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Simulation of Two-Phase Flowback Phenomena in Shale Gas Wells
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作者 Yongwei Duan Zhaopeng Zhu +2 位作者 Hui He Gaoliang Xuan Xuemeng Yu 《Fluid Dynamics & Materials Processing》 EI 2024年第2期349-364,共16页
The gas-water two-phaseflow occurring as a result of fracturingfluidflowback phenomena is known to impact significantly the productivity of shale gas well.In this work,this two-phaseflow has been simulated in the framework... The gas-water two-phaseflow occurring as a result of fracturingfluidflowback phenomena is known to impact significantly the productivity of shale gas well.In this work,this two-phaseflow has been simulated in the framework of a hybrid approach partially relying on the embedded discrete fracture model(EDFM).This model assumes the region outside the stimulated reservoir volume(SRV)as a single-medium while the SRV region itself is described using a double-medium strategy which can account for thefluid exchange between the matrix and the micro-fractures.The shale gas adsorption,desorption,diffusion,gas slippage effect,fracture stress sensitivity,and capillary imbibition have been considered.The shale gas production,pore pressure distribution and water saturation distribution in the reservoir have been simulated.The influences of hydraulic fracture geometry and nonorthogonal hydraulic fractures on gas production have been determined and discussed accordingly.The simulation results show that the daily gas production has an upward and downward trend due to the presence of a large amount of fracturingfluid in the reservoir around the hydraulic fracture.The smaller the angle between the hydraulic fracture and the wellbore,the faster the daily production of shale gas wells decreases,and the lower the cumulative production.Nonplanar fractures can increase the control volume of hydraulic fractures and improve the production of shale gas wells. 展开更多
关键词 Shale gas fracturingfluid backflow the stimulated reservoir volume gas-water two-phase production
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Identifying the enhancement mechanism of Al/MoO_(3) reactive multilayered films on the ignition ability of semiconductor bridge using a one-dimensional gas-solid two-phase flow model
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作者 Jianbing Xu Yuxuan Zhou +3 位作者 Yun Shen Yueting Wang Yinghua Ye Ruiqi Shen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期168-179,共12页
Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement m... Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement mechanism of RMFs on semiconductor bridge(SCB)during the ignition process is crucial for the engineering and practical application of advanced initiator and pyrotechnics devices.In this study,a one-dimensional(1D)gas-solid two-phase flow ignition model was established to study the ignition process of ESCB to charge particles based on the reactivity of Al/MoO_(3) RMFs.In order to fully consider the coupled exothermic between the RMFs and the SCB plasma during the ignition process,the heat release of chemical reaction in RMFs was used as an internal heat source in this model.It is found that the exothermal reaction in RMFs improved the ignition performance of SCB.In the process of plasma rapid condensation with heat release,the product of RMFs enhanced the heat transfer process between the gas phase and the solid charge particle,which accelerated the expansion of hot plasma,and heated the solid charge particle as well as gas phase region with low temperature.In addition,it made up for pressure loss in the gas phase.During the plasma dissipation process,the exothermal chemical reaction in RMFs acted as the main heating source to heat the charge particle,making the surface temperature of the charge particle,gas pressure,and gas temperature rise continuously.This result may yield significant advantages in providing a universal ignition model for miniaturized ignition devices. 展开更多
关键词 Ignition enhancement mechanism 1D gas-solid two-phase flow Al/MoO_(3)reactive multilayered films Semiconductor bridge Miniaturized ignition device
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A Note on an Order Level Inventory Model with Varying Two-Phased Demand and Time-Proportional Deterioration
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作者 Sephali Mohanty Trailokyanath Singh +1 位作者 Sudhansu Sekhar Routary Chinmayee Naik 《American Journal of Operations Research》 2024年第1期59-73,共15页
