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Development and application of a two-dimensional water quality model for the Daqinghe River Mouth of the Dianchi Lake 被引量:12
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作者 CHEN Qiuwen TAN Kui +1 位作者 ZHU Chuanbao LI Ruonan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2009年第3期313-318,共6页
Water quality models are important tools to support the optimization of aquatic ecosystem rehabilitation programs and assess their efficiency. Basing on the flow conditions of the Daqinghe River Mouth of the Dianchi L... Water quality models are important tools to support the optimization of aquatic ecosystem rehabilitation programs and assess their efficiency. Basing on the flow conditions of the Daqinghe River Mouth of the Dianchi Lake, China, a two-dimensional water quality model was developed in the research. The hydrodynamics module was numerically solved by the alternating direction iteration (ADI) method. The parameters of the water quality module were obtained through the in situ experiments and the laboratory analyses that were conducted from 2006 to 2007. The model was calibrated and verified by the observation data in 2007. Among the four modelled key variables, i.e., water level, COD (in CODcr), NH4+-N and PO43-P the minimum value of the coefficient of determination (COD) was 0.69, indicating the model performed reasonably well. The developed model was then applied to simulate the water quality changes at a downstream cross-section assuming that the designed restoration programs were implemented. According to the simulated results, the restoration programs could cut down the loads of COD and PO43-P about 15%. Such a load reduction, unfortunately, would have very little effect on the NH4^+-N removal. Moreover, the water quality at the outlet cross-section would be still in class V (3838-02), indicating more measures should be taken to further reduce the loads. The study demonstrated the capability of water quality models to support aquatic ecosystem restorations. 展开更多
关键词 two-dimensional water quality model parameter estimation restoration program evaluation Dianchi Lake
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Simulation of two-dimensional interior ballistics model of solid propellant electrothermal-chem ical launch with discharge rod plasma generator 被引量:6
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作者 Yan-jie Ni Yong Jin +3 位作者 Niankai Cheng Chun-xia Yang Hai-yuan Li Bao-ming Li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2017年第4期249-256,共8页
Instead of the capillary plasma generator(CPG),a discharge rod plasma generator(DRPG)is used in the30 mm electrothermal-chemical(ETC)gun to improve the ignition uniformity of the solid propellant.An axisymmetric two-d... Instead of the capillary plasma generator(CPG),a discharge rod plasma generator(DRPG)is used in the30 mm electrothermal-chemical(ETC)gun to improve the ignition uniformity of the solid propellant.An axisymmetric two-dimensional interior ballistics model of the solid propellant ETC gun(2D-IB-SPETCG)is presented to describe the process of the ETC launch.Both calculated pressure and projectile muzzle velocity accord well with the experimental results.The feasibility of the 2D-IB-SPETCG model is proved.Depending on the experimental data and initial parameters,detailed distribution of the ballistics parameters can be simulated.With the distribution of pressure and temperature of the gas phase and the propellant,the influence of plasma during the ignition process can be analyzed.Because of the radial flowing plasma,the propellant in the area of the DRPG is ignited within 0.01 ms,while all propellant in the chamber is ignited within 0.09 ms.The radial ignition delay time is much less than the axial delay time.During the ignition process,the radial pressure difference is less than 5 MPa at the place 0.025 m away from the breech.The radial ignition uniformity is proved.The temperature of the gas increases from several thousand K(conventional ignition)to several ten thousand K(plasma ignition).Compare the distribution of the density and temperature of the gas,we know that low density and high temperature gas appears near the exits of the DRPG,while high density and low temperature gas appears at the wall near the breech.The simulation of the 2D-IB-SPETCG model is an effective way to investigate the interior ballistics process of the ETC launch.The 2D-IB-SPETC model can be used for prediction and improvement of experiments. 展开更多
