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Application of Scaffolding Theory to Higher Vocational Students Classroom Interaction in English Teaching
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作者 罗晗 《海外英语》 2013年第12X期60-61,共2页
Scaffolding theory is one of the mature teaching methods of constructivism model . The effective interaction between teachers and students is one characteristic of scaffold teaching. This paper aims at combining scaff... Scaffolding theory is one of the mature teaching methods of constructivism model . The effective interaction between teachers and students is one characteristic of scaffold teaching. This paper aims at combining scaffolding theory with classroom interaction in teaching higher vocational students English to help students arouse interest and enhance their comprehensive ability in English learning. 展开更多
关键词 scaffolding THEORY CLASSROOM interaction HIGHER VO
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Effective Teaching and Learning: Scaffolding in Reading Class
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作者 岳宏艳 《海外英语》 2015年第22期287-288,共2页
This paper explores a teaching method—scaffolding in reading class, and also studies its background theories and proposes effective plans to carry out the scaffolding method. By this cooperative teaching and learning... This paper explores a teaching method—scaffolding in reading class, and also studies its background theories and proposes effective plans to carry out the scaffolding method. By this cooperative teaching and learning, students can not only complete teaching activities with the help of the teacher and students themselves, but also cultivate their abilities to use English and think critically. 展开更多
关键词 scaffolding READING PLAN
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The “Wrong Love” Between the Zone of Proximal Development and Scaffolding:An Interview With Prof.James P.Lantolf 被引量:8
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作者 Lili QIN 《Chinese Journal of Applied Linguistics》 2022年第1期138-149,152,共13页
The zone of proximal development(ZPD) and the scaffolding theory are very different,both in terms of their theoretical origins and connotations,and can even be said to be very different.However,during the development ... The zone of proximal development(ZPD) and the scaffolding theory are very different,both in terms of their theoretical origins and connotations,and can even be said to be very different.However,during the development of the two concepts,some scholars have misunderstood them,resulting in the two being mistaken for similar concepts and therefore often confused.Professor James Lantolf from Pennsylvania State University(State College,USA) was interviewed by Professor Lili Qin from Dalian University of Foreign Studies(Dalian,China) and provides an indepth analysis of these issues.The interview begins with the theoretical roots,connotations and definitions of the ZPD and scaffolding concepts,and then unravels the story of how they have been“mistakenly loved for life”,and ultimately it is made clear that the two concepts are completely different in their practical application to language teaching and should not continue to be used interchangeably. 展开更多
关键词 ZPD scaffolding Development INTERNALIZATION IMITATION
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Lexical Chunks as Scaffolding in College English Teaching
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作者 蒋素兰 《海外英语》 2012年第15期22-23,共2页
Lexical chunks minimize the language learners'burden of memorization and play a very important role in saving language pro cessing efforts so as to improve the learners'language fluency,appropriacy and idiomat... Lexical chunks minimize the language learners'burden of memorization and play a very important role in saving language pro cessing efforts so as to improve the learners'language fluency,appropriacy and idiomaticity.Lexical chunks are taken as"scaffolding"in college English teaching to effectively enhance learners'language proficiency. 展开更多
关键词 LEXICAL chunks scaffolding CHUNK COMPETENCE writin
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Undiscovered pathology of transient scaffolding remains a driver of failures in clinical trials
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作者 Alexander N Kharlamov 《World Journal of Cardiology》 CAS 2018年第10期165-186,共22页
AIM To statistically examine the released clinical trials and meta-analyses of polymeric bioresorbable scaffolds resuming the main accomplishments in the field with a translation to the routine clinical practice. METH... AIM To statistically examine the released clinical trials and meta-analyses of polymeric bioresorbable scaffolds resuming the main accomplishments in the field with a translation to the routine clinical practice. METHODS The statistical power in clinical trials such as ABSORB Japan, ABSORB China, EVERBIO II, AIDA, and few meta-analyses by the post hoc odds ratio-based sample size calculation, and the patterns of artery remodeling published in papers from ABSORB A and B trials were evaluated. RESULTS The phenomenal admiration from the first ABSORB studies in 2006-2013 was replaced by the tremendous disappointment in 2014-2017 due to reported relatively higher rates of target lesion failure(a mean prevalence of 9.16%) and device thrombosis(2.38%) in randomized controlled trials. Otherwise, bioresorbable vascular scaffold(BVS) performs as well as the metallic drugeluting stent(DES) with a trend toward some benefits for cardiac mortality [risk ratio(RR), 0.58-0.94, P > 0.05]. The underpowered design was confirmed for some studies such as ABSORB Japan, ABSORB China, EVERBIO Ⅱ, AIDA trials, and meta-analyses of Polimeni, Collet, and Mahmoud with some unintentional bias(judged by the asymmetrical