The main purpose of this paper is to generalize the effect of two-phased demand and variable deterioration within the EOQ (Economic Order Quantity) framework. The rate of deterioration is a linear function of time. Th... The main purpose of this paper is to generalize the effect of two-phased demand and variable deterioration within the EOQ (Economic Order Quantity) framework. The rate of deterioration is a linear function of time. The two-phased demand function states the constant function for a certain period and the quadratic function of time for the rest part of the cycle time. No shortages as well as partial backlogging are allowed to occur. The mathematical expressions are derived for determining the optimal cycle time, order quantity and total cost function. An easy-to-use working procedure is provided to calculate the above quantities. A couple of numerical examples are cited to explain the theoretical results and sensitivity analysis of some selected examples is carried out. 展开更多
关键词 Deteriorating Items EOQ (Economic Order Quantity) INVENTORY Time-Proportional Deterioration two-phased Demand
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Numerical modeling and parametric sensitivity analysis of heat transfer and two-phase oil and water flow characteristics in horizontal and inclined flowlines using OpenFOAM
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作者 Nsidibe Sunday Abdelhakim Settar +1 位作者 Khaled Chetehouna Nicolas Gascoin 《Petroleum Science》 SCIE EI CAS CSCD 2023年第2期1183-1199,共17页
Estimating the oil-water temperatures in flowlines is challenging especially in deepwater and ultra-deepwater offshore applications where issues of flow assurance and dramatic heat transfer are likely to occur due to ... Estimating the oil-water temperatures in flowlines is challenging especially in deepwater and ultra-deepwater offshore applications where issues of flow assurance and dramatic heat transfer are likely to occur due to the temperature difference between the fluids and the surroundings. Heat transfer analysis is very important for the prediction and prevention of deposits in oil and water flowlines, which could impede the flow and give rise to huge financial losses. Therefore, a 3D mathematical model of oil-water Newtonian flow under non-isothermal conditions is established to explore the complex mechanisms of the two-phase oil-water transportation and heat transfer in different flowline inclinations. In this work, a non-isothermal two-phase flow model is first modified and then implemented in the InterFoam solver by introducing the energy equation using OpenFOAM® code. The Low Reynolds Number (LRN) k-ε turbulence model is utilized to resolve the turbulence phenomena within the oil and water mixtures. The flow patterns and the local heat transfer coefficients (HTC) for two-phase oil-water flow at different flowlines inclinations (0°, +4°, +7°) are validated by the experimental literature results and the relative errors are also compared. Global sensitivity analysis is then conducted to determine the effect of the different parameters on the performance of the produced two-phase hydrocarbon systems for effective subsea fluid transportation. Thereafter, HTC and flow patterns for oil-water flows at downward inclinations of 4°, and 7° can be predicted by the models. The velocity distribution, pressure gradient, liquid holdup, and temperature variation at the flowline cross-sections are simulated and analyzed in detail. Consequently, the numerical model can be generally applied to compute the global properties of the fluid and other operating parameters that are beneficial in the management of two-phase oil-water transportation. 展开更多
关键词 Flow assurance Flow pattern Heat transfer Flowlines two-phase flow Global sensitivity analysis
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Simulation of Gas-Water Two-Phase Flow in Tight Gas Reservoirs Considering the Gas Slip Effect
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作者 Mingjing Lu Zenglin Wang +3 位作者 Aishan Li Liaoyuan Zhang Bintao Zheng Zilin Zhang 《Fluid Dynamics & Materials Processing》 EI 2023年第5期1269-1281,共13页
A mathematical model for the gas-water two-phase flow in tight gas reservoirs is elaborated.The model can account for the gas slip effect,stress sensitivity,and high-speed non-Darcy factors.The related equations are s... A mathematical model for the gas-water two-phase flow in tight gas reservoirs is elaborated.The model can account for the gas slip effect,stress sensitivity,and high-speed non-Darcy factors.The related equations are solved in the framework of a finite element method.The results are validated against those obtained by using the commercial software CMG(Computer Modeling Group software for advanced recovery process simulation).It is shown that the proposed method is reliable.It can capture the fracture rejection characteristics of tight gas reservoirs better than the CMG.A sensitivity analysis of various control factors(initial water saturation,reservoir parameters,and fracturing parameters)affecting the production in tight gas wells is conducted accordingly.Finally,a series of theoretical arguments are provided for a rational and effective development/exploitation of tight sandstone gas reservoirs. 展开更多