关键词 Electrothermal-chemical LAUNCH Interior BALLISTICS SIMULATION Two-phase flow two-dimensional model
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Performance assessment of two-dimensional hydraulic models for generation of flood inundation maps in mountain river basins 被引量:3
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作者 Juan Pinos Luis Timbe 《Water Science and Engineering》 EI CAS CSCD 2019年第1期11-18,共8页
Hydraulic models for the generation of flood inundation maps are not commonly applied in mountain river basins because of the difficulty in modeling the hydraulic behavior and the complex topography. This paper presen... Hydraulic models for the generation of flood inundation maps are not commonly applied in mountain river basins because of the difficulty in modeling the hydraulic behavior and the complex topography. This paper presents a comparative analysis of the performance of four twodimensional hydraulic models (HEC-RAS 2D, Iber 2D, Flood Modeller 2D, and PCSWMM 2D) with respect to the generation of flood inundation maps. The study area covers a 5-km reach of the Santa B-arbara River located in the Ecuadorian Andes, at 2330 masl, in Gualaceo. The model's performance was evaluated based on the water surface elevation and flood extent, in terms of the mean absolute difference and measure of fit. The analysis revealed that, for a given case, Iber 2D has the best performance in simulating the water level and inundation for flood events with 20- and 50-year return periods, respectively, followed by Flood Modeller 2D, HEC-RAS 2D, and PCSWMM 2D in terms of their performance. Grid resolution, the way in which hydraulic structures are mimicked, the model code, and the default value of the parameters are considered the main sources of prediction uncertainty. 展开更多
关键词 two-dimensional HYDRAULIC models FLOOD modeling FLOOD extent Water surface ELEVATION High MOUNTAIN river Ecuador
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HIGH RESOLUTION PARAMETRIC MODELLING FOR TWO-DIMENSIONAL RADAR TARGET USING PRONY ALGORITHM 被引量:2
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作者 Wang Jun (Institute of Electronic Engineering, Chinese Academy of Engineering and Physics, Mianyang 621900) 《Journal of Electronics(China)》 2000年第1期38-45,共8页
On the conditions of low-resolution radar, a parametric model for two-dimensional radar target is described here according to the theory of electromagnetic scattering and the geometrical theory of diffraction. A high ... On the conditions of low-resolution radar, a parametric model for two-dimensional radar target is described here according to the theory of electromagnetic scattering and the geometrical theory of diffraction. A high resolution estimation algorithm to extract the model parameters is also developed by building the relation of the scattering model and Prony model. The analysis of Cramer-Rao bound and simulation show that the method here has better statistical performance. The simulated analysis also indicates that the accurate extraction of the diffraction coefficient of scattering center is restricted by signal to noise ratio, radar center frequency and radar bandwidth. 展开更多
关键词 two-dimensional RADAR SCATTERING center attributes PARAMETRIC modelling PRONY algorithm RESOLUTION
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A Numerical Algorithm Based on Quadratic Finite Element for Two-Dimensional Nonlinear Time Fractional Thermal Diffusion Model 被引量:3
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作者 Yanlong Zhang Baoli Yin +2 位作者 Yue Cao Yang Liu Hong Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第3期1081-1098,共18页
In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-d... In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-dimensional nonlinear time fractional thermal diffusion model.The time Caputo fractional derivative is approximated by using the L2-1formula,the first-order derivative and nonlinear term are discretized by some second-order approximation formulas,and the quadratic finite element is used to approximate the spatial direction.The error accuracy O(h3+t2)is obtained,which is verified by the numerical results. 展开更多
关键词 Quadratic finite element two-dimensional nonlinear time fractional thermal diffusion model L2-1formula.