Funnel plot). Scaffold thrombosis rates with Absorb BRS were comparable with DES performed with a so-called strategy of the BVS implantation with optimized pre-dilation(P), sizing(S) and post-dilation(P)(PSP) implantation(RR, PSP vs no PSP 0.37) achieving 0.35 per 100 patient-years, which is comparable to the RR 0.49 with bare-metal stents and the RR 1.06 with everolimus DES. Both ABSORB Ⅱ and ABSORB Ⅲ trials were powered enough for a five-year follow-up, but the results were not entirely conclusive due to the mostly non-significant fashion of data. The powered metaanalyses were built mostly on statistically poor findings. CONCLUSION The misunderstanding of the pathology of transient scaffolding drives the failures of the clinical trials. More bench studies of the vascular response are required. Several next-generation BVS including multifunctional electronic scaffold grant cardiology with a huge promise to make BVS technology great again. 展开更多
关键词 BIORESORBABLE scaffold Device THROMBOSIS Clinical outcomes Statistics INTRAVASCULAR imaging Arterial remodeling TRANSIENT scaffolding
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How to Promote Learner-Learner Scaffolding in ESL Classroom
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作者 周玥 《海外英语》 2016年第17期228-229,231,共3页
The current study attempts to investigate learner-learner scaffolding in ESL classroom.Analyzing how learners providing scaffolding with each other,and presenting methods how to promote learner-learner scaffolding.In ... The current study attempts to investigate learner-learner scaffolding in ESL classroom.Analyzing how learners providing scaffolding with each other,and presenting methods how to promote learner-learner scaffolding.In this paper,discourse analysis methodology utilized to carry out the research.In the study,the data collected from the transcripts of audio and video- recorded interaction during lessons in ESL classrooms at advanced level.The finding indicated that effective scaffolding among learners can promote their metacognition.It is hoped that the present study can serve to raise teachers' awareness of the importance of learner-learner scaffolding in English language teaching and learning. 展开更多
关键词 learner-learner scaffolding ESL classroom classroom interaction
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Insights into Nano-and Micro-Structured Scaffolds for Advanced Electrochemical Energy Storage 被引量:1
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作者 Jiajia Qiu Yu Duan +4 位作者 Shaoyuan Li Huaping Zhao Wenhui Ma Weidong Shi Yong Lei 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第7期187-230,共44页
Adopting a nano-and micro-structuring approach to fully unleashing the genuine potential of electrode active material benefits in-depth understandings and research progress toward higher energy density electrochemical... Adopting a nano-and micro-structuring approach to fully unleashing the genuine potential of electrode active material benefits in-depth understandings and research progress toward higher energy density electrochemical energy stor-age devices at all technology readiness levels.Due to various challenging issues,especially limited stability,nano-and micro-structured(NMS)electrodes undergo fast electrochemical performance degradation.The emerging NMS scaffold design is a pivotal aspect of many electrodes as it endows them with both robustness and electrochemical performance enhancement,even though it only occupies comple-mentary and facilitating components for the main mechanism.However,extensive efforts are urgently needed toward optimizing the stereoscopic geometrical design of NMS scaffolds to minimize the volume ratio and maximize their functionality to fulfill the ever-increasing dependency and desire for energy power source supplies.This review will aim at highlighting these NMS scaffold design strategies,summariz-ing their corresponding strengths and challenges,and thereby outlining the potential solutions to resolve these challenges,design principles,and key perspectives for future research in this field.Therefore,this review will be one of the earliest reviews from this viewpoint. 展开更多
关键词 Nano-and micro-structured Interconnected porous scaffolds Electrode design Electrochemical energy storage
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Discussion on Scaffolding Teaching Mode of Traditional Chinese Medicine under the Background of Internet
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作者 Ying MEI Fang CHEN +4 位作者 Ran ZHAO Ming LIU Dong LIU Zhibin JIANG Xiaogang LI 《Agricultural Biotechnology》 CAS 2023年第2期111-116,共6页
This study was conducted to explore the construction of scaffolding teaching mode of Traditional Chinese Medicine under the background of"Internet+".The students of Grade 2018 majoring in traditional Chinese... This study was conducted to explore the construction of scaffolding teaching mode of Traditional Chinese Medicine under the background of"Internet+".The students of Grade 2018 majoring in traditional Chinese medicine were selected as the object,and some chapters of the textbook of traditional Chinese medicine were selected and taught by the traditional teaching mode while interspersing the scaffolding teaching mode,in order to help the implementation of the scaffolding teaching model.We adopted the methods of setting up situational scaffolding,question scaffolding and guide scaffolding to carry out relevant teaching contents.The scaffolding instruction model has a good degree of participation,and to a certain extent,it stimulates students'self-consciousness and enthusiasm,and improves their ability of analyzing and solving problems and their spirit of innovation. 展开更多
关键词 Traditional Chinese medicine scaffolding teaching Internet+