关键词 Tight gas reservoir gas-water two-phase flow numerical simulation fractured horizontal well gas slip effect
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Transient pressure analysis of polymer flooding fractured wells with oil-water two-phase flow
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作者 WANG Yang YU Haiyang +2 位作者 ZHANG Jia FENG Naichao CHENG Shiqing 《Petroleum Exploration and Development》 2023年第1期175-182,共8页
The oil-water two-phase flow pressure-transient analysis model for polymer flooding fractured well is established by considering the comprehensive effects of polymer shear thinning,shear thickening,convection,diffusio... The oil-water two-phase flow pressure-transient analysis model for polymer flooding fractured well is established by considering the comprehensive effects of polymer shear thinning,shear thickening,convection,diffusion,adsorption retention,inaccessible pore volume and effective permeability reduction.The finite volume difference and Newton iteration methods are applied to solve the model,and the effects of fracture conductivity coefficient,injected polymer mass concentration,initial polymer mass concentration and water saturation on the well-test type curves of polymer flooding fractured wells are discussed.The results show that with the increase of fracture conductivity coefficient,the pressure conduction becomes faster and the pressure drop becomes smaller,so the pressure curve of transitional flow goes downward,the duration of bilinear flow becomes shorter,and the linear flow appears earlier and lasts longer.As the injected polymer mass concentration increases,the effective water phase viscosity increases,and the pressure loss increases,so the pressure and pressure derivative curves go upward,and the bilinear flow segment becomes shorter.As the initial polymer mass concentration increases,the effective water phase viscosity increases,so the pressure curve after the wellbore storage segment moves upward as a whole.As the water saturation increases,the relative permeability of water increases,the relative permeability of oil decreases,the total oil-water two-phase mobility becomes larger,and the pressure loss is reduced,so the pressure curve after the wellbore storage segment moves downward as a whole.The reliability and practicability of this new model are verified by the comparison of the results from simplified model and commercial well test software,and the actual well test data. 展开更多
关键词 fractured vertical well polymer flooding two-phase flow well test analysis model type curve influence factor
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Pore-Scale Investigation of Coupled Two-Phase and Reactive Transport in the Cathode Electrode of Proton Exchange Membrane Fuel Cells 被引量:1
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作者 Shengjie Ye Yuze Hou +2 位作者 Xing Li Kui Jiao Qing Du 《Transactions of Tianjin University》 EI CAS 2023年第1期1-13,共13页
A three-dimensional multicomponent multiphase lattice Boltzmann model(LBM)is established to model the coupled two-phase and reactive transport phenomena in the cathode electrode of proton exchange membrane fuel cells.... A three-dimensional multicomponent multiphase lattice Boltzmann model(LBM)is established to model the coupled two-phase and reactive transport phenomena in the cathode electrode of proton exchange membrane fuel cells.The gas diff usion layer(GDL)and microporous layer(MPL)are stochastically reconstructed with the inside dynamic distribution of oxygen and liquid water resolved,and the catalyst layer is simplifi ed as a superthin layer to address the electrochemical reaction,which provides a clear description of the fl ooding eff ect on mass transport and performance.Diff erent kinds of electrodes are reconstructed to determine the optimum porosity and structure design of the GDL and MPL by comparing the transport resistance and per-formance under the fl ooding condition.The simulation results show that gradient porosity GDL helps to increase the reactive area and average concentration under fl ooding.The presence of the MPL ensures the oxygen transport space and reaction area because liquid water cannot transport through micropores.Moreover,the MPL helps in the uniform distribution of oxygen for an effi cient in-plane transport capacity.Crack and perforation structures can accelerate the water transport in the assembly.The systematic perforation design yields the best performance under fl ooding by separating the transport of liquid water and oxygen. 展开更多
关键词 Proton exchange membrane fuel cell Lattice Boltzmann model ELECTRODE water management two-phase fl ow Reactive transport
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Numerical Simulation of a Two-Phase Flow with Low Permeability anda Start-Up Pressure Gradient
