The domestication and artificial selection of wild boars have led to dramatic morphological and behavioral changes,especially in East Chinese(ECN)pigs.Here,we provide insights into the population structure and current...The domestication and artificial selection of wild boars have led to dramatic morphological and behavioral changes,especially in East Chinese(ECN)pigs.Here,we provide insights into the population structure and current genetic diversity of representative ECN pig breeds.We identify a 500-kb region containing six tooth development-relevant genes with almost completely different haplotypes between ECN pigs and Chinese wild boars or European domestic pigs.Notably,the c.195A>G missense mutation in exon 2 of AMBN may cause alterations in its protein structure associated with tusk degradation in ECN pigs.In addition,ESR1 may play an important role in the reproductive performance of ECN pigs.A major haplotype of the large lop ear-related MSRB3 gene and eight alleles in the deafness-related GRM7 gene may affect ear morphology and hearing in ECN pigs.Interestingly,we find that the two-end black(TEB)coat color in Jinhua pigs is most likely caused by EDNRB with genetic mechanisms different from other Chinese TEB pigs.This study identifies key loci that may be artificially selected in Chinese native pigs related to the tusk,coat color,and ear morphology,thus providing new insights into the genetic mechanisms of domesticated pigs.展开更多
基金supported by Chinese Postdoctoral Science Foundation(2020M682735)the National Natural Science Foundation of China(31702089)Jiangxi Youth Science Foundation(20202BABL215021)。
文摘The domestication and artificial selection of wild boars have led to dramatic morphological and behavioral changes,especially in East Chinese(ECN)pigs.Here,we provide insights into the population structure and current genetic diversity of representative ECN pig breeds.We identify a 500-kb region containing six tooth development-relevant genes with almost completely different haplotypes between ECN pigs and Chinese wild boars or European domestic pigs.Notably,the c.195A>G missense mutation in exon 2 of AMBN may cause alterations in its protein structure associated with tusk degradation in ECN pigs.In addition,ESR1 may play an important role in the reproductive performance of ECN pigs.A major haplotype of the large lop ear-related MSRB3 gene and eight alleles in the deafness-related GRM7 gene may affect ear morphology and hearing in ECN pigs.Interestingly,we find that the two-end black(TEB)coat color in Jinhua pigs is most likely caused by EDNRB with genetic mechanisms different from other Chinese TEB pigs.This study identifies key loci that may be artificially selected in Chinese native pigs related to the tusk,coat color,and ear morphology,thus providing new insights into the genetic mechanisms of domesticated pigs.