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Critical Reflection:Using Peer Scaffolding to Facilitate Students' Awareness of Collaboration
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作者 郑丽婷 《海外英语》 2016年第5期187-189,共3页
Traditional spoon-fed teaching in English classroom has exposed students to a trouble where they might lack enough collaborative experiences of language use in solving daily problems.In order to solve the problem,teac... Traditional spoon-fed teaching in English classroom has exposed students to a trouble where they might lack enough collaborative experiences of language use in solving daily problems.In order to solve the problem,teachers are facing the challenge of prompting peer interaction within a scaffold.So the question of how to improve students’awareness of collaboration in English classes has become the main focus of this article.It will try to discuss about the concept of peer scaffolding while at the same time,reflect on a detailed lesson plan which uses it to raise students’awareness to cooperate in problem solving. 展开更多
关键词 PEER scaffolding AWARENESS of COLLABORATION LESSON PLAN
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Effects of Peer-scaffolding on EFL Students in Completing a Collaborative Oral Task
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作者 韩笑晨 《海外英语》 2017年第1期220-221,224,共3页
This mini research explored effects of peer-scaffolding on EFL students through a collaborative oral task. In general,there are two research questions. The first one is: What kind of peer scaffolding behaviors can be ... This mini research explored effects of peer-scaffolding on EFL students through a collaborative oral task. In general,there are two research questions. The first one is: What kind of peer scaffolding behaviors can be reflected from the two participants? While the other is: How do these peer scaffolding behaviors affect or help EFL students to complete the collaborative oral task? From the research, 10 scaffolding behaviors were analyzed and classified into 5 aspects. Meanwhile, effects of peer-scaffolding can be investigated from 5 aspects mentioned above. In short, all the peer-scaffolding behaviors in this study play a positive role in helping two participants to complete the task. 展开更多
关键词 Peer-scaffolding scaffolding behaviors Effects of peer-scaffolding
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Scaffolding Information of Learner’s Dictionaries for L2 Writing: A User Perspective
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作者 YANG Na LI Yan ZHENG Jie 《Sino-US English Teaching》 2021年第3期51-59,共9页
As a major resource and tool of language learning, learner’s dictionaries have provided sufficient information forL2 writing, which serves as a good guide of peer feedback. Hence, learner’s dictionaries are an indis... As a major resource and tool of language learning, learner’s dictionaries have provided sufficient information forL2 writing, which serves as a good guide of peer feedback. Hence, learner’s dictionaries are an indispensable partof scaffolding in the L2 writing feedback system. However, the effects of dictionary use in L2 writing have longbeen ignored either in L2 writing pedagogy or in learner lexicography. By applying the concept of “scaffolding” topeer feedback as the theoretical framework, this study first clarifies three distinct types of scaffolding informationpresented in current English learner’s dictionaries, and then makes an investigation into EFL learners’ perceptionand practical use of scaffolding information in their English writing. Results show that most EFL learners havepositive attitudes towards scaffolding information and its role in motivating effective feedback in English writing.But their practical use of such information is not satisfactory owing to their inadequate skills and knowledge ofdictionary use. This reflects a high demand of a dictionary use course in universities, which will help to raise EFLlearners’ dictionary use efficiency as well as improve English teachers’ lexicographical expertise in English writingpedagogy. 展开更多
关键词 scaffolding information learner’s dictionaries peer feedback
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Study on the Scaffolding Teaching of Three-dimensional Animation Foundation based on Modularization
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作者 Suran KONG 《International Journal of Technology Management》 2015年第3期110-112,共3页
In this paper, the teaching of course Three-dimensional Animation Foundation is designed mainly based on teaching content modularization and scaffolding teaching model. The modularized content design for Three-dimensi... In this paper, the teaching of course Three-dimensional Animation Foundation is designed mainly based on teaching content modularization and scaffolding teaching model. The modularized content design for Three-dimensional Animation Foundation is specifically expounded, and also the ideas for developing the scaffolding teaching model are analyzed. How to integrate the scaffolding teaching model into course teaching is introduced in details. Finally, new methods for guiding students to think independently in course teaching and improve students' self-awareness and self-learning ability are proposed. 展开更多
关键词 MODULARIZATION scaffolding model autonomous learning
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The Analysis of Scaffolding Instruction Application in Senior High School English Writing Teaching —— Based on Students of Zuoyun High School in Datong
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作者 雷叶华 《海外英语》 2019年第18期270-271,共2页