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作者 Xuanyu Dong Jingyao Yang 《Fluid Dynamics & Materials Processing》 EI 2023年第1期175-185,共11页
A new numerical model for low-permeability reservoirs is developed.The model incorporates the nonlinear characteristics of oil-water two-phase flows while taking into account the initiation pressure gradient.Related n... A new numerical model for low-permeability reservoirs is developed.The model incorporates the nonlinear characteristics of oil-water two-phase flows while taking into account the initiation pressure gradient.Related numerical solutions are obtained using a finite difference method.The correctness of the method is demonstrated using a two-dimensional inhomogeneous low permeability example.Then,the differences in the cumulative oil and water production are investigated for different starting water saturations.It is shown that when the initial water saturation grows,the water content of the block continues to rise and the cumulative oil production gradually decreases. 展开更多
关键词 Low-permeability reservoirs two-phase flow water cut start-up pressure gradient non-darcy flow
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An analytical model for water-oil two-phase flow in inorganic nanopores in shale oil reservoirs 被引量:2
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作者 Ran Li Zhangxin Chen +2 位作者 Keliu Wu Xing Hao Jinze Xu 《Petroleum Science》 SCIE CAS CSCD 2021年第6期1776-1787,共12页
The existence of water phase occupies oil flow area and impacts the confined oil flow behavior at the solid substrate in inorganic nanopores of shale oil reservoirs,resulting in a completely different flow pattern whe... The existence of water phase occupies oil flow area and impacts the confined oil flow behavior at the solid substrate in inorganic nanopores of shale oil reservoirs,resulting in a completely different flow pattern when compared with the single oil phase flow.This study proposes an analytical model to describe the water-oil two-phase flow.In this model,water slippage at the solid substrate is considered while oil slip is introduced to calculate the oil movement at the solid-oil boundary in dry conditions.It is proven that the oil flow profiles of both the two-phase model and single-phase model show parabolic shapes,but the oil flow capacity drops when water takes up the flow space and the impact of water is more significant when the pore dimension is smaller than 30 nm.Also,the oil flow velocity at a pore center is found to drop linearly given a larger water saturation in wet conditions.The effects of surface wettability and oil properties on water-oil flow are also discussed.Compared with the existing singlephase models,this model describes oil flow pattern in the wet condition with the incorporation of the influence of nanopore properties,which better predicts the oil transport in actual reservoir conditions.Water-oil relative permeability curves are also obtained to improve oil yield. 展开更多
关键词 Shale oil water films two-phase flow NANOPORE
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Experimental assessment of two-phase bubble pump for solar water heating 被引量:3
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作者 CHUNG Han-shik WOO Ju-sik +2 位作者 SHIN Yong-han KIM Jun-hyo JEONG Hyo-min 《Journal of Central South University》 SCIE EI CAS 2012年第6期1590-1599,共10页
The research goal is to develop a new solar water heater system(SWHS) that uses a solar bubble pump instead of an electric pump.The pump is powered by the steam produced from an evacuated tube collector.Therefore,heat... The research goal is to develop a new solar water heater system(SWHS) that uses a solar bubble pump instead of an electric pump.The pump is powered by the steam produced from an evacuated tube collector.Therefore,heat could be transferred downward from the collector to a hot water storage tank.The designed system consists of two sets of heat-pipe evacuated tube collectors,a solar bubble pump installed at an upper level and a water storage tank with a heat exchanger at a lower level.Discharge heads of 1 and 5 m were tested.The bubble pump could operate at the collector temperature of about 90-100 ℃ and vapor gage pressure of 80-90 kPa.It is found that water circulation within the SWHS depends on the incident solar intensity and system discharge head.Experimental investigations are conducted to obtain the system thermal efficiencies from the hourly,daily and long-term performance tests.The thermal performance of the proposed system is compared with conventional solar water heaters.The results show that the proposed system achieves system characteristic efficiency of 10% higher than that of the conventional systems using electric pump if taking the consumption of electric power into account.And the former is a zero carbon system. 展开更多
关键词 太阳能热水器 气泡泵 试验评价 性能测试系统 真空管集热器 贮热水箱 电力消耗 电动泵