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Global Two-Dimensional Chemistry Model and Simulation of Atmospheric Chemical Composition 被引量:1
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作者 张仁健 王明星 曾庆存 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2000年第1期72-82,共11页
A global two-dimensional zonally averaged chemistry model is developed to study the chemi-cal composition of atmosphere. The region of the model is from 90°S to 90°N and from the ground to the altitude of 20... A global two-dimensional zonally averaged chemistry model is developed to study the chemi-cal composition of atmosphere. The region of the model is from 90°S to 90°N and from the ground to the altitude of 20 km with a resolution of 5° x 1 km. The wind field is residual circulation calcu-lated from diabatic rate. 34 species and 104 chemical and photochemical reactions are considered in the model. The sources of CH4, CO and NOx, which are divided into seasonal sources and non-seasonal sources, are parameterized as a function of latitude and time. The chemical composi-tion of atmosphere was simulated with emission level of CH4, CO and NOx in 1990. The results are compared with observations and other model results, showing that the model is successful to simu-late the atmospheric chemical composition and distribution of CH4. Key words Global two-dimensional chemistry model - Atmospheric composition - Emission This work was supported by the State Key Program for basic research “ Climate Dynamics and Cli-mate Prediction Theory” (Pandeng-yu-21).The authors would like to express their thanks to the National Oceanic and Atmospheric Administration (NOAA), Climate Monitoring and Diagnostics Laboratory (CMDL), Carbon Cycle Group for providing the observational data of CO and CH4. 展开更多
关键词 Global two-dimensional chemistry model Atmospheric composition EMISSION
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Comprehensive two-dimensional river ice model based on boundary-fitted coordinate transformation method 被引量:1
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作者 Ze-yu MAO Jing YUAN +2 位作者 Jun BAO Xiao-fan PENG Guo-qiang TANG 《Water Science and Engineering》 EI CAS CSCD 2014年第1期90-105,共16页
River ice is a natural phenomenon in cold regions, influenced by meteorology, geomorphology, and hydraulic conditions. River ice processes involve complex interactions between hydrodynamic, mechanical, and thermal pro... River ice is a natural phenomenon in cold regions, influenced by meteorology, geomorphology, and hydraulic conditions. River ice processes involve complex interactions between hydrodynamic, mechanical, and thermal processes, and they are also influenced by weather and hydrologic conditions. Because natural rivers are serpentine, with bends, narrows, and straight reaches, the commonly-used one-dimensional river ice models and two-dimensional models based on the rectangular Cartesian coordinates are incapable of simulating the physical phenomena accurately. In order to accurately simulate the complicated river geometry and overcome the difficulties of numerical simulation resulting from both complex boundaries and differences between length and width scales, a two-dimensional river ice numerical model based on a boundary-fitted coordinate transformation method was developed. The presented model considers the influence of the frazil ice accumulation under ice cover and the shape of the leading edge of ice cover during the freezing process. The model is capable of determining the velocity field, the distribution of water temperature, the concentration distribution of frazil ice, the transport of floating ice, the progression, stability, and thawing of ice cover, and the transport, accumulation, and erosion of ice under ice cover. A MacCormack scheme was used to solve the equations numerically. The model was validated with field observations from the Hequ Reach of the Yellow River. Comparison of simulation results with field data indicates that the model is capable of simulating the river ice process with high accuracy. 展开更多
关键词 two-dimensional river ice numerical model boundary-fitted coordinate technology river ice process freeze-up MacCormack scheme natural river
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基于多Agent传动关系的股市趋势预测
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作者 鲍志 姚宏亮 +2 位作者 方帅 杨静 俞奎 《计算机工程》 CAS CSCD 北大核心 2024年第3期267-276,共10页
股市趋势预测是机器学习领域中一个具有挑战性的任务。由于一些因素对于股市的影响是动态且不确定的,导致股市趋势难以预测。针对已有方法在股市预测时存在的灵敏性差、适应力弱等问题,从快变量和慢变量的传动关系出发,利用Agent技术对... 股市趋势预测是机器学习领域中一个具有挑战性的任务。由于一些因素对于股市的影响是动态且不确定的,导致股市趋势难以预测。针对已有方法在股市预测时存在的灵敏性差、适应力弱等问题,从快变量和慢变量的传动关系出发,利用Agent技术对股市中的快周期和慢周期进行联合建模,提出一种多Agent传动影响图(MATID)股市趋势预测方法。给出股市中快周期和慢周期的划分标准,并引入周期能量的概念;通过对相关趋势指标的特征融合,给出周期能量的量化计算方法;通过分析快周期和慢周期的动态作用过程,给出传动因子的表示方法;将快周期和慢周期分别对应成不同的Agent,利用多Agent影响图模型建模快周期和慢周期的传动过程;利用股市振子模型表示快Agent和慢Agent之间的传动效用,利用联合树的自动推理技术对股市趋势进行预测。在不同样本数量和不同股市趋势下进行实验,结果表明,与门控循环单元、S-LSTM和Hybrid-RNN预测方法相比,MATID方法预测精确率提升1.5%~7.0%,召回率提升5.4%~6.7%,F1值提升3.7%~6.2%,具有良好的灵敏性和适应力。 展开更多
关键词 agent传动影响图 周期传动 振子模型 效用函数 联合树
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Effect of neutral polymeric bonding agent on tensile mechanical properties and damage evolution of NEPE propellant