This study aims to investigate the relationship between English Writing achievement and scaffolding instruction with 100 Students from Zuoyun high school as subjects in a quantitative method.Results show that:1)On the... This study aims to investigate the relationship between English Writing achievement and scaffolding instruction with 100 Students from Zuoyun high school as subjects in a quantitative method.Results show that:1)On the whole,high school students have good use of scaffolding in English writing.2)The application of scaffolding instruction in high school English writing teaching has a significant positive correlation with English writing performance.3)On the whole,there is a significant difference in the application of the scaffolds in English writing between high and low-score group students. 展开更多
关键词 the application of scaffolding instruction English writing SCORES STUDENTS in Grade One of high school
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Application of Scaffolding Instructional Models to English Listening Comprehension
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作者 Xu Shuling 《International Journal of Technology Management》 2013年第7期34-36,共3页
The paper tries to research Scaffolding Instructional Model in listening English teaching. There will be the theoretical research of Scaffolding Instructional Model and then the findings confirmed by the questionnaire... The paper tries to research Scaffolding Instructional Model in listening English teaching. There will be the theoretical research of Scaffolding Instructional Model and then the findings confirmed by the questionnaire. The subjects in the experiment is a group of 80 students randomly selected from the Grade Three at a senior high school in Yili. The questionnaire I presents that the students are on the close level of English listening. They are divided into Experimental Group and Control Group. The Scaffolding Instructional Model will be used on the Experimental Group and Control Group will take the traditional teaching method. After four weeks two groups will attend the listening post-test and questionnaire II. According to the analysis of experimental data, the Experimental Group would get better listening comprehension grades than the Control Group. 展开更多
关键词 scaffolding instruction English listening teaching senior English
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Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images
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作者 Anil AAcar Evangelos Daskalakis +4 位作者 Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第1期74-87,共14页
Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering applications.The use of advanced ... Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering applications.The use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and scaffolds.However,these sophisticated techniques can be timeconsuming,labor-intensive,and expensive.Moreover,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma patients.In this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a patient.These modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during surgery.The proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or segmentation.This algorithm can generate both patient-specific and average bone models.Additionally,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or images.The algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM process.Guidelines and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects. 展开更多
关键词 Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds
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Application of Scaffolding in Combination with Other Teaching Strategies in Translation Lessons among Senior High School Students in China
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作者 Longxiang Shen Yu Zhao Shangyang Wang 《Journal of Contemporary Educational Research》 2021年第5期72-75,共4页
This study measures the effectiveness of combining group discussions,pre-questionings,or both with scaffolding teaching strategies in translation lessons based on Angelelli's translation competence model.However,i... This study measures the effectiveness of combining group discussions,pre-questionings,or both with scaffolding teaching strategies in translation lessons based on Angelelli's translation competence model.However,in practice,the feasibility of using the Angelelli’s scoring scale to measure translation competence requires further verification by other empirical studies.The results of this study are only for reference,in hope that future researchers may contribute to the improvement in this subject. 展开更多
关键词 scaffolding TRANSLATION Teaching
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Biological scaffold as potential platforms for stem cells:Current development and applications in wound healing
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作者 Jie-Yu Xiang Lin Kang +7 位作者 Zi-Ming Li Song-Lu Tseng Li-Quan Wang Tian-Hao Li Zhu-Jun Li Jiu-Zuo Huang Nan-Ze Yu Xiao Long 《World Journal of Stem Cells》 SCIE 2024年第4期334-352,共19页
Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address ... Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin regeneration.However,the use of stem cells in skin regeneration presents several challenges.Recently,stem cells and biomaterials have been identified as crucial components of the wound-healing process.Combination therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable attention.Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the ECM.These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing.This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine functions.Additionally,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity. 展开更多
关键词 Stem-cell-based therapy Biological scaffolds Wound healing Extracellular matrix mimicry Cellular activities enhancement scaffold characteristics
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3D-printed Mg-1Ca/polycaprolactone composite scaffolds with promoted bone regeneration