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Aqueous Two-Phase Interfacial Assembly of COF Membranes for Water Desalination 被引量:1
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作者 Hongjian Wang Jiashuai Zhao +6 位作者 Yang Li Yu Cao Ziting Zhu Meidi Wang Runnan Zhang Fusheng Pan Zhongyi Jiang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第12期491-504,共14页
Aqueous two-phase system features with ultralow interfacial tension and thick interfacial region,affording unique confined space for membrane assembly.Here,for the first time,an aqueous two-phase interfacial assembly ... Aqueous two-phase system features with ultralow interfacial tension and thick interfacial region,affording unique confined space for membrane assembly.Here,for the first time,an aqueous two-phase interfacial assembly method is proposed to fabricate covalent organic framework(COF)membranes.The aqueous solution containing polyethylene glycol and dextran undergoes segregated phase separation into two water-rich phases.By respectively distributing aldehyde and amine monomers into two aqueous phases,a series of COF membranes are fabricated at water-water interface.The resultant membranes exhibit high NaCl rejection of 93.0-93.6% and water permeance reaching 1.7-3.7 L m^(−2) h^(−1) bar^(−1),superior to most water desalination membranes.Interestingly,the interfacial tension is found to have pronounced effect on membrane structures.The appropriate interfacial tension range(0.1-1.0 mN m^(−1))leads to the tight and intact COF membranes.Furthermore,the method is extended to the fabrication of other COF and metal-organic polymer membranes.This work is the first exploitation of fabricating membranes in all-aqueous system,confering a green and generic method for advanced membrane manufacturing. 展开更多
关键词 Covalent organic framework membranes Aqueous two-phase Interfacial polymerization Molecular separation water desalination
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Study on two-phase cloud dispersion from liquefied CO_(2) release
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作者 Chaojie Li Xianxin Fang +2 位作者 Meiling Sun Jihai Duan Weiwen Wang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第8期37-45,共9页
The knowledge of two-phase cloud dispersion mechanism from HLG(hazardous liquefied gas) release is the prerequisite for accurate assessment and precise rescue of such accidents. In this paper, an experiment of two-pha... The knowledge of two-phase cloud dispersion mechanism from HLG(hazardous liquefied gas) release is the prerequisite for accurate assessment and precise rescue of such accidents. In this paper, an experiment of two-phase cloud dispersion from liquefied CO_(2) hole release is performed. The source terms, such as vapour mass fraction, release velocity and mean droplet diameter, are calculated based on thermodynamic theory. Taking phase transition of CO_(2) droplets to gas into account, CFD(computational fluid dynamics) model for two-phase cloud dispersion is established. The predicted cloud temperatures at the downstream agree well with the experimental data, with the maximum relative error of 5.8% and average relative error of 2.3%. The consequence distances in the downstream direction and in the crosswise direction calculated through two-phase model are larger than those through single-phase model,with the relative differences of 57.8% and 53.6% respectively. CO_(2) concentration calculated by twophase model is smaller in the vicinity of release hole, and larger beyond 0.135 m downstream. A smaller leakage rate results in a lower CO_(2) concentration and a higher cloud temperature. 展开更多
关键词 two-phase cloud Carbon dioxide CFD DISPERSION Phase change
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Liquid-liquid two-phase flow in a wire-embedded concentric microchannel: Flow pattern and mass transfer performance
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作者 Ming Chen Huiyan Jiao +3 位作者 Jun Li Zhibin Wang Feng He Yang Jin 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第4期281-289,共9页
In this work, flow pattern and mass transfer of liquid-liquid two-phase flow in a wire-embedded concentric microchannel are studied using toluene-water system. Droplet flow, slug flow, oval flow and annular flow are o... In this work, flow pattern and mass transfer of liquid-liquid two-phase flow in a wire-embedded concentric microchannel are studied using toluene-water system. Droplet flow, slug flow, oval flow and annular flow are observed in the wire-embedded concentric microchannel. The effects of embedded wires and physical properties on flow patterns are investigated. The embedded wire insert is conducive to the formation of annular flow. The flow pattern distribution regions are distinguished by the Caaq(capillary number)±We_(org)(Weber number) flow pattern map. When Weorg<0.001, slug flow is the main flow pattern, and when Weorg>0.1, annular flow is the main flow pattern. Oval flow and droplet flow are between We_(org)= 0.001-0.1, and oval flow is transformed into droplet flow with the increase of Caaq. The effect of flow rate, phase ratio, initial acetic acid concentration, insert shape and flow patterns on mass transfers are studied. Mass transfer process is enhanced under annular flow conditions, the volumetric mass transfer coefficient is up to 0.36 s^(-1) because of the high interfacial area and interface renewal rate of annular flow. 展开更多