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作者 M.Wubuliaisan Yanqing Wu +3 位作者 Xiao Hou Kun Yang Hongzheng Duan Xinmei Yin 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期357-367,共11页
Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of ne... Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of new generations of the NEPE propellant with better mechanical properties. Therefore,understanding the effects of NPBA on the deformation and damage evolution of the NEPE propellant is fundamental to material design and applications. This paper studies the uniaxial tensile and stress relaxation responses of the NEPE propellant with different amounts of NPBA. The damage evolution in terms of interface debonding is further investigated using a cohesive-zone model(CZM). Experimental results show that the initial modulus and strength of the NEPE propellant increase with the increasing amount of NPBA while the elongation decreases. Meanwhile, the relaxation rate slows down and a higher long-term equilibrium modulus is reached. Experimental and numerical analyses indicate that interface debonding and crack propagation along filler-matrix interface are the dominant damage mechanism for the samples with a low amount of NPBA, while damage localization and crack advancement through the matrix are predominant for the ones with a high amount of NPBA. Finally, crosslinking density tests and simulation results also show that the effect of the bonding agent is interfacial rather than due to the overall crosslinking density change of the binder. 展开更多
关键词 Solid propellant Bonding agent Mechanical properties Damage evolution Cohesive-zone model Interface debonding
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DETERMINATION OF PARAMETERS IN A TWO-DIMENSIONAL MODEL FOR FIXED-BED ADSORBERS
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作者 韩振为 周明 余国琮 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 1997年第1期43-51,共9页
A new method is proposed for the determination of the parameters in a two-dimensionalmodel which characterizes the properties of axial and radial mixing and mass transport in afixed-bed adsorber.Parameter estimation f... A new method is proposed for the determination of the parameters in a two-dimensionalmodel which characterizes the properties of axial and radial mixing and mass transport in afixed-bed adsorber.Parameter estimation for the model is carried out with methane-air-5A molecularsieve in a bed under the condition of step injection of tracer from a point on the main axis of thebed by the curve fitting method in the time domain. 展开更多
关键词 ADSORPTION FIXED-BED two-dimensional model PARAMETER ESTIMATION
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Two-dimensional hydrodynamic robust numerical model of soil erosion based on slopes and river basins
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作者 KANG Yongde HUANG Miansong +2 位作者 HOU Jingming TONG Yu PAN Zhanpeng 《Journal of Arid Land》 SCIE CSCD 2021年第10期995-1014,共20页
Erosion is an important issue in soil science and is related to many environmental problems,such as soil erosion and sediment transport.Establishing a simulation model suitable for soil erosion prediction is of great ... Erosion is an important issue in soil science and is related to many environmental problems,such as soil erosion and sediment transport.Establishing a simulation model suitable for soil erosion prediction is of great significance not only to accurately predict the process of soil separation by runoff,but also improve the physical model of soil erosion.In this study,we develop a graphic processing unit(GPU)-based numerical model that combines two-dimensional(2D)hydrodynamic and Green-Ampt(G-A)infiltration modelling to simulate soil erosion.A Godunov-type scheme on a uniform and structured square grid is then generated to solve the relevant shallow water equations(SWEs).The highlight of this study is the use of GPU-based acceleration technology to enable numerical models to simulate slope and watershed erosion in an efficient and high-resolution manner.The results show that the hydrodynamic model performs well in simulating soil erosion process.Soil erosion is studied by conducting calculation verification at the slope and basin scales.The first case involves simulating soil erosion process of a slope surface under indoor artificial rainfall conditions from 0 to 1000 s,and there is a good agreement between the simulated values and the measured values for the runoff velocity.The second case is a river basin experiment(Coquet River Basin)that involves watershed erosion.Simulations of the erosion depth change and erosion cumulative amount of the basin during a period of 1-40 h show an elevation difference of erosion at 0.5-3.0 m,especially during the period of 20-30 h.Nine cross sections in the basin are selected for simulation and the results reveal that the depth of erosion change value ranges from-0.86 to-2.79 m and the depth of deposition change value varies from 0.38 to 1.02 m.The findings indicate that the developed GPU-based hydrogeomorphological model can reproduce soil erosion processes.These results are valuable for rainfall runoff and soil erosion predictions on rilled hillslopes and river basins. 展开更多
