The study on designs for the baseline parameterization has aroused attention in recent years. This paper focuses on two-level regular designs for the baseline parameterization. A general result on the relationship bet...The study on designs for the baseline parameterization has aroused attention in recent years. This paper focuses on two-level regular designs for the baseline parameterization. A general result on the relationship between K-aberration and word length pattern is developed.展开更多
The inverse heat conduction method is one of methods to identify the casting simulation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized funct...The inverse heat conduction method is one of methods to identify the casting simulation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized functional was established, and the functional was solved by the sensitivity coefficient and Newtonaphson iteration method. Moreover, the orthogonal experimental design was used to estimate the appropriate initial value and variation domain of each variable to decrease the number of iteration and improve the identification accuracy and efficiency. It illustrated a detailed case of AlSiTMg sand mold casting and the temperature measurement experiment was done. The physical properties of sand mold and the interracial heat transfer coefficient were identified at the meantime. The results indicated that the new regularization method was efficient in overcoming the ill-posedness of the inverse heat conduction problem and improving the stability and accuracy of the solutions.展开更多
Dear Editor,Compared with traditional technologies affecting gene expression,changing DNA sequences of target genes is one of the most outstanding characters of CRISPR(Clustered Regularly Interspaced Short Palindromic...Dear Editor,Compared with traditional technologies affecting gene expression,changing DNA sequences of target genes is one of the most outstanding characters of CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats).Single-guide RNAs(sgRNAs)guiding endonuclease Cas to target sites is a crucial step of CRISPR-Cas system for changing DNA sequences.An ideal sgRNA should only bind to the target gene.However,similar sequences of non-target sites can also be recognized leading to off-target effects[1].展开更多
Mukerjee and Wu（2001） employed projective geometry theory to find the wordlength pattern of a regular mixed factorial design in terms of its complementary set, but only for the numbers of words of length 3 or 4. In ...Mukerjee and Wu（2001） employed projective geometry theory to find the wordlength pattern of a regular mixed factorial design in terms of its complementary set, but only for the numbers of words of length 3 or 4. In this paper, by introducing a concept of consulting design and based on the connection between factorial design theory and coding theory, we obtain some combinatorial identities that relate the wordlength pattern of a regular mixed-level （2^r）2^n factorial design to that of its consulting design. Consequently, a general rule for identifying minimum aberration （2^r）2^n factorial designs through their consulting designs is established. It is an improvement and generalization of the related result in Mukerjee and Wu（2001）.展开更多
In order to meet the rapid needs of processing square hole in mechanical equipment, the paper expounds the square hole processing method： planetary wheel method, and analyze the principle of tooling structure and pro...In order to meet the rapid needs of processing square hole in mechanical equipment, the paper expounds the square hole processing method： planetary wheel method, and analyze the principle of tooling structure and process with computer graphics parameters design. The results that, as long as the appropriate parameters, using the above method not only can punch the square hole, can also be processed triangle, the five angle and hexagonal regular polygon holes. The square hole processing method can provide theoretical basis and engineering reliable reference for related engineering and technical personnel.展开更多
在我国经济快速发展的背景下,人们的日常生产和生活质量得到有效提高,建筑行业也得到了快速发展。在建筑行业快速发展的过程中,BIM(Building Information Modeling,建筑信息模型)技术逐渐出现在人们的视野当中,并且得到水利工程领域的重...在我国经济快速发展的背景下,人们的日常生产和生活质量得到有效提高,建筑行业也得到了快速发展。在建筑行业快速发展的过程中,BIM(Building Information Modeling,建筑信息模型)技术逐渐出现在人们的视野当中,并且得到水利工程领域的重视,加强了BIM技术在水利工程设计过程中的应用。BIM技术在水利工程设计应用的过程当中仍然会存在一些常见的问题,这就需要建筑单位相关部门对BIM技术运用过程进行研究论述。基于此,该文首先从两个方面分析了BIM技术的概述,其次从4个方面分析了BIM技术在水利工程设计中的重要性,再次从8个方面提出了BIM在水利工程设计中的应用,最后提出了加强对技术的定期维护与检查工作。展开更多
文摘The study on designs for the baseline parameterization has aroused attention in recent years. This paper focuses on two-level regular designs for the baseline parameterization. A general result on the relationship between K-aberration and word length pattern is developed.
文摘The inverse heat conduction method is one of methods to identify the casting simulation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized functional was established, and the functional was solved by the sensitivity coefficient and Newtonaphson iteration method. Moreover, the orthogonal experimental design was used to estimate the appropriate initial value and variation domain of each variable to decrease the number of iteration and improve the identification accuracy and efficiency. It illustrated a detailed case of AlSiTMg sand mold casting and the temperature measurement experiment was done. The physical properties of sand mold and the interracial heat transfer coefficient were identified at the meantime. The results indicated that the new regularization method was efficient in overcoming the ill-posedness of the inverse heat conduction problem and improving the stability and accuracy of the solutions.
基金This work was supported by National Natural Science Foundation of China(Grant No.32100501)Shenzhen Science and Technology Program(Grant No.RCBS20210609103819020)J.Z.was funded by the Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(2021C02070-1).
文摘Dear Editor,Compared with traditional technologies affecting gene expression,changing DNA sequences of target genes is one of the most outstanding characters of CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats).Single-guide RNAs(sgRNAs)guiding endonuclease Cas to target sites is a crucial step of CRISPR-Cas system for changing DNA sequences.An ideal sgRNA should only bind to the target gene.However,similar sequences of non-target sites can also be recognized leading to off-target effects[1].
文摘Mukerjee and Wu（2001） employed projective geometry theory to find the wordlength pattern of a regular mixed factorial design in terms of its complementary set, but only for the numbers of words of length 3 or 4. In this paper, by introducing a concept of consulting design and based on the connection between factorial design theory and coding theory, we obtain some combinatorial identities that relate the wordlength pattern of a regular mixed-level （2^r）2^n factorial design to that of its consulting design. Consequently, a general rule for identifying minimum aberration （2^r）2^n factorial designs through their consulting designs is established. It is an improvement and generalization of the related result in Mukerjee and Wu（2001）.
文摘In order to meet the rapid needs of processing square hole in mechanical equipment, the paper expounds the square hole processing method： planetary wheel method, and analyze the principle of tooling structure and process with computer graphics parameters design. The results that, as long as the appropriate parameters, using the above method not only can punch the square hole, can also be processed triangle, the five angle and hexagonal regular polygon holes. The square hole processing method can provide theoretical basis and engineering reliable reference for related engineering and technical personnel.
文摘在我国经济快速发展的背景下,人们的日常生产和生活质量得到有效提高,建筑行业也得到了快速发展。在建筑行业快速发展的过程中,BIM(Building Information Modeling,建筑信息模型)技术逐渐出现在人们的视野当中,并且得到水利工程领域的重视,加强了BIM技术在水利工程设计过程中的应用。BIM技术在水利工程设计应用的过程当中仍然会存在一些常见的问题,这就需要建筑单位相关部门对BIM技术运用过程进行研究论述。基于此,该文首先从两个方面分析了BIM技术的概述,其次从4个方面分析了BIM技术在水利工程设计中的重要性,再次从8个方面提出了BIM在水利工程设计中的应用,最后提出了加强对技术的定期维护与检查工作。