关键词 Flow pattern Mass transfer Microchannels two-phase flow
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Simulation of gas–liquid two-phase flow in a flow-focusing microchannel with the lattice Boltzmann method
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作者 冯凯 杨刚 张会臣 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第11期527-536,共10页
A lattice Boltzmann method for gas–liquid two-phase flow involving non-Newtonian fluids is developed. Bubble formation in a flow-focusing microchannel is simulated by the method. The influences of flow rate ratio, su... A lattice Boltzmann method for gas–liquid two-phase flow involving non-Newtonian fluids is developed. Bubble formation in a flow-focusing microchannel is simulated by the method. The influences of flow rate ratio, surface tension,wetting properties, and rheological characteristics of the fluid on the two-phase flow are analyzed. The results indicate that the flow pattern transfers from slug flow to dry-plug flow with a sufficiently small capillary number. Due to the presence of three-phase contact lines, the contact angle has a more significant effect on the dry-plug flow pattern than on the slug flow pattern. The deformation of the front and rear meniscus of a bubble in the shear-thinning fluid can be explained by the variation of the capillary number. The reduced viscosity and increased contact angle are beneficial for the drag reduction in a microchannel. It also demonstrates the effectiveness of the current method to simulate the gas–liquid two-phase flow in a microchannel. 展开更多
关键词 two-phase flow lattice Boltzmann method pressure drop flow-focusing microchannel
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Comprehensive modeling of frictional pressure drop during carbon dioxide two-phase flow inside channels using intelligent and conventional methods
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作者 Mohammad Amin Moradkhani Seyyed Hossein Hosseini Mengjie Song 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第11期108-119,共12页
Environmentally friendly nature of CO_(2),associated with its safety and high efficiency,has made it a widely used working fluid in heat exchangers.Since CO_(2)has strange thermophysical features,specific models are r... Environmentally friendly nature of CO_(2),associated with its safety and high efficiency,has made it a widely used working fluid in heat exchangers.Since CO_(2)has strange thermophysical features,specific models are required to estimate its two-phase characteristics,particularly frictional pressure drop(FPD).Herein,a widespread dataset,comprising 1195 experimental samples for two-phase FPD of CO_(2)was adopted from 10 sources to fulfill this requirement.The literature correlations failed to provide satisfactory precisions and exhibited the average absolute relative errors(AAREs)between 29.29% and 67.69% from the analyzed data.By inspiring the theoretical method of Lockhart and Martinelli,three intelligent FPD models were presented,among which the Gaussian process regression approach surpassed the others with AARE and R^(2)values of 5.48% and 98.80%,respectively in the test stage.A novel simple correlation was also derived based on the least square fitting method,which yielded opportune predictions with AARE of 19.76% for all data.The truthfulness of the newly proposed models was assessed through a variety of statistical and visual analyses,and the results affirmed their high reliability over a broad range of conditions,channel sizes and flow patterns.Furthermore,the novel models performed favorably in describing the physical attitudes corresponding to two-phase FPD of CO_(2).Eventually,the importance of operating factors in controlling the FPD was discussed through a sensitivity analysis. 展开更多
关键词 CO_(2) two-phase flow Frictional pressuredrop Intelligent approaches CORRELATION
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Characterisation and separation of infectious bursal disease virus-like particles using aqueous two-phase systems
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作者 Hui Yi Leong Xiao-Qian Fu +2 位作者 Xiang-Yu Liu Shan-Jing Yao Dong-Qiang Lin 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第5期72-78,共7页