关键词 soil erosion two-dimensional modelling rainfall runoff Green-Ampt model gully erosion
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Impact of Large Fresh Water Discharges into Hakata Bay Due to Torrential Rain Using Nested Two-Dimensional Convective-Dispersive Model
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作者 A. Fukuda T. Tabata +2 位作者 Y. Honda K. Hiramatsu M. Harada 《Journal of Water Resource and Protection》 2017年第6期553-565,共13页
In this study, numerical simulation of a two-dimensional convective-dispersive model in Hakata Bay, Japan, is performed to analyze the impact of major river discharges due to torrential rain in Fukuoka City. Tank mode... In this study, numerical simulation of a two-dimensional convective-dispersive model in Hakata Bay, Japan, is performed to analyze the impact of major river discharges due to torrential rain in Fukuoka City. Tank models are applied to calculate river discharges, which are taken into consideration as river inflow in the hydrodynamic model of Hakata Bay. A two-way nesting “edge” technique is developed and applied in the model in order to consider the influence of narrow and complex geographical features. The area around “Island City” and Imazu Bay are calculated in high resolution. The resulting model has high reproducibility since the calculated river discharges, tidal current, and salinity show good agreement with observed data. To analyze the impact of large river discharges, the calculation period is set from 11 September 2002 to 21 September 2002 since there was torrential rain on September 16 in the given year in Fukuoka City (163.5 mm/d). The results show that low-salinity water covered the whole of the inner part of Hakata Bay, and water of lower salinity than outer sea water (<34.0 psu) spread out to the bay’s mouth two days after the torrential rain event. Fresh water covered the entire area of Imazu Bay and flowed out from the mouth of the Bay after the torrential rain event. The behavior of fresh water after a few days of torrential rain was remarkably different from normal discharge river flow. These results indicate that the environment in Imazu Bay can be degraded severely by torrential rain. Therefore, countermeasures to protect ecosystems in Hakata Bay must be examined immediately. 展开更多
关键词 two-dimensional Convective-Dispersive model Edge NESTING Tank model TORRENTIAL Rain Hakata BAY
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Vertical two-dimensional non-hydrostatic pressure model with single layer
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作者 康玲 郭晓明 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2013年第6期721-730,共10页
The vertical two-dimensional non-hydrostatic pressure models with multiple layers can make prediction more accurate than those obtained by the hydrostatic pres- sure assumption. However, they are time-consuming and un... The vertical two-dimensional non-hydrostatic pressure models with multiple layers can make prediction more accurate than those obtained by the hydrostatic pres- sure assumption. However, they are time-consuming and unstable, which makes them unsuitable for wider application. In this study, an efficient model with a single layer is developed. Decomposing the pressure into the hydrostatic and dynamic components and integrating the x-momentum equation from the bottom to the free surface can yield a horizontal momentum equation, in which the terms relevant to the dynamic pressure are discretized semi-implicitly. The convective terms in the vertical momentum equation are ignored, and the rest of the equation is approximated with the Keller-box scheme. The velocities expressed as the unknown dynamic pressure are substituted into the continuity equation, resulting in a tri-diagonal linear system solved by the Thomas algorithm. The validation of solitary and sinusoidal waves indicates that the present model can provide comparable results to the models with multiple layers but at much lower computation cost. 展开更多
关键词 Key words vertical two-dimensional model non-hydrostatic pressure single layer Thomas algorithm wave
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The Model for Linear Magnetoresistance of Two-Dimensional Metal-Semiconductor Composites with Interfacial Shells
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作者 徐洁 王国栋 +2 位作者 李山东 李强 高小洋 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第9期123-127,共5页
A metal-semiconductor composite with the interracial shells is investigated theoretically for the large linear mag- netoresistance effect of high doping Ag2+δ Se and Ag2+δ te materials. The magnetoresistance (MR... A metal-semiconductor composite with the interracial shells is investigated theoretically for the large linear mag- netoresistance effect of high doping Ag2+δ Se and Ag2+δ te materials. The magnetoresistance (MR) of composites is a function of the magnetic field, temperature, the conductivities of two phases without magnetic field, and the thickness and conductivity of the interracial shells. The MR increases with the increase of the magnetic field and with the decrease of temperature, and no saturation is found even under the high magnetic field. Moreover, it is interestingly found that the interracial shell is an important factor for the MR of the composites. The MR increases with the thickness and the conductivity of the interfacial shells. Lastly, the theoretical results on the MR are compared with the experimental data. It is found that the value of the MR of the composite with the interfacial shell is larger than that without the interfacial shell. 展开更多
