The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system(RIENGS).With the growing level of coupling between electric a...The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system(RIENGS).With the growing level of coupling between electric and natural gas systems,it is critical to enhance the load restoration capability of both systems.This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming(MISOCP)model.The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems,minimizing the total system load loss cost and repair time.In addition,a bi-directional gas flow model is used to describe the natural gas system,which can provide the RIENGS with more flexibility for load restoration during natural gas system failure.Finally,the effectiveness of the proposed approach is verified by conducting case studies on the test systems RIENGS E13-G7 and RIENGS E123-G20.展开更多
Recent studies of the space debris environment in Low Earth Orbit(LEO)have shown that the critical density of space debris has been reached in certain regions.The Active Debris Removal(ADR)mission,to mitigate the spac...Recent studies of the space debris environment in Low Earth Orbit(LEO)have shown that the critical density of space debris has been reached in certain regions.The Active Debris Removal(ADR)mission,to mitigate the space debris density and stabilize the space debris environment,has been considered as a most effective method.In this paper,a novel two-level optimization strategy for multi-debris removal mission in LEO is proposed,which includes the low-level and high-level optimization process.To improve the overall performance of the multi-debris active removal mission and obtain multiple Pareto-optimal solutions,the ADR mission is seen as a Time-Dependant Traveling Salesman Problem(TDTSP)with two objective functions to minimize the total mission duration and the total propellant consumption.The problem includes the sequence optimization to determine the sequence of removal of space debris and the transferring optimization to define the orbital maneuvers.Two optimization models for the two-level optimization strategy are built in solving the multi-debris removal mission,and the optimal Pareto solution is successfully obtained by using the non-dominated sorting genetic algorithm II(NSGA-II).Two test cases are presented,which show that the low level optimization strategy can successfully obtain the optimal sequences and the initial solution of the ADR mission and the high level optimization strategy can efficiently and robustly find the feasible optimal solution for long duration perturbed rendezvous problem.展开更多
Following injury in central nervous system（CNS）,there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.T...Following injury in central nervous system（CNS）,there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.The proliferation of a large number of astrocytes results in the formation of glial scar.展开更多
The pricey prawn scandal of Qingdao in the 2015 National Day Holiday,not only violates the principle of integrity management,but also seriously damages the image of Qingdao—World Famous Tourist City.This study applie...The pricey prawn scandal of Qingdao in the 2015 National Day Holiday,not only violates the principle of integrity management,but also seriously damages the image of Qingdao—World Famous Tourist City.This study applies image repair strategies to Qingdao municipal government departments' attempt to restore its damaged image in crisis communication.Through a discourse analysis,it is found that the government departments mainly adopt the following strategies: denial,evasion of responsibility(defeasibility),reduction of offensiveness(bolstering,compensation),corrective action and mortification.Then we evaluate the effectiveness of this image repair effort.展开更多
A model of dynamic programming for repairing strategies of concrete structures during a projected service period is proposed, which takes into account the degradation in strength of components and the probability of a...A model of dynamic programming for repairing strategies of concrete structures during a projected service period is proposed, which takes into account the degradation in strength of components and the probability of accidental load. This model takes the safety grade of a structural system as the state variable of repairing strategies, and incorporates economic factors including expected repair cost, property loss due to structure failure, goods and material loss due to structure failure, loss of production interrupt due to structure failure, and inspection cost in decision making. It is found that the optimal repairing strategies are sensitive to the probability of accidental loads as well as the failure costs. The practicality of the model is demonstrated by an example.展开更多
Neuronal regeneration in the peripheral nervous system arises via a synergistic interplay of neurotrophic factors,integrins,cytoskeletal proteins,mechanical cues,cytokines,stem cells,glial cells and astrocytes.
背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed...背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed数据库2000-2023年发表的文献,英文检索词为“gradient,bone regeneration,scaffold”,最终筛选后对76篇文献进行分析总结。结果与结论:①作为骨骼系统组织高效、高质量修复的重要手段,梯度人工骨修复支架目前针对骨组织、骨-软骨、肌腱-骨组织的天然梯度特征进行了仿生设计,这些支架能够一定程度地从结构、成分上模拟原生组织的细胞外基质,从而促进细胞黏附、迁移、增殖和分化,促进受损组织向原生状态再生恢复。②先进制造技术为梯度人工骨修复支架制备提供了更多可能;目前已经开发了通过空间差异化纤维排布和生物活性物质加载构建的梯度电纺纤维支架;分层叠加、分级孔隙率与生物3D打印技术制造的梯度3D打印支架;原位分层注射、简单逐层叠加、冷冻干燥法制造的梯度水凝胶支架;另外还包括其他方式或多方法联用的支架;这些支架在体外实验中展示了良好的生物相容性,在小型动物实验中能够加速组织再生并且观察到组织学结构明显改善。③目前开发的梯度人工骨修复支架仍需进一步优化,提高在梯度尺度上的匹配性,进一步明确材料与组织相互作用,避免降解产物导致的副反应等问题,未来需要结合相关学科优势与临床需求进一步优化。展开更多
基金funded by the Science and Technology Project of State Grid Jilin Electric Power Co.,Ltd.(Project Name:Research onDistributionNetworkResilience Assessment and Improvement Technology for Natural Disaster Areas).