Infectious bursal disease(IBD)causes considerable economic losses in the commercial poultry industry worldwide.The principal way to control IBD virus(IBDV),the causative agent of IBD,is still through vaccination progr... Infectious bursal disease(IBD)causes considerable economic losses in the commercial poultry industry worldwide.The principal way to control IBD virus(IBDV),the causative agent of IBD,is still through vaccination programs.Virus-like particles(VLPs)are recognised as a safe and potent recombinant vaccine platform.This research work explores the characterisation and separation of infectious bursal disease virus-like particles(IBD-VLPs)from crude feedstock.Various characteristics were studied with highperformance size-exclusion chromatography(HP-SEC),sodium dodecyl sulphate–polyacrylamide gel electrophoresis(SDS-PAGE)and transmission electron microscopy(TEM)analyses.Subsequently,the separation of IBD-VLPs using polyethylene glycol(PEG)/sodium citrate-based aqueous two-phase systems(ATPSs)was conducted and optimised.Moreover,a scale-up study of the best ATPS constituted of 15%PEG 6000,11%sodium citrate and 10%crude feedstock was performed to compare the separation performance of IBD-VLPs with and without centrifugation-assisted.The results indicated that the optimised ATPS with centrifugation-assisted for both 5 g and 50 g systems showed good recovery of IBDVLPs of>97%in the interphase between the PEG-rich top and salt-rich bottom phases.These optimised systems also showed high removal efficiencies of impurities of>95%.The results demonstrated that aqueous two-phase extraction could be a promising technology for efficient VLPs separation. 展开更多
关键词 Aqueous two-phase extraction Infectious bursal disease virus POLYMERS SALT SEPARATION Virus-like particle
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Performance analyses of two-phase closed thermosyphons for road embankments in the high-latitude permafrost regions
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作者 WANG Guan-fu LIN Chuang +3 位作者 ZHU Long FENG De-cheng XIN Yang-yang ZHANG Feng 《Journal of Mountain Science》 SCIE CSCD 2023年第11期3138-3153,共16页
Two-phase closed thermosyphons(TPCTs)are widely used in infrastructure constructions in permafrost regions.Due to different climatic conditions,the effectiveness of TPCT will also be different,especially in the extrem... Two-phase closed thermosyphons(TPCTs)are widely used in infrastructure constructions in permafrost regions.Due to different climatic conditions,the effectiveness of TPCT will also be different,especially in the extremely cold region of the Da Xing'anling Mountains.In this study,a series of three-dimensional finite element TPCT embankment models were established based on the ZhanglingMohe highway TPCT test section in Da Xing'anling Mountains,and the thermal characteristics and the cooling effect of the TPCTs were analyzed.The results indicated that the TPCTs installed in the northeastern high-latitude regions is effective in cooling and stabilizing the embankment.The working cycle of the TPCTs is nearly 7 months,and the cooling range of the TPCTs can reach 3 m in this region.However,due to the extremely low temperature,the TPCT generates a large radial gradient in the permafrost layer.Meanwhile,by changing the climate conditions,the same type of TPCT embankment located in the Da Xing'anling Mountains,the Xiao Xing'anling Mountains,and the Qinghai-Tibet Plateau permafrost regions were simulated.Based on the comparison of the climate differences between the Qinghai-Tibet Plateau and Northeast China,the differences in the effectiveness of TPCTs were studied.Finally,the limitations of using existing TPCTs in high-latitude permafrost regions of China were discussed and the potential improvements of the TPCT in cold regions were presented. 展开更多
关键词 PERMAFROST Highway embankment two-phase closed thermosyphon Numerical simulation Climatic condition Cooling performance
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Experimental Investigation of Regular or Wavy Two-Phase Flow in a Manifold
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作者 Xiaowei Nie Lihui Ma +7 位作者 Yiqiu Xu Dong Sun Weibo Zheng Liang Zhou Xiaodong Wang Xiaohan Zhang Weijia Dong Yunfei Li 《Fluid Dynamics & Materials Processing》 EI 2023年第1期37-50,共14页
An experimental study was conducted to investigate the properties of stratified regular or wavy two-phase flow in two parallel separators located after a manifold.A total of 103 experiments with various gas and liquid... An experimental study was conducted to investigate the properties of stratified regular or wavy two-phase flow in two parallel separators located after a manifold.A total of 103 experiments with various gas and liquid velocity combinations in three inlet pipes were conducted,including 77 groups of outlet pipe resistance symmetry and 26 groups of outlet pipe resistance asymmetry trials.The experimental results have revealed that when the gas-liquid flow rate is low,the degree of uneven splitting is high,and“extreme”conditions are attained.When the superficial gas velocity is greater than that established in the extreme case,the direction of the liquid-phase displacement is reversed,while that of the gas remains unchanged.Thus,the degree of gas phase bias tends to be mitigated with an increase in the gas velocity,while the uneven splitting degree of liquid approaches 10%.Finally,varying the gas-phase outlet pipe resistance is shown to effectively change the gas-liquid two-phase flow distribution. 展开更多