关键词 The model for Linear Magnetoresistance of two-dimensional Metal-Semiconductor Composites with Interfacial Shells Ag MR
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Inflation Cosmological Solutions in Two-Dimensional Brans-Dicke Gravity Model
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作者 颜骏 陶必友 《Journal of Southwest Jiaotong University(English Edition)》 2007年第4期365-367,共3页
The purpose of this paper is to study cosmological properties of two-dimensional Brans-Dicke gravity model. For massless scatar field, the new cosmological solutions are found by integration of field equation, these s... The purpose of this paper is to study cosmological properties of two-dimensional Brans-Dicke gravity model. For massless scatar field, the new cosmological solutions are found by integration of field equation, these solutions correspond to the inflation solutions with positive cosmological constant. The result of this paper show that the inflation process of universe is controlled by the classical and quantum effect of the scalar field. 展开更多
关键词 Brans-Dicke model two-dimensional gravity Inflation cosmological solutions
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“Products-Knowledge” Two-Dimensional Increment Model of Fashion Industry Value Chain Based on Industry Analysis
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作者 刘畅 黄震宇 《Journal of Donghua University(English Edition)》 EI CAS 2016年第4期660-664,共5页
Fashion industry has a complex characteristic for it spans the first, second, and third industries. In addition, the characteristic of creative industry has high value-added for its knowledge outputting, which makes t... Fashion industry has a complex characteristic for it spans the first, second, and third industries. In addition, the characteristic of creative industry has high value-added for its knowledge outputting, which makes the traditional value-added analysis based on supply chain not easy and good enough to interpret its industry value-added features. From the perspective of "products-knowledge" two-dimensional analysis,a fashion industry value chain increment model is built,by simulating the process of "product flow" and "information flow" value-added. The fashion industry value chain increment model provides an effective way for the enterprise strategy formulation and production strategy adjustment. 展开更多
关键词 fashion industry value chain increment "products knowledge" two-dimensional model SVM industry analysis
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AN EXPLORATION TO THE MODELLING OF TWO-DIMENSIONAL COMPLEX TURBULENT SHEAR FLOWS
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《Chinese Journal of Aeronautics》 SCIE EI CAS 1988年第2期79-86,共8页
The regions with shear stress and mean velocity gradient of opposite sign often existin complex turbulent shear flows.In these cases,the eddy viscosity hypothesis breaksdown.Hinze regards the,departure from eddy visco... The regions with shear stress and mean velocity gradient of opposite sign often existin complex turbulent shear flows.In these cases,the eddy viscosity hypothesis breaksdown.Hinze regards the,departure from eddy viscosity hypothesis as a result from transportationof mean momentum over distance by the large structures and arrives at a shearstress expression including the second order derivatives of the mean velocity.However,hisexpression greatly overestimates the shear stress.This implies that the flow particles areunlikely to have enough memory of the mean momentum over distance.By assuming thedeparture from eddy viscosity hypothesis as a result from transportation of the shear stresscontained in smaller eddies over distance by the large structures,the present author hasarrived at a new shear stress expression.The shear stress estimated so far is in goodagreement with the experiments. 展开更多
关键词 AN EXPLORATION TO THE modelLING OF two-dimensional COMPLEX TURBULENT SHEAR FLOWS
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A Cautionary Note on the Application of GIS in Spatial Optimization Modeling
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作者 Bin Zhou 《Journal of Geographic Information System》 2024年第1期89-113,共25页
Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which ... Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which require attention. This paper serves as a cautionary note to demonstrate two problems associated with applying GIS in spatial optimization, using a capacitated p-median facility location optimization problem as an example. The first problem involves errors in interpolating spatial variations of travel costs from using kriging, a common set of techniques for raster files. The second problem is inaccuracy in routing performed on a graph directly created from polyline shapefiles, a common vector file type. While revealing these problems, the paper also suggests remedies. Specifically, interpolation errors can be eliminated by using agent-based spatial modeling while the inaccuracy in routing can be improved through altering the graph topology by splitting the long edges of the shapefile. These issues suggest the need for caution in applying GIS in spatial optimization study. 展开更多
