Using a discretized finite difference method, a numerical model was developed to study the interaction of regular waves with a perforated breakwater. Considering a non-viscous, non-rotational fluid, the governing equa...Using a discretized finite difference method, a numerical model was developed to study the interaction of regular waves with a perforated breakwater. Considering a non-viscous, non-rotational fluid, the governing equations of Laplacian velocity potential were developed, and specific conditions for every single boundary were defined. The final developed model was evaluated based on an existing experimental result. The evaluated model was used to simulate the condition for various wave periods from 0.6 to 2 s. The reflection coefficient and transmission coefficient of waves were examined with different breakwater porosities, wave steepnesses, and angular frequencies. The results show that the developed model can suitably present the effect of the structural and hydraulic parameters on the reflection and transmission coefficients. It was also found that with the increase in wave steepness, the reflection coefficient increased logarithmically, while the transmission coefficient decreased logarithmically.展开更多
Inflammation is an established etiopathogenesis factor of infantile spasms（IS）, a therapy-resistant epileptic syndrome of infancy. We investigated the IS-associated transcriptomic alterations of neurotransmission in...Inflammation is an established etiopathogenesis factor of infantile spasms（IS）, a therapy-resistant epileptic syndrome of infancy. We investigated the IS-associated transcriptomic alterations of neurotransmission in rat hypothalamic arcuate nucleus, how they are corrected by antiinflamatory treatments and whether there are sex differences. IS was triggered by repeated intraperitoneal administration of N-methyl-D-aspartic acid following anti-inflammatory treatment（adreno-cortico-tropic-hormone（ACTH） or PMX53）or normal saline vehicle to prenatally exposed to betamethasone young rats. We found that treatments with both ACTH and PMX53 resulted in substantial recovery of the genomic fabrics of all types of synaptic transmission altered by IS. While ACTH represents the first line of treatment for IS, the even higher efficiency of PMX53（an antagonist of the complement C5 a receptor） in restoring the normal transcriptome was not expected. In addition to the childhood epilepsy, the recovery of the neurotransmission genomic fabrics by PMX53 also gives hope for the autism spectrum disorders that share a high comorbidity with IS. Our results revealed significant sex dichotomy in both IS-associated transcriptomic alterations（males more affected） and in the efficiency of PMX53 anti-inflammatory treatment（better for males）. Our data further suggest that anti-inflammatory treatments correcting alterations in the inflammatory transcriptome may become successful therapies for refractory epilepsies.展开更多
A hybrid algorithm is presented for nonuniform lossy multiconductor transmission lines (MTL) connected by arbitrary linear load networks. The networks are characterized by a state-variable equation which allows a gene...A hybrid algorithm is presented for nonuniform lossy multiconductor transmission lines (MTL) connected by arbitrary linear load networks. The networks are characterized by a state-variable equation which allows a general characterization of dynamic elements in the cascade networks. The method is achieved by the finite difference-time domain (FDTD) algorithm for the MTL, and the skin effect is taken into account, the more accurate method is used to compute the skin effect. And this method is combined with the computation of the nonuniform transmission lines. Finally, several numerical examples are given, these results indicate that: the current of the lossy MTL is smaller than the lossless of the MTL; and when the load networks contain the dynamic element, the transition time of the current is longer than the MTL connected by resistance only.展开更多
Reliability level of HVDC power transmission systems becomes an important factor impacting the entire power grid.The author analyzes the reliability of HVDC power transmission systems owned by SGCC since 2003 in respe...Reliability level of HVDC power transmission systems becomes an important factor impacting the entire power grid.The author analyzes the reliability of HVDC power transmission systems owned by SGCC since 2003 in respect of forced outage times,forced energy unavailability,scheduled energy unavailability and energy utilization eff iciency.The results show that the reliability level of HVDC power transmission systems owned by SGCC is improving.By analyzing different reliability indices of HVDC power transmission system,the maximum asset benef its of power grid can be achieved through building a scientif ic and reasonable reliability evaluation system.展开更多
The distributed parameters of the transmission lines have the significant impact to the signal propagation. In the conventional method of the distributed parameter extraction,the discontinuity of inverse trigonometric...The distributed parameters of the transmission lines have the significant impact to the signal propagation. In the conventional method of the distributed parameter extraction,the discontinuity of inverse trigonometric or hyperbolic can arise the problem about phase ambiguity which causes significant errors for transmission models. A difference iteration method（ DIM） is proposed for extracting distributed parameters of high frequency transmission line structure in order to overcome the phase ambiguity in the conventional method（ CM）. The formulations of the proposed method are first derived for two-conductor and multi-conductor lines. Then the validation is performed for the models of micro-strip transmission line. Numerical results demonstrate that the proposed DIM can solve the problem about the phase ambiguity and the extracted distributed parameters are accurate and efficient for a wide range of the frequencies of interest and line lengths.展开更多
文摘Using a discretized finite difference method, a numerical model was developed to study the interaction of regular waves with a perforated breakwater. Considering a non-viscous, non-rotational fluid, the governing equations of Laplacian velocity potential were developed, and specific conditions for every single boundary were defined. The final developed model was evaluated based on an existing experimental result. The evaluated model was used to simulate the condition for various wave periods from 0.6 to 2 s. The reflection coefficient and transmission coefficient of waves were examined with different breakwater porosities, wave steepnesses, and angular frequencies. The results show that the developed model can suitably present the effect of the structural and hydraulic parameters on the reflection and transmission coefficients. It was also found that with the increase in wave steepness, the reflection coefficient increased logarithmically, while the transmission coefficient decreased logarithmically.