关键词 Uneven phase distribution two-phase flow MANIFOLD asymmetric resistance
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A two-phase type-curve method with multiscale fluid transport mechanisms in hydraulically fractured shale reservoirs
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作者 Feng-Yuan Zhang Lin-Jun Zou +3 位作者 Zhen-Hua Rui Hamid Emami-Meybodi Luis F.Ayala Zheng-Xin Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2023年第4期2253-2267,共15页
The quantitative understanding of hydraulic fracture(HF)properties guides accurate production forecasts and reserve estimation.Type curve is a powerful technique to characterize HF and reservoir properties from flowba... The quantitative understanding of hydraulic fracture(HF)properties guides accurate production forecasts and reserve estimation.Type curve is a powerful technique to characterize HF and reservoir properties from flowback and long-term production data.However,two-phase flow of water and hydrocarbon after an HF stimulation together with the complex transport mechanisms in shale nanopores exacerbate the nonlinearity of the transport equation,causing errors in type-curve analysis.Accordingly,we propose a new two-phase type-curve method to estimate HF properties,such as HF volume and permeability of fracture,through the analysis of flowback data of multi-fractured shale wells.The proposed type curve is based on a semianalytical solution that couples the two-phase flow from the matrix with the flow in HF by incorporating matrix influx,slippage effect,stress dependence,and the spatial variation of fluid properties in inorganic and organic pores.For the first time,multiple fluid transport mechanisms are considered into two-phase type-curve analysis for shale reservoirs.We analyze the flowback data from a multi-fractured horizontal well in a shale gas reservoir to verify the field application of the proposed method.The results show that the fracture properties calculated by the type-curve method are in good agreement with the long-time production data. 展开更多
关键词 Type curve two-phase flow Flowback analysis Fluid transport mechanisms Shale reservoir
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Experiments on two-phase flow in hydraulic jump on pebbled rough bed:Part 1–Turbulence properties and particle chord time and length
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作者 Farhad Bahmanpouri Carlo Gualtieri Hubert Chanson 《Water Science and Engineering》 EI CAS CSCD 2023年第4期359-368,共10页
This study reported and discussed turbulence characteristics,such as turbulence intensity,correlation time scales,and advective length scales.The characteristic air–water time scale,including the particle chord time ... This study reported and discussed turbulence characteristics,such as turbulence intensity,correlation time scales,and advective length scales.The characteristic air–water time scale,including the particle chord time and length and their probability density functions(PDFs),was investigated.The results demonstrated that turbulence intensity was relatively greater on a rough bed in the roller length,whereas further downstream,the decay rate was higher.In addition,the relationship between turbulence intensity and dimensionless bubble count rate reflected an increase in turbulence intensity associated with the number of entrained particles.Triple decomposition analysis(TDA)was performed to determine the contributions of slow and fast turbulent components.The TDA results indicated that,regardless of bed type and inflow conditions,the sum of the band-pass(T'_(u))and high-pass(T″_(u))filtered turbulence intensities was equal to the turbulence intensity of the raw signal data(T_(u)).T″_(u) highlighted a higher turbulence intensity and larger vorticities on the rough bed for an identical inflow Froude number.Additional TDA results were presented in terms of the interfacial velocity,auto-and cross-correlation time scales,and longitudinal advection length scale,with the effects of low-and high-frequency signal components on each highlighted parameter.The analysis of the air chord time indicated an increase in the proportion of small bubbles moving downstream.The second part of this research focused on the basic properties of particle grouping and clustering. 展开更多
关键词 Hydraulic jump Pebbled rough bed Turbulence intensity Particle chord time two-phase flow
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