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作者 Xiao Zhao Siyi Wang +6 位作者 Feilong Wang Yuan Zhu Ranli Gu Fan Yang Yongxiang Xu Dandan Xia Yunsong Liu 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第3期966-979,共14页
In bone tissue engineering,polycaprolactone(PCL)is a promising material with good biocompatibility,but its poor degradation rate,mechanical strength,and osteogenic properties limit its application.In this study,we dev... In bone tissue engineering,polycaprolactone(PCL)is a promising material with good biocompatibility,but its poor degradation rate,mechanical strength,and osteogenic properties limit its application.In this study,we developed an Mg-1Ca/polycaprolactone(Mg-1Ca/PCL)composite scaffolds to overcome these limitations.We used a melt blending method to prepare Mg-1Ca/PCL composites with Mg-1Ca alloy powder mass ratios of 5,10,and 20 wt%.Porous scaffolds with controlled macro-and microstructure were printed using the fused deposition modeling method.We explored the mechanical strength,biocompatibility,osteogenesis performance,and molecular mechanism of the Mg-1Ca/PCL composites.The 5 and 10 wt%Mg-1Ca/PCL composites were found to have good biocompatibility.Moreover,they promoted the mechanical strength,proliferation,adhesion,and osteogenic differentiation of human bone marrow stem cells(hBMSCs)of pure PCL.In vitro degradation experiments revealed that the composite material stably released Mg_(2)+ions for a long period;it formed an apatite layer on the surface of the scaffold that facilitated cell adhesion and growth.Microcomputed tomography and histological analysis showed that both 5 and 10 wt%Mg-1Ca/PCL composite scaffolds promoted bone regeneration bone defects.Our results indicated that the Wnt/β-catenin pathway was involved in the osteogenic effect.Therefore,Mg-1Ca/PCL composite scaffolds are expected to be a promising bone regeneration material for clinical application.Statement of significance:Bone tissue engineering scaffolds have promising applications in the regeneration of critical-sized bone defects.However,there remain many limitations in the materials and manufacturing methods used to fabricate scaffolds.This study shows that the developed Ma-1Ca/PCL composites provides scaffolds with suitable degradation rates and enhanced boneformation capabilities.Furthermore,the fused deposition modeling method allows precise control of the macroscopic morphology and microscopic porosity of the scaffold.The obtained porous scaffolds can significantly promote the regeneration of bone defects. 展开更多
关键词 3D printing Bone tissue engineering MAGNESIUM OSTEOGENIC POLYCAPROLACTONE scaffold.
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Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering
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作者 Amit Kumar Singh Krishna Pramanik Amit Biswas 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第1期57-73,共17页
Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of... Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue regeneration.We experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and differentiation.The resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)printing.Morphological studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural stability.The scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue engineering.The tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of gelatin.The enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue regeneration.In vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold surface.In addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its potential for use in bone-tissue engineering. 展开更多
关键词 scaffold Biomaterial Sodium alginate CHITOSAN GELATIN 3D printing Tissue engineering
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In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds
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作者 Yanhao Hou Weiguang Wang Paulo Bartolo 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第5期651-669,共19页
Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field.Due to the intrinsic limitations of PCL,carbon nanomateria... Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field.Due to the intrinsic limitations of PCL,carbon nanomaterials are often investigated to reinforce the PCL scaffolds.Despite several studies that have been conducted on carbon nanomaterials,such as graphene(G)and graphene oxide(GO),certain challenges remain in terms of the precise design of the biological and nonbiological properties of the scaffolds.This paper addresses this limitation by investigating both the nonbiological(element composition,surface,degradation,and thermal and mechanical properties)and biological characteristics of carbon nanomaterial-reinforced PCL scaffolds for bone tissue engineering applications.Results showed that the incorporation of G and GO increased surface properties(reduced modulus and wettability),material crystallinity,crystallization temperature,and degradation rate.However,the variations in compressive modulus,strength,surface hardness,and cell metabolic activity strongly depended on the type of reinforcement.Finally,a series of phenomenological models were developed based on experimental results to describe the variations of scaffold’s weight,fiber diameter,porosity,and mechanical properties as functions of degradation time and carbon nanomaterial concentrations.The results presented in this paper enable the design of three-dimensional(3D)bone scaffolds with tuned properties by adjusting the type and concentration of different functional fillers. 展开更多
关键词 Additive manufacturing Bone tissue engineering Carbon nanomaterial GRAPHENE Graphene oxide scaffold
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