基金supported by Citizens United for Research in Epilepsy (CURE) Infantile Spasms Research Initiative(to LV and DAI)NIH grant NS-072966(to LV)
文摘Inflammation is an established etiopathogenesis factor of infantile spasms（IS）, a therapy-resistant epileptic syndrome of infancy. We investigated the IS-associated transcriptomic alterations of neurotransmission in rat hypothalamic arcuate nucleus, how they are corrected by antiinflamatory treatments and whether there are sex differences. IS was triggered by repeated intraperitoneal administration of N-methyl-D-aspartic acid following anti-inflammatory treatment（adreno-cortico-tropic-hormone（ACTH） or PMX53）or normal saline vehicle to prenatally exposed to betamethasone young rats. We found that treatments with both ACTH and PMX53 resulted in substantial recovery of the genomic fabrics of all types of synaptic transmission altered by IS. While ACTH represents the first line of treatment for IS, the even higher efficiency of PMX53（an antagonist of the complement C5 a receptor） in restoring the normal transcriptome was not expected. In addition to the childhood epilepsy, the recovery of the neurotransmission genomic fabrics by PMX53 also gives hope for the autism spectrum disorders that share a high comorbidity with IS. Our results revealed significant sex dichotomy in both IS-associated transcriptomic alterations（males more affected） and in the efficiency of PMX53 anti-inflammatory treatment（better for males）. Our data further suggest that anti-inflammatory treatments correcting alterations in the inflammatory transcriptome may become successful therapies for refractory epilepsies.
文摘A hybrid algorithm is presented for nonuniform lossy multiconductor transmission lines (MTL) connected by arbitrary linear load networks. The networks are characterized by a state-variable equation which allows a general characterization of dynamic elements in the cascade networks. The method is achieved by the finite difference-time domain (FDTD) algorithm for the MTL, and the skin effect is taken into account, the more accurate method is used to compute the skin effect. And this method is combined with the computation of the nonuniform transmission lines. Finally, several numerical examples are given, these results indicate that: the current of the lossy MTL is smaller than the lossless of the MTL; and when the load networks contain the dynamic element, the transition time of the current is longer than the MTL connected by resistance only.
文摘Reliability level of HVDC power transmission systems becomes an important factor impacting the entire power grid.The author analyzes the reliability of HVDC power transmission systems owned by SGCC since 2003 in respect of forced outage times,forced energy unavailability,scheduled energy unavailability and energy utilization eff iciency.The results show that the reliability level of HVDC power transmission systems owned by SGCC is improving.By analyzing different reliability indices of HVDC power transmission system,the maximum asset benef its of power grid can be achieved through building a scientif ic and reasonable reliability evaluation system.
基金supported by the National Natural Science Foundation of China(61201082)the Youth Science and Engineering Planning Project of Communication University of China(3132018XNG1817)
文摘The distributed parameters of the transmission lines have the significant impact to the signal propagation. In the conventional method of the distributed parameter extraction,the discontinuity of inverse trigonometric or hyperbolic can arise the problem about phase ambiguity which causes significant errors for transmission models. A difference iteration method（ DIM） is proposed for extracting distributed parameters of high frequency transmission line structure in order to overcome the phase ambiguity in the conventional method（ CM）. The formulations of the proposed method are first derived for two-conductor and multi-conductor lines. Then the validation is performed for the models of micro-strip transmission line. Numerical results demonstrate that the proposed DIM can solve the problem about the phase ambiguity and the extracted distributed parameters are accurate and efficient for a wide range of the frequencies of interest and line lengths.
