optimization,the proposed framework is achieved by considering dynamic multi-performance objectives and selecting trajectories that satisfy feasibility,optimality,and adaptability.Extensive simulations and experiments are performed,and the results demonstrate the framework’s feasibility and effectiveness,which avoids both dynamic and static obstacles and applies to various scenarios with multi-source interactive traffic participants.Moreover,we prove that the proposed method can guarantee real-time planning and safety requirements compared to drivers’manipulation.