关键词 Spatial Optimization GIS agent-Based model Covariance Function INTERPOLATION
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Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease 被引量:7
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作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第7期1158-1176,共19页
The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intr... The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles,together with loss of cholinergic neurons,synaptic alterations,and chronic inflammation within the brain.These lead to progressive impairment of cognitive function.There is evidence of innate immune activation in AD with microgliosis.Classically-activated microglia(M1 state) secrete inflammatory and neurotoxic mediators,and peripheral immune cells are recruited to inflammation sites in the brain.The few drugs approved by the US FDA for the treatment of AD improve symptoms but do not change the course of disease progression and may cause some undesirable effects.Translation of active and passive immunotherapy targeting Aβ in AD animal model trials had limited success in clinical trials.Treatment with immunomodulatory/anti-inflammatory agents early in the disease process,while not preventive,is able to inhibit the inflammatory consequences of both Aβ and tau aggregation.The studies described in this review have identified several agents with immunomodulatory properties that alleviated AD pathology and cognitive impairment in animal models of AD.The majority of the animal studies reviewed had used transgenic models of early-onset AD.More effort needs to be given to creat models of late-onset AD.The effects of a combinational therapy involving two or more of the tested pharmaceutical agents,or one of these agents given in conjunction with one of the cell-based therapies,in an aged animal model of AD would warrant investigation. 展开更多
关键词 Alzheimer’s disease NEUROPATHOLOGY cognitive deficits behavioral deficits IMMUNOMODULATORY agents animal models AMYLOID deposits GLIOSIS
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Neuroprotection by immunomodulatory agents in animal models of Parkinson's disease 被引量:7
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作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第9期1493-1506,共14页
Parkinson’s disease(PD) is an age-related neurodegenerative disease for which the characteristic motor symptoms emerge after an extensive loss of dopamine containing neurons.The cell bodies of these neurons are pre... Parkinson’s disease(PD) is an age-related neurodegenerative disease for which the characteristic motor symptoms emerge after an extensive loss of dopamine containing neurons.The cell bodies of these neurons are present in the substantia nigra,with the nerve terminals being in the striatum.Both innate and adaptive immune responses may contribute to dopaminergic neurodegeneration and disease progression is potentially linked to these.Studies in the last twenty years have indicated an important role for neuroinflammation in PD through degeneration of the nigrostriatal dopaminergic pathway.Characteristic of neuroinflammation is the activation of brain glial cells,principally microglia and astrocytes that release various soluble factors.Many of these factors are proinflammatory and neurotoxic and harmful to nigral dopaminergic neurons.Recent studies have identified several different agents with immunomodulatory properties that protected dopaminergic neurons from degeneration and death in animal models of PD.All of the agents were effective in reducing the motor deficit and alleviating dopaminergic neurotoxicity and,when measured,preventing the decrease of dopamine upon being administered therapeutically after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,6-hydroxydopamine,rotenone-lesioning or delivery of adeno-associated virus-α-synuclein to the ventral midbrain of animals.Some of these agents were shown to exert an anti-inflammatory action,decrease oxidative stress,and reduce lipid peroxidation products.Activation of microglia and astrocytes was also decreased,as well as infiltration of T cells into the substantia nigra.Pretreatment with fingolimod,tanshinoine I,dimethyl fumarate,thalidomide,or cocaine-and amphetamine-regulated transcript peptide as a preventive strategy ameliorated motor deficits and nigral dopaminergic neurotoxicity in brain-lesioned animals.Immunomodulatory agents could be used to treat patients with early clinical signs of the disease or potentially even prior to disease onset in those identified as having pre-disposing risk,including genetic factors. 展开更多
关键词 Parkinson's disease immunomodulatory agents NEUROPROTECTION INFLAMMATION oxidative stress animal models MICROGLIOSIS ASTROGLIOSIS
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