文摘The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system(RIENGS).With the growing level of coupling between electric and natural gas systems,it is critical to enhance the load restoration capability of both systems.This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming(MISOCP)model.The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems,minimizing the total system load loss cost and repair time.In addition,a bi-directional gas flow model is used to describe the natural gas system,which can provide the RIENGS with more flexibility for load restoration during natural gas system failure.Finally,the effectiveness of the proposed approach is verified by conducting case studies on the test systems RIENGS E13-G7 and RIENGS E123-G20.
基金the Open Research Foundation of Science and Technology in Aerospace Flight Dynamics Laboratory of China(GF2018005).
文摘Recent studies of the space debris environment in Low Earth Orbit(LEO)have shown that the critical density of space debris has been reached in certain regions.The Active Debris Removal(ADR)mission,to mitigate the space debris density and stabilize the space debris environment,has been considered as a most effective method.In this paper,a novel two-level optimization strategy for multi-debris removal mission in LEO is proposed,which includes the low-level and high-level optimization process.To improve the overall performance of the multi-debris active removal mission and obtain multiple Pareto-optimal solutions,the ADR mission is seen as a Time-Dependant Traveling Salesman Problem(TDTSP)with two objective functions to minimize the total mission duration and the total propellant consumption.The problem includes the sequence optimization to determine the sequence of removal of space debris and the transferring optimization to define the orbital maneuvers.Two optimization models for the two-level optimization strategy are built in solving the multi-debris removal mission,and the optimal Pareto solution is successfully obtained by using the non-dominated sorting genetic algorithm II(NSGA-II).Two test cases are presented,which show that the low level optimization strategy can successfully obtain the optimal sequences and the initial solution of the ADR mission and the high level optimization strategy can efficiently and robustly find the feasible optimal solution for long duration perturbed rendezvous problem.
基金supported by National Basic Research Program of China(973 Program,2014CB542205)Hong Kong RGC grant+2 种基金Hong Kong Health and Medical Research Fundfoundation for Distinguished Young Talents in Higher Education of Guangdong(Yq2013023)the Leading Talents of Guangdong Province(87014002)
文摘Following injury in central nervous system（CNS）,there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.The proliferation of a large number of astrocytes results in the formation of glial scar.
文摘The pricey prawn scandal of Qingdao in the 2015 National Day Holiday,not only violates the principle of integrity management,but also seriously damages the image of Qingdao—World Famous Tourist City.This study applies image repair strategies to Qingdao municipal government departments' attempt to restore its damaged image in crisis communication.Through a discourse analysis,it is found that the government departments mainly adopt the following strategies: denial,evasion of responsibility(defeasibility),reduction of offensiveness(bolstering,compensation),corrective action and mortification.Then we evaluate the effectiveness of this image repair effort.
基金Funded by the National Key Project on Basic Research and Applied Research (85-40).
文摘A model of dynamic programming for repairing strategies of concrete structures during a projected service period is proposed, which takes into account the degradation in strength of components and the probability of accidental load. This model takes the safety grade of a structural system as the state variable of repairing strategies, and incorporates economic factors including expected repair cost, property loss due to structure failure, goods and material loss due to structure failure, loss of production interrupt due to structure failure, and inspection cost in decision making. It is found that the optimal repairing strategies are sensitive to the probability of accidental loads as well as the failure costs. The practicality of the model is demonstrated by an example.
基金CSIRO, the ARC and the NHMRC for providing funding that supported this work
文摘Neuronal regeneration in the peripheral nervous system arises via a synergistic interplay of neurotrophic factors,integrins,cytoskeletal proteins,mechanical cues,cytokines,stem cells,glial cells and astrocytes.
文摘背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed数据库2000-2023年发表的文献,英文检索词为“gradient,bone regeneration,scaffold”,最终筛选后对76篇文献进行分析总结。结果与结论:①作为骨骼系统组织高效、高质量修复的重要手段,梯度人工骨修复支架目前针对骨组织、骨-软骨、肌腱-骨组织的天然梯度特征进行了仿生设计,这些支架能够一定程度地从结构、成分上模拟原生组织的细胞外基质,从而促进细胞黏附、迁移、增殖和分化,促进受损组织向原生状态再生恢复。②先进制造技术为梯度人工骨修复支架制备提供了更多可能;目前已经开发了通过空间差异化纤维排布和生物活性物质加载构建的梯度电纺纤维支架;分层叠加、分级孔隙率与生物3D打印技术制造的梯度3D打印支架;原位分层注射、简单逐层叠加、冷冻干燥法制造的梯度水凝胶支架;另外还包括其他方式或多方法联用的支架;这些支架在体外实验中展示了良好的生物相容性,在小型动物实验中能够加速组织再生并且观察到组织学结构明显改善。③目前开发的梯度人工骨修复支架仍需进一步优化,提高在梯度尺度上的匹配性,进一步明确材料与组织相互作用,避免降解产物导致的副反应等问题,未来需要结合相关学科优势与临床需求进一